메뉴 건너뛰기




Volumn 52, Issue 9, 2013, Pages 1063-1070

Understanding efficacy end-points in studies of field-directed therapy for actinic keratosis

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; EFLORNITHINE; FLUOROURACIL; IMIQUIMOD; TOPICAL AGENT; TRIAMCINOLONE;

EID: 84882608600     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2012.05776.x     Document Type: Article
Times cited : (24)

References (58)
  • 1
    • 84882639040 scopus 로고    scopus 로고
    • Treating AKs: what are your best options?
    • Hubbs L, Tuleya S. Treating AKs: what are your best options? Skin Aging 2005; 13: 36-42.
    • (2005) Skin Aging , vol.13 , pp. 36-42
    • Hubbs, L.1    Tuleya, S.2
  • 2
    • 66649122857 scopus 로고    scopus 로고
    • Actinic keratoses: natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial
    • Criscione VD, Weinstock MA, Naylor MF, et al. Actinic keratoses: natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Cancer 2009; 115: 2523-2530.
    • (2009) Cancer , vol.115 , pp. 2523-2530
    • Criscione, V.D.1    Weinstock, M.A.2    Naylor, M.F.3
  • 3
    • 72249108186 scopus 로고    scopus 로고
    • Topical management of actinic keratosis and field cancerization
    • Stockfleth E. Topical management of actinic keratosis and field cancerization. G Ital Dermatol Venereol 2009; 144: 459-462.
    • (2009) G Ital Dermatol Venereol , vol.144 , pp. 459-462
    • Stockfleth, E.1
  • 4
    • 70350707932 scopus 로고    scopus 로고
    • Optimizing management of actinic keratosis and photodamaged skin: utilizing a stepwise approach
    • Lee AD, Jorizzo JL. Optimizing management of actinic keratosis and photodamaged skin: utilizing a stepwise approach. Cutis 2009; 84: 169-175.
    • (2009) Cutis , vol.84 , pp. 169-175
    • Lee, A.D.1    Jorizzo, J.L.2
  • 5
    • 33745295528 scopus 로고    scopus 로고
    • Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel
    • Berman B, Bienstock L, Kuritzky L, et al. Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel. J Fam Pract 2006; 55(Suppl): 1-8.
    • (2006) J Fam Pract , vol.55 , Issue.SUPPL. , pp. 1-8
    • Berman, B.1    Bienstock, L.2    Kuritzky, L.3
  • 6
    • 65749118370 scopus 로고    scopus 로고
    • Randomized double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis
    • Anderson L, Schmieder GJ, Werschler WP, et al. Randomized double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. J Am Acad Dermatol 2009; 60: 934-943.
    • (2009) J Am Acad Dermatol , vol.60 , pp. 934-943
    • Anderson, L.1    Schmieder, G.J.2    Werschler, W.P.3
  • 7
    • 59249107100 scopus 로고    scopus 로고
    • Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study
    • Huyke C, Reuter J, Rödig M, et al. Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study. J Dtsch Dermatol Ges 2009; 7: 128-133.
    • (2009) J Dtsch Dermatol Ges , vol.7 , pp. 128-133
    • Huyke, C.1    Reuter, J.2    Rödig, M.3
  • 8
    • 84882691555 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Green tea extract in treating patients with actinic keratosis [WWW document]. Available at: [accessed on 13 October 2011].
    • ClinicalTrials.gov. (2010) Green tea extract in treating patients with actinic keratosis [WWW document]. Available at: http://clinicaltrials.gov/show/NCT00005097 [accessed on 13 October 2011].
    • (2010)
  • 9
    • 45749148641 scopus 로고    scopus 로고
    • A phase II dose-ranging study of topical resiquimod to treat actinic keratosis
    • Szeimies RM, Bichel J, Ortonne JP, et al. A phase II dose-ranging study of topical resiquimod to treat actinic keratosis. Br J Dermatol 2008; 159: 205-210.
    • (2008) Br J Dermatol , vol.159 , pp. 205-210
    • Szeimies, R.M.1    Bichel, J.2    Ortonne, J.P.3
  • 10
    • 0036845121 scopus 로고    scopus 로고
    • A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses
    • Stockfleth E, Meyer T, Benninghoff B, et al. A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol 2002; 138: 1498-1502.
    • (2002) Arch Dermatol , vol.138 , pp. 1498-1502
    • Stockfleth, E.1    Meyer, T.2    Benninghoff, B.3
  • 11
    • 34447291575 scopus 로고    scopus 로고
    • Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head
    • Jorizzo J, Dinehart S, Matheson R, et al. Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol 2007; 57: 265-268.
    • (2007) J Am Acad Dermatol , vol.57 , pp. 265-268
    • Jorizzo, J.1    Dinehart, S.2    Matheson, R.3
  • 12
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    • Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004; 50: 714-721.
    • (2004) J Am Acad Dermatol , vol.50 , pp. 714-721
    • Lebwohl, M.1    Dinehart, S.2    Whiting, D.3
  • 13
    • 17444394323 scopus 로고    scopus 로고
    • Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double-blind, parallel-group, vehicle-controlled trials
    • Korman N, Moy R, Ling M, et al. Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double-blind, parallel-group, vehicle-controlled trials. Arch Dermatol 2005; 141: 467-473.
    • (2005) Arch Dermatol , vol.141 , pp. 467-473
    • Korman, N.1    Moy, R.2    Ling, M.3
  • 14
    • 4644304377 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled clinical trial with histology
    • Szeimies RM, Gerritsen MJ, Gupta G, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled clinical trial with histology. J Am Acad Dermatol 2004; 51: 547-555.
    • (2004) J Am Acad Dermatol , vol.51 , pp. 547-555
    • Szeimies, R.M.1    Gerritsen, M.J.2    Gupta, G.3
  • 15
    • 0036788815 scopus 로고    scopus 로고
    • Cycle therapy of actinic keratoses of the face and scalp with 5% topical imiquimod cream: an open-label trial
    • Salasche SJ, Levine N, Morrison L. Cycle therapy of actinic keratoses of the face and scalp with 5% topical imiquimod cream: an open-label trial. J Am Acad Dermatol 2002; 47: 571-577.
    • (2002) J Am Acad Dermatol , vol.47 , pp. 571-577
    • Salasche, S.J.1    Levine, N.2    Morrison, L.3
  • 16
    • 34250674001 scopus 로고    scopus 로고
    • Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head
    • Alomar A, Bichel J, McRae S. Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head. Br J Dermatol 2007; 157: 133-141.
    • (2007) Br J Dermatol , vol.157 , pp. 133-141
    • Alomar, A.1    Bichel, J.2    McRae, S.3
  • 17
    • 36549011170 scopus 로고    scopus 로고
    • A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up
    • Krawtchenko N, Roewert-Huber J, Ulrich M, et al. A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up. Br J Dermatol 2007; 157(Suppl 2): 34-40.
    • (2007) Br J Dermatol , vol.157 , Issue.SUPPL. 2 , pp. 34-40
    • Krawtchenko, N.1    Roewert-Huber, J.2    Ulrich, M.3
  • 18
    • 36549032062 scopus 로고    scopus 로고
    • Multicentre, open-label study using imiquimod 5% cream in one or two 4-week courses of treatment for multiple actinic keratoses on the head
    • Stockfleth E, Sterry W, Carey-Yard M, Bichel J. Multicentre, open-label study using imiquimod 5% cream in one or two 4-week courses of treatment for multiple actinic keratoses on the head. Br J Dermatol 2007; 157(Suppl 2): 41-46.
    • (2007) Br J Dermatol , vol.157 , Issue.SUPPL. 2 , pp. 41-46
    • Stockfleth, E.1    Sterry, W.2    Carey-Yard, M.3    Bichel, J.4
  • 19
    • 36549087129 scopus 로고    scopus 로고
    • Topical immunomodulation under systemic immunosuppression: results of a multicentre, randomized, placebo-controlled safety and efficacy study of imiquimod 5% cream for the treatment of actinic keratoses in kidney, heart, and liver transplant patients
    • Ulrich C, Bichel J, Euvrard S, et al. Topical immunomodulation under systemic immunosuppression: results of a multicentre, randomized, placebo-controlled safety and efficacy study of imiquimod 5% cream for the treatment of actinic keratoses in kidney, heart, and liver transplant patients. Br J Dermatol 2007; 157(Suppl 2): 25-31.
    • (2007) Br J Dermatol , vol.157 , Issue.SUPPL. 2 , pp. 25-31
    • Ulrich, C.1    Bichel, J.2    Euvrard, S.3
  • 20
    • 34249701713 scopus 로고    scopus 로고
    • Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp
    • Tanghetti E, Werschler P. Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp. J Drugs Dermatol 2007; 6: 144-147.
    • (2007) J Drugs Dermatol , vol.6 , pp. 144-147
    • Tanghetti, E.1    Werschler, P.2
  • 21
    • 63049138720 scopus 로고    scopus 로고
    • Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head
    • Rivers JK, Rosoph L, Provost N, Bissonnette R. Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head. J Cutan Med Surg 2008; 12: 97-101.
    • (2008) J Cutan Med Surg , vol.12 , pp. 97-101
    • Rivers, J.K.1    Rosoph, L.2    Provost, N.3    Bissonnette, R.4
  • 22
    • 67650921494 scopus 로고    scopus 로고
    • Treatment of multiple, multiform actinic keratoses on the head with imiquimod 5% cream
    • Stockfleth E, Ulrich C, Lange-Asschenfeldt B, et al. Treatment of multiple, multiform actinic keratoses on the head with imiquimod 5% cream. Eur J Dermatol 2009; 19: 355-359.
    • (2009) Eur J Dermatol , vol.19 , pp. 355-359
    • Stockfleth, E.1    Ulrich, C.2    Lange-Asschenfeldt, B.3
  • 23
    • 68749122243 scopus 로고    scopus 로고
    • Intraindividual, right-left comparison of topical 5-aminolevulinic acid photodynamic therapy vs. 5% imiquimod cream for actinic keratoses on the upper extremities
    • Sotiriou E, Apalla Z, Maliamani F, et al. Intraindividual, right-left comparison of topical 5-aminolevulinic acid photodynamic therapy vs. 5% imiquimod cream for actinic keratoses on the upper extremities. J Eur Acad Dermatol Venereol 2009; 23: 1061-1065.
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , pp. 1061-1065
    • Sotiriou, E.1    Apalla, Z.2    Maliamani, F.3
  • 24
    • 70349304409 scopus 로고    scopus 로고
    • Effect of dosing frequency on the safety and efficacy of imiquimod 5% cream for treatment of actinic keratosis on the forearms and hands: a phase II, randomized, placebo-controlled trial
    • Gebauer K, Shumack S, Cowen PS. Effect of dosing frequency on the safety and efficacy of imiquimod 5% cream for treatment of actinic keratosis on the forearms and hands: a phase II, randomized, placebo-controlled trial. Br J Dermatol 2009; 161: 897-903.
    • (2009) Br J Dermatol , vol.161 , pp. 897-903
    • Gebauer, K.1    Shumack, S.2    Cowen, P.S.3
  • 25
    • 3142692799 scopus 로고    scopus 로고
    • Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial
    • Jorizzo J, Weiss J, Furst K, et al. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. Arch Dermatol 2004; 140: 813-816.
    • (2004) Arch Dermatol , vol.140 , pp. 813-816
    • Jorizzo, J.1    Weiss, J.2    Furst, K.3
  • 26
    • 0035986664 scopus 로고    scopus 로고
    • Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis
    • Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther 2002; 24: 990-1000.
    • (2002) Clin Ther , vol.24 , pp. 990-1000
    • Loven, K.1    Stein, L.2    Furst, K.3    Levy, S.4
  • 27
    • 0036690189 scopus 로고    scopus 로고
    • Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks
    • Weiss J, Menter A, Hevia O, et al. Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. Cutis 2002; 70(Suppl 2): 22-29.
    • (2002) Cutis , vol.70 , Issue.SUPPL. 2 , pp. 22-29
    • Weiss, J.1    Menter, A.2    Hevia, O.3
  • 28
    • 1942434789 scopus 로고    scopus 로고
    • Intermittent topical 5-fluorouracil is effective without significant irritation in the treatment of actinic keratoses but prolongs treatment duration
    • Labandeira J, Pereiro M Jr, Valdes F, Toribio J. Intermittent topical 5-fluorouracil is effective without significant irritation in the treatment of actinic keratoses but prolongs treatment duration. Dermatol Surg 2004; 30: 517-520.
    • (2004) Dermatol Surg , vol.30 , pp. 517-520
    • Labandeira, J.1    Pereiro Jr, M.2    Valdes, F.3    Toribio, J.4
  • 29
    • 33646171365 scopus 로고    scopus 로고
    • One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study
    • Jorizzo J, Weiss J, Vamvakias G. One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study. J Drugs Dermatol 2006; 5: 133-139.
    • (2006) J Drugs Dermatol , vol.5 , pp. 133-139
    • Jorizzo, J.1    Weiss, J.2    Vamvakias, G.3
  • 30
    • 33646204466 scopus 로고    scopus 로고
    • Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp
    • Smith SR, Morhenn VB, Piacquadio DJ. Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp. J Drugs Dermatol 2006; 5: 156-159.
    • (2006) J Drugs Dermatol , vol.5 , pp. 156-159
    • Smith, S.R.1    Morhenn, V.B.2    Piacquadio, D.J.3
  • 31
    • 60349098402 scopus 로고    scopus 로고
    • Adherence to a topical regimen of 5-fluorouracil, 0.5%, cream for the treatment of actinic keratoses
    • Yentzer B, Hick J, Williams L, et al. Adherence to a topical regimen of 5-fluorouracil, 0.5%, cream for the treatment of actinic keratoses. Arch Dermatol 2009; 145: 203-205.
    • (2009) Arch Dermatol , vol.145 , pp. 203-205
    • Yentzer, B.1    Hick, J.2    Williams, L.3
  • 32
    • 33750091315 scopus 로고    scopus 로고
    • Efficacy of 3% diclofenac gel for the treatment of actinic keratoses: a randomized, double-blind, placebo controlled study
    • Fariba I, Ali A, Hossein SA, et al. Efficacy of 3% diclofenac gel for the treatment of actinic keratoses: a randomized, double-blind, placebo controlled study. Indian J Dermatol Venereol Leprol 2006; 72: 346-349.
    • (2006) Indian J Dermatol Venereol Leprol , vol.72 , pp. 346-349
    • Fariba, I.1    Ali, A.2    Hossein, S.A.3
  • 33
    • 0035659622 scopus 로고    scopus 로고
    • Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses
    • Wolf JE Jr, Taylor JR, Tschen E, Kang S. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol 2001; 40: 709-713.
    • (2001) Int J Dermatol , vol.40 , pp. 709-713
    • Wolf Jr, J.E.1    Taylor, J.R.2    Tschen, E.3    Kang, S.4
  • 34
    • 0036178561 scopus 로고    scopus 로고
    • Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel
    • Rivers JK, Arlette J, Shear N, et al. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol 2002; 146: 94-100.
    • (2002) Br J Dermatol , vol.146 , pp. 94-100
    • Rivers, J.K.1    Arlette, J.2    Shear, N.3
  • 35
    • 7644224775 scopus 로고    scopus 로고
    • Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze)
    • Nelson C, Rigel D, Smith S, et al. Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol 2004; 3: 401-407.
    • (2004) J Drugs Dermatol , vol.3 , pp. 401-407
    • Nelson, C.1    Rigel, D.2    Smith, S.3
  • 36
    • 52449126834 scopus 로고    scopus 로고
    • Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery
    • Berlin JM, Rigel DS. Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery. J Drugs Dermatol 2008; 7: 669-673.
    • (2008) J Drugs Dermatol , vol.7 , pp. 669-673
    • Berlin, J.M.1    Rigel, D.S.2
  • 37
    • 77949403672 scopus 로고    scopus 로고
    • Defining endpoints in clinical trials on atrial fibrillation
    • Camm AJ, Reiffel JA. Defining endpoints in clinical trials on atrial fibrillation. Eur Heart J Suppl 2008; 10(Suppl H): H55-H78.
    • (2008) Eur Heart J Suppl , vol.10 , Issue.SUPPL.
    • Camm, A.J.1    Reiffel, J.A.2
  • 38
    • 33747596885 scopus 로고    scopus 로고
    • Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: critical review and meta-analysis of efficacy studies
    • Gupta AK, Davey V, Mcphail H. Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: critical review and meta-analysis of efficacy studies. J Cutan Med Surg 2005; 9: 209-214.
    • (2005) J Cutan Med Surg , vol.9 , pp. 209-214
    • Gupta, A.K.1    Davey, V.2    Mcphail, H.3
  • 39
    • 77955440071 scopus 로고    scopus 로고
    • Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment
    • Kaur RR, Alikahn A, Mailbach HI. Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. J Dermatolog Treat 2010; 21: 267-271.
    • (2010) J Dermatolog Treat , vol.21 , pp. 267-271
    • Kaur, R.R.1    Alikahn, A.2    Mailbach, H.I.3
  • 40
    • 34047184786 scopus 로고    scopus 로고
    • Assessing clinically meaningful end points for the management of actinic keratosis with diclofenac 3% gel
    • Rivers JK, Wolf J. Assessing clinically meaningful end points for the management of actinic keratosis with diclofenac 3% gel. Acta Derm Venereol 2007; 87: 188-189.
    • (2007) Acta Derm Venereol , vol.87 , pp. 188-189
    • Rivers, J.K.1    Wolf, J.2
  • 41
    • 27744588722 scopus 로고    scopus 로고
    • Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies
    • Pirard D, Vereecken P, Mélot C, Heenen M. Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies. Arch Dermatol Res 2005; 297: 185-189.
    • (2005) Arch Dermatol Res , vol.297 , pp. 185-189
    • Pirard, D.1    Vereecken, P.2    Mélot, C.3    Heenen, M.4
  • 42
    • 0033928866 scopus 로고    scopus 로고
    • Histopathology of incipient intraepidermal squamous cell carcinoma "actinic keratosis"
    • Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma "actinic keratosis". J Am Acad Dermatol 2000; 2(1 pt 2): S11-S17.
    • (2000) J Am Acad Dermatol , vol.2 , Issue.1 PT 2
    • Cockerell, C.J.1
  • 43
    • 0037244413 scopus 로고    scopus 로고
    • Photodynamic therapy: is it a valuable treatment option for actinic keratoses?
    • Chamberlain AJ, Kurwa HA. Photodynamic therapy: is it a valuable treatment option for actinic keratoses? Am J Clin Dermatol 2003; 4: 149-155.
    • (2003) Am J Clin Dermatol , vol.4 , pp. 149-155
    • Chamberlain, A.J.1    Kurwa, H.A.2
  • 44
    • 59849109705 scopus 로고    scopus 로고
    • Retrospective, descriptive, observational study of multiple actinic keratoses with topical methyl aminolevulinate and red light: results in clinical practice and correlation with fluorescence imaging
    • Fernández-Guarino M, Harto A, Sánchez-Ronco M, et al. Retrospective, descriptive, observational study of multiple actinic keratoses with topical methyl aminolevulinate and red light: results in clinical practice and correlation with fluorescence imaging. Actas Dermosfiliogr 2008; 99: 779-787.
    • (2008) Actas Dermosfiliogr , vol.99 , pp. 779-787
    • Fernández-Guarino, M.1    Harto, A.2    Sánchez-Ronco, M.3
  • 45
    • 77949272216 scopus 로고    scopus 로고
    • Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles
    • Swanson N, Abramovits W, Berman B, et al. Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles. J Am Acad Dermatol 2010; 62: 582-590.
    • (2010) J Am Acad Dermatol , vol.62 , pp. 582-590
    • Swanson, N.1    Abramovits, W.2    Berman, B.3
  • 46
    • 33749481832 scopus 로고    scopus 로고
    • A clinical comparison and long-term follow-up of topical 5-fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses
    • Ostertag JU, Quaedvlieg PJ, van der Geer S, et al. A clinical comparison and long-term follow-up of topical 5-fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses. Lasers Surg Med 2006; 38: 731-739.
    • (2006) Lasers Surg Med , vol.38 , pp. 731-739
    • Ostertag, J.U.1    Quaedvlieg, P.J.2    van der Geer, S.3
  • 47
    • 34548824355 scopus 로고    scopus 로고
    • The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams
    • Price NM. The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. J Drugs Dermatol 2007; 6: 778-781.
    • (2007) J Drugs Dermatol , vol.6 , pp. 778-781
    • Price, N.M.1
  • 48
    • 60849118650 scopus 로고    scopus 로고
    • Topical sulindac combined with hydrogen peroxide in the treatment of actinic keratoses
    • Resnick L, Rabinovitz H, Binninger D, et al. Topical sulindac combined with hydrogen peroxide in the treatment of actinic keratoses. J Drugs Dermatol 2009; 8: 29-32.
    • (2009) J Drugs Dermatol , vol.8 , pp. 29-32
    • Resnick, L.1    Rabinovitz, H.2    Binninger, D.3
  • 49
    • 77950483002 scopus 로고    scopus 로고
    • Topical treatment of actinic keratoses with low-dose 5-fluorouracil in combination with salicylic acid - pilot study
    • Schlaak M, Simon JC. Topical treatment of actinic keratoses with low-dose 5-fluorouracil in combination with salicylic acid - pilot study. J Dtsch Dermatol Ges 2010; 8: 174-178.
    • (2010) J Dtsch Dermatol Ges , vol.8 , pp. 174-178
    • Schlaak, M.1    Simon, J.C.2
  • 50
    • 57349151103 scopus 로고    scopus 로고
    • Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses
    • Mastrolonardo M. Topical diclofenac 3% gel plus cryotherapy for treatment of multiple and recurrent actinic keratoses. Clin Exp Dermatol 2009; 34: 33-35.
    • (2009) Clin Exp Dermatol , vol.34 , pp. 33-35
    • Mastrolonardo, M.1
  • 51
    • 60849138793 scopus 로고    scopus 로고
    • Treatment of actinic keratoses with sequential use of photodynamic therapy and imiquimod 5% cream
    • Shaffelburg M. Treatment of actinic keratoses with sequential use of photodynamic therapy and imiquimod 5% cream. J Drugs Dermatol 2009; 8: 35-39.
    • (2009) J Drugs Dermatol , vol.8 , pp. 35-39
    • Shaffelburg, M.1
  • 52
    • 19444381829 scopus 로고    scopus 로고
    • Treatment of actinic keratoses with sequential combination of 5-fluorouracil and photodynamic therapy
    • Gilbert DJ. Treatment of actinic keratoses with sequential combination of 5-fluorouracil and photodynamic therapy. J Drugs Dermatol 2005; 4: 161-163.
    • (2005) J Drugs Dermatol , vol.4 , pp. 161-163
    • Gilbert, D.J.1
  • 53
    • 84882683078 scopus 로고    scopus 로고
    • Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study
    • Van Der Geer S, Krekels GA. Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study. J Dermatolog Treat 2009; 1: 1-7.
    • (2009) J Dermatolog Treat , vol.1 , pp. 1-7
    • Van Der Geer, S.1    Krekels, G.A.2
  • 54
    • 33746645957 scopus 로고    scopus 로고
    • Adherence in dermatology: a review of the last 20 years
    • Hodari KT, Nanton JR, Carroll CL, et al. Adherence in dermatology: a review of the last 20 years. J Dermatolog Treat 2006; 17: 136-142.
    • (2006) J Dermatolog Treat , vol.17 , pp. 136-142
    • Hodari, K.T.1    Nanton, J.R.2    Carroll, C.L.3
  • 55
    • 34447550756 scopus 로고    scopus 로고
    • Poor adherence to treatments: a fundamental principle of dermatology
    • Alt SM, Brodell RT, Balkrishnan R, Feldman SR. Poor adherence to treatments: a fundamental principle of dermatology. Arch Dermatol 2007; 143: 912-915.
    • (2007) Arch Dermatol , vol.143 , pp. 912-915
    • Alt, S.M.1    Brodell, R.T.2    Balkrishnan, R.3    Feldman, S.R.4
  • 56
    • 28644434323 scopus 로고    scopus 로고
    • Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer
    • Hess LM, Saboda K, Malone DC, et al. Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2579-2583.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 2579-2583
    • Hess, L.M.1    Saboda, K.2    Malone, D.C.3
  • 57
    • 84882721858 scopus 로고    scopus 로고
    • Randomized, parallel-group, double-blind, vehicle-controlled, multicenter phase 3 study of the efficacy and safety of PEP005 (ingenol mebutate) gel, 0.015% in patients with actinic keratoses on the head. Presented at: 22nd World Congress of Dermatology; 24-29 May 2011; Seoul, Korea. Poster P2181.
    • Lebwohl M, Melgaard A, Xu Z. Randomized, parallel-group, double-blind, vehicle-controlled, multicenter phase 3 study of the efficacy and safety of PEP005 (ingenol mebutate) gel, 0.015% in patients with actinic keratoses on the head. Presented at: 22nd World Congress of Dermatology; 24-29 May 2011; Seoul, Korea. Poster P2181.
    • Lebwohl, M.1    Melgaard, A.2    Xu, Z.3
  • 58
    • 66349099884 scopus 로고    scopus 로고
    • Improving adherence to topical treatment
    • Feldman SR. Improving adherence to topical treatment. Cutis 2009; 83: 215-217.
    • (2009) Cutis , vol.83 , pp. 215-217
    • Feldman, S.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.