메뉴 건너뛰기




Volumn 18, Issue 3, 2015, Pages 301-312

The differential roles of Slit2-exon 15 splicing variants in angiogenesis and HUVEC permeability

Author keywords

Angiogenesis; Chicken chorioallantoic membrane assay; Human umbilical vein endothelial cells; Permeability; Robo1; Robo4; Slit2 splicing variants; Tube formation

Indexed keywords

ROBO1 PROTEIN; ROBO4 PROTEIN; SLIT2 PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; CONDITIONED MEDIUM; IMMUNOGLOBULIN RECEPTOR; NERVE PROTEIN; ROBO4 PROTEIN, HUMAN; ROUNDABOUT RECEPTOR; SIGNAL PEPTIDE; SLIT HOMOLOG 2 PROTEIN;

EID: 84931564106     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-015-9467-4     Document Type: Article
Times cited : (18)

References (39)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84860366086 scopus 로고    scopus 로고
    • Antiangiogenic therapy—evolving view based on clinical trial results
    • COI: 1:CAS:528:DC%2BC38XmtlGgur4%3D, PID: 22330688
    • Jayson GC, Hicklin DJ, Ellis LM (2012) Antiangiogenic therapy—evolving view based on clinical trial results. Nat Rev Clin Oncol 9(5):297–303
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.5 , pp. 297-303
    • Jayson, G.C.1    Hicklin, D.J.2    Ellis, L.M.3
  • 3
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • COI: 1:CAS:528:DC%2BC3MXmtlemurg%3D, PID: 21593862
    • Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307
    • (2011) Nature , vol.473 , Issue.7347 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • COI: 1:CAS:528:DC%2BD1cXovV2lsrk%3D
    • Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev 8(8):592–603
    • (2008) Nat Rev , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 5
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • COI: 1:CAS:528:DC%2BD2MXnvFar, PID: 15637262
    • Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706):58–62
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 6
    • 0037108922 scopus 로고    scopus 로고
    • SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers
    • COI: 1:CAS:528:DC%2BD38XotFykt7Y%3D, PID: 12384551
    • Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER, Latif F (2002) SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res 62(20):5874–5880
    • (2002) Cancer Res , vol.62 , Issue.20 , pp. 5874-5880
    • Dallol, A.1    Da Silva, N.F.2    Viacava, P.3    Minna, J.D.4    Bieche, I.5    Maher, E.R.6    Latif, F.7
  • 7
    • 0037374598 scopus 로고    scopus 로고
    • SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells
    • COI: 1:CAS:528:DC%2BD3sXhs1agt7g%3D, PID: 12615722
    • Dallol A, Morton D, Maher ER, Latif F (2003) SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. Cancer Res 63(5):1054–1058
    • (2003) Cancer Res , vol.63 , Issue.5 , pp. 1054-1058
    • Dallol, A.1    Morton, D.2    Maher, E.R.3    Latif, F.4
  • 9
    • 38649122691 scopus 로고    scopus 로고
    • Slit2 involvement in glioma cell migration is mediated by Robo1 receptor
    • COI: 1:CAS:528:DC%2BD1cXivFygsb0%3D, PID: 17968499
    • Mertsch S, Schmitz N, Jeibmann A, Geng JG, Paulus W, Senner V (2008) Slit2 involvement in glioma cell migration is mediated by Robo1 receptor. J Neurooncol 87(1):1–7
    • (2008) J Neurooncol , vol.87 , Issue.1
    • Mertsch, S.1    Schmitz, N.2    Jeibmann, A.3    Geng, J.G.4    Paulus, W.5    Senner, V.6
  • 11
    • 73249126948 scopus 로고    scopus 로고
    • Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity
    • COI: 1:CAS:528:DC%2BC3cXotVOkug%3D%3D, PID: 20008733
    • Yiin JJ, Hu B, Jarzynka MJ, Feng H, Liu KW, Wu JY, Ma HI, Cheng SY (2009) Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity. Neuro-oncology 11(6):779–789
    • (2009) Neuro-oncology , vol.11 , Issue.6 , pp. 779-789
    • Yiin, J.J.1    Hu, B.2    Jarzynka, M.J.3    Feng, H.4    Liu, K.W.5    Wu, J.Y.6    Ma, H.I.7    Cheng, S.Y.8
  • 12
    • 33744952643 scopus 로고    scopus 로고
    • Robo4 signaling in endothelial cells implies attraction guidance mechanisms
    • COI: 1:CAS:528:DC%2BD28XjsFWjtro%3D, PID: 16481322
    • Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R (2006) Robo4 signaling in endothelial cells implies attraction guidance mechanisms. J Biol Chem 281(16):11347–11356
    • (2006) J Biol Chem , vol.281 , Issue.16 , pp. 11347-11356
    • Kaur, S.1    Castellone, M.D.2    Bedell, V.M.3    Konar, M.4    Gutkind, J.S.5    Ramchandran, R.6
  • 14
    • 59649086084 scopus 로고    scopus 로고
    • Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors
    • COI: 1:CAS:528:DC%2BD1MXhs1Kmu70%3D, PID: 18948384
    • Sheldon H, Andre M, Legg JA, Heal P, Herbert JM, Sainson R, Sharma AS, Kitajewski JK, Heath VL, Bicknell R (2009) Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors. Faseb J 23(2):513–522
    • (2009) Faseb J , vol.23 , Issue.2 , pp. 513-522
    • Sheldon, H.1    Andre, M.2    Legg, J.A.3    Heal, P.4    Herbert, J.M.5    Sainson, R.6    Sharma, A.S.7    Kitajewski, J.K.8    Heath, V.L.9    Bicknell, R.10
  • 16
    • 77952876991 scopus 로고    scopus 로고
    • Slit–Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis
    • COI: 1:CAS:528:DC%2BC3cXmslOnsLo%3D, PID: 20438712
    • Yang XM, Han HX, Sui F, Dai YM, Chen M, Geng JG (2010) Slit–Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis. Biochem Biophys Res Commun 396(2):571–577
    • (2010) Biochem Biophys Res Commun , vol.396 , Issue.2 , pp. 571-577
    • Yang, X.M.1    Han, H.X.2    Sui, F.3    Dai, Y.M.4    Chen, M.5    Geng, J.G.6
  • 17
    • 77952772883 scopus 로고    scopus 로고
    • Potential anti-angiogenic role of Slit2 in corneal neovascularization
    • COI: 1:CAS:528:DC%2BC3cXmtFCgsr0%3D, PID: 20298689
    • Han X, Zhang MC (2010) Potential anti-angiogenic role of Slit2 in corneal neovascularization. Exp Eye Res 90(6):742–749
    • (2010) Exp Eye Res , vol.90 , Issue.6 , pp. 742-749
    • Han, X.1    Zhang, M.C.2
  • 18
    • 33645300138 scopus 로고    scopus 로고
    • Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation
    • COI: 1:CAS:528:DC%2BD28Xhs1GqsLs%3D, PID: 16439689
    • Liu D, Hou J, Hu X, Wang X, Xiao Y, Mou Y, De Leon H (2006) Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Circ Res 98(4):480–489
    • (2006) Circ Res , vol.98 , Issue.4 , pp. 480-489
    • Liu, D.1    Hou, J.2    Hu, X.3    Wang, X.4    Xiao, Y.5    Mou, Y.6    De Leon, H.7
  • 20
    • 10044233924 scopus 로고    scopus 로고
    • Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit
    • COI: 1:CAS:528:DC%2BD2cXpsFahtbc%3D, PID: 15496984
    • Howitt JA, Clout NJ, Hohenester E (2004) Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit. EMBO J 23(22):4406–4412
    • (2004) EMBO J , vol.23 , Issue.22 , pp. 4406-4412
    • Howitt, J.A.1    Clout, N.J.2    Hohenester, E.3
  • 21
    • 2942738863 scopus 로고    scopus 로고
    • Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding
    • COI: 1:CAS:528:DC%2BD2cXltVCju7s%3D, PID: 15207848
    • Liu Z, Patel K, Schmidt H, Andrews W, Pini A, Sundaresan V (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol Cell Neurosci 26(2):232–240
    • (2004) Mol Cell Neurosci , vol.26 , Issue.2 , pp. 232-240
    • Liu, Z.1    Patel, K.2    Schmidt, H.3    Andrews, W.4    Pini, A.5    Sundaresan, V.6
  • 22
    • 34548321393 scopus 로고    scopus 로고
    • Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3
    • COI: 1:CAS:528:DC%2BD2sXpt1aksrY%3D
    • Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA (2007) Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. Acta Crystallogr A 63(Pt 9):961–968
    • (2007) Acta Crystallogr A , vol.63 , pp. 961-968
    • Morlot, C.1    Hemrika, W.2    Romijn, R.A.3    Gros, P.4    Cusack, S.5    McCarthy, A.A.6
  • 23
    • 79960700661 scopus 로고    scopus 로고
    • A novel exon 15-deleted, splicing variant of Slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer
    • COI: 1:CAS:528:DC%2BC3MXptVOnsbY%3D, PID: 21264840
    • Lin YY, Yang CH, Sheu GT, Huang CY, Wu YC, Chuang SM, Fann MJ, Chang H, Lee H, Chang JT (2011) A novel exon 15-deleted, splicing variant of Slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer. Cancer 117(15):3404–3415
    • (2011) Cancer , vol.117 , Issue.15 , pp. 3404-3415
    • Lin, Y.Y.1    Yang, C.H.2    Sheu, G.T.3    Huang, C.Y.4    Wu, Y.C.5    Chuang, S.M.6    Fann, M.J.7    Chang, H.8    Lee, H.9    Chang, J.T.10
  • 26
    • 1842632667 scopus 로고    scopus 로고
    • Endothelial cell-cell junctions: happy together
    • COI: 1:CAS:528:DC%2BD2cXivV2itr0%3D, PID: 15071551
    • Dejana E (2004) Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol 5(4):261–270. doi:10.1038/nrm1357
    • (2004) Nat Rev Mol Cell Biol , vol.5 , Issue.4 , pp. 261-270
    • Dejana, E.1
  • 27
    • 84887212399 scopus 로고    scopus 로고
    • The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    • PID: 19212436
    • Alghisi GC, Ponsonnet L, Ruegg C (2009) The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 4(2):e4449. doi:10.1371/journal.pone.0004449
    • (2009) PLoS One , vol.4 , Issue.2 , pp. e4449
    • Alghisi, G.C.1    Ponsonnet, L.2    Ruegg, C.3
  • 28
    • 0035495401 scopus 로고    scopus 로고
    • Putting tumours in context
    • COI: 1:STN:280:DC%2BD387mvVOhtw%3D%3D
    • Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev 1(1):46–54
    • (2001) Nat Rev , vol.1 , Issue.1 , pp. 46-54
    • Bissell, M.J.1    Radisky, D.2
  • 29
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • COI: 1:CAS:528:DC%2BD38Xjslahtbs%3D, PID: 12004111
    • Wiseman BS, Werb Z (2002) Stromal effects on mammary gland development and breast cancer. Science 296(5570):1046–1049
    • (2002) Science , vol.296 , Issue.5570 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 30
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • COI: 1:CAS:528:DC%2BC3MXhtFyjurzO, PID: 21742796
    • Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91(3):1071–1121
    • (2011) Physiol Rev , vol.91 , Issue.3 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6    Jain, R.K.7
  • 31
    • 84860826598 scopus 로고    scopus 로고
    • A roundabout way to cancer
    • COI: 1:CAS:528:DC%2BC38XhsFOnurnO, PID: 22588058
    • Ballard MS, Hinck L (2012) A roundabout way to cancer. Adv Cancer Res 114:187–235. doi:10.1016/B978-0-12-386503-8.00005-3
    • (2012) Adv Cancer Res , vol.114 , pp. 187-235
    • Ballard, M.S.1    Hinck, L.2
  • 32
    • 10744224816 scopus 로고    scopus 로고
    • Induction of tumor angiogenesis by Slit–Robo signaling and inhibition of cancer growth by blocking Robo activity
    • PID: 12892710
    • Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG (2003) Induction of tumor angiogenesis by Slit–Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4(1):19–29
    • (2003) Cancer Cell , vol.4 , Issue.1 , pp. 19-29
    • Wang, B.1    Xiao, Y.2    Ding, B.B.3    Zhang, N.4    Yuan, X.5    Gui, L.6    Qian, K.X.7    Duan, S.8    Chen, Z.9    Rao, Y.10    Geng, J.G.11
  • 34
    • 77950546322 scopus 로고    scopus 로고
    • Repulsive axon guidance molecule Slit3 is a novel angiogenic factor
    • COI: 1:CAS:528:DC%2BD1MXhsVGku7nP, PID: 19741192
    • Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, Wang L (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood 114(19):4300–4309. doi:10.1182/blood-2008-12-193326
    • (2009) Blood , vol.114 , Issue.19 , pp. 4300-4309
    • Zhang, B.1    Dietrich, U.M.2    Geng, J.G.3    Bicknell, R.4    Esko, J.D.5    Wang, L.6
  • 35
    • 11244262363 scopus 로고    scopus 로고
    • Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration
    • COI: 1:CAS:528:DC%2BD2MXitVGitw%3D%3D, PID: 15486058
    • Suchting S, Heal P, Tahtis K, Stewart LM, Bicknell R (2005) Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. FASEB J 19(1):121–123. doi:10.1096/fj.04-1991fje
    • (2005) FASEB J , vol.19 , Issue.1 , pp. 121-123
    • Suchting, S.1    Heal, P.2    Tahtis, K.3    Stewart, L.M.4    Bicknell, R.5
  • 36
    • 1242265735 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling
    • COI: 1:CAS:528:DC%2BD2cXhtFChtrk%3D, PID: 14761655
    • Steigemann P, Molitor A, Fellert S, Jackle H, Vorbruggen G (2004) Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Curr Biol 14(3):225–230. doi:10.1016/j.cub.2004.01.006
    • (2004) Curr Biol , vol.14 , Issue.3 , pp. 225-230
    • Steigemann, P.1    Molitor, A.2    Fellert, S.3    Jackle, H.4    Vorbruggen, G.5
  • 37
    • 0034960507 scopus 로고    scopus 로고
    • Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein
    • COI: 1:CAS:528:DC%2BD3MXltVSrsLc%3D, PID: 11426225
    • Hu H (2001) Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein. Nat Neurosci 4(7):695–701. doi:10.1038/89482
    • (2001) Nat Neurosci , vol.4 , Issue.7 , pp. 695-701
    • Hu, H.1
  • 39
    • 84864879887 scopus 로고    scopus 로고
    • Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
    • PID: 22460450
    • Shang B, Cao Z, Zhou Q (2012) Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives. Front Med 6(1):67–78. doi:10.1007/s11684-012-0176-8
    • (2012) Front Med , vol.6 , Issue.1 , pp. 67-78
    • Shang, B.1    Cao, Z.2    Zhou, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.