Claudin-4 controls the proliferation, apoptosis, migration and in vivo growth of MCF-7 breast cancer cells

Oncology Reports

Volumn 34, Issue 2, 2015, Pages 681-690

  Ma, Xiaotang ^a   Miao, Huilai ^a   Jing, Baoguo ^a   Pan, Qunwen ^a   Zhang, Huiting ^a   Chen, Yanfang ^a   Zhang, Dan ^a   Liang, Zhongzeng ^a   Wen, Zhili ^b   Li, Mingyi ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Breast cancer; Claudin 4; Mcf 7 cell function; Methylation; Tumorigenesis

Indexed keywords

CLAUDIN 4; SHORT HAIRPIN RNA; CLDN4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; BREAST CANCER CELL LINE; BREAST CARCINOGENESIS; CELL CYCLE; CELL MIGRATION; CLAUDIN 4 GENE; CONTROLLED STUDY; DEMETHYLATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; REGULATORY MECHANISM; TUMOR GROWTH; UPREGULATION; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; CELL MOTION; CELL PROLIFERATION; DNA METHYLATION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL MOVEMENT; CELL PROLIFERATION; CLAUDIN-4; DNA METHYLATION; FEMALE; HUMANS; MCF-7 CELLS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; UP-REGULATION;

EID: 84931390698     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4037     Document Type: Article

References (39)

1. Myal Y, Leygue E and Blanchard AA: Claudin 1 in breast tumorigenesis: Revelation of a possible novel 'claudin high' subset of breast cancers. J Biomed Biotechnol 2010: 956897, 2010.
2. Singh AB, Sharma A and Dhawan P: Claudin family of proteins and cancer: An overview. J Oncol 2010: 541957, 2010.
3. Tsukita S, Furuse M and Itoh M: Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2: 285-293, 2001.
4. Matter K and Balda MS: Signalling to and from tight junctions. Nat Rev Mol Cell Biol 4: 225-236, 2003.
5. Furuse M and Tsukita S: Claudins in occluding junctions of humans and flies. Trends Cell Biol 16: 181-188, 2006.
6. Van Itallie CM and Anderson JM: Claudins and epithelial paracellular transport. Annu Rev Physiol 68: 403-429, 2006.
7. Morin PJ: Claudin proteins in human cancer: Promising new targets for diagnosis and therapy. Cancer Res 65: 9603-9606, 2005.
8. Soini Y: Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours. Histopathology 46: 551-560, 2005.
9. Sakaguchi T, Suzuki S, Higashi H, Inaba K, Nakamura S, Baba S, Kato T and Konno H: Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma. J Surg Res 147: 123-131, 2008.
10. Escudero-Esparza A, Jiang WG and Martin TA: The Claudin family and its role in cancer and metastasis. Front Biosci 16: 1069-1083, 2011.
11. Boireau S, Buchert M, Samuel MS, Pannequin J, Ryan JL, Choquet A, Chapuis H, Rebillard X, Avancès C, Ernst M, et al: DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis 28: 246-258, 2007.
12. Liu Y, Sun W, Zhang K, Zheng H, Ma Y, Lin D, Zhang X, Feng L, Lei W, Zhang Z, et al: Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung Cancer 56: 307-317, 2007.
13. Paschoud S, Bongiovanni M, Pache JC and Citi S: Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol 20: 947-954, 2007.
14. Resnick MB, Konkin T, Routhier J, Sabo E and Pricolo VE: Claudin-1 is a strong prognostic indicator in stage II colonic cancer: A tissue microarray study. Mod Pathol 18: 511-518, 2005.
15. Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, Hakamada K, Sasaki M and Kijima H: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med 20: 139-143, 2007.
16. Blanchard AA, Skliris GP, Watson PH, Murphy LC, Penner C, Tomes L, Young TL, Leygue E and Myal Y: Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype. Virchows Arch 454: 647-656, 2009.
17. Osanai M, Murata M, Chiba H, Kojima T and Sawada N: Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells. Cancer Sci 98: 1557-1562, 2007.
18. Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, Jirstrom K, Landberg G, Martin F, Duffy MJ, et al: Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer 124: 2088-2097, 2009.
19. Kolokytha P, Yiannou P, Keramopoulos D, Kolokythas A, Nonni A, Patsouris E and Pavlakis K: Claudin-3 and claudin-4: Distinct prognostic significance in triple-negative and luminal breast cancer. Appl Immunohistochem Mol Morphol 22: 125-131, 2014.
20. Szasz AM, Nemeth Z, Gyorffy B, Micsinai M, Krenacs T, Baranyai Z, Harsanyi L, Kiss A, Schaff Z, Tokes AM, et al: Identification of a claudin-4 and E-cadherin score to predict prognosis in breast cancer. Cancer Sci 102: 2248-2254, 2011.
21. Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP and Sukumar S: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033, 2003.
22. Wu Q, Liu Y, Ren Y, Xu X, Yu L, Li Y and Quan C: Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. Eur J Cancer Prev 19: 186-194, 2010.
23. Litkouhi B, Kwong J, Lo CM, Smedley JG III, McClane BA, Aponte M, Gao Z, Sarno JL, Hinners J, Welch WR, et al: Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia 9: 304-314, 2007.
24. Abuazza G, Becker A, Williams SS, Chakravarty S, Truong HT, Lin F and Baum M: Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins. Am J Physiol Renal Physiol 291: F1132-F1141, 2006.
25. Oliveira SS and Morgado-Díaz JA: Claudins: Multifunctional players in epithelial tight junctions and their role in cancer. Cell Mol Life Sci 64: 17-28, 2007.
26. Lazarevich NL and Fleishman DI: Tissue-specific transcription factors in progression of epithelial tumors. Biochemistry 73: 573-591, 2008.
27. Zavala-Zendejas VE, Torres-Martinez AC, Salas-Morales B, Fortoul TI, Montaño LF and Rendon-Huerta EP: Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate. Cancer Invest 29: 1-11, 2011.
28. Itoh M, Furuse M, Morita K, Kubota K, Saitou M and Tsukita S: Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 147: 1351-1363, 1999.
29. Balda MS, Garrett MD and Matter K: The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol 160: 423-432, 2003.
30. Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S and Sasaki T: Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. Biochem Biophys Res Commun 308: 270-275, 2003.
31. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001.
32. Guo Y, Xu X, Liu Z, Zhang T, Zhang X, Wang L, Wang M, Liu Y, Lu Y, Liu Y, et al: Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer. Diagn Pathol 7: 111, 2012.
33. Armstrong SM, Wang C, Tigdi J, Si X, Dumpit C, Charles S, Gamage A, Moraes TJ and Lee WL: Influenza infects lung microvascular endothelium leading to microvascular leak: Role of apoptosis and claudin-5. PLoS One 7: e47323, 2012.
34. Akasaka H, Sato F, Morohashi S, Wu Y, Liu Y, Kondo J, Odagiri H, Hakamada K and Kijima H: Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells. BMC Cancer 10: 548, 2010.
35. Michl P, Barth C, Buchholz M, Lerch MM, Rolke M, Holzmann KH, Menke A, Fensterer H, Giehl K, Löhr M, et al: Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res 63: 6265-6271, 2003.
36. Agarwal R, D'Souza T and Morin PJ: Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res 65: 7378-7385, 2005.
37. Hashimi SM, Yu S, Alqurashi N, Ipe DS and Wei MQ: Immunotoxin-mediated targeting of claudin-4 inhibits the proliferation of cancer cells. Int J Oncol 42: 1911-1918, 2013.
38. Esteller M: Relevance of DNA methylation in the management of cancer. Lancet Oncol 4: 351-358, 2003.
39. Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayashi H, Iacobuzio-Donahue CA, Rosty C and Goggins M: Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 63: 4158-4166, 2003.