Swiss clinical practice guidelines on field cancerization of the skin

Swiss Medical Weekly

Volumn 144, Issue , 2014, Pages

  Hofbauer, Günther ^a   Anliker, Mark ^b   Boehncke, Wolf Henning ^c   Brand, Christoph ^d   Braun, Ralph ^a   Gaide, Olivier ^e   Hafner, Jürg ^a   Hunger, Robert ^f   Itin, Peter ^g   Kaeuper, Gina ^h   Lautenschlager, Stephan ⁱ   Mainetti, Carlo ^j   Streit, Markus ^k  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d LUZERNER KANTONSSPITAL   (Switzerland)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f Klinik und Poliklinik fur Dermatologie   (Switzerland)

^g Universitatsspital Basel Dermatologie   (Switzerland)

^h Stadtspital Triemli ^*  (United States)

ⁱ TRIEMLI HOSPITAL   (Switzerland)

^j REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^k CANTONAL HOSPITAL AARAU   (Switzerland)

more..

Author keywords

Actinic keratosis; Clinical practice guidelines; Field cancerization of the skin; Management recommendations; Non melanoma skin cancer

Indexed keywords

AMINOLEVULINIC ACID; AZATHIOPRINE; CALCINEURIN INHIBITOR; CAPECITABINE; CYCLOSPORIN; DICLOFENAC; FLUOROURACIL; IMIQUIMOD; INGENOL MEBUTATE; MYCOPHENOLIC ACID; PLACEBO; PREDNISOLONE; RAPAMYCIN; RESIQUIMOD; RETINOID; SALICYLIC ACID; SUNSCREEN;

ACTINIC KERATOSIS; ADOLESCENT; ALOPECIA; APOPTOSIS; APPLICATION SITE REACTION; APPLICATION SITE SCABBING; ARTICLE; BASAL CELL CARCINOMA; BLISTER; BOWEN DISEASE; CANCER PATIENT; CANCER PREVENTION; CANCER REGISTRY; CARBON DIOXIDE LASER; CHEMEXFOLIATION; CHILD; CLINICAL ASSESSMENT; CLINICAL PRACTICE; CLOTHING; CONTROLLED STUDY; CRYOTHERAPY; CURETTAGE; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; EARLY DIAGNOSIS; EDUCATION; EPIDERMIS; EPILUMINESCENCE MICROSCOPY; ERYTHEMA; ESTHETIC SURGERY; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERKERATOSIS; HYPOPIGMENTATION; IMMUNOCOMPROMISED PATIENT; INCIDENCE; LIFESTYLE; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NON MELANOMA SKIN CANCER; PAIN; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PRACTICE GUIDELINE; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDY; QUALITY OF LIFE; RADIATION EXPOSURE; RISK FACTOR; SKIN ABRASION; SKIN ATROPHY; SKIN CANCER; SKIN DISCOMFORT; SKIN EDEMA; SKIN EXAMINATION; SKIN INJURY; SKIN REDNESS; SKIN TRANSPLANTATION; SQUAMOUS CELL CARCINOMA; SUNBURN; SWISS; TREATMENT DURATION; ULCER; ULTRAVIOLET RADIATION; ADVERSE EFFECTS; AGE; CARCINOMA, SQUAMOUS CELL; EPIDEMIOLOGY; INTRADERMAL DRUG ADMINISTRATION; KERATOSIS, ACTINIC; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOCHEMOTHERAPY; RADIOTHERAPY; SEX DIFFERENCE; SKIN; SKIN NEOPLASMS; SWITZERLAND;

ADMINISTRATION, CUTANEOUS; AGE FACTORS; CARCINOMA, SQUAMOUS CELL; CLOTHING; COMBINED MODALITY THERAPY; CRYOTHERAPY; HUMANS; IMMUNOCOMPROMISED HOST; KERATOSIS, ACTINIC; PHOTOCHEMOTHERAPY; PRACTICE GUIDELINES AS TOPIC; RADIOTHERAPY; RISK FACTORS; SEX FACTORS; SKIN; SKIN NEOPLASMS; SUNSCREENING AGENTS; SWITZERLAND; ULTRAVIOLET RAYS;

EID: 84931409557     PISSN: 14247860     EISSN: 14243997     Source Type: Journal    
DOI: 10.4414/smw.2014.14026     Document Type: Article

References (122)

1. OCEBM Levels of Evidence Working Group. The Oxford 2011 Levels of Evidence. Oxford Centre for Evidence-Based Medicine. Available at: http://www.cebm.net/index.aspx?o=5653. Accessed October 15, 2013.
2. Marks R, Foley P, Goodman G, Hage BH, Selwood TS. Spontaneous remission of solar keratoses: the case for conservative management. Br J Dermatol. 1986;115:649-55.
3. Anwar J, Wrone DA, Kimyai-Asadi A, Alam M. The development of actinic keratosis into invasive squamous cell carcinoma: evidence and evolving classification schemes. Clin Dermatol. 2004;22:189-96.
4. Roewert-Huber J, Stockfleth E, Keri H. Pathology and pathobiology of actinic (solar) keratosis-an update. Br J Dermatol. 2007;157:18-20.
5. Rossi R, Mori M, Lotti T. Actinic keratosis. Int J Dermatol. 2007;46:895-904.
6. Ackerman AB, Mones JM. Solar (actinic) keratosis is squamous cell carcinoma. Br J Dermatol. 2006;155:9-22.
7. Tabor MP, Brakenhoff RH, Van Houten VM, Kummer JA, Snel MH, Snijders PJ, et al. Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res. 2001;7:1523-32.
8. Wennberg AM, Stenquist B, Stockfleth E, Keohane S, Lear JT, Jemec G, et al. Photodynamic therapy with methyl aminolevulinate for prevention of new skin lesions in transplant recipients: a randomized study. Transplantation. 2008;86:423-9.
9. Wulf HC, Pavel S, Stender I, Bakker-Wensveen CA. Topical photodynamic therapy for prevention of new skin lesions in renal transplant patients. Acta Derm Venereol. 2006;86:25-8.
10. Lucas R, McMichael T, Smith W, Armstrong B. Solar ultraviolet radiation: global burden of disease from solar ultraviolet radiation. World Health Organization. Environmental Burden of Disease Series, No. 13. 2006.
11. Frost CA, Green AC. Epidemiology of solar keratoses. Br J Dermatol. 1994;131:455-64.
12. Traianou A, Ulrich M, Apalla Z, De Vries E, Bakirtzi K, Kalabalikis D, et al. EPIDERM Group. Risk factors for actinic keratosis in eight European centres: a case-control study. Br J Dermatol. 2012;167:36-42.
13. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet. 1988;1:795-97.
14. Mittelbronn MA, Mullins DL, Ramos-Caro FA, Flowers FP. Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma. Int J Dermatol. 1998;37:677-81.
15. Dodson JM, DeSpain J, Hewett JE, Clark DP. Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. Arch Dermatol. 1991;127:1029-31.
16. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol. 2000;42:23-4.
17. Werner RN, Sammain A, Erdmann R, Hartmann V, Stockfleth E, Nast A. The natural history of actinic keratosis: a systematic review. Br J Dermatol. 2013;169:502-18.
18. Bulliard JL, Panizzon RG, Levi F. [Epidemiology of epithelial skin cancers]. Rev Med Suisse. 2009;5:882, 884-8. Article in French.
19. Stang A, Stausberg J, Boedeker W, Kerek-Bodden H, Jockel KH. Nationwide hospitalization costs of skin melanoma and non-melanoma skin cancer in Germany. J Eur Acad Dermatol Venereol. 2008;22:65-72.
20. Reinau D, Meier C, Gerber N, Hofbauer G, Surber C. Sun protective behavior of primary and secondary school students in North-Western Switzerland. Swiss Med Wkly. 2012;142:w13520.
21. Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet. 1999;354:723-9.
22. Van Der Pols JC, Williams GM, Pandeya N, Logan V, Green AC. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer Epidemiol Biomarkers Prev. 2006;15:2546-8.
23. Gordon LG, Scuffham PA, Van Der Pols JC, McBride P, Williams GM, Green AC. Regular sunscreen use is a cost-effective approach to skin cancer prevention in subtropical settings. J Invest Dermatol. 2009;129:2766-71.
24. Ulrich C, Jürgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, et al. Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study. Br J Dermatol. 2009;161:78-84.
25. Kadakia KC, Barton DL, Loprinzi CL, Sloan JA, Otley CC, Diekmann BB, et al. Randomized controlled trial of acitretin versus placebo in patients at high risk for basal cell or squamous cell carcinoma of the skin (North Central Cancer Treatment Group Study 969251). Cancer. 2012;118:2128-37.
26. Endrizzi BT, Lee PK. Management of carcinoma of the skin in solid organ transplant recipients with oral capecitabine. Dermatol Surg. 2009;35:1567-72.
27. Jirakulaporn T, Endrizzi B, Lindgren B, Mathew J, Lee PK, Dudek AZ. Capecitabine for skin cancer prevention in solid organ transplant recipients. Clin Transplant. 2011;25:541-48.
28. Hofbauer GF, Anliker M, Arnold A, Binet I, Hunger R, Kempf W, et al. SGDV working group for organ transplant recipients. Swiss clinical practice guidelines for skin cancer in organ transplant recipients. Swiss Med Wkly. 2009;139:407-15.
29. Huerta-Brogeras M, Olmos O, Borbujo J, Hernández-Núñez A, Castaño E, Romero-Maté A, et al. Validation of dermoscopy as a real-time noninvasive diagnostic imaging technique for actinic keratosis. Arch Dermatol. 2012;148:1159-64.
30. Peris K, Micantonio T, Piccolo D, Fargnoli MC. Dermoscopic features of actinic keratosis. J Dtsch Dermatol Ges. 2007;5:970-6.
31. Zalaudek I, Giacomel J, Schmid K, Bondino S, Rosendahl C, Cavicchini S, et al. Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. J Am Acad Dermatol. 2012;66:589-97.
32. Wolf JE Jr, Rigel DS. Understanding efficacy end-points in studies of field-directed therapy for actinic keratosis. Int J Dermatol. 2013;52:1063-70.
33. Chen SC, Hill ND, Veledar E, Swetter SM, Weinstock MA. Reliability of quantification measures of actinic keratosis. Br J Dermatol. 2013;169:1219-22.
34. Elliott R. Non-adherence to medicines: not solved but solvable. J Health Serv Res Policy. 2009;14:58-61.
35. Lebwohl M, Swanson N, Anderson LL, Melgaard A, Xu Z, Berman B. Ingenol mebutate gel for actinic keratosis. N Engl J Med. 2012;366:1010-19.
36. Nashan D, Meiss F, Müller M. Therapeutic strategies for actinic keratosis-a systematic review. Eur J Dermatol. 2013;23:14-32.
37. Darlington S, Williams G, Neale R, Frost C, Green A. A randomized controlled trial to assess sunscreen application and beta carotene supplementation in the prevention of solar keratoses. Arch Dermatol. 2003;139:451-5.
38. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N Engl J Med. 1993;329:1147-51.
39. Ferrandiz L, Ruiz-de-Casas A, Trakatelli M, De Vries E, Ulrich M, Aquilina S, et al. EPIDERM Group. Assessing physicians' preferences on skin cancer treatment in Europe. Br J Dermatol 2012;167:29-35.
40. Thai KE, Fergin P, Freeman M, Vinciullo C, Francis D, Spelman L, et al. A prospective study of the use of cryosurgery for the treatment of actinic keratoses. Int J Dermatol. 2004;43:687-92.
41. Kaufmann R, Spelman L, Weightman W, Reifenberger J, Szeimies RM, Verhaeghe E, et al. Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities. Br J Dermatol. 2008;158:994-9.
42. Krawtchenko N, Roewert-Huber J, Ulrich M, Mann I, Sterry W, Stockfleth E. A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up. Br J Dermatol. 2007;157:34-40.
43. Gupta AK, Paquet M. Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow-up on a Cochrane review. Br J Dermatol. 2013;169:250-9.
44. Zouboulis CC. Cryosurgery in dermatology. Eur J Dermatol. 1998;8:466-74.
45. Chiarello SE. Cryopeeling (extensive cryosurgery) for treatment of actinic keratoses: an update and comparison. Dermatol Surg. 2000;26:728-32.
46. Gupta AK. The management of actinic keratoses in the United States with topical fluorouracil: a pharmacoeconomic evaluation. Cutis. 2002;70:30-6.
47. Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther. 2002;24:990-1000.
48. Jorizzo J, Stewart D, Bucko A, Davis SA, Espy P, Hino P, et al. Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. Cutis. 2002;70:335-9.
49. Weiss J, Menter A, Hevia O, Jones T, Ling M, Rist T, et al. Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. Cutis. 2002;70:22-9.
50. Stockfleth E, Kerl H, Zwingers T, Willers C. Low-dose 5-fluorouracil in combination with salicylic acid as a new lesion-directed option to treat topically actinic keratoses: histological and clinical study results. Br J Dermatol. 2011;165:1101-8.
51. Rundhaug JE, Fischer SM. Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem Photobiol. 2008;84:322-9.
52. Fecker LF, Stockfleth E, Nindl I, Ulrich C, Forschner T, Eberle J. The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs). Br J Dermatol. 2007;156:25-33.
53. Rivers JK, Arlette J, Shear N, Guenther L, Carey W, Poulin Y. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol. 2002;146:94-100.
54. Wolf JE Jr, Taylor JR, Tschen E, Kang S. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol. 2001;40:709-713.
55. Pirard D, Vereecken P, Melot C, Heenen M. Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies. Arch Dermatol Res. 2005;297:185-9.
56. Nelson C, Rigel D, Smith S, Swanson N, Wolf J. Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol. 2004;3:401-7.
57. Nelson C, Rigel D. Long-term follow up of diclofenac sodium 3% in 2.5% hyaluronic acid gel for actinic keratosis: one-year evaluation. J Clin Aesthet Dermatol. 2009;2:20-5.
58. Ulrich C, Hackethal M, Ulrich M, Howorka A, Forschner T, Sterry W, et al. Treatment of multiple actinic keratoses with topical diclofenac 3% gel in organ-transplant recipients: a series of six cases. Br J Dermatol. 2007;156:40-2.
59. Ulrich C, Johannsen A, Röwert-Huber J, Ulrich M, Sterry W, Stockfleth E. Results of a randomized, placebo-controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses. Eur J Dermatol. 2010;20:482-8.
60. Korman N, Moy R, Ling M, Matheson R, Smith S, McKane S, et al. Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, doubleblind, parallel-group, vehicle-controlled trials. Arch Dermatol. 2005;141:467-73.
61. Szeimies RM, Gerritsen MJ, Gupta G, Ortonne JP, Serresi S, Bichel J, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol. 2004;51:547-55.
62. Lee PK, Harwell WB, Loven KH, Phillips TJ, Whiting DA, Andres KL, et al. Long-term clinical outcomes following treatment of actinic keratosis with imiquimod 5% cream. Dermatol Surg. 2005;31:659-64.
63. Jorizzo J, Dinehart S, Matheson R, Moore JK, Ling M, Fox TL, et al. Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol. 2007;57:265-8.
64. Alomar A, Bichel J, McRae S. Vehicle-controlled, randomized, doubleblind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head. Br J Dermatol. 2007;157:133-41.
65. Benson E. Imiquimod: potential risk of an immunostimulant. Australas J Dermatol. 2004;45:123-4.
66. Patel U, Mark NM, Machler BC, Levine VJ. Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism. Br J Dermatol. 2011;164:670-2.
67. Fanti PA, Dika E, Vaccari S, Miscial C, Varotti C. Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. Int J Dermatol. 2006;45:1464-5.
68. Wolfe CM, Tafuri N, Hatfield K. Exacerbation of myasthenia gravis during imiquimod treatment. J Drugs Dermatol. 2007;6:745-6.
69. Swanson N, Abramovits W, Berman B, Kulp J, Rigel DS, Levy S. Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles. J Am Acad Dermatol. 2010;62:582-90.
70. Hanke CW, Beer KR, Stockfleth E, Wu J, Rosen T, Levy S. Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 3-week cycles. J Am Acad Dermatol. 2010;62:573-81.
71. Dockrell DH, Kinghorn GR. Imiquimod and resiquimod as novel immunomodulators. J Antimicrob Chemother. 2001;48:751-5.
72. Fujisawa H, Shivji GM, Kondo S, Wang B, Tomai MA, Miller RL, et al. Effect of a novel topical immunomodulator, S-28463, on keratinocyte cytokine gene expression and production. J Interferon Cytokine Res. 1996;16:555-9.
73. Szeimies RM, Bichel J, Ortonne JP, Stockfleth E, Lee J, Meng TC. A phase II dose-ranging study of topical resiquimod to treat actinic keratosis. Br J Dermatol. 2008;159:205-10.
74. Rosen RH, Gupta AK, Tyring SK. Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune response. J Am Acad Dermatol. 2012;66:486-93.
75. Lebwohl M, Shumack S, Stein Gold L, Melgaard A, Larsson T, Tyring SK. Long-term follow-up study of ingenol mebutate gel for the treatment of actinic keratoses. JAMA Dermatol. 2013;149:666-70.
76. Jarret M, Katsamas J, Cawkill K, Henderson L, Welburn P. A pharmacokinetic study using a highly sensitive and specific method to determine systemic exposure of ingenol mebutate and its two main metabolites, PEP015 and PEP025 in human whole blood after topical administration. J Am Acad Dermatol. 2013;68: AB156.
77. Braathen LR, Szeimies RM, Basset-Seguin N, Bissonnette R, Foley P, Pariser D, et al. International Society for Photodynamic Therapy in Dermatology. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. J Am Acad Dermatol. 2007;56:125-43.
78. Morton CA, Brown SB, Collins S, Ibbotson S, Jenkinson H, Kurwa H, et al. Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol. 2002;146:552-67.
79. Morton CA, McKenna KE, Rhodes LE; British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group. Guidelines for topical photodynamic therapy: update. Br J Dermatol. 2008;159:1245-66.
80. Morton CA, Szeimies RM, Sidoroff A, Braathen LR. European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications-actinic keratoses, Bowen's disease, basal cell carcinoma. J Eur Acad Dermatol Venereol. 2013;27:536-44.
81. Morton CA, Szeimies RM, Sidoroff A, Braathen LR. European guidelines for topical photodynamic therapy part 2: emerging indications-field cancerization, photorejuvenation, and inflammatory/infective dermatoses. J Eur Acad Dermatol Venereol. 2013;27:672-9.
82. Jeffes EW, McCullough JL, Weinstein GD, Kaplan R, Glazer SD, Taylor JR. Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light. J Am Acad Dermatol. 2001;45:96-104.
83. Piacquadio DJ, Chen DM, Farber HF, Fowler JF Jr, Glazer SD, Goodman JJ, et al. Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. Arch Dermatol. 2004;140:41-6.
84. Tarstedt M, Rosdahl I, Berne B, Svanberg K, Wennberg AM. A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix) - PDT in actinic keratosis of the face and scalp. Acta Derm Venereol. 2005;85:424-8.
85. Szeimies RM, Torezan L, Niwa A, Valente N, Unger P, Kohl E, et al. Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy. Br J Dermatol. 2012;167:150-9.
86. Wiegell SR, Wulf HC, Szeimies RM, Basset-Seguin N, Bissonnette R, Gerritsen MJ, et al. Daylight photodynamic therapy for actinic keratosis: an international consensus: International Society for Photodynamic Therapy in Dermatology. J Eur Acad Dermatol Venereol. 2012;26:673-9.
87. Wiegell SR, Haedersdal M, Phillipsen PA, Eriksen P, Enk CD, Wulf HC. Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study. Br J Dermatol. 2008;158:740-6.
88. Wiegell SR, Haedersdal M, Eriksen P, Wulf HC. Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home-based daylight exposure: a double-blinded randomized clinical trial. Br J Dermatol. 2009;160:1308-14.
89. Wiegell SR, Fabricius S, Stender IM, Berne B, Kroon S, Andersen BL, et al. A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. Br J Dermatol. 2011;164:1083-90.
90. Barta U, Gräfe T, Wollina U. Radiation therapy for extensive actinic keratosis. J Eur Acad Dermatol Venereol. 2000;14:293-5.
91. Dinehart SM, Graham M, Maners A. Radiation therapy for widespread actinic keratoses. J Clin Aesthet Dermatol. 2011;4:47-50.
92. Pipitone MA, Gloster HM. Superficial squamous cell carcinomas and extensive actinic keratoses of the scalp treated with radiation therapy. Dermatol Surg. 2006;32:756-9.
93. Caccialanza M, Piccinno R, Beretta M, Gnecchi L. Results and side effects of dermatologic radiotherapy: a retrospective study of irradiated cutaneous epithelial neoplasms. J Am Acad Dermatol. 1999;41:589-94.
94. Emmett AJ, Broadbent GD. Shave excision of superficial solar skin lesions. Plast Reconstr Surg. 1987;80:47-54.
95. Van Zuuren EJ, Posma AN, Scholtens RE, Vermeer BJ, Van Der Woude FJ, Bouwes Bavinck JN. Resurfacing the back of the hand as treatment and prevention of multiple skin cancers in kidney transplant recipients. J Am Acad Dermatol. 1994;31:760-4.
96. Weinstock MA, Bingham SF, DiGiovanna JJ, Rizzo AE, Marcolivio K, Hall R, et al. Veterans Affairs Topical Tretinoin Chemoprevention Trial Group. Tretinoin and the prevention of keratinocyte carcinoma (basal and squamous cell carcinoma of the skin): a Veterans Affairs randomized chemoprevention trial. J Invest Dermatol. 2012;132:1583-90.
97. Hantash BM, Stewart DB, Cooper ZA, Rehmus WE, Koch RJ, Swetter SM. Facial resurfacing for nonmelanoma skin cancer prophylaxis. Arch Dermatol. 2006;142:976-82.
98. Shaffelburg M. Treatment of actinic keratoses with sequential use of photodynamic therapy and imiquimod 5% cream. J Drugs Dermatol. 2009;8:35-39.
99. Serra-Guillén C, Nagore E, Hueso L, Traves V, Messeguer F, Sanmartín O, et al. A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. J Am Acad Dermatol. 2012;66:e131-e7.
100. Galitzer BI. Effect of retinoid pretreatment on outcomes of patients treated by photodynamic therapy for actinic keratosis of the hand and forearm. J Drugs Dermatol. 2011;10:1124-32.
101. Martin G. Prospective, case-based assessment of sequential therapy with topical fluorouracil cream 0.5% and ALA-PDT for the treatment of actinic keratosis. J Drugs Dermatol. 2011;10:372-8.
102. Van Der Geer S, Krekels GA. Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study. J Dermatolog Treat. 2009;20:259-65.
103. Jorizzo JL, Markowitz O, Lebwohl MG, Bourcier M, Kulp J, Meng TC, et al. A randomized, double-blinded, placebo-controlled, multicenter, efficacy and safety study of 3.75% imiquimod cream following cryosurgery for the treatment of actinic keratoses. J Drugs Dermatol. 2010;9:1101-8.
104. Tan JK, Thomas DR, Poulin Y, Maddin F, Tang J. Efficacy of imiquimod as an adjunct to cryotherapy for actinic keratoses. J Cutan Med Surg. 2007;11:195-201.
105. Berlin JM, Rigel DS. Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery. J Drugs Dermatol. 2008;7:669-73.
106. Mastrolonardo M. Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses. Clin Exp Dermatol. 2009;34:33-5.
107. Jorizzo J, Weiss J, Furst K, VandePol C, Levy SF. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery. Arch Dermatol. 2004;140:813-6.
108. ® for the treatment of actinic keratosis on the face and scalp. Available at: http://clinicaltrials.gov/ct2/show/NCT01541553?term=ingenol+mebutate+cryotherapy&rank=2. Accessed June 4, 2013.
109. Swanson N, Berman B, Goldenberg G, Hanke W, Tyring S, Werschler WP, et al. Evaluation of topical treatment with ingenol mebutate gel 0.015%, 3 weeks after cryosurgery of actinic keratosis on the face and scalp. In: Proceedings from 22nd Congress of the European Academy of Dermatology and Venereology; October 2-6, 2013; Istanbul, Turkey. Abstract P532.
110. Price NM. The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. J Drugs Dermatol. 2007;6:778-81.
111. Ondo AL, Padilla RS, Miedler JD, Cockerell CJ, Kemer JD, Steiner RL, et al. Treatment-refractory actinic keratoses successfully treated using simultaneous combination topical 5-fluorouracil cream and imiquimod cream: a case-control study. Dermatol Surg. 2012;38:1469-76.
112. Ulrich C, Christophers E, Sterry W, Meyer T, Stockfleth E. [Skin diseases in organ transplant patients]. Hautarzt. 2002;53:524-33.
113. Stockfleth E, Ulrich C, Meyer T, Christophers E. Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment. Recent Results Cancer Res. 2002;160:251-8.
114. Keller B, Braathen LR, Marti HP, Hunger RE. Skin cancers in renal transplant recipients: a description of the renal transplant cohort in Bern. Swiss Med Wkly. 2010;140:w13036.
115. Euvrard S, Morelon E, Rostaing L, Goffin E, Brocard A, Tromme I, et al. TUMORAPA Study Group. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med. 2012;367:329-39.
116. Hofbauer GF, Attard NR, Harwood CA, McGregor JM, Dziunycz P, Iotzova-Weiss G, et al. Reversal of UVA skin photosensitivity and DNA damage in kidney transplant recipients by replacing azathioprine. Am J Transplant. 2012;12:218-25.
117. O'Donovan P, Perrett CM, Zhang X, Montaner B, Xu YZ, Harwood CA, et al. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science. 2005;309:1871-4.
118. Perrett CM, Walker SL, O'Donovan P, Warwick J, Harwood CA, Karran P, et al. Azathioprine treatment photosensitizes human skin to ultraviolet A radiation. Br J Dermatol. 2008;159:198-204.
119. Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O, et al. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol. 1999;40:177-86.
120. Tessari G, Girolomoni G. Nonmelanoma skin cancer in solid organ transplant recipients: update on epidemiology, risk factors, and management. Dermatol Surg. 2012;38:1622-30.
121. Rüegg CP, Graf N, Mühleisen B, Szucs TD, French LE, Surber C, et al. Squamous cell carcinoma of the skin induces considerable sustained cost of care in organ transplant recipients. J Am Acad Dermatol. 2012;67:1242-49.
122. Ulrich C, Bichel J, Euvrard S, Guidi B, Proby CM, Van De Kerkhof PC, et al. Topical immunomodulation under systemic immunosuppression: results of a multicentre, randomized, placebo-controlled safety and efficacy study of imiquimod 5% cream for the treatment of actinic keratoses in kidney, heart, and liver transplant patients. Br J Dermatol. 2007;157:25-31.