-
1
-
-
84873993908
-
Current approaches and future directions in the treatment of HER2-positive breast cancer
-
Hurvitz SA, Hu Y, O'Brien N and Finn RS. Current approaches and future directions in the treatment of HER2-positive breast cancer. Cancer Treat Rev 2013; 39:219-229.
-
(2013)
Cancer Treat Rev
, vol.39
, pp. 219-229
-
-
Hurvitz, S.A.1
Hu, Y.2
O'Brien, N.3
Finn, R.S.4
-
2
-
-
60849097255
-
Gene-expression signatures in breast cancer
-
Sotiriou C and Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med. 2009; 360:790-800.
-
(2009)
N Engl J Med
, vol.360
, pp. 790-800
-
-
Sotiriou, C.1
Pusztai, L.2
-
3
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Jr., Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005; 353:1673-1684.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer, C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
-
4
-
-
84887465848
-
Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers
-
Fink MY and Chipuk JE. Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers. Genes Cancer. 2013; 4:187-195.
-
(2013)
Genes Cancer
, vol.4
, pp. 187-195
-
-
Fink, M.Y.1
Chipuk, J.E.2
-
5
-
-
0023196582
-
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
-
Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR and Aaronson SA. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 1987; 237:178-182.
-
(1987)
Science
, vol.237
, pp. 178-182
-
-
Di Fiore, P.P.1
Pierce, J.H.2
Kraus, M.H.3
Segatto, O.4
King, C.R.5
Aaronson, S.A.6
-
6
-
-
84873918443
-
Activating HER2 mutations in HER2 gene amplification negative breast cancer
-
Bose R, Kavuri SM, Searleman AC, Shen W, Shen D, Koboldt DC, Monsey J, Goel N, Aronson AB, Li S, Ma CX, Ding L, Mardis ER and Ellis MJ. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov. 2013; 3:224-237.
-
(2013)
Cancer Discov
, vol.3
, pp. 224-237
-
-
Bose, R.1
Kavuri, S.M.2
Searleman, A.C.3
Shen, W.4
Shen, D.5
Koboldt, D.C.6
Monsey, J.7
Goel, N.8
Aronson, A.B.9
Li, S.10
Ma, C.X.11
Ding, L.12
Mardis, E.R.13
Ellis, M.J.14
-
7
-
-
37049183697
-
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235:177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
8
-
-
33745828702
-
EGF-ERBB signalling: towards the systems level
-
Citri A and Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 2006; 7:505-516.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
9
-
-
84892959147
-
The immune system and response to HER2-targeted treatment in breast cancer
-
Bianchini G and Gianni L. The immune system and response to HER2-targeted treatment in breast cancer. Lancet Oncol. 2014; 15:e58-68.
-
(2014)
Lancet Oncol
, vol.15
, pp. e58-e68
-
-
Bianchini, G.1
Gianni, L.2
-
10
-
-
65349101151
-
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D and Sliwkowski MX. Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell. 2009; 15:429-440.
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
Fields, C.4
Lewis Phillips, G.D.5
Friedman, L.S.6
Sampath, D.7
Sliwkowski, M.X.8
-
11
-
-
56449111358
-
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
-
Eichhorn PJ, Gili M, Scaltriti M, Serra V, Guzman M, Nijkamp W, Beijersbergen RL, Valero V, Seoane J, Bernards R and Baselga J. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res. 2008; 68:9221-9230.
-
(2008)
Cancer Res
, vol.68
, pp. 9221-9230
-
-
Eichhorn, P.J.1
Gili, M.2
Scaltriti, M.3
Serra, V.4
Guzman, M.5
Nijkamp, W.6
Beijersbergen, R.L.7
Valero, V.8
Seoane, J.9
Bernards, R.10
Baselga, J.11
-
12
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M, Botero ML, Llonch E, Atzori F, Di Cosimo S, Maira M, Garcia-Echeverria C, Parra JL, Arribas J and Baselga J. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res. 2008; 68:8022-8030.
-
(2008)
Cancer Res
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
Eichhorn, P.J.4
Valero, V.5
Guzman, M.6
Botero, M.L.7
Llonch, E.8
Atzori, F.9
Di Cosimo, S.10
Maira, M.11
Garcia-Echeverria, C.12
Parra, J.L.13
Arribas, J.14
Baselga, J.15
-
13
-
-
25144448121
-
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif
-
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC and Funk WD. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J Mol Evol. 2005; 61:372-380.
-
(2005)
J Mol Evol
, vol.61
, pp. 372-380
-
-
Tang, Y.T.1
Hu, T.2
Arterburn, M.3
Boyle, B.4
Bright, J.M.5
Emtage, P.C.6
Funk, W.D.7
-
14
-
-
52449084681
-
Characterization of the topology and functional domains of RKTG
-
Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS and Chen Y. Characterization of the topology and functional domains of RKTG. Biochem J. 2008; 414:399-406.
-
(2008)
Biochem J
, vol.414
, pp. 399-406
-
-
Luo, X.1
Feng, L.2
Jiang, X.3
Xiao, F.4
Wang, Z.5
Feng, G.S.6
Chen, Y.7
-
15
-
-
35448964335
-
Spatial regulation of Raf kinase signaling by RKTG
-
Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z and Chen Y. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci USA. 2007; 104:14348-14353.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14348-14353
-
-
Feng, L.1
Xie, X.2
Ding, Q.3
Luo, X.4
He, J.5
Fan, F.6
Liu, W.7
Wang, Z.8
Chen, Y.9
-
16
-
-
49649127212
-
Suppressive function of RKTG on chemical carcinogeninduced skin carcinogenesis in mouse
-
Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z and Chen Y. Suppressive function of RKTG on chemical carcinogeninduced skin carcinogenesis in mouse. Carcinogenesis. 2008; 29:1632-1638.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1632-1638
-
-
Xie, X.1
Zhang, Y.2
Jiang, Y.3
Liu, W.4
Ma, H.5
Wang, Z.6
Chen, Y.7
-
17
-
-
46949085149
-
RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells
-
Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, Wang Z and Chen Y. RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis. 2008; 29:1157-1163.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1157-1163
-
-
Fan, F.1
Feng, L.2
He, J.3
Wang, X.4
Jiang, X.5
Zhang, Y.6
Wang, Z.7
Chen, Y.8
-
18
-
-
79954571639
-
Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition
-
Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, Pan Y, Wang Z and Chen Y. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res. 2011; 71:2959-2968.
-
(2011)
Cancer Res
, vol.71
, pp. 2959-2968
-
-
Jiang, Y.1
Xie, X.2
Li, Z.3
Wang, Z.4
Zhang, Y.5
Ling, Z.Q.6
Pan, Y.7
Wang, Z.8
Chen, Y.9
-
19
-
-
84888216790
-
PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
-
Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, Zhang Y, Xiao F, Pan Y, Liu Y, Guo F and Chen Y. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013; 154:4525-4535.
-
(2013)
Endocrinology
, vol.154
, pp. 4525-4535
-
-
Wang, L.1
Wang, X.2
Li, Z.3
Xia, T.4
Zhu, L.5
Liu, B.6
Zhang, Y.7
Xiao, F.8
Pan, Y.9
Liu, Y.10
Guo, F.11
Chen, Y.12
-
20
-
-
77957564884
-
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma
-
Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, Fang J and Chen Y. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010; 29:5404-5415.
-
(2010)
Oncogene
, vol.29
, pp. 5404-5415
-
-
Zhang, Y.1
Jiang, X.2
Qin, X.3
Ye, D.4
Yi, Z.5
Liu, M.6
Bai, O.7
Liu, W.8
Xie, X.9
Wang, Z.10
Fang, J.11
Chen, Y.12
-
21
-
-
84868610225
-
PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers
-
Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, Pan Y, Wu G, Ling ZQ, Fang J and Chen Y. PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis. 2012; 33:2228-2235.
-
(2012)
Carcinogenesis
, vol.33
, pp. 2228-2235
-
-
Wang, X.1
Li, X.2
Fan, F.3
Jiao, S.4
Wang, L.5
Zhu, L.6
Pan, Y.7
Wu, G.8
Ling, Z.Q.9
Fang, J.10
Chen, Y.11
-
22
-
-
84903688501
-
A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers
-
Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, Wang Z and Chen Y. A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol. 2014; 25:1363-1372.
-
(2014)
Ann Oncol
, vol.25
, pp. 1363-1372
-
-
Ling, Z.Q.1
Guo, W.2
Lu, X.X.3
Zhu, X.4
Hong, L.L.5
Wang, Z.6
Wang, Z.7
Chen, Y.8
-
23
-
-
84914704228
-
Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma
-
Wu HG, Zhang WJ, Ding Q, Peng G, Zou ZW, Liu T, Cao RB, Fei SJ, Li PC, Yang KY, Hu JL, Dai XF, Wu G and Li PD. Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma. Oncol Rep. 2014; 32:2687-2695.
-
(2014)
Oncol Rep
, vol.32
, pp. 2687-2695
-
-
Wu, H.G.1
Zhang, W.J.2
Ding, Q.3
Peng, G.4
Zou, Z.W.5
Liu, T.6
Cao, R.B.7
Fei, S.J.8
Li, P.C.9
Yang, K.Y.10
Hu, J.L.11
Dai, X.F.12
Wu, G.13
Li, P.D.14
-
24
-
-
84906227159
-
HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285
-
Takagi S, Banno H, Hayashi A, Tamura T, Ishikawa T and Ohta Y. HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285. Oncoscience. 2014; 1:196-204.
-
(2014)
Oncoscience
, vol.1
, pp. 196-204
-
-
Takagi, S.1
Banno, H.2
Hayashi, A.3
Tamura, T.4
Ishikawa, T.5
Ohta, Y.6
-
25
-
-
84905009151
-
Targeting HER2(+) breast cancer: the TBK1/IKKepsilon axis
-
Jiang Z, Liu JC, Chung PE, Egan SE and Zacksenhaus E. Targeting HER2(+) breast cancer: the TBK1/IKKepsilon axis. Oncoscience. 2014; 1:180-182.
-
(2014)
Oncoscience
, vol.1
, pp. 180-182
-
-
Jiang, Z.1
Liu, J.C.2
Chung, P.E.3
Egan, S.E.4
Zacksenhaus, E.5
|