Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis

Rheumatology International

Volumn 35, Issue 8, 2015, Pages 1325-1333

  Quax, R A M ^a   Koper, J W ^a   Huisman, A M ^b   Weel, A ^a,c   Hazes, J M W ^a   Lamberts, S W J ^a   Feelders, R A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SINT FRANCISCUS GASTHUIS   (Netherlands)

^c Maasstad Hospital Rotterdam   (Netherlands)

Author keywords

Glucocorticoid receptor gene polymorphisms; Glucocorticoid sensitivity; Glucocorticoid induced transcript 1 gene polymorphisms; Rheumatoid arthritis

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN, HUMAN; NR3C1 PROTEIN, HUMAN;

ADULT; ALLELE; ALLELISM; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE; DRUG EFFICACY; DRUG SENSITIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE; GENE CONTROL; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOCORTICOID INDUCED TRANSCRIPT 1 GENE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MUSCULOSKELETAL SYSTEM EXAMINATION; MUSCULOSKELETAL SYSTEM PARAMETERS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RITCHIE ARTICULAR INDEX; SEX DIFFERENCE; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; AGED; ARTHRITIS, RHEUMATOID; COHORT ANALYSIS; GENETICS; HAPLOTYPE; SEVERITY OF ILLNESS INDEX;

ADULT; AGED; ARTHRITIS, RHEUMATOID; COHORT STUDIES; FEMALE; GLUCOCORTICOIDS; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, GLUCOCORTICOID; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84931575910     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-015-3235-z     Document Type: Article

References (28)

1. van der Linden MP, le Cessie S, Raza K, van der Woude D, Knevel R, Huizinga TW, van der Helm-van Mil AH (2010) Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheum 62(12):3537–3546. doi:10.1002/art.27692
2. Kyburz D, Gabay C, Michel BA, Finckh A (2011) The long-term impact of early treatment of rheumatoid arthritis on radiographic progression: a population-based cohort study. Rheumatology 50(6):1106–1110. doi:10.1093/rheumatology/keq424 (Oxford)
3. Finckh A, Liang MH, van Herckenrode CM, de Pablo P (2006) Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: a meta-analysis. Arthritis Rheum 55(6):864–872. doi:10.1002/art.22353
4. Nell VP, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS (2004) Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology 43(7):906–914. doi:10.1093/rheumatology/keh199 (Oxford)
5. de Jong PH, Quax RA, Huisman M, Gerards AH, Feelders RA, de Sonnaville PB, Luime JJ, Weel AE, Hazes JM (2012) Response to glucocorticoids at 2 weeks predicts the effectiveness of DMARD induction therapy at 3 months: post hoc analyses from the tREACH study. Ann Rheum Dis. doi:10.1136/annrheumdis-2012-202152
6. Quax RA, Manenschijn L, Koper JW, Hazes JM, Lamberts SW, van Rossum EF, Feelders RA (2013) Glucocorticoid sensitivity in health and disease. Nat Rev Endocrinol 9(11):670–686. doi:10.1038/nrendo.2013.183
7. Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF Jr, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST (2011) Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med 365(13):1173–1183. doi:10.1056/NEJMoa0911353
8. De Iudicibus S, Stocco G, Martelossi S, Londero M, Ebner E, Pontillo A, Lionetti P, Barabino A, Bartoli F, Ventura A, Decorti G (2011) Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases. J Clin Gastroenterol 45(1):e1–e7. doi:10.1097/MCG.0b013e3181e8ae93
9. Manenschijn L, van den Akker EL, Lamberts SW, van Rossum EF (2009) Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci 1179:179–198. doi:10.1111/j.1749-6632.2009.05013.x
10. Russcher H, van Rossum EF, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW (2005) Increased expression of the glucocorticoid receptor-a translational isoform as a result of the ER22/23EK polymorphism. Mol Endocrinol 19(7):1687–1696. doi:10.1210/me.2004-0467
11. van den Akker EL, Russcher H, van Rossum EF, Brinkmann AO, de Jong FH, Hokken A, Pols HA, Koper JW, Lamberts SW (2006) Glucocorticoid receptor polymorphism affects transrepression but not transactivation. J Clin Endocrinol Metab 91(7):2800–2803. doi:10.1210/jc.2005-2119
12. Derijk RH, Schaaf MJ, Turner G, Datson NA, Vreugdenhil E, Cidlowski J, de Kloet ER, Emery P, Sternberg EM, Detera-Wadleigh SD (2001) A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol 28(11):2383–2388
13. Claessen SJ, Hazes JM, Huisman MA, van Zeben D, Luime JJ, Weel AE (2009) Use of risk stratification to target therapies in patients with recent onset arthritis; design of a prospective randomized multicenter controlled trial. BMC Musculoskelet Disord 10:71. doi:10.1186/1471-2474-10-71
14. Bingham CO 3rd, Pohl C, Woodworth TG, Hewlett SE, May JE, Rahman MU, Witter JP, Furst DE, Strand CV, Boers M, Alten RE (2009) Developing a standardized definition for disease “flare” in rheumatoid arthritis (OMERACT 9 Special Interest Group). J Rheumatol 36(10):2335–2341. doi:10.3899/jrheum.090369
15. Van Riel PL, van Gestel AM, Scott DG (2000) Interpreting disease course. In: van Riel PL, van Gestel AM, Scott DG (eds) EULAR handbook of clinical assessments of disease activity in rheumatoid arthritis. van Zuiden Communications, Alphen aan den Rijn, pp 39–43
16. van Oosten MJ, Dolhain RJ, Koper JW, van Rossum EF, Emonts M, Han KH, Wouters JM, Hazes JM, Lamberts SW, Feelders RA (2010) Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis. Arthritis Res Ther 12(4):R159. doi:10.1186/ar3118
17. Barnes PJ, Adcock IM (2009) Glucocorticoid resistance in inflammatory diseases. Lancet 373(9678):1905–1917. doi:10.1016/S0140-6736(09)60326-3
18. Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, Combe B, Cutolo M, de Wit M, Dougados M, Emery P, Gibofsky A, Gomez-Reino JJ, Haraoui B, Kalden J, Keystone EC, Kvien TK, McInnes I, Martin-Mola E, Montecucco C, Schoels M, van der Heijde D (2010) Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 69(4):631–637. doi:10.1136/ard.2009.123919
19. Smolen JS, Landewe R, Breedveld FC, Dougados M, Emery P, Gaujoux-Viala C, Gorter S, Knevel R, Nam J, Schoels M, Aletaha D, Buch M, Gossec L, Huizinga T, Bijlsma JW, Burmester G, Combe B, Cutolo M, Gabay C, Gomez-Reino J, Kouloumas M, Kvien TK, Martin-Mola E, McInnes I, Pavelka K, van Riel P, Scholte M, Scott DL, Sokka T, Valesini G, van Vollenhoven R, Winthrop KL, Wong J, Zink A, van der Heijde D (2010) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 69(6):964–975. doi:10.1136/ard.2009.126532
20. van den Berge M, Hiemstra PS, Postma DS (2011) Genetics of glucocorticoids in asthma. N Engl J Med 365(25):2434–2435. doi:10.1056/NEJMc1112547#SA1
21. Chapman MS, Askew DJ, Kuscuoglu U, Miesfeld RL (1996) Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Mol Endocrinol 10(8):967–978
22. Forslind K, Hafstrom I, Ahlmen M, Svensson B (2007) Sex: a major predictor of remission in early rheumatoid arthritis? Ann Rheum Dis 66(1):46–52. doi:10.1136/ard.2006.056937
23. Hyrich KL, Watson KD, Silman AJ, Symmons DP (2006) Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology 45(12):1558–1565. doi:10.1093/rheumatology/kel149 (Oxford)
24. Mancarella L, Bobbio-Pallavicini F, Ceccarelli F, Falappone PC, Ferrante A, Malesci D, Massara A, Nacci F, Secchi ME, Manganelli S, Salaffi F, Bambara ML, Bombardieri S, Cutolo M, Ferri C, Galeazzi M, Gerli R, Giacomelli R, Grassi W, Lapadula G, Cerinic MM, Montecucco C, Trotta F, Triolo G, Valentini G, Valesini G, Ferraccioli GF (2007) Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA study. J Rheumatol 34(8):1670–1673
25. Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, Skakic V, Badsha H, Peets T, Baranauskaite A, Geher P, Ujfalussy I, Skopouli FN, Mavrommati M, Alten R, Pohl C, Sibilia J, Stancati A, Salaffi F, Romanowski W, Zarowny-Wierzbinska D, Henrohn D, Bresnihan B, Minnock P, Knudsen LS, Jacobs JW, Calvo-Alen J, Lazovskis J, Pinheiro Gda R, Karateev D, Andersone D, Rexhepi S, Yazici Y, Pincus T (2009) Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study. Arthritis Res Ther 11(1):R7. doi:10.1186/ar2591
26. Ordovas JM (2007) Gender, a significant factor in the cross talk between genes, environment, and health. Gend Med 4 Suppl B:S111–S122. doi:10.1016/S1550-8579(07)80052-0
27. Harbuz MS, Jessop DS (1999) Is there a defect in cortisol production in rheumatoid arthritis? Rheumatology 38(4):298–302 (Oxford)
28. Maltese P, Palma L, Sfara C, de Rocco P, Latiano A, Palmieri O, Corritore G, Annese V, Magnani M (2012) Glucocorticoid resistance in Crohn’s disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms. Pharmacogenomics J 12(5):432–438. doi:10.1038/tpj.2011.26