Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management

Resuscitation

Volumn 92, Issue , 2015, Pages 154-159

  Gagnon, David J ^a   Nielsen, Niklas ^b   Fraser, Gilles L ^a   Riker, Richard R ^a   Dziodzio, John ^a   Sunde, Kjetil ^c   Hovdenes, Jan ^d   Stammet, Pascal ^e   Friberg, Hans ^f   Rubertsson, Sten ^g   Wanscher, Michael ^h   Seder, David B ^a  

^a MAINE MEDICAL CENTER   (United States)

^b HELSINGBORG HOSPITAL   (Sweden)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e CENTRE HOSPITALIER DE LUXEMBOURG   (Luxembourg)

^f LUND UNIVERSITY   (Sweden)

^g UPPSALA UNIVERSITY   (Sweden)

^h University of Copenhagen   (Denmark)

Author keywords

Antibiotics; Cardiac arrest; Hypothermia; Intensive care; Pneumonia; Temperature

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BRAIN INJURY; COHORT ANALYSIS; COMATOSE PATIENT; CONTROLLED STUDY; FEMALE; GLASGOW COMA SCALE; HEART ARREST; HOSPITAL ADMISSION; HUMAN; HYPOTHERMIA; INCIDENCE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGISTER; RETROSPECTIVE STUDY; RETURN OF SPONTANEOUS CIRCULATION; RHYTHM; SEPSIS; SURVIVOR; TARGETED TEMPERATURE MANAGEMENT; ADVERSE EFFECTS; BODY TEMPERATURE; CLINICAL TRIAL; EUROPE; FOLLOW UP; INDUCED HYPOTHERMIA; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; RESUSCITATION; UNITED STATES;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BODY TEMPERATURE; CARDIOPULMONARY RESUSCITATION; EUROPE; FEMALE; FOLLOW-UP STUDIES; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; INCIDENCE; MALE; MIDDLE AGED; PNEUMONIA; REGISTRIES; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 84931570209     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2015.01.035     Document Type: Article

References (39)

1. Peberdy M.A., Callaway C.W., Neumar R.W., et al. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122:S768-S786.
2. Nolan J.P., Morley P.T., Vanden Hoek T.L., et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003, 108:118-121.
3. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556. Hypothermia after Cardiac Arrest Study Group.
4. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563.
5. MacLaren R., Gallagher J., Shin J., Varnado S., Nguyen L. Assessment of adverse events and predictors of neurological recovery after therapeutic hypothermia. Ann Pharmacother 2014, 48:17-25.
6. Nielsen N., Sunde K., Hovdenes J., et al. Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia. Crit Care Med 2011, 39:57-64.
7. Noyes A.M., Lundbye J.B. Managing the complications of mild therapeutic hypothermia in the cardiac arrest patient. J Intensive Care Med 2013, pii:0885066613516416 [Epub ahead of print].
8. Jarrah S., Dziodzio J., Lord C., et al. Surface cooling after cardiac arrest: effectiveness, skin safety, and adverse events in routine clinical practice. Neurocrit Care 2011, 14:382-388.
9. Soleimanpour H., Rahmani F., Golzari S.E., Safari S. Main complications of mild induced hypothermia after cardiac arrest: a review article. J Cardiovasc Thorac Res 2014, 6:1-8.
10. Xiao G., Guo Q., Shu M., et al. Safety profile and outcome of mild therapeutic hypothermia in patients following cardiac arrest: systematic review and meta-analysis. Emerg Med J 2013, 30:91-100.
11. Mongardon N., Perbet S., Lemiale V., et al. Infectious complications in out-of-hospital cardiac arrest patients in the therapeutic hypothermia era. Crit Care Med 2011, 39:1359-1364.
12. Tsai M.S., Chiang W.C., Lee C.C., et al. Infections in the survivors of out-of-hospital cardiac arrest in the first 7 days. Intensive Care Med 2005, 31:621-626.
13. Geurts M., Macleod M.R., Kollmar R., Kremer P.H., van der Worp H.B. Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis. Crit Care Med 2014, 42:231-242.
14. Gajic O., Festic E., Afessa B. Infectious complications in survivors of cardiac arrest admitted to the medical intensive care unit. Resuscitation 2004, 60:65-69.
15. Nielsen N., Hovdenes J., Nilsson F., et al. Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. Acta Anaesthesiol Scand 2009, 53:926-934.
16. Woo J.H., Lim Y.S., Yang H.J., et al. Factors associated with pneumonia in post-cardiac arrest patients receiving therapeutic hypothermia. Am J Emerg Med 2014, 32:150-155.
17. Perbet S., Mongardon N., Dumas F., et al. Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. Am J Respir Crit Care Med 2011, 184:1048-1054.
18. Nielsen N., Wetterslev J., Cronberg T., et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013, 369:2197-2206.
19. Kalanuria A., Zai W., Mirski M. Ventilator-associated pneumonia in the ICU. Crit Care 2014, 18:208.
20. Sirvent J.M., Torres A., El-Ebiary M., Castro P., de Batlle J., Bonet A. Protective effect of intravenously administered cefuroxime against nosocomial pneumonia in patients with structural coma. Am J Respir Crit Care Med 1997, 155:1729-1734.
21. Acquarolo A., Urli T., Perone G., Giannotti C., Candiani A., Latronico N. Antibiotic prophylaxis of early onset pneumonia in critically ill comatose patients. A randomized study. Intensive Care Med 2005, 31:510-516.
22. Langhelle A., Nolan J., Herlitz J., et al. Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care: the Utstein style. Resuscitation 2005, 66:271-283.
23. Jennett B., Bond M. Assessment of outcome after severe brain damage. Lancet 1975, 1:480-484.
24. Moss M., Wellman D.A., Cotsonis G.A. An appraisal of multivariable logistic models in the pulmonary and critical care literature. Chest 2003, 123:923-928.
25. Arrich J., Holzer M., Havel C., Müllner M., Herkner H. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2012, 9:CD004128.
26. Hong J.M., Lee J.S., Song H.J., Jeong H.S., Choi H.A., Lee K. Therapeutic hypothermia after recanalization in patients with acute ischemic stroke. Stroke 2014, 45:134-140.
27. Crossley S., Reid J., McLatchie R., et al. A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury. Crit Care 2014, 18:R75.
28. Levi A.D., Green B.A., Wang M.Y., et al. Clinical application of modest hypothermia after spinal cord injury. J Neurotrauma 2009, 26:407-415.
29. Stravitz R.T., Lee W.M., Kramer A.H., Kramer D.J., Hynan L., Blei A.T. Therapeutic hypothermia for acute liver failure: toward a randomized, controlled trial in patients with advanced hepatic encephalopathy. Neurocrit Care 2008, 9:90-96.
30. Seule M.A., Muroi C., Mink S., Yonekawa Y., Keller E. Therapeutic hypothermia in patients with aneurysmal subarachnoid hemorrhage, refractory intracranial hypertension, or cerebral vasospasm. Neurosurgery 2009, 64:86-92.
31. Adrie C., Adib-Conquy M., Laurent I., et al. Successful cardiopulmonary resuscitation after cardiac arrest as a sepsis-like syndrome. Circulation 2002, 106:562-568.
32. Vincent J.L., Zambon M. Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management. Clin Chest Med 2006, 27:725-731.
33. Bronchard R., Albaladejo P., Brezac G., et al. Early onset pneumonia: risk factors and consequences in head trauma patients. Anesthesiology 2004, 100:234-239.
34. Seder D.B., Van der Kloot T.E. Methods of cooling: practical aspects of therapeutic temperature management. Crit Care Med 2009, 37:S211-S222.
35. Zygun D.A., Zuege D.J., Boiteau P.J., et al. Ventilator-associated pneumonia in severe traumatic brain injury. Neurocrit Care 2006, 5:108-114.
36. Rello J., Ollendorf D.A., Oster G., et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002, 122:2115-2121.
37. Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications (ANTHARTIC) Clinicaltrials.gov (accessed October 28, 2014).
38. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171:388-416. American Thoracic Society, Infectious Diseases Society of America.
39. Torres A., Ewig S., Lode H., Carlet J. Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med 2009, 35:9-29. European HAP Working Group.