Role of alpha-2 adrenoceptors in regulation of giant migrating contractions and defecation in conscious dogs

Digestive Diseases and Sciences

Volumn 52, Issue 9, 2007, Pages 2204-2210

  Nagao, Munenori ^a   Shibata, Chikashi ^a   Funayama, Yuji ^a   Fukushima, Kouhei ^a   Takahashi, Ken Ichi ^a   Jin, Xue Lin ^a   Kudoh, Katsuyoshi ^a   Sasaki, Iwao ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Defecation; Extrinsic denervation; Giant migrating contractions; Ileocolonic loop; Yohimbine

Indexed keywords

ACETYLCHOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ATROPINE; FK 224; HEXAMETHONIUM; NALOXONE; ONDANSETRON; YOHIMBINE;

ACETYLCHOLINE RELEASE; ADRENERGIC ACTIVITY; ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON MOTILITY; DEFECATION; DENERVATION; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; GIANT MIGRATING CONTRACTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEM FUNCTION; PRIORITY JOURNAL; REGULATORY MECHANISM;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; COLON; CONSCIENCE; DEFECATION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL MOTILITY; PERIPHERAL NERVOUS SYSTEM; RECEPTORS, ADRENERGIC, ALPHA-2; YOHIMBINE;

EID: 34547851740     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9154-9     Document Type: Article

References (24)

1. 2-adrenoceptor. Pharmacol Rev 35:143-180
2. Fargeas MJ, Fioramonti J, Bueno L (1986) Central alpha 2-adrenergic control of the pattern of small intestinal motility in rats. Gastroenterology 91:1470-1475
3. Doherty NS, Hancock AA (1983) Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility. J Pharmacol Exp Ther 225:269-274
4. Umezawa T, Guo S, Jiao Y, Hisamitsu T (2003) Effect of clonidine on colonic motility in rats. Auton Neurosci 107:32-36
5. Malcom A, Camilleri M (2000) Coloanal motor coordination in association with high-amplitude colonic contractions after phrmacological stimulation. Am J Gastroenterol 95:715-719
6. 2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon. Eur J Pharmacol 279:123-133
7. Yoshida N, Ito T, Karasawa T, Itoh Z (1991) AS-4370, a new gastrokinetic agent enhances upper gastrointestinal motor activity in conscious dogs. J Pharmacol Exp Ther 257:781-787
8. Sellers AF, Lowe JE, Cummings JF (1985) Trials of serotonin, substance P and alpha 2-adrenergic receptor effects on the equine large colon. Cornell Vet 75:319-323
9. Karaus M, Sarna SK (1987) Giant migrating contractions during defecation in the dog colon. Gastroenterology 92:925-933
10. Shibata C, Sasaki I, Matsuno S, Mizumoto A, Iwanaga Y, Itoh Z (1993) Characterization of colonic motor activity in conscious dogs. J Gastrointest Motil 5:9-16
11. Sarna SK, Condon R, Cowles V (1984) Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol 246:G355-G360
12. Sarna SK (1992) Effect of fluid perfusion and cleansing on canine colonic motor activity. Am J Physiol 262:G62-G68
13. Nagakura Y, Kiso T, Miyata K, Ito H, Iwaoka K, Yamaguchi T (2002) The effect of the selective 5-HT(3) receptor agonist on ferret gut motility. Life Sci 71:1313-1319
14. Hou JY, Otterson MF, Sarna SK (1989) Local effect of substance P on colonic motor activity in different experimental states. Am J Physiol 256:G997-G1004
15. Fioramonti J, Fargeas MJ, Bueno L (1984) The involvement of opiate receptors in the effects of trimebutine on intestinal motility in the conscious dog. J Pharm Pharmacol 36:618-621
16. Gillis RA, Souza JD, Hicks KA, Mangel AW, Pagani FD, Hamilton BL, Garvey TQ3rd, Pace DG, Browne RK, Norman WP (1987) Inhibitory control of proximal colonic motility by the sympathetic nervous system. Am J Physiol 253:G531-G539
17. Shibata C, Sasaki I, Naito H, Tsuchiya T, Takahashi M, Ohtani N, Matsuno S (1995) Intragastric capsaicin stimulates colonic motility via a neural reflex in conscious dogs. Gastroenterology 109:1197-1205
18. Shibata C, Sasaki I, Naito H, Ueno T, Mastuno S (1999) Intragastric capsaicin stimulates motility of upper gut and proximal colon via distinct pathways in conscious dogs. Dig Dis Sci 44:1083-1089
19. Shibata C, Sasaki I, Matsuno S, Mizumoto A, Itoh Z (1991) Colonic motility in innervated and extrinsically denervated loop in dogs. Gastroenterology 101:1571-1578
20. Shibata C, Jin XL, Naito H, Matsuno S, Sasaki I (2002) Intraileal capsaicin inhibits gastrointestinal contractions via a neural reflex in conscious dogs. Gastroenterology 123:1904-1911
21. Wen J, Phillips SF, Sarr MG, Kost LJ, Holst JJ (1995) PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon. Am J Physiol 269:G945-G952
22. Sarr MG, Duenes JA, Tanaka M (1989) A model of jejunoileal in vivo neural isolation of the entire jejunoileum: transplantation and the effects on intestinal motility. J Surg Res 47:266-272
23. Baig MK, Wexner SD (2004) Postoperative ileus: a review. Dis Colon Rectum 47:516-526
24. Talley NJ (2004) Management of chronic constipation. Rev Gastroenterol Disord 4:18-24