Nephrin and endothelial injury

Current Opinion in Nephrology and Hypertension

Volumn 18, Issue 1, 2009, Pages 3-8

  Hauser, Peter V ^a   Collino, Federica ^a   Bussolati, Benedetta ^a   Camussi, Giovanni ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

Author keywords

Endothelium; Nephrin; Podocytes; Preeclampsia; Renal injury

Indexed keywords

ANGIOTENSIN II; CYTOKINE; ENDOTHELIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHRIN; VASCULOTROPIN;

APOPTOSIS; CELL DAMAGE; CELL INTERACTION; CYTOSKELETON; DIABETES MELLITUS; DIABETIC NEPHROPATHY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; HUMAN; HYPERGLYCEMIA; HYPERTENSION; KIDNEY FAILURE; LIPID DIET; NONHUMAN; PODOCYTE; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEINURIA; REVIEW;

ANIMALS; DIABETIC NEPHROPATHIES; DIETARY FATS; ENDOTHELIAL CELLS; ENDOTHELIUM; FEMALE; HUMANS; HYPERTENSION; KIDNEY; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; PODOCYTES; PRE-ECLAMPSIA; PREGNANCY; SIGNAL TRANSDUCTION;

EID: 58149260236     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32831a4713     Document Type: Review

References (35)

1. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003; 83:253-307.
2. Kestila M, Lenkkeri U, Mannikko M, et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1:575-582.
3. Ruotsalainen V, Ljungberg P, Wartiovaara J, et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci USA 1999;96:7962-7967.
4. Rodewald R, Karnovsky MJ. Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 1974; 60:423-433.
5. Obeidova H, Merta M, Reiterova J, et al. Genetic basis of nephrotic syndrome: review. Prague Med Rep 2006; 107:5-16.
6. Jones N, Blasutig IM, Eremina V, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006; 440:818-823.
7. Palmen T, Ahola H, Palgi J, et al. Nephrin is expressed in the pancreatic beta cells. Diabetologia 2001; 44:1274-1280.
8. Zanone MM, Favaro E, Camussi G. From endothelial to Beta cells: insights into pancreatic islet microendothelium. Curr Diabetes Rev 2008; 4:1-9.
9. Camussi G, Mariano F, Biancone L, et al. Effect of cytokines on the cytoskeleton of resident glomerular cells. Kidney Int Suppl 1993; 39:S32-S36.
10. Garg P, Verma R, Holzman LB. Slit diaphragm junctional complex and regulation of the cytoskeleton. Nephron Exp Nephrol 2007; 106:e67-e72.
11. Ichimura K, Kurihara H, Sakai T. Actin filament organization of foot processes in vertebrate glomerular podocytes. Cell Tissue Res 2007; 329:541-557.
12. Schlondorff J. Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands. Kidney Int 2008; 73:524-526.
13. Doublier S, Ruotsalainen V, Salvidio G, et al. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 2001; 158:1723-1731.
14. • Zhu J, Sun N, Aoudjit L, et al. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 2008; 73:556-566. This article is the first demonstration of the mechanism involved in nephrinmediated actin reorganization.
15. Foster RR, Saleem MA, Mathieson PW, et al. Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. Am J Physiol Renal Physiol 2005; 288:F48-F57.
16. • Tapia R, Guan F, Gershin I, et al. Semaphorin3a disrupts podocyte foot processes causing acute proteinuria. Kidney Int 2008; 73:733-740. This article implicates for the first time semophorin3a in the regulation of the slit diaphragm.
17. Guan F, Villegas G, Teichman J, et al. Autocrine VEGF: a system in podocytes regulates podocin and its interaction with CD2AP. Am J Physiol Renal Physiol 2006; 291:F422-F428.
18. Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-658.
19. Levine PJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350:672-683.
20. Sugimoto H, Hamano Y, Charytan D, et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003; 278:12605-12608.
21. • Collino F, Bussolati B, Gerbaudo E, et al. Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. Am J Physiol Renal Physiol 2008; 294:F1185-F1194. This study shows the mechanism of nephrin loss induced by preeclamptic sera.
22. Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 2003; 52:1023-1030.
23. Liebau MC, Lang D, Bohm J, et al. Functional expression of the reninangiotensin system in human podocytes. Am J Physiol Renal Physiol 2006; 290:F710-F719.
24. •• Isermann B, Vinnikov IA, Madhusudhan T, et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007; 13:1349-1358. This study describes for the first time a protective role of activated protein C in diabetic nephropathy.
25. Durvasula RV, Shankland SJ. Activation of a local renin angiotensin system in podocytes by glucose. Am J Physiol Renal Physiol 2008; 294:F830-F839.
26. Ideura H, Hiromura K, Hiramatsu N, et al. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. Am J Physiol Renal Physiol 2007; 293:F1214-F1221.
27. Reiser J, Mundel P. Dual effects of RAS blockade on blood pressure and podocyte function. Curr Hypertens Rep 2007; 9:403-408.
28. Vaziri ND, Bai Y, Ni Z, et al. Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction. J Pharmacol Exp Ther 2007; 323:85-93.
29. Hoffmann S, Podlich D, Hahnel B, et al. Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats. J Am Soc Nephrol 2004; 15:1475-1487.
30. Sharma M, Sharma R, Greene AS, et al. Documentation of angiotensin II receptors in glomerular epithelial cells. Am J Physiol 1998; 274:F623-F627.
31. • Jia J, Ding G, Zhu J, et al. Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis. Am J Nephrol 2008; 28:500-507. The study provides a direct demonstration that angiotensin II alters the expression of nephrin in vivo.
32. •• Knight SF, Quigley JE, Yuan J, et al. Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet. Hypertension 2008; 51:352-359. This study shows the combined effect of high fat diet and hypertension on endothelial and renal dysfunction and implicates MCP-1 as the main mechanism.
33. Burt D, Salvidio G, Tarabra E, et al. The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes. Am J Pathol 2007; 171:1789-1799.
34. Chow F, Ozols E, Nikolic-Paterson DJ, et al. Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int 2004; 65:116-128.
35. Wada T, Yokoyama H, Furuichi K, et al. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). FASEB J 1996; 10:1418-1425.