Paracrine regulation of glioma cells invasion by astrocytes is mediated by glial-derived neurotrophic factor

International Journal of Cancer

Volumn 137, Issue 5, 2015, Pages 1012-1020

  Shabtay Orbach, Ayelet ^a   Amit, Moran ^a,b   Binenbaum, Yoav ^a   Na'Ara, Shorook ^a,b   Gil, Ziv ^a,b  

^a Clinical Research Center at Rambam   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

astrocytes; glial derived neurotrophic factor; glioma; invasion; MAPK; RET

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ENZYME INHIBITOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; PROTEIN KINASE B; PYRAZOLOPYRIMIDINE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CULTURE MEDIUM; PROTEIN RET;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE COURSE; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; FEMALE; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; ONCOGENE RET; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR INVASION; TUMOR VOLUME; ANIMAL; BRAIN TUMOR; CELL MOTION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHARMACOLOGY; PHOSPHORYLATION; SECRETION (PROCESS); TUMOR CELL LINE;

ANIMALS; ASTROCYTES; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; GLIOMA; HUMANS; MICE; PARACRINE COMMUNICATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RET;

EID: 84931568285     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29380     Document Type: Article

References (49)

1. Hess KR, Broglio KR, Bondy ML,. Adult glioma incidence trends in the United States, 1977-2000. Cancer 2004; 101: 2293-9.
2. Deorah S, Lynch CF, Sibenaller ZA, et al., Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 2006; 20: E1.
3. Giese A, Bjerkvig R, Berens ME, et al., Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol 2003; 21: 1624-36.
4. Hoelzinger DB, Demuth T, Berens ME,. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst 2007; 99: 1583-93.
5. Nakada M, Nakada S, Demuth T, et al., Molecular targets of glioma invasion. Cell Mol Life Sci 2007; 64: 458-78.
6. Zhang M, Olsson Y,. Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain. Expression of endothelin-like immunoreactivity in reactive astrocytes and activation of microglial cells. J Neurol Sci 1995; 134: 26-32.
7. Adamek D, Radwanska E, Gajda M,. Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. Folia Neuropathol 2009; 47: 240-6.
8. Wierzba-Bobrowicz T, Kuchna I, Matyja E,. Reaction of microglial cells in human astrocytomas (preliminary report). Folia Neuropathol 1994; 32: 251-2.
9. Zhang M, Olsson Y,. Hematogenous metastases of the human brain-characteristics of peritumoral brain changes: a review. J Neurooncol 1997; 35: 81-9.
10. Marchetti D, Li J, Shen R,. Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res 2000; 60: 4767-70.
11. Rao JS,. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 2003; 3: 489-501.
12. Sierra A, Price JE, Garcia-Ramirez M, et al., Astrocyte-derived cytokines contribute to the metastatic brain specificity of breast cancer cells. Lab Invest 1997; 77: 357-68.
13. Beck KD, Valverde J, Alexi T, et al., Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 1995; 373: 339-41.
14. Henderson CE, Phillips HS, Pollock RA, et al., GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 1994; 266: 1062-4.
15. Jing S, Wen D, Yu Y, et al., GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 1996; 85: 1113-24.
16. Nozaki C, Asai N, Murakami H, et al., Calcium-dependent Ret activation by GDNF and neurturin. Oncogene 1998; 16: 293-9.
17. Poteryaev D, Titievsky A, Sun YF, et al., GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1. FEBS Lett 1999; 463: 63-6.
18. Runeberg-Roos P, Saarma M,. Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases. Ann Med 2007; 39: 572-80.
19. Trupp M, Arenas E, Fainzilber M, et al., Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 1996; 381: 785-9.
20. Trupp M, Scott R, Whittemore SR, et al., Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J Biol Chem 1999; 274: 20885-94.
21. Lu DY, Leung YM, Cheung CW, et al., Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells. Biochem Pharmacol 2010; 80: 1201-9.
22. Pozas E, Ibáñez CF,. GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron 2005; 45: 701-13.
23. Song H, Moon A,. Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways. Neurosci Res 2006; 56: 29-38.
24. You L, Ebner S, Kruse FE,. Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. Invest Ophthalmol Vis Sci 2001; 42: 2496-504.
25. Wiesenhofer B, Weis C, Humpel C,. Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments. Antisense Nucleic Acid Drug Dev 2000; 10: 311-21.
26. Saura J, Tusell JM, Serratosa J,. High-yield isolation of murine microglia by mild trypsinization. Glia 2003; 44: 183-9.
27. Rodriguez LG, Wu X, Guan JL,. Wound-healing assay. Methods Mol Biol 2005; 294: 23-9.
28. Gil Z, Cavel O, Kelly K, et al., Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst 2010; 102: 107-18.
29. Vivanco I, Sawyers CL,. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
30. Carlomagno F, Vitagliano D, Guida T, et al., The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res 2002; 62: 1077-82.
31. Carniti C, Perego C, Mondellini P, et al., PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting. Cancer Res 2003; 63: 2234-43.
32. Puduvalli VK,. Brain metastases: biology and the role of the brain microenvironment. Curr Oncol Rep 2001; 3: 467-75.
33. Badie B, Schartner JM,. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 2000; 46: 957-61; discussion 961-52.
34. Roggendorf W, Strupp S, Paulus W,. Distribution and characterization of microglia/macrophages in human brain tumors. Acta Neuropathol 1996; 92: 288-93.
35. Platten M, Kretz A, Naumann U, et al., Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Ann Neurol 2003; 54: 388-92.
36. Ku MC, Wolf SA, Respondek D, et al., GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis. Acta Neuropathol 2013; 125: 609-20.
37. Bramanti V, Campisi A, Tomassoni D, et al., Astroglial-conditioned media and growth factors modulate proliferation and differentiation of astrocytes in primary culture. Neurochem Res 2007; 32: 49-56.
38. Wiesenhofer B, Weis C, Humpel C,. Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments. Antisense Nucleic Acid Drug Dev 2000; 10: 311-21.
39. Couldwell WT, Fraser G, De Vellis G, et al., Malignant glioma-derived soluble factors regulate proliferation of normal adult human astrocytes. J Neuropathol Exp Neurol 1992; 51: 506-13.
40. Altar CA, DiStefano PS,. Neurotrophin trafficking by anterograde transport. Trends Neurosci 1998; 21: 433-7.
41. Batchelor PE, Liberatore GT, Wong JY, et al., Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neurosci 1999; 19: 1708-16.
42. Tang MJ, Worley D, Sanicola M, et al., The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells. J Cell Biol 1998; 142: 1337-45.
43. Veit C, Genze F, Menke A, et al., Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Cancer Res 2004; 64: 5291-300.
44. Knowles PP, Murray-Rust J, Kjaer S, et al., Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 2006; 281: 33577-87.
45. Hanke JH, Gardner JP, Dow RL, et al., Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 1996; 271: 695-701.
46. Edery P, Lyonnet S, Mulligan LM, et al., Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 1994; 367: 378-80.
47. Melillo RM, Barone MV, Lupoli G, et al., Ret-mediated mitogenesis requires Src kinase activity. Cancer Res 1999; 59: 1120-6.
48. Ng WH, Wan GQ, Peng ZN, et al., Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci 2009; 16: 427-36.
49. Wan G, Too HP,. A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration. J Neurochem 2010; 115: 759-70.