Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs

Journal of Gastrointestinal Surgery

Volumn 19, Issue 7, 2015, Pages 1342-1349

  Someya, Soutoku ^a   Nagao, Munenori ^a   Shibata, Chikashi ^a   Tanaka, Naoki ^a   Sasaki, Hiroyuki ^a   Kikuchi, Daisuke ^a   Miyachi, Tomohiro ^a   Naitoh, Takeshi ^a   Unno, Michiaki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Allyl isothiocyanate; Giant migrating contractions; TRPA1

Indexed keywords

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE; ACETANILIDE DERIVATIVE; ALLYL ISOTHIOCYANATE; ATROPINE; CAPSAICIN; CAPSAZEPINE; GANGLION BLOCKING AGENT; HEXAMETHONIUM; ISOTHIOCYANIC ACID DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; ONDANSETRON; PURINE DERIVATIVE; SEROTONIN ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

AGONISTS; ANALOGS AND DERIVATIVES; ANASTOMOSIS; ANIMAL; COLON; DEFECATION; DENERVATION; DOG; DRUG EFFECTS; GASTROINTESTINAL MOTILITY; ILEUM; INNERVATION; INTESTINE INNERVATION; PHYSIOLOGY; SURGERY;

ACETANILIDES; ANASTOMOSIS, SURGICAL; ANIMALS; ATROPINE; CAPSAICIN; COLON; DEFECATION; DENERVATION; DOGS; ENTERIC NERVOUS SYSTEM; GANGLIONIC BLOCKERS; GASTROINTESTINAL MOTILITY; HEXAMETHONIUM; ILEUM; ISOTHIOCYANATES; MUSCARINIC ANTAGONISTS; ONDANSETRON; PURINES; SEROTONIN ANTAGONISTS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84931564951     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-015-2813-4     Document Type: Article

References (22)

1. Cortright DN, Krause JE, Broom DC. TRP channels and pain. Biochim Biophys Acta 2007;1772,978-988.
2. Tominaga M, Caterina MJ. Thermosensation and pain. J Neurobiol 2004;61:3-12.
3. Uchida K, Tominaga M. The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion. Endocr J 2011;58(12):1021-8.
4. Taylor-Clark TE, Undem BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 2010;588(Pt 3):423-433.
5. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 2011;15:70-80.
6. Shibata C, Sasaki I, Matsuno S, Mizumoto A, Iwanaga Y, Itoh Z. Characterization of colonic motor activity in conscious dogs. J Gastrointest Motil 1993;5:9–16.
7. Shibata C, Sasaki I, Matsuno S, Mizumoto A, Itoh Z. Colonic motility in innervated and extrinsically denervated loops in dogs. Gastroenterology. 1991;101:1571-8.
8. Sarna SK, Condon R, Cowles V. Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol 1984;246: G355-60.
9. Karaus M, Sarna SK. Giant migrating contractions during defecations in the dog colon. Gastroenterology 1987;92:925-933.
10. Matsushima Y, Okamoto E, Toyosaka A. Studies on colonic motor correlates of spontaneous defecation in conscious dogs. Jpn J Smooth Muscle Res 1989;25:137-146.
11. Hayashi K, Shibata C, Nagao M, Sato M, Kakyo M, Kinouchi M, Saijo F, Miura K, Ogawa H, Sasaki I. Intracolonic capsaicin stimulates colonic motility and defecation in conscious dogs. Surgery 2010;147:789-797.
12. Kikuchi D, Shibata C, Imoto H, Someya S, Miyachi T, Miura K, Naitoh T, Unno M. Role of the intraluminal contents and the continuity of intrinsic neurons in intracolonic capsaicin-induced contraction and defection in dogs. Surg Today 2014;44:152-159.
13. Doihara H, Nozawa K, Kawabata-shoda E, Kojima R, Yokoyama T, Ito H. Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs. Eur J Pharmacol 2009;617:124-149.
14. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine D, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824.
15. Kikuchi D, Shibata C, Imoto H, Naitoh T, Miura K, Unno M. Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs. Tohoku J Exp Med 2013;230(4):197-204.
16. Galligan JJ, Furness JB, Costa M. Migration of the myoelectric complex after interruption of the myenteric plexus: intestinal transection and regeneration of enteric nerves in the guinea pig. Gastroenterology. 1989;97:1135-1146.
17. Penuelas A, Tashima K, Tsuchiya S, Matsumoto K, Nakamura T, Horie S, Yano S. Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. Eur J Pharmacol 2007;576:143-150.
18. Yongwoo J, Yunjong L, Sung MK, Young DY, Jooyoung J, Uhtaek O. Quantitative analysis of TRP channel genes in mouse organs. Arch Parm Res 2012;35:1823-1830.
19. Tabe Y, Mochiki E, Yanai M, Toyomasu Y, Ando H, Ohno T, Yamauchi H, Fukasawa T, Yamaguchi S, Tsutsumi S, Asao T, Kuwano H. Characterization of special propulsive contractions during rectal evacuation in a canine model of intestinal extrinsic denervation and rectal transection. Int J Colorectal Dis 2010;25:53-61.
20. Nagao M, Shibata C, Funayama Y, Fukushima K, Takahashi K, Jin XL, Kudoh K, Sasaki I. Role of alpha-2 adrenoceptors in regulation of giant migrating contractions and defecation in conscious dogs. Dig Dis Sci 2007;52:2204-2210.
21. Sarr MG, Duenes JA, Tanaka M. A model of jejunoileal in vivo neural isolation of the entire jejunoileum: transplantation and the effects on intestinal motility. J Surg Res 1989;47:266-272.
22. Shibata C, Sasaki I, Naito H, Ueno T, Mastuno S. Intragastric capsaicin stimulates motility of upper gut and proximal colon via distinct pathways in conscious dogs. Dig Dis Sci 1999;44:1083-1089.