Clinical significance of IgA anticardiolipin and anti-β2 -GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome

Clinical Rheumatology

Volumn 25, Issue 2, 2006, Pages 199-204

  Samarkos, M ^a   Davies, K A ^b   Gordon, C ^c   Loizou, S ^d  

^a EVANGELISMOS HOSPITAL   (Greece)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Anti 2 GP1; Anticardiolipin antibodies; Antiphospholipid antibodies; Antiphospholipid syndrome; IgA; Immunoglobulins; Systemic lupus erythematosus

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; RECURRENT ABORTION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; VEIN THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTICARDIOLIPIN; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHNIC GROUPS; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 33644853666     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-005-1156-z     Document Type: Article

References (28)

1. Asherson RA, Cervera R (1993) Anticardiolipin antibodies, chronic biologic false-positive tests for syphilis and other antiphospholipid antibodies. In: Wallace DJ, Hahn BH (eds) Dubois' lupus erythematosus. Lea & Febiger, Philadelphia, pp 233-245
2. Feinstein DI, Francis RB (1993) The lupus anticoagulant and anticardiolipin antibodies. In: Wallace DJ, Hahn BH (eds) Dubois' lupus erythematosus. Lea & Febiger, Philadelphia, pp 246-253
3. Arvieux J, Roussel B, Jacob MC, Colomb MG (1991) Measurement of anti-phospholipid antibodies by ELISA using beta 2-glycoprotein I as an antigen. J Immunol Methods 143:223-229
4. Alarcon-Segovia D, Deleze M, Oria CV et al (1989) Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. Medicine 68:353-365
5. Weidmann CE, Wallace DJ, Peter JB, Knight PJ, Bear MB, Klinenberg JR (1988) Studies of IgG, IgM and IgA antiphospholipid antibody isotypes in systemic lupus erythematosus. J Rheumatol 15:74-79
6. Molina JF, Gutierrez-Urena S, Molina J et al (1997) Variability of anticardiolipin antibody isotype distribution in 3 geographic populations of patients with systemic lupus erythematosus. J Rheumatol 24:291-296
7. Loizou S, Cofiner C, Weetman AP, Walport MJ (1992) Immunoglobulin class and IgG subclass distribution of anticardiolipin antibodies in patients with systemic lupus erythematosus and associated disorders. Clin Exp Immunol 90:434-439
8. Selva-O'Callaghan A, Ordi-Ros J, Monegal-Ferran F, Martinez N, Cortes-Hernandez F, Vilardell-Tarres M (1998) IgA anticardiolipin antibodies-relation with other antiphospholipid antibodies and clinical significance. Thromb Haemost 79:282-285
9. Lakos G, Kiss E, Regeczy N et al (1999) Isotype distribution and clinical relevance of anti-beta2-glycoprotein I (beta2-GPI) antibodies: importance of IgA isotype. Clin Exp Immunol 117:574-579
10. Fanopoulos D, Teodorescu MR, Varga J, Teodorescu M (1998) High frequency of abnormal levels of IgA anti-beta2-glycoprotein I antibodies in patients with systemic lupus erythematosus: Relationship with antiphospholipid syndrome. J Rheumatol 25:675-680
11. Galeazzi M, Sebastiani GD, Tincani A, Piette JC, Allegri F, Morozzi G et al (2000) HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus 9:47-55
12. Spadaro A, Riccieri V, Terracina S, Rinaldi T, Taccari E, Zoppini A (2000) Class specific rheumatoid factors and antiphospholipid syndrome in systemic lupus erythematosus. Lupus 9:56-60
13. Gharavi AE, Harris EN, Asherson RA, Hughes GR (1987) Anticardiolipin antibodies: Isotype distribution and phospholipid specificity. Ann Rheum Dis 46:1-6
14. Lopez LR, Santos ME, Espinoza LR, La Rosa FG (1992) Clinical significance of immunoglobulin A versus immunoglobulins G and M anti-cardiolipin antibodies in patients with systemic lupus erythematosus. Correlation with thrombosis, thrombocytopenia, and recurrent abortion. Am J Clin Pathol 98:449-454
15. Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Koike T (1998) IgA class anti-beta2-glycoprotein I in patients with systemic lupus erythematosus. J Rheumatol 25:74-78
16. Guerin J, Casey E, Feighery C, Jackson J (1999) Anti-beta 2-glycoprotein I antibody isotype and IgG subclass in antiphospholipid syndrome patients. Autoimmunity 31:109-116
17. 2 -glycoprotein I antibodies: importance of IgA isotype. Clin Exp Immunol 117:574-579
18. Lee SS, Cho ML, Joo YS, Kim WU, Hong YS, Min JK et al (2001) Isotypes of anti-beta2-glycoprotein I antibodies: Association with thrombosis in patients with systemic lupus erythematosus. J Rheumatol 28:520-524
19. Bertolaccini ML, Atsumi T, Escudero CA, Khamashta MA, Hughes GR (2001) The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus. J Rheumatol 28:2637-2643
20. Samarkos M, Asherson RA, Loizou S (2001) The clinical significance of IgA antiphospholipid antibodies. J Rheumatol 28:694-697
21. Samarkos M, Davies KA, Gordon C, Walport MJ, Loizou S (2001) IgG subclass distribution of antibodies against beta(2)-GP1 and cardiolipin in patients with systemic lupus erythematosus and primary antiphospholipid syndrome, and their clinical associations. Rheumatology (Oxford) 40:1026-1032
22. Tan EM, Cohen AS, Fries JF (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277
23. Loizou S, Samarkos M, Norsworthy PJ, Cazabon JK, Walport MJ, Davies KA (2000) Significance of anticardiolipin and anti-beta(2)-glycoprotein I antibodies in lupus nephritis. Rheumatology (Oxford) 39:962-968
24. Polz E, Wurm H, Kostner GM (1981) Studies on the composition of the protein part of triglyceride rich lipoproteins of human serum: Isolation of polymorphic forms of beta 2-glycoprotein-I. Artery 9:305-315
25. Cucurull E, Espinoza LR, Mendez E et al (1999) Anticardiolipin and anti-beta2glycoprotein-I antibodies in patients with systemic lupus erythematosus: Comparison between Colombians and Spaniards. Lupus 8:134-141
26. Cucurull E, Gharavi AE, Diri E, Mendez E, Kapoor D, Espinoza LR (1999) IgA anticardiolipin and anti-beta2-glycoprotein I are the most prevalent isotypes in African American patients with systemic lupus erythematosus. Am J Med Sci 318:55-60
27. Kalunian KC, Peter JB, Middlekauff HR et al (1988) Clinical significance of a single test for anti-cardiolipin antibodies in patients with systemic lupus erythematosus. Am J Med 85:602-608
28. Tajima C, Suzuki Y, Mizushima Y, Ichikawa Y (1998) Clinical significance of immunoglobulin A antiphospholipid antibodies: Possible association with skin manifestations and small vessel vasculitis. J Rheumatol 25:1730-1736