Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis

American Journal of Reproductive Immunology

Volumn 74, Issue 1, 2015, Pages 89-97

  Dan, Song ^a   Wei, Wang ^a   Yichao, Shi ^a   Hongbo, Cheng ^a   Shenmin, Yang ^a   Jiaxiong, Wang ^a   Hong, Li ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Assisted reproductive technology; Natural killer cells; Prednisolone; Unexplained recurrent miscarriage

Indexed keywords

PREDNISOLONE;

ARTICLE; BIRTH RATE; CELL DENSITY; CORTICOSTEROID THERAPY; DRUG EFFECT; FEMALE; GESTATIONAL AGE; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; META ANALYSIS; METHODOLOGY; NATURAL KILLER CELL; PREGNANCY OUTCOME; PREGNANCY RATE; PREGNANT WOMAN; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; TREATMENT OUTCOME; ABORTION, HABITUAL; DRUG EFFECTS; IMMUNOLOGY; LEUKOCYTE COUNT; NIDATION; PREGNANCY; PROCEDURES;

ABORTION, HABITUAL; EMBRYO IMPLANTATION; FEMALE; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; LIVE BIRTH; PREDNISOLONE; PREGNANCY; PREGNANCY RATE; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 84931565118     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12373     Document Type: Article

References (28)

1. Moffett-King A: Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2:656-663.
2. Moffett A, Regan L, Braude P: Natural killer cells, miscarriage, and infertility. BMJ 2004; 329:1283-1285.
3. Karami N, Boroujerdnia MG, Nikbakht R, Khodadadi A: Enhancement of peripheral blood CD56 dim cell and NK cell cytotoxicity in women with recurrent spontaneous abortion or in vitro fertilization failure. J Reprod Immunol 2012; 95:87-92.
4. Thum MY, Bhaskaran S, Abdalla HI, Ford B, Sumar N, Shehata H, Bansal AS: An increase in the absolute count of CD56dimCD16+ CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod 2004; 19:2395-2400.
5. Lachapelle MH, Miron P, Hemmings R, Roy DC. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol. 1996; 156: 4027-4034.
6. Clifford K, Flanagan AM, Regan L: Endometrial CD56 natural killer cells in women with recurrent miscarriage: a histomorphometric study. Hum Reprod 1999; 14:2727-2730.
7. Yamada H, Morikawa M, Kato EH, Shimada S, Kobashi G, Minakami H: Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype. Am J Reprod Immunol 2003; 50:351-354.
8. Liu B, Mariee N, Laird S, Smith J, Li J, Li TC: The prognostic value of uNK cell count and histological dating in the mid-luteal phase of women with reproductive failure. Eur J Obstet Gynecol Reprod Biol 2014; 181:171-175.
9. Thum MY, Bhaskaran S, Bansal AS, Shehata H, Ford B, Sumar N, Abdalla HI: Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome. Hum Reprod 2005; 20:1272-1276.
10. Quenby S, Kalumbi C, Bates M, Farquharson R, Vince G: Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril 2005; 84:980-984.
11. Addison RS, Maguire DJ, Mortimer RH, Roberts MS, Cannell GR: Pathway and kinetics of prednisolone metabolism in the human placenta. J Steroid Biochem Mol Biol 1993; 44:315-320.
12. Moffitt D, Queenan JT Jr, Veeck LL, Schoolcraft W, Miller CE, Muasher SJ: Low-dose glucocorticoids after in vitro fertilization and embryo transfer have no significant effect on pregnancy rate. Fertil Steril 1995; 63:571-577.
13. Lee KA, Koo JJ, Yoon TK, Do BR, KO JJ, Cha KK: Immunosuppression by corticosteroid has no effect on the pregnancy rate in routine in-vitro fertilization/embryo transfer patients. Hum Reprod 1994; 9:1832-1835.
14. Ubaldi F, Rienzi L, Ferrero S, Anniballo R, Iacobelli M, Cobellis L, Greco E: Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. Hum Reprod 2002; 17:1544-1547.
15. Tang AW, Alfirevic Z, Turner MA, Drury J, Quenby S: Prednisolone Trial: study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium. Trials 2009; 10:102.
16. Tang AW, Alfirevic Z, Turner MA, Drury JA, Small R, Quenby S: A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant. Hum Reprod 2013; 28:1743-1752.
17. Gomaa MF, Elkholy AG, El-Said MM, Abdel-Salam NE. Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome inpatients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Arch Gynecol Obstet 2014; 290:757-762.
18. Duvan CI, Ozmen B, Satiroglu H, Atabekoglu CS, Berker B: Does addition of low dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. J Assist Reprod Genet 2006; 23:15-21.
19. Revelli A, Dolfin E, Gennarelli G, Lantieri T, Massobrio M, Holte JG, Tur-Kaspa I: Low-dose acetylsalicylic acid plus prednisolone as an adjuvant treatment in IVF: a prospective, randomized study. Fertil Steril 2008; 90:1685-1691.
20. KrigsteinM S: Prednisolone for repeated implantation failure associated with high natural killer cell levels. J Obstet Gynaecol 2012; 32:518-519.
21. Quenby S, Farquharson R, Young M, Vince G: Successful pregnancy outcome following 19 consecutive miscarriages: case report. Hum Reprod 2003; 18:2562-2564.
22. Alhalabi M, Samawi S, Taha A, Kafri N, Modi S, Khatib A, Sharif J, Othman A. Prednisolone improves implantation in ICSI patients with high peripheral CD69 + NK Cells. Hum Reprod 2011; (26 Suppl 1):249.
23. Mottla GL, Smotrich DB, Gindoff PR, Stillman RJ: Increasing clinical pregnancy rates after IVF/ET. Can immunosuppression help? J Reprod Med 1996; 41:889-891.
24. Polak de Fried E, Blanco L, Lancuba S, Asch RH: Improvement of clinical pregnancy rate and implantation rate of in-vitro fertilization-embryo transfer patients by using methylprednisone. Hum Reprod 1993; 8:393-395.
25. Siristatidis C, Chrelias C, Creatsa M, Varounis C, Vrachnis N, Iliodromiti Z, Kassanos D: Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial. Hum Fertil (Camb) 2013; 16:207-210.
26. Thum MY, Bhaskaran S, Abdalla HI, Ford B, Sumar N, Bansal A: Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity. Am J Reprod Immunol 2008; 59:259-265.
27. Henderson TA, Saunders PT, Moffett-King A, Groome NP, Critchley HO: Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab 2003; 88:440-449.
28. Vitale C, Chiossone L, Cantoni C, Morreale G, Cottalasso F, Moretti S, Pistorio A, Haupt R, Lanino E, Dini G, Moretta L, Mingari MC: The corticosteroid-induced inhibitory effect on NK cell function reflects down-regulation and/or dysfunction of triggering receptors involved in natural cytotoxicity. Eur J Immunol 2004; 34:3028-3038.