Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity

American Journal of Reproductive Immunology

Volumn 59, Issue 3, 2008, Pages 259-265

  Thum, Meen Yau ^a,b,c   Bhaskaran, Shree ^b   Abdalla, Hossam I ^a   Ford, Brian ^b   Sumar, Nazira ^b   Bansal, Amolak ^b  

^a LISTER HOSPITAL   (United Kingdom)

^b EPSOM AND ST HELIER UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

Cytotoxicity; IVIG; NK cell; Prednisolone; VF

Indexed keywords

IMMUNOGLOBULIN G; PREDNISOLONE;

ADULT; ANAMNESIS; ARTICLE; BLOOD SAMPLING; CELL ISOLATION; CELL KILLING; CELL STRAIN K 562; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTOTOXICITY; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; OBSERVATIONAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; SPONTANEOUS ABORTION; STATISTICAL ANALYSIS; STUDENT T TEST; TARGET CELL; TREATMENT FAILURE;

ABORTION, HABITUAL; ADULT; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSION; INFERTILITY; K562 CELLS; KILLER CELLS, NATURAL; PREDNISOLONE; PREGNANCY;

EID: 39149096621     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00574.x     Document Type: Article

References (32)

1. Cooper MA, Fehniger TA, Caligiuri MA: The biology of human natural killer-cell subsets. Trends Immunol 2001; 22:633-640.
2. Robertson MJ, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 1990; 76:2421-2438.
3. Shigeru S, Akitoshi N, Subaru MH, Shiozaki A: The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy. J Reprod Immunol 2008; 77:14-22.
4. Higuma-Myojo S, Sasaki Y, Miyazaki S, Sakai M, Siozaki A, Miwa N, Saito S: Cytokine profile of natural killer cells in early human pregnancy. Am J Reprod Immunol 2005; 54:21-29.
5. Moffett-King AM: Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2:656-663.
6. Coulam CB, Roussev RG: Correlation of NK cell activation and inhibition markers with NK cytoxicity among women experiencing immunologic implantation failure after in vitro fertilization and embryo transfer. J Assist Reprod Genet 2003; 20:58-62.
7. + NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod 2004; 19:2395-2400.
8. Ntrivalas EI, Kwak-Kim JYH, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, Mantouvalos HP, Beer AE: Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001; 16:855-861.
9. Matsubayashi H, Shida M, Kondo A, Suzuki T, Sugi T, Izumi S, Hosaka T, Makino T: Preconception peripheral natural killer cell activity as a predictor of pregnancy outcome in patients with unexplained infertility. Am J Reprod Immunol 2005; 53:126-131.
10. Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Morikawa M, Sakuragi N, Fujimoto S: High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent abortion. Am J Reprod Immunol 2001; 46:132-136.
11. Fukui A, Fujii S, Yamaguchi E, Kimura H, Sato S, Saito Y: Natural killer cell subpopulations and cytotoxicity for infertile patients undergoing in vitro fertilisation. Am J Reprod Immunol 1999; 41:413-422.
12. Gilman-Sachs A, DuChateau BK, Aslakson CJ, Wohlgemuth GP, Kwak JY, Beer AE, Beaman KD: Natural killer (NK) cell subsets and NK cell cytotoxicity in women with histories of recurrent spontaneous abortions. Am J Reprod Immunol 1999; 41:99-105.
13. Ruiz JE, Kwak JY, Baum L, Gilman-Sachs A, Beaman KD, Kim YB, Beer AE: Effect of intravenous immunoglobulin G on natural killer cell cytotoxicity in vitro in women with recurrent spontaneous abortion. J Reprod Immunol 1996; 31:125-141.
14. Szereday L, Spath P, Szekeres-Bartho J: Natural killer cell activity and cytokine production after in vitro immunoglobulin treatment of lymphocytes derived from pregnant women with or without risk for spontaneous abortion. Am J Reprod Immunol 1999; 42:282-287.
15. + cells. Early Pregnancy 2000; 4:90-98.
16. Stricker RB, Steinleitner A, Bookoff CN, Weckstein LN, Winger EE: Successful treatment of immunologic abortion with low-dose intravenous immunoglobulin. Fertil Steril 2000; 73:536-540.
17. Forges T, Monnier-Barbarino P, Guillet-May F, Faure GC, Bene MC: Corticosteroids in patients with antiovarian antibodies undergoing in vitro fertilization: A prospective pilot study. Eur J Clin Pharmacol 2006; 62:699-705.
18. Taniguchi F: Results of prednisolone given to improve the outcome of in vitro fertilization-embryo transfer in women with antinuclear antibodies. J Reprod Med 2005; 50:383-388.
19. Quenby S, Kalumbi C, Bates M, Farquharson R, Vince G: Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril 2005; 84:980-984.
20. Hasegawa I, Yamanoto Y, Suzuki M, Murakawa H, Kurabayashi T, Takakuwa K, Tanaka K: Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization. Fertil Steril 1998; 70:1044-1048.
21. Mottla GL, Smotrich DB, Gindoff PR, Stillman RJ: Increasing clinical pregnancy rates after IVF/ET. Can immunosuppression help? J Reprod Med 1996; 41:889-891.
22. Ando T, Suganuma N, Furuhashi M, Asada Y, Kondo I, Tomoda Y: Successful glucocorticoid treatment for patients with abnormal autoimmunity on in vitro fertilization and embryo transfer. J Assist Reprod Genet 1996; 13:776-781.
23. Polak de Fried E, Blanco L, Lancuba S, Asch RH: Improvement of clinical pregnancy rate and implantation rate of in-vitro fertilization-embryo transfer patients by using methylprednisone. Hum Reprod 1993; 8:393-395.
24. Chang L, Gusewitch GA, Chritton BW, Folz JC, Lebeck LK, Nehlsen-Cannarella SL: Rapid flow cytometric assay for the assessment of NK cell activity. J Immunol Methods 1993; 166:45-54.
25. Hatam L, Schuval S, Bonagura VR: Flow cytometric analysis of NK cell function as a clinical assay. Cytometry 1994; 16:59-68.
26. Thum MY, Abdalla HI, Bhaskaran S, Harden EL, Ford B, Sumar N, Shehata H, Bansal A: The relationship of systemic TNF-alpha and IFN-gamma with IVF treatment outcome and peripheral blood NK cells. Am J Reprod Immunol 2007; 57:210-217.
27. Fasouliotis SJ, Spandorfer SD, Witkin SS, Schattman G, Liu HC, Roberts JE, Rosenwaks Z: Maternal serum levels of interferon-gamma and interleukin-2 soluble receptor-alpha predict the outcome of early IVF pregnancies. Hum Reprod 2004; 19:1357-1363.
28. Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, Ashkanani L: Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001; 16:2219-2226.
29. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R: Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000; 15:713-718.
30. Xu B, Makris A, Thornton C, Hennessy A: Glucocorticoids inhibit placental cytokines from cultured normal and preeclamptic placental explants. Placenta 2005; 26:654-660.
31. Kwak-Kim JY, Gilman-Sachs A, Kim CE: T helper 1 and 2 immune responses in relationship to pregnancy, nonpregnancy, recurrent spontaneous abortions and infertility of repeated implantation failures. Chem Immunol Allergy 2005; 88:64-79.
32. Steer JH, Vuong Q, Joyce DA: Suppression of human monocyte tumour necrosis factor-alpha release by glucocorticoid therapy: Relationship to systemic monocytopaenia and cortisol suppression. Br J Clin Pharmacol 1997; 43:383-389.