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Volumn 2014, Issue , 2014, Pages

Management of the Bleeding Patient Receiving New Oral Anticoagulants: A Role for Prothrombin Complex Concentrates

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; ACTIVATED PROTHROMBIN COMPLEX; ANTICOAGULANT AGENT; APIXABAN; BLOOD CLOTTING FACTOR 9 COMPLEX; DABIGATRAN; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; THROMBOCYTE CONCENTRATE; WARFARIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 7A; PROTHROMBIN COMPLEX CONCENTRATES; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE;

EID: 84931325490     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/583794     Document Type: Review
Times cited : (42)

References (48)
  • 2
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • J. van Ryn, J. Stangier, S. Haertter, et al., "Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity, " Thrombosis & Haemostasis, vol. 103, no. 6, pp. 1116-1127, 2010.
    • (2010) Thrombosis & Haemostasis , vol.103 , Issue.6 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 3
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development
    • B. I. Eriksson, D. J. Quinlan, and J. I. Weitz, "Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development, " Clinical Pharmacokinetics, vol. 48, pp. 1-22, 2009.
    • (2009) Clinical Pharmacokinetics , vol.48 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 4
    • 80052351015 scopus 로고    scopus 로고
    • Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
    • P. C. Wong, D. J. P. Pinto, and D. Zhang, "Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor, " Journal of Thrombosis and Thrombolysis, vol. 31, no. 4, pp. 478-492, 2011.
    • (2011) Journal of Thrombosis and Thrombolysis , vol.31 , Issue.4 , pp. 478-492
    • Wong, P.C.1    Pinto, D.J.P.2    Zhang, D.3
  • 5
    • 84897895391 scopus 로고    scopus 로고
    • How i treat target-specific oral anticoagulant-associated homorrhage
    • D. M. Siegal, D. A. Garcia, and M. A. Crowther, "How I treat target-specific oral anticoagulant-associated homorrhage, " Blood, vol. 123, pp. 1152-1158, 2014.
    • (2014) Blood , vol.123 , pp. 1152-1158
    • Siegal, D.M.1    Garcia, D.A.2    Crowther, M.A.3
  • 7
    • 84896466200 scopus 로고    scopus 로고
    • FactorXa inhibitors vswarfarin for preventing stroke and thromboembolism in pateints with atrial fibrillation
    • K. M. Bruins Slot and E. Berge, "FactorXa inhibitors vswarfarin for preventing stroke and thromboembolism in pateints with atrial fibrillation, " JAMA, vol. 311, pp. 1150-1151, 2014.
    • (2014) JAMA , vol.311 , pp. 1150-1151
    • Bruins Slot, K.M.1    Berge, E.2
  • 8
    • 84903376055 scopus 로고    scopus 로고
    • Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation
    • G. Stepanyan, N. Badhwar, R. J. Lee, et al., "Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation, " Journal of Interventional Cardiac Electrophysiology, vol. 40, pp. 33-38, 2014.
    • (2014) Journal of Interventional Cardiac Electrophysiology , vol.40 , pp. 33-38
    • Stepanyan, G.1    Badhwar, N.2    Lee, R.J.3
  • 10
    • 84935834621 scopus 로고    scopus 로고
    • CSL Behring GmbH
    • CSL Behring GmbH, "Kcentra prescribing information, " http://labeling.cslbehring.com/PI/US/Kcentra/EN/Kcentra-Prescribing-Information.pdf.
    • Kcentra Prescribing Information
  • 12
    • 84874945921 scopus 로고    scopus 로고
    • Clinical experience with oral versus intravenous vitamin K for warfarin reversal (CME)
    • R. Meehan, M. Tavares, and J. Sweeney, "Clinical experience with oral versus intravenous vitamin K for warfarin reversal (CME), " Transfusion, vol. 53, no. 3, pp. 491-498, 2013.
    • (2013) Transfusion , vol.53 , Issue.3 , pp. 491-498
    • Meehan, R.1    Tavares, M.2    Sweeney, J.3
  • 13
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex vivo study in healthy volunteers
    • R. Marlu, E. Hodaj, A. Paris, P. Albaladejo, J. L. Cracowski, and G. Pernod, "Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers, " Thrombosis and Haemostasis, vol. 108, no. 2, pp. 217-224, 2012.
    • (2012) Thrombosis and Haemostasis , vol.108 , Issue.2 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Cracowski, J.L.5    Pernod, G.6
  • 14
    • 84858755308 scopus 로고    scopus 로고
    • The successful reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat tail bleeding model do not correlate with ex vivo markers of anticoagulation
    • J. van Ryn, J. Schurer, M. Kink-Eiband, and A. Clemens, "The successful reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat tail bleeding model do not correlate with ex vivo markers of anticoagulation, " Blood, vol. 118, p. 2316, 2011.
    • (2011) Blood , vol.118 , pp. 2316
    • Van Ryn, J.1    Schurer, J.2    Kink-Eiband, M.3    Clemens, A.4
  • 15
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • E. S. Eerenberg, P. W. Kamphuisen, M. K. Sijpkens, J. C. Meijers, H. R. Buller, and M. Levi, "Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects, " Circulation, vol. 124, no. 14, pp. 1573-1579, 2011.
    • (2011) Circulation , vol.124 , Issue.14 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 16
    • 67849124919 scopus 로고    scopus 로고
    • Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate
    • J. van Ryn, D. Ruehl, H. Priepke, H. Hauel, and W. Wienan, "Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate, " Haematologica, vol. 93, p. 148, 2008.
    • (2008) Haematologica , vol.93 , pp. 148
    • Van Ryn, J.1    Ruehl, D.2    Priepke, H.3    Hauel, H.4    Wienan, W.5
  • 17
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rFVIIa) and hemodialysis tomanage massive dabigatran-associated postcardiac surgery bleeding
    • T. Warkentin, P. Margetts, S. Connolly, A. Lamy, C. Ricci, and J. Eikelboom, "Recombinant factor VIIa (rFVIIa) and hemodialysis tomanage massive dabigatran-associated postcardiac surgery bleeding, " Blood, vol. 119, pp. 2172-2174, 2012.
    • (2012) Blood , vol.119 , pp. 2172-2174
    • Warkentin, T.1    Margetts, P.2    Connolly, S.3    Lamy, A.4    Ricci, C.5    Eikelboom, J.6
  • 18
    • 84860746568 scopus 로고    scopus 로고
    • Neurosurgical complications of direct thrombin inhibitors-catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran
    • S. T. Garber, W. Sivakumar, and R. H. Schmidt, "Neurosurgical complications of direct thrombin inhibitors-catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran, " Journal of Neurosurgery, vol. 116, no. 5, pp. 1093-1096, 2012.
    • (2012) Journal of Neurosurgery , vol.116 , Issue.5 , pp. 1093-1096
    • Garber, S.T.1    Sivakumar, W.2    Schmidt, R.H.3
  • 19
    • 84856936368 scopus 로고    scopus 로고
    • Epidural hematoma and intraoperative hemorrhage in a spine trauma patient on pradaxa (dabigatran)
    • E. Truumees, T. Gaudu, C. Dieterichs, M. Geck, and J. Stokes, "Epidural hematoma and intraoperative hemorrhage in a spine trauma patient on pradaxa (dabigatran), " Spine, vol. 37, pp. E863-E865, 2012.
    • (2012) Spine , vol.37 , pp. E863-E865
    • Truumees, E.1    Gaudu, T.2    Dieterichs, C.3    Geck, M.4    Stokes, J.5
  • 20
    • 84865815830 scopus 로고    scopus 로고
    • Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: Implications for emergency surgery and resuscitation
    • A. Lillo-Le Louet, M. Wolf, L. Soufir, et al., "Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation, " Thrombosis and Haemostasis, vol. 108, no. 3, pp. 583-585, 2012.
    • (2012) Thrombosis and Haemostasis , vol.108 , Issue.3 , pp. 583-585
    • Lillo-Le Louet, A.1    Wolf, M.2    Soufir, L.3
  • 22
    • 84893171895 scopus 로고    scopus 로고
    • Reversing the new oral anticoagulants with prothrombin comlpex concentrates (PCCs): What is the evidence?
    • G. Dickneite and M. Hoffman, "Reversing the new oral anticoagulants with prothrombin comlpex concentrates (PCCs): what is the evidence?"Thrombosis and Haemostasis, vol. 111, no. 2, pp. 189-198, 2014.
    • (2014) Thrombosis and Haemostasis , vol.111 , Issue.2 , pp. 189-198
    • Dickneite, G.1    Hoffman, M.2
  • 23
    • 84874256149 scopus 로고    scopus 로고
    • Reversal of apixaban induced alterations of hemostasis by different coagulation factor concentrates: Studies in vitro with circulating human blood
    • G. Escolar, J. Reverter, J. Villalta, V. Sanz, P. Molina, and M. Diaz-Ricart, "Reversal of apixaban induced alterations of hemostasis by different coagulation factor concentrates: Studies in vitro with circulating human blood, " Circulation, vol. 126, p. 521, 2012.
    • (2012) Circulation , vol.126 , pp. 521
    • Escolar, G.1    Reverter, J.2    Villalta, J.3    Sanz, V.4    Molina, P.5    Diaz-Ricart, M.6
  • 24
    • 78549256425 scopus 로고    scopus 로고
    • The contemporary role of blood products and components used in trauma resuscitation
    • article 63
    • D. J. Dries, "The contemporary role of blood products and components used in trauma resuscitation, " Scand inavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 18, no. 1, article 63, 2010.
    • (2010) Scand Inavian Journal of Trauma, Resuscitation and Emergency Medicine , vol.18 , Issue.1
    • Dries, D.J.1
  • 26
    • 84860437704 scopus 로고    scopus 로고
    • Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: A pilot study
    • T. Thiele, A. Sumnig, G. Hron, et al., "Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study, " Journal of Thrombosis and Haemostasis, vol. 10, pp. 968-971, 2012.
    • (2012) Journal of Thrombosis and Haemostasis , vol.10 , pp. 968-971
    • Thiele, T.1    Sumnig, A.2    Hron, G.3
  • 29
    • 84883749228 scopus 로고    scopus 로고
    • Management of bleeding associated with dabigatran and rivaroxaban: A survey of current practices
    • L. M. Baumann Kreuziger and M. T. Reding, "Management of bleeding associated with dabigatran and rivaroxaban: a survey of current practices, " Thrombosis Research, vol. 132, no. 2, pp. e161-e163, 2013.
    • (2013) Thrombosis Research , vol.132 , Issue.2 , pp. e161-e163
    • Baumann Kreuziger, L.M.1    Reding, M.T.2
  • 31
    • 82955247833 scopus 로고    scopus 로고
    • Principles and practice of thromboelastography in Clinical Coagulation Management and Transfusion Practice
    • D. Bolliger, M. D. Seeberger, and K. A. Tanaka, "Principles and practice of thromboelastography in Clinical Coagulation Management and Transfusion Practice, " Transfusion Medicine Reviews, vol. 26, no. 1, pp. 1-13, 2012.
    • (2012) Transfusion Medicine Reviews , vol.26 , Issue.1 , pp. 1-13
    • Bolliger, D.1    Seeberger, M.D.2    Tanaka, K.A.3
  • 33
    • 84890079735 scopus 로고    scopus 로고
    • A prospective evaluation of platelet function in patients on antiplatelet therapy with traumatic intracranial hemorrhage
    • B. Joseph, V. Pandit, M. Sadoun, et al., "A prospective evaluation of platelet function in patients on antiplatelet therapy with traumatic intracranial hemorrhage, " Journal of Trauma and Acute Care Surgery, vol. 75, pp. 900-994, 2013.
    • (2013) Journal of Trauma and Acute Care Surgery , vol.75 , pp. 900-994
    • Joseph, B.1    Pandit, V.2    Sadoun, M.3
  • 34
    • 84864567317 scopus 로고    scopus 로고
    • Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: A systematic review
    • D. K. Nishijima, S. Zehtabchi, J. Berrong, and E. Legome, "Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: a systematic review, " Journal of Trauma and Acute Care Surgery, vol. 72, pp. 1658-1663, 2012.
    • (2012) Journal of Trauma and Acute Care Surgery , vol.72 , pp. 1658-1663
    • Nishijima, D.K.1    Zehtabchi, S.2    Berrong, J.3    Legome, E.4
  • 35
    • 84873388955 scopus 로고    scopus 로고
    • Antiplatelet therapy is not associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    • J. N. Harr, E. E. Moore, J. Johnson, et al., "Antiplatelet therapy is not associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients, " Critical Care Medicine, vol. 41, pp. 399-404, 2013.
    • (2013) Critical Care Medicine , vol.41 , pp. 399-404
    • Harr, J.N.1    Moore, E.E.2    Johnson, J.3
  • 36
    • 84894195056 scopus 로고    scopus 로고
    • The impact of preinjury anticoagulants and prescription antiplatelet agents on outcomes in older patients with traumatic brain injury
    • K. A. Peck, R. Y. Calvo, M. S. Schechter, et al., "The impact of preinjury anticoagulants and prescription antiplatelet agents on outcomes in older patients with traumatic brain injury, " Journal of Trauma and Acute Care Surgery, vol. 76, pp. 431-436, 2014.
    • (2014) Journal of Trauma and Acute Care Surgery , vol.76 , pp. 431-436
    • Peck, K.A.1    Calvo, R.Y.2    Schechter, M.S.3
  • 37
    • 84887547696 scopus 로고    scopus 로고
    • Anticoagulant and antiplatelet medications encountered in emergency surgery patients: A review of reversal strategies
    • J. L. Gordon, T. C. Fabian, M. D. Lee, and M. Dugdale, "Anticoagulant and antiplatelet medications encountered in emergency surgery patients: a review of reversal strategies, " The Journal of Trauma and Acute Care Surgery, vol. 75, no. 3, pp. 475-486, 2013.
    • (2013) The Journal of Trauma and Acute Care Surgery , vol.75 , Issue.3 , pp. 475-486
    • Gordon, J.L.1    Fabian, T.C.2    Lee, M.D.3    Dugdale, M.4
  • 38
    • 84865793090 scopus 로고    scopus 로고
    • Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
    • M. D. Lambourne, L. J. Eltringham Smith, S. Gataiance, D. M. Arnold, M. A. Crowther, and W. P. Sheffield, "Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate, " Journal of Thrombosis and Haemostasis, vol. 10, no. 9, pp. 1830-1840, 2012.
    • (2012) Journal of Thrombosis and Haemostasis , vol.10 , Issue.9 , pp. 1830-1840
    • Lambourne, M.D.1    Eltringham Smith, L.J.2    Gataiance, S.3    Arnold, D.M.4    Crowther, M.A.5    Sheffield, W.P.6
  • 39
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (beriplex P/N) in a rabbitmodel
    • I. Pragst, S. H. Zeitler, B. Doerr, et al., "Reversal of dabigatran anticoagulation by prothrombin complex concentrate (beriplex P/N) in a rabbitmodel, " Journal of Thrombosis and Haemostasis, vol. 10, no. 9, pp. 1841-1848, 2012.
    • (2012) Journal of Thrombosis and Haemostasis , vol.10 , Issue.9 , pp. 1841-1848
    • Pragst, I.1    Zeitler, S.H.2    Doerr, B.3
  • 40
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • W. Zhou, S. Schwarting, S. Illanes, et al., "Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran, " Stroke, vol. 42, pp. 3594-3599, 2011.
    • (2011) Stroke , vol.42 , pp. 3594-3599
    • Zhou, W.1    Schwarting, S.2    Illanes, S.3
  • 42
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • article e10
    • M. K. Wychowski and P. Kouides, "Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment, " Annals of Pharmacotherapy, vol. 46, no. 4, article e10, 2012.
    • (2012) Annals of Pharmacotherapy , vol.46 , Issue.4
    • Wychowski, M.K.1    Kouides, P.2
  • 43
    • 84867344952 scopus 로고    scopus 로고
    • Reversal of dabigatran-induced bleeding with a prothrombin complex concentrate and fresh frozen plasma
    • L. E. Dumkow, J. R. Voss, M. Peters, and D. L. Jennings, "Reversal of dabigatran-induced bleeding with a prothrombin complex concentrate and fresh frozen plasma, " American Journal of Health-System Pharmacy, vol. 69, no. 19, pp. 1646-1650, 2012.
    • (2012) American Journal of Health-System Pharmacy , vol.69 , Issue.19 , pp. 1646-1650
    • Dumkow, L.E.1    Voss, J.R.2    Peters, M.3    Jennings, D.L.4
  • 44
    • 73649136214 scopus 로고    scopus 로고
    • Prothrombin complex concentrate reverses the effects of high-dose rivaroxaban in rats
    • article 183
    • E. Perzborn and H. Tinel, "Prothrombin complex concentrate reverses the effects of high-dose rivaroxaban in rats, " Journal of Thrombosis and Haemostasis, vol. 7, article 183, 2009.
    • (2009) Journal of Thrombosis and Haemostasis , vol.7
    • Perzborn, E.1    Tinel, H.2
  • 45
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    • A. Godier, A. Miclot, B. Le Bonniec, et al., "Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model, " Anesthesiology, vol. 116, pp. 94-102, 2012.
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1    Miclot, A.2    Le Bonniec, B.3
  • 46
    • 84879671176 scopus 로고    scopus 로고
    • Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates
    • E. Perzborn, A. Gruber, H. Tinel, et al., "Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates, " Thrombosis and Haemostasis, vol. 110, no. 1, pp. 162-172, 2013.
    • (2013) Thrombosis and Haemostasis , vol.110 , Issue.1 , pp. 162-172
    • Perzborn, E.1    Gruber, A.2    Tinel, H.3
  • 47
    • 84883812030 scopus 로고    scopus 로고
    • In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban
    • J. Dinkelaar, P. J. Molenaar, M. Ninivaggi, B. de Laat, H. J. M. Brinkman, and A. Leyte, "In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban, " Journal of Thrombosis and Haemostasis, vol. 11, no. 6, pp. 1111-1118, 2013.
    • (2013) Journal of Thrombosis and Haemostasis , vol.11 , Issue.6 , pp. 1111-1118
    • Dinkelaar, J.1    Molenaar, P.J.2    Ninivaggi, M.3    De Laat, B.4    Brinkman, H.J.M.5    Leyte, A.6


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