IgA antiphospholipid antibodies and anti-domain 1 of beta 2 glycoprotein 1 antibodies are associated with livedo reticularis and heart valve disease in antiphospholipid syndrome

Advances in Clinical and Experimental Medicine

Volumn 23, Issue 5, 2014, Pages 729-733

  Cies̈la, Marek ^a   Wypasek, Ewa ^a,b   Undas, Anetta ^a,b  

^a Krakowski Szpital Specjalistyczny Im Jana Pawła II   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Antiphospholipid syndrome; Beta 2 glycoprotein 1; Domain 1; Heart valve disease; Livedo reticularis

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

ADULT; ANTIBODY BLOOD LEVEL; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL FEATURE; FEMALE; HUMAN; LIVEDO RETICULARIS; MALE; THROMBOCYTOPENIA; VALVULAR HEART DISEASE;

EID: 84931385188     PISSN: 18995276     EISSN: 24512680     Source Type: Journal    
DOI: 10.17219/acem/27570     Document Type: Article

References (15)

1. de Laat B, Mertens K, de Groot PG: Mechanisms of disease: antiphospholipid antibodies - from clinical association to pathologic mechanism. Nat Clin Pract Rheumatol 2008, 4,192-199.
2. Jeleniewicz R, Majdan M, Targońska-Stępniak B, Dryglewska M: Prevalence of antiphospholipid antibodies in rheumatoid arthritis patients and relationship with disease activity. Pol Arch Med Wewn 2012,122,480-486.
3. Lakos G, Kiss E, Regëczy N, Tarján P, Soltész P, Zeher M, Bodolay E, Szakony S, Sipka S, Szegedi G: Isotype distribution and clinical relevance of anti-beta2-glycoprotein I (beta2-GPI) antibodies: importance of IgA isotype. Clin Exp Immunol 1999, 117, 574-579.
4. Marchetti T, Cohen M, Gris JC, de Moerloose P: Diagnosis and management of obstetrical antiphospholipid syndrome: where do we stand? Pol Arch Med Wewn 2013, 123, 713-720.
5. Krause I, Lev S, Fraser A, Blank M, Lorber M, Stojanovich L, Rovensky J, Chapman J, Shoenfeld Y: Close association between valvar heart disease and central nervous system manifestations in the antiphospholipid syndrome. Ann Rheum Dis 2005, 64, 1490-1493.
6. de Groot PG, Urbanus RT: The future of antiphospholipid antibody testing. Semin Thromb Hemost 2013, 38, 412-420.
7. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA: International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006, 4, 295-306.
8. Andreoli L, Fredi M, Nalli C, Piantoni S, Reggia R, Dall'Ara F, Tincani A: Clinical Significance of IgA Anti-Cardiolipin and IgA Anti-β2Glycoprotein I Antibodies. Curr Rheumatol Rep 2013, 15, 343. doi: 10.1007/sl 1926-013-0343-1.
9. Sebastiani GD, Galeazzi M, Tincani A, Piette JC, Font J, Allegri F, Mathieu A, Smolen J, de Ramon Garrido E, Fernandez-Nebro A, Jedryka-Goral A, Papasteriades C, Morozzi G, Bellisai F, De Pitá O, Marcolongo R: Anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Prevalence and clinical associations. European Concerted Action on the Immunogenetics of SLE. Scand J Rheumatol 1999, 28, 344-351.
10. Samarkos M, Davies KA, Gordon C, Loizou S: Clinical significance of IgA anticardiolipin and anti-β2-GPI antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome. Clin Rheumatol 2006, 25, 199-204.
11. Mahler M, Norman GL, Meroni PL, Khamashta M: Autoantibodies to domain 1 of beta 2 glycoprotein 1 : A promising candidate biomarker for risk management in antiphospholipid syndrome. Autoimmun Rev 2012,12, 313-317.
12. de Laat B, Derksen RH, Urbanus RT, de Groot PG: IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005,105,1540-1545.
13. de Laat B, Pengo V, Pabinger I, Musial J, Voskuyl AE, Bultink IE, Ruffatti A, Rozman B, Kveder T, de Moerloose P, Boehlen F, Rand J, Ulcova-Gallova Z, Mertens K, de Groot PG: The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost 2009,7,1767-1773.
14. Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, de Groot PG: Update of the guidelines for lupus anticoagulant detection. J Thromb Haemost 2009, 7,1737-1740.
15. Toubi E, Krause I, Fraser A, Lev S, Stojanovich L, Rovensky J, Blank M, Shoenfeld Y: Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholipid syndrome. Clin Exp Rheumatol 2005, 23, 499-504.