Characterization of multiple constituents in Kai-Xin-San prescription and rat plasma after oral administration by liquid chromatography with quadrupole time-of-flight tandem mass spectrometry

Journal of Separation Science

Volumn 38, Issue 12, 2015, Pages 2068-2075

  Zhang, Xiaowen ^a   Li, Qing ^a   Lv, Chunxiao ^a   Xu, Huarong ^a   Liu, Xujia ^a   Sui, Zhenyu ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Kai Xin San; Traditional Chinese medicine; Ultra high performance liquid chromatography

Indexed keywords

BODY FLUIDS; CHEMICAL ANALYSIS; CHROMATOGRAPHY; DIAGNOSIS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MEDICINE; NEURODEGENERATIVE DISEASES; RATS; RESEARCH AIRCRAFT; SPECTROMETRY;

ALZHEIMER'S DISEASE; KAI-XIN-SAN; MASS SPECTROMETRY DATA; QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; QUADRUPOLE TIME-OF-FLIGHT TANDEM MASS SPECTROMETRIES; QUADRUPOLE-TIME-OF-FLIGHT MASS SPECTROMETER; TRADITIONAL CHINESE MEDICINE; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

LIQUID CHROMATOGRAPHY;

CHIKUSETSU SAPONIN; CHINESE DRUG; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 5; GINSENOSIDE RH 2; GINSENOSIDE RH 3; GINSENOSIDE RK1; HERBACEOUS AGENT; KAI XIN SAN; OLIGOSACCHARIDE; SAPONIN; TENUIFOLIOSE A; TENUIFOLIOSE C; TENUIFOLIOSE D; TENUIFOLIOSE E; TENUIFOLIOSE G; TENUIFOLIOSE H; TENUIFOLIOSE I; TENUIFOLIOSE J; TENUIFOLIOSE K; TENUIFOLIOSE L; TENUIFOLIOSE O; UNCLASSIFIED DRUG; UNINDEXED DRUG; ESTER; TERPENE;

ANIMAL EXPERIMENT; ARTICLE; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ALZHEIMER DISEASE; ANIMAL; BLOOD; BLOOD ANALYSIS; CHEMISTRY; CHINESE MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PLASMA; PROCEDURES; SPRAGUE DAWLEY RAT;

POLYGALA; RATTUS;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUGS, CHINESE HERBAL; ESTERS; MEDICINE, CHINESE TRADITIONAL; OLIGOSACCHARIDES; PLASMA; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TERPENES;

EID: 84931577494     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201500123     Document Type: Article

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