miR-20b is up-regulated in brain metastases from primary breast cancers

Oncotarget

Volumn 6, Issue 14, 2015, Pages 12188-12195

  Ahmad, Aamir ^a   Ginnebaugh, Kevin R ^a   Sethi, Seema ^a   Chen, Wei ^a   Ali, Rouba ^a   Mittal, Sandeep ^a   Sarkar, Fazlul H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain metastasis; Breast cancer; miR 20b

Indexed keywords

MICRORNA 20B; MICRORNA;

ARTICLE; BRAIN METASTASIS; BREAST CANCER; CANCER CELL LINE; CANCER PATIENT; CANCER PROGNOSIS; CANCER THERAPY; CLINICAL ARTICLE; COHORT ANALYSIS; COLONY FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MCF 7 CELL LINE; MDA MB 231 CELL LINE; RETROSPECTIVE STUDY; TUMOR INVASION; UPREGULATION; BRAIN TUMOR; BREAST TUMOR; FEMALE; GENETIC TRANSFECTION; GENETICS; METASTASIS; PATHOLOGY; PROGNOSIS; RISK FACTOR; SECONDARY;

BRAIN NEOPLASMS; BREAST NEOPLASMS; FEMALE; HUMANS; MICRORNAS; NEOPLASM METASTASIS; PROGNOSIS; RISK FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84931032813     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3664     Document Type: Article

References (35)

1. Siegel RL, Miller KD and Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015; 65:5-29.
2. DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014; 64:252-271.
3. Jaboin JJ, Ferraro DJ, Dewees TA, Rich KM, Chicoine MR, Dowling JL, Mansur DB, Drzymala RE, Simpson JR, Magnuson WJ, Patel AH and Zoberi I. Survival following gamma knife radiosurgery for brain metastasis from breast cancer. Radiat Oncol. 2013; 8:131.
4. Bollig-Fischer A, Michelhaugh S, Ali-Fehmi R and Mittal S. The molecular genomics of metastatic brain tumours. OA molecular oncology. 2013; 1.
5. Wang L and Wang J. MicroRNA-mediated breast cancer metastasis: from primary site to distant organs. Oncogene. 2012; 31:2499-2511.
6. Ahmed A, Ali AS, Ali S, Ahmad A, Philip PA and Sarkar FH. (2012). MicroRNAs in breast cancer research: progress and promise. In: Ahmad A, ed. Breast Cancer Metastasis and Drug Resistance. (New York: Springer), pp. 399-413.
7. Tang J, Ahmad A and Sarkar FH. The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis. Int J Mol Sci. 2012; 13:13414-13437.
8. Tang J, Ahmad A and Sarkar FH. MicroRNAs in breast cancer therapy. Curr Pharm Des. 2014; 20:5268-5274.
9. Okuda H, Xing F, Pandey PR, Sharma S, Watabe M, Pai SK, Mo YY, Iiizumi-Gairani M, Hirota S, Liu Y, Wu K, Pochampally R and Watabe K. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res. 2013; 73:1434-1444.
10. Zhang L, Sullivan PS, Goodman JC, Gunaratne PH and Marchetti D. MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase. Cancer Res. 2011; 71:645-654.
11. Hwang SJ, Seol HJ, Park YM, Kim KH, Gorospe M, Nam DH and Kim HH. MicroRNA-146a suppresses metastatic activity in brain metastasis. Mol Cells. 2012; 34:329-334.
12. Ahmad A, Sethi S, Chen W, Ali-Fehmi R, Mittal S and Sarkar FH. Up-regulation of microRNA-10b is associated with the development of breast cancer brain metastasis. Am J Transl Res. 2014; 6:384-390.
13. Li D, Ilnytskyy Y, Kovalchuk A, Khachigian LM, Bronson RT, Wang B and Kovalchuk O. Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer. Oncotarget. 2013; 4:1373-1387.
14. Zhou W, Shi G, Zhang Q, Wu Q, Li B and Zhang Z. MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN). Cell Biosci. 2014; 4:62.
15. Wikman H, Lamszus K, Detels N, Uslar L, Wrage M, Benner C, Hohensee I, Ylstra B, Eylmann K, Zapatka M, Sauter G, Kemming D, Glatzel M, Muller V, Westphal M and Pantel K. Relevance of PTEN loss in brain metastasis formation in breast cancer patients. Breast Cancer Res. 2012; 14:R49.
16. Albiges L, Andre F, Balleyguier C, Gomez-Abuin G, Chompret A and Delaloge S. Spectrum of breast cancer metastasis in BRCA1 mutation carriers: highly increased incidence of brain metastases. Ann Oncol. 2005; 16:1846-1847.
17. Castellano L, Giamas G, Jacob J, Coombes RC, Lucchesi W, Thiruchelvam P, Barton G, Jiao LR, Wait R, Waxman J, Hannon GJ and Stebbing J. The estrogen receptoralpha-induced microRNA signature regulates itself and its transcriptional response. Proc Natl Acad Sci USA. 2009; 106:15732-15737.
18. Yoneda T, Williams PJ, Hiraga T, Niewolna M and Nishimura R. A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res. 2001; 16:1486-1495.
19. Lim E and Lin NU. Updates on the management of breast cancer brain metastases. Oncology (Williston Park). 2014; 28:572-578.
20. Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO and Gelmon K. Metastatic behavior of breast cancer subtypes. J Clin Oncol. 2010; 28:3271-3277.
21. Duchnowska R, Jassem J, Goswami CP, Dundar M, Gokmen-Polar Y, Li L, Woditschka S, Biernat W, Sosinska-Mielcarek K, Czartoryska-Arlukowicz B, Radecka B, Tomasevic Z, Stepniak P, Wojdan K, Sledge GW, Jr., Steeg PS, et al. Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients. J Neurooncol. 2015; 122(1):205-216.
22. Zhang T, Li Q, Xu B, Zhang P, Yuan P, Ma F, Wang J and Fan Y. [Breast cancer brain metastases: clinical and prognostic characteristics of different biological subtypes]. Zhonghua Zhong Liu Za Zhi. 2014; 36:697-702.
23. Niikura N, Hayashi N, Masuda N, Takashima S, Nakamura R, Watanabe K, Kanbayashi C, Ishida M, Hozumi Y, Tsuneizumi M, Kondo N, Naito Y, Honda Y, Matsui A, Fujisawa T, Oshitanai R, et al. Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis. Breast Cancer Res Treat. 2014; 147:103-112.
24. Zhang J, Sr., Zhang L, Yan Y, Li S, Xie L, Zhong W, Lv J, Zhang X, Bai Y and Cheng Z. Are Capecitabine and the Active Metabolite 5-FU CNS Penetrable to Treat Breast Cancer Brain Metastasis?. Drug Metab Dispos. 2014; 43:411-417.
25. Cheung TH, Man KN, Yu MY, Yim SF, Siu NS, Lo KW, Doran G, Wong RR, Wang VW, Smith DI, Worley MJ, Jr., Berkowitz RS, Chung TK and Wong YF. Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm. Cell Cycle. 2012; 11:2876-2884.
26. Hui AB, Lin A, Xu W, Waldron L, Perez-Ordonez B, Weinreb I, Shi W, Bruce J, Huang SH, O'Sullivan B, Waldron J, Gullane P, Irish JC, Chan K and Liu FF. Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma. Clin Cancer Res. 2013; 19:2154-2162.
27. Cascio S, D'Andrea A, Ferla R, Surmacz E, Gulotta E, Amodeo V, Bazan V, Gebbia N and Russo A. miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol. 2010; 224(1):242-249.
28. Perez-Rivas LG, Jerez JM, Carmona R, de Luque V, Vicioso L, Claros MG, Viguera E, Pajares B, Sanchez A, Ribelles N, Alba E and Lozano J. A microRNA signature associated with early recurrence in breast cancer. PLoS One. 2014; 9:e91884.
29. Miranda PJ, Vimalraj S and Selvamurugan N. A feedback expression of microRNA-590 and activating transcription factor-3 in human breast cancer cells. Int J Biol Macromol. 2014; 72c:145-150.
30. Landais S, Landry S, Legault P and Rassart E. Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res. 2007; 67:5699-5707.
31. Sun Y, Wu J, Wu SH, Thakur A, Bollig A, Huang Y and Liao DJ. Expression profile of microRNAs in c-Myc induced mouse mammary tumors. Breast Cancer Res Treat. 2009; 118:185-196.
32. Guo J, Miao Y, Xiao B, Huan R, Jiang Z, Meng D and Wang Y. Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 2009; 24:652-657.
33. Zhu J, Chen L, Zou L, Yang P, Wu R, Mao Y, Zhou H, Li R, Wang K, Wang W, Hua D and Zhang X. MiR-20b,-21, and-130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer. Hum Immunol. 2014; 75:348-353.
34. Li Q, Yang J, Yu Q, Wu H, Liu B, Xiong H, Hu G, Zhao J, Yuan X and Liao Z. Associations between single-nucleotide polymorphisms in the PI3K-PTEN-AKT-mTOR pathway and increased risk of brain metastasis in patients with nonsmall cell lung cancer. Clin Cancer Res. 2013; 19:6252-6260.
35. Bucheit AD, Chen G, Siroy A, Tetzlaff M, Broaddus R, Milton D, Fox P, Bassett R, Hwu P, Gershenwald JE, Lazar AJ and Davies MA. Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations. Clin Cancer Res. 2014; 20:5527-5536.