Overexpression of cutaneous mitochondrial superoxide dismutase in recent-onset type 2 diabetes

Diabetologia

Volumn 58, Issue 7, 2015, Pages 1621-1625

  Ziegler, Dan ^a,b   Strom, Alexander ^a   Brüggemann, Jutta ^a   Ziegler, Iris ^a   Ringel, Bernd ^a   Püttgen, Sonja ^a   Roden, Michael ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Heart rate variability; Oxidative stress; Peripheral nerve function; Superoxide dismutase; Sympathovagal balance; Type 2 diabetes

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL ENZYME; CD31 ANTIGEN; GLYCOSYLATED HEMOGLOBIN; SUPEROXIDE DISMUTASE;

ADULT; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENDOTHELIUM CELL; FEMALE; HEART RATE VARIABILITY; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; NERVE CONDUCTION; NERVE FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CONDUCTION; SKIN; SKIN BIOPSY; SKIN FUNCTION; ADRENERGIC SYSTEM; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HEART RATE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; VAGUS NERVE;

ANTIGENS, CD31; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; ENDOTHELIAL CELLS; FEMALE; HEART RATE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; NEURAL CONDUCTION; PERIPHERAL NERVES; PROSPECTIVE STUDIES; SKIN; SUPEROXIDE DISMUTASE; SYMPATHETIC NERVOUS SYSTEM; VAGUS NERVE;

EID: 84931577256     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3609-5     Document Type: Article

References (10)

1. Nishikawa T, Edelstein D, Du XL et al (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787–790
2. Zelko IN, Mariani TJ, Folz RJ (2002) Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33:337–349
3. Ziegler D, Papanas N, Zhivov A et al (2014) Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes. Diabetes 63:2454–2463
4. Dyck PJ, Albers JW, Andersen H et al (2011) Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev 27:620–628
5. Vincent AM, Russell JW, Sullivan KA et al (2007) SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy. Exp Neurol 208:216–227
6. Papanas N, Ziegler D (2014) Efficacy of α-lipoic acid in diabetic neuropathy. Expert Opin Pharmacother 15:2721–2731
7. Danson EJ, Paterson DJ (2006) Reactive oxygen species and autonomic regulation of cardiac excitability. J Cardiovasc Electrophysiol 17(Suppl 1):S104–S112
8. Manzella D, Barbieri M, Ragno E, Paolisso G (2001) Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes. Am J Clin Nutr 73:1052–1057
9. Chan SH, Chan JY (2012) Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone. J Appl Physiol 113:1921–1928
10. Quattrini C, Jeziorska M, Boulton AJ, Malik RA (2008) Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy. Diabetes Care 31:140–145