MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5

Oncotarget

Volumn 6, Issue 15, 2015, Pages 13164-13175

  Fang, Yuan ^a   Zhu, Xiaoxia ^a   Wang, Jian ^a   Li, Na ^a   Li, Dianhe ^a   Sakib, Nazmus ^a   Sha, Zhou ^a   Song, Wen ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

ARHGAP5; Metastasis; MiR 744; Nasopharyngeal carcinoma; Tumorigenesis

Indexed keywords

ANTAGOMIR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MICRORNA; MICRORNA 744; RHO GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 5; UNCLASSIFIED DRUG; ARHGAP5 PROTEIN, HUMAN; MIRN744 MICRORNA, HUMAN; ONCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PROMOTER REGION; PROTO ONCOGENE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; DISEASE COURSE; GENETIC TRANSCRIPTION; METABOLISM; NASOPHARYNGEAL NEOPLASMS; PHYSIOLOGY; SECONDARY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DISEASE PROGRESSION; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICRORNAS; NASOPHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84931086712     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3754     Document Type: Article

References (30)

1. Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell. 2009; 136:586-91.
2. Chen HC, Chen GH, Chen YH, Liao WL, Liu CY, Chang KP, et al. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer. 2009; 100:1002-11.
3. Li T, Chen JX, Fu XP, Yang S, Zhang Z, Chen KhH, et al. microRNA expression profiling of nasopharyngeal carcinoma. Oncol Rep. 2011; 25:1353-63.
4. Wong AM, Kong KL, Tsang JW, Kwong DL, Guan XY. Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. Cancer. 2012; 118:698-710.
5. Li G, Wu ZY, Peng Y, Liu X, Lu J, Wang L, et al. MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett. 2010; 18. 299:29-36.
6. Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, et al. MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res. 2011; 71:225-33.
7. Zhu X, Zhang X, Wang H, Song Q, Zhang G, Yang L, et al. MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncol Rep. 2012; 28:218-24.
8. Song Q, Li Y, Zheng X, Fang Y, Chao Y, Yao K, et al. MTA1 contributes to actin cytoskeleton reorganization and metastasis of nasopharyngeal carcinoma by modulating Rho GTPases and Hedgehog signaling. Int J Biochem Cell B. 2013; 45:1439-1446.
9. Song Q, Zhang H, Wang M, Song W, Ying M, Fang Y, et al. MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo. J Exp Clin Cancer Res. 2013; 32:54.
10. Nurul-Syakima AM, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A, Learn-Han L. Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med. 2011; 28:327-36.
11. Parris TZ, Danielsson A, Nemes S, Kovács A, Delle U, Fallenius G, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma. Clin Cancer Res. 2010; 16:3860-74.
12. Yu J, Zhou H, Jin Y, Bai J, Yu Y, Geng J, et al. Three distinct regions of allelic deletion on chromosome 17 involved in sporadic gastric cancer. Hepatogastroenterology. 2008; 55:1487-91.
13. Nakanishi H, Matsumoto S, Iwakawa R, Kohno T, Suzuki K, Tsuta K, Matsuno Y, et al. Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas. Cancer Res. 2009; 69:1615-23.
14. Slovak ML, Bedell V, Hsu YH, Estrine DB, Nowak NJ, Delioukina ML, et al. Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma. Clin Cancer Res. 2011; 17:3443-54.
15. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, et al. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012; 40:1695-707.
16. Wang WJ, Wu SP, Liu JB, Shi YS, Huang X, Zhang QB, et al. MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells. Cancer Res. 2013; 73:1219-31.
17. Chan SH, Huang WC, Chang JW, Chang KJ, Kuo WH, Wang MY, et al. MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis. Oncogene. 2014; 33:4496-507.
18. Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, et al. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene. 2014; 33:1181-1189.
19. Song MY, Pan KF, Su HJ, Zhang L, Ma JL, Li JY, et al. Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One. 2012; 7:e33608.
20. Kubiczkova L, Kryukov F, Slaby O, Dementyeva E, Jarkovsky J, Nekvindova J, et al. Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. Haematologica. 2014; 99:511-8.
21. Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, et al. Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744. Br J Cancer. 2013; 108:2304-11.
22. Lin F, Ding R, Zheng S, Xing D, Hong W, Zhou Z, et al. Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma. Cancer Cell Int. Jun 22;14:58.
23. Henson BJ, Bhattacharjee S, O'Dee DM, Feingold E, Gollin SM. Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009; 48:569-582.
24. Zhang H, Luo XQ, Feng DD, Zhang XJ, Wu J, Zheng YS, et al. Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. Mol Cancer. 2011; 10:108.
25. McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, et al. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res. 2010; 12:R73.
26. Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, et al. A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Cancer Lett. 2009; 275:27-34.
27. Bustos RI, Forget MA, Settleman JE, Hansen SH. Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr Biol. 2008; 18:1606-1611.
28. Guegan F, Tatin F, Leste-Lasserre T, Drutel G, Genot E, Moreau V. p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2. J Cell Sci. 2008; 121:2054-2061.
29. Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K, et al. Profiling of Virus-encoded MicroRNAs in Epstein-Barr Virus-associated Gastric Carcinoma and their Roles in Gastric Carcinogenesis. J Virol. 2015; Mar 4;. pii: JVI.03639-14 [Epub ahead of print].
30. Anastasiadou E, Garg N, Bigi R, Yadav S, Campese AF, Lapenta C, et al. Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells. Int J Cancer. 2015; Feb 20;. doi:10.1002/ijc.29489. [Epub ahead of print].