Glucocorticoid resistance in Crohn's disease and ulcerative colitis: An association study investigating GR and FKBP5 gene polymorphisms

Pharmacogenomics Journal

Volumn 12, Issue 5, 2012, Pages 432-438

  Maltese, P ^a   Palma, L ^a   Sfara, C ^a   De Rocco, P ^a   Latiano, A ^b   Palmieri, O ^b   Corritore, G ^b   Annese, V ^c   Magnani, M ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

FKBP5; glucocorticoid receptor; glucocorticoid therapy; inflammatory bowel disease; single nucleotide polymorphisms

Indexed keywords

GENOMIC DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PREDNISONE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DNA DENATURATION; DRUG EFFICACY; FEMALE; FKB5 GENE; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GR GENE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GENETIC ASSOCIATION STUDIES; GLUCOCORTICOIDS; HUMANS; MALE; METABOLISM, INBORN ERRORS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID; TACROLIMUS BINDING PROTEINS;

EID: 84866738606     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2011.26     Document Type: Article

References (33)

1. Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol 2003; 178: 339-346.
2. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009; 373: 1905-1917.
3. Zhang X, Clark AF, Yorio T. FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest Ophthalmol Vis Sci 2008; 49: 1037-1047.
4. Chrousos GP, Renquist D, Brandon D, Eil C, Pugeat M, Vigersky R et al. Glucocorticoid hormone resistance during primate evolution: receptormediated mechanisms. Proc Natl Acad Sci USA 1982; 79: 2036-2040.
5. Denny WB, Valentine DL, Reynolds PD, Smith DF, Scammell JG. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 2000; 141: 4107-4113.
6. Fuller PJ, Smith BJ, Rogerson FM. Cortisol resistance in the New World revisited. Trends Endocrinol Metab 2004; 15: 296-299.
7. Reynolds PD, Ruan Y, Smith DF, Scammell JG. Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. J Clin Endocrinol Metab 1999; 84: 663-669.
8. Wochnik GM, Ruegg J, Abel GA, Schmidt U, Holsboer F, Rein T. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem 2005; 280: 4609-4616.
9. Koenen KC, Saxe G, Purcell S, Smoller JW, Bartholomew D, Miller A et al. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry 2005; 10: 1058-1059.
10. Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008; 299: 1291-1305.
11. Kirchheiner J, Lorch R, Lebedeva E, Seeringer A, Roots I, Sasse J et al. Genetic variants in FKBP5 affecting response to antidepressant drug treatment. Pharmacogenomics 2008; 9: 841-846.
12. Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS et al. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry 2009; 14: 261-268.
13. Binder EB. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009; 34(Suppl 1): S186-S195.
14. Tatro ET, Everall IP, Masliah E, Hult BJ, Lucero G, Chana G et al. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J Neuroimmune Pharmacol 2009; 4: 218-226.
15. Zobel A, Schuhmacher A, Jessen F, Hofels S, von WO, Metten M et al. DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int J Neuropsychopharmacol 2010; 13: 649-660.
16. Wust S, van Rossum EF, Federenko IS, Koper JW, Kumsta R, Hellhammer DH. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 2004; 89: 565-573.
17. Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 2007; 62: 863-869.
18. van Rossum EF, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W et al. Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med 2004; 117: 158-162.
19. Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S et al. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 2008; 28: 389-398.
20. Vermeer H, Hendriks-Stegeman BI, van SD, Rijkers GT, van Buul-Offers SC, Jansen M. An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Mol Cell Endocrinol 2004; 218: 49-55.
21. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007; 104: 15858-15863.
22. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429.
23. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19(Suppl A): 5-36.
24. Orlando A, Armuzzi A, Papi C, Annese V, Ardizzone S, Biancone L et al. The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guidelines: the use of tumor necrosis factor-alpha antagonist therapy in inflammatory bowel disease. Dig Liver Dis 2011; 43: 1-20.
25. Maltese P, Canestrari E, Palma L, Ruzzo A, Corini F, Menotta M et al. High resolution melting (HRM) analysis for the detection of ER22/23EK, BclI, and N363S polymorphisms of the glucocorticoid receptor gene. J Steroid Biochem Mol Biol 2009; 113: 269-274.
26. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
27. Summers RW, Switz DM, Sessions Jr JT, Becktel JM, Best WR, Kern Jr F et al. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology 1979; 77: 847-869.
28. Malchow H, Ewe K, Brandes JW, Goebell H, Ehms H, Sommer H et al. European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment. Gastroenterology 1984; 86: 249-266.
29. Goebell H, Forster S, Dirks E, Hotz J, Schaarschmidt K, Eigler FW. Crohn disease: clinical disease pattern in relation to site. A prospective analysis of 300 patients]. Med Klin (Munich) 1987; 82: 1-8.
30. Goldberg HI, Caruthers Jr SB, Nelson JA, Singleton JW. Radiographic findings of the National Cooperative Crohn's Disease Study. Gastroenterology 1979; 77: 925-937.
31. Zou YF, Wang F, Feng XL, Li WF, Tao JH, Pan FM et al. Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders. Neurosci Lett 2010; 484: 56-61.
32. Hawkins GA, Lazarus R, Smith RS, Tantisira KG, Meyers DA, Peters SP et al. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol 2009; 123: 1376-1383.
33. Ririe KM, Rasmussen RP, Wittwer CT. Product differentiation by analysis of DNA melting curves during the polymerase chain reaction. Anal Biochem 1997; 245: 154-160.