-
1
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
International Multiple Sclerosis Genetics C, Wellcome Trust Case Control C. Sawcer S, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476(7359):214-19
-
(2011)
Nature
, vol.476
, Issue.7359
, pp. 214-219
-
-
Sawcer, S.1
-
2
-
-
77949424680
-
Environmental factors and their timing in adult-onset multiple sclerosis
-
Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nature Rev Neurol 2010;6(3):156-66
-
(2010)
Nature Rev Neurol
, vol.6
, Issue.3
, pp. 156-166
-
-
Handel, A.E.1
Giovannoni, G.2
Ebers, G.C.3
Ramagopalan, S.V.4
-
3
-
-
77649237783
-
Multiple sclerosis: Geoepidemiology, genetics and the environment
-
Milo R, Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev 2010;9(5):A387-94
-
(2010)
Autoimmun Rev
, vol.9
, Issue.5
, pp. A387-A394
-
-
Milo, R.1
Kahana, E.2
-
4
-
-
33746588738
-
The epidemiology of multiple sclerosis in Europe
-
Pugliatti M, Rosati G, Carton H, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol 2006;13(7):700-22
-
(2006)
Eur J Neurol
, vol.13
, Issue.7
, pp. 700-722
-
-
Pugliatti, M.1
Rosati, G.2
Carton, H.3
-
5
-
-
37349118328
-
Quality of life in people with multiple sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study
-
Wu N, Minden SL, Hoaglin DC, et al. Quality of life in people with multiple sclerosis: data from the Sonya Slifka Longitudinal Multiple Sclerosis Study. J Health Hum Serv Adm 2007;30(3):233-67
-
(2007)
J Health Hum Serv Adm
, vol.30
, Issue.3
, pp. 233-267
-
-
Wu, N.1
Minden, S.L.2
Hoaglin, D.C.3
-
6
-
-
84885371836
-
Emerging injectable therapies for multiple sclerosis
-
Oh J, Calabresi PA. Emerging injectable therapies for multiple sclerosis. Lancet Neurol 2013;12(11):1115-26
-
(2013)
Lancet Neurol
, vol.12
, Issue.11
, pp. 1115-1126
-
-
Oh, J.1
Calabresi, P.A.2
-
7
-
-
0027418515
-
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group
-
Apr;
-
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology 1993 Apr;43(4):655-61
-
(1993)
Neurology
, vol.43
, Issue.4
, pp. 655-661
-
-
-
8
-
-
0008678962
-
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
-
Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996;39(3):285-94
-
(1996)
Ann Neurol
, vol.39
, Issue.3
, pp. 285-294
-
-
Jacobs, L.D.1
Cookfair, D.L.2
Rudick, R.A.3
-
9
-
-
0345601517
-
PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
-
Nov 7;
-
Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet 1998;Nov 7;352(9139):1498-504
-
(1998)
Lancet
, vol.352
, Issue.9139
, pp. 1498-1504
-
-
-
10
-
-
79951508577
-
Interferon therapy in relapsing-remitting multiple sclerosis: A systematic review and meta-analysis of the comparative trials
-
Oliver BJ, Kohli E, Kasper LH. Interferon therapy in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of the comparative trials. J Neurol Sci 2011;302(1-2):96-105
-
(2011)
J Neurol Sci
, vol.302
, Issue.1-2
, pp. 96-105
-
-
Oliver, B.J.1
Kohli, E.2
Kasper, L.H.3
-
11
-
-
0035018884
-
Injectable medication for the treatment of multiple sclerosis: The influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject
-
Mohr DC, Boudewyn AC, Likosky W, et al. Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann behave Med 2001;23(2):125-32
-
(2001)
Ann Behave Med
, vol.23
, Issue.2
, pp. 125-132
-
-
Mohr, D.C.1
Boudewyn, A.C.2
Likosky, W.3
-
12
-
-
70249142877
-
Addressing the need for increased adherence to multiple sclerosis therapy: Can delivery technology enhance patient motivation?
-
Lugaresi A. Addressing the need for increased adherence to multiple sclerosis therapy: can delivery technology enhance patient motivation? Expert Opin Drug Deliv 2009;6(9):995-1002
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.9
, pp. 995-1002
-
-
Lugaresi, A.1
-
13
-
-
84931064423
-
-
U.S. Food and Drug Administration. [Last Accessed 15 April 2015]
-
U.S. Food and Drug Administration. Novel New Drugs 2014 Summary. 2014. Available from: http://www.fda.gov [Last Accessed 15 April 2015]
-
(2014)
Novel New Drugs 2014 Summary.
-
-
-
14
-
-
84931074563
-
-
European Medicines Agency. [Last Accessed 15 April 2015]
-
European Medicines Agency. Plegridy: peginterferon beta-1a. 2015. Available from: http://www.ema. europa.eu/ema [Last Accessed 15 April 2015]
-
(2015)
Plegridy: Peginterferon beta-1a.
-
-
-
15
-
-
84897574115
-
Multiple sclerosis: Current and emerging disease-modifying therapies and treatment strategies
-
Wingerchuk DM, Carter JL. Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. Mayo Clin Proc 2014;89(2):225-40
-
(2014)
Mayo Clin Proc
, vol.89
, Issue.2
, pp. 225-240
-
-
Wingerchuk, D.M.1
Carter, J.L.2
-
16
-
-
84903217919
-
An update on new and emerging therapies for relapsing-remitting multiple sclerosis
-
Weinstock-Guttman B. An update on new and emerging therapies for relapsing-remitting multiple sclerosis. Am J Manag Care 2013;19(17 Suppl):s343-54
-
(2013)
Am J Manag Care
, vol.19
, Issue.17
, pp. s343-s354
-
-
Weinstock-Guttman, B.1
-
17
-
-
84860495711
-
Persistency of neutralizing antibodies depends on titer and interferon-beta preparation
-
Hegen H, Schleiser M, Gneiss C, et al. Persistency of neutralizing antibodies depends on titer and interferon-beta preparation. Mult Scler 2012;18(5):610-15
-
(2012)
Mult Scler
, vol.18
, Issue.5
, pp. 610-615
-
-
Hegen, H.1
Schleiser, M.2
Gneiss, C.3
-
18
-
-
84863186662
-
Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: Tolerability and adherence
-
Giovannoni G, Southam E, Waubant E. Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence. Mult Scler 2012;18(7):932-46
-
(2012)
Mult Scler
, vol.18
, Issue.7
, pp. 932-946
-
-
Giovannoni, G.1
Southam, E.2
Waubant, E.3
-
19
-
-
84861749627
-
State of the art in PEGylation: The great versatility achieved after forty years of research
-
Pasut G, Veronese FM. State of the art in PEGylation: the great versatility achieved after forty years of research. J Control Rel 2012;161(2):461-72
-
(2012)
J Control Rel
, vol.161
, Issue.2
, pp. 461-472
-
-
Pasut, G.1
Veronese, F.M.2
-
20
-
-
51549092094
-
The impact of PEGylation on biological therapies. BioDrugs : Clinical immunotherapeutics
-
Veronese FM, Mero A. The impact of PEGylation on biological therapies. BioDrugs : clinical immunotherapeutics. Biopharm Gene Ther 2008;22(5):315-29
-
(2008)
Biopharm Gene Ther
, vol.22
, Issue.5
, pp. 315-329
-
-
Veronese, F.M.1
Mero, A.2
-
22
-
-
52749092565
-
PEGylation: An approach for drug delivery. A review
-
Jain A, Jain SK. PEGylation: an approach for drug delivery. A review. Crit Rev Ther Drug Carrier Syst 2008;25(5):403-47
-
(2008)
Crit Rev Ther Drug Carrier Syst
, vol.25
, Issue.5
, pp. 403-447
-
-
Jain, A.1
Jain, S.K.2
-
23
-
-
31544475726
-
N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model
-
Baker DP, Lin EY, Lin K, et al. N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model. Bioconjug Chem 2006;17(1):179-88
-
(2006)
Bioconjug Chem
, vol.17
, Issue.1
, pp. 179-188
-
-
Baker, D.P.1
Lin, E.Y.2
Lin, K.3
-
24
-
-
77957359421
-
PEGylated interferon beta-1a: Meeting an unmet medical need in the treatment of relapsing multiple sclerosis
-
Baker DP, Pepinsky RB, Brickelmaier M, et al. PEGylated interferon beta-1a: meeting an unmet medical need in the treatment of relapsing multiple sclerosis. J interferon Cytokine Res 2010;30(10):777-85
-
(2010)
J Interferon Cytokine Res
, vol.30
, Issue.10
, pp. 777-785
-
-
Baker, D.P.1
Pepinsky, R.B.2
Brickelmaier, M.3
-
25
-
-
17644380925
-
Pharmacokinetics and pharmacodynamics of PEGylated IFN-beta 1a following subcutaneous administration in monkeys
-
Mager DE, Neuteboom B, Jusko WJ. Pharmacokinetics and pharmacodynamics of PEGylated IFN-beta 1a following subcutaneous administration in monkeys. Pharm Res 2005;22(1):58-61
-
(2005)
Pharm Res
, vol.22
, Issue.1
, pp. 58-61
-
-
Mager, D.E.1
Neuteboom, B.2
Jusko, W.J.3
-
26
-
-
0035020761
-
Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity
-
Pepinsky RB, LePage DJ, Gill A, et al. Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity. J Pharmacol Exp Ther 2001;297(3):1059-66
-
(2001)
J Pharmacol Exp Ther
, vol.297
, Issue.3
, pp. 1059-1066
-
-
Pepinsky, R.B.1
Lepage, D.J.2
Gill, A.3
-
27
-
-
60749088601
-
Interferon beta-1a induces tumor necrosis factor receptor 1 but decreases tumor necrosis factor receptor 2 leukocyte mRNA levels in relapsing-remitting multiple sclerosis
-
Reuss R, Pohle S, Retzlaff K, et al. Interferon beta-1a induces tumor necrosis factor receptor 1 but decreases tumor necrosis factor receptor 2 leukocyte mRNA levels in relapsing-remitting multiple sclerosis. Neuroimmunomodulation 2009;16(3):171-6
-
(2009)
Neuroimmunomodulation
, vol.16
, Issue.3
, pp. 171-176
-
-
Reuss, R.1
Pohle, S.2
Retzlaff, K.3
-
28
-
-
79958108785
-
The mechanism of action of interferon-beta in relapsing multiple sclerosis
-
Kieseier BC. The mechanism of action of interferon-beta in relapsing multiple sclerosis. CNS Drugs 2011;25(6):491-502
-
(2011)
CNS Drugs
, vol.25
, Issue.6
, pp. 491-502
-
-
Kieseier, B.C.1
-
29
-
-
84861812635
-
A novel PEGylated interferon beta-1a for multiple sclerosis: Safety, pharmacology, and biology
-
Hu X, Miller L, Richman S, et al. A novel PEGylated interferon beta-1a for multiple sclerosis: safety, pharmacology, and biology. J Clin Pharmacol 2012;52(6):798-808
-
(2012)
J Clin Pharmacol
, vol.52
, Issue.6
, pp. 798-808
-
-
Hu, X.1
Miller, L.2
Richman, S.3
-
30
-
-
0345602735
-
Beta-2 microglobulin and neopterin as markers of disease activity in multiple sclerosis
-
Bagnato F, Durastanti V, Finamore L, et al. Beta-2 microglobulin and neopterin as markers of disease activity in multiple sclerosis. Neurol Sci 2003;24(Suppl 5):S301-4
-
(2003)
Neurol Sci
, vol.24
, pp. S301-S304
-
-
Bagnato, F.1
Durastanti, V.2
Finamore, L.3
-
31
-
-
84930011481
-
Pharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis in the randomized ADVANCE study
-
Hu X, Cui Y, White J, et al. Pharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis in the randomized ADVANCE study. Br J Clin Pharmacol 2015;79(3):514-22
-
(2015)
Br J Clin Pharmacol
, vol.79
, Issue.3
, pp. 514-522
-
-
Hu, X.1
Cui, Y.2
White, J.3
-
34
-
-
84920982799
-
Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta-1a in subjects with normal or impaired renal function
-
Hu X, Seddighzadeh A, Stecher S, et al. Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta-1a in subjects with normal or impaired renal function. J Clin Pharmacol 2015;55(2):179-88
-
(2015)
J Clin Pharmacol
, vol.55
, Issue.2
, pp. 179-188
-
-
Hu, X.1
Seddighzadeh, A.2
Stecher, S.3
-
35
-
-
84937032543
-
Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE
-
[Last Accessed 28 November 2014]
-
Kieseier BC, Arnold DL, Balcer LJ, et al. Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE. Multiple Scler 2014 [Last Accessed 28 November 2014]
-
(2014)
Multiple Scler
-
-
Kieseier, B.C.1
Arnold, D.L.2
Balcer, L.J.3
-
36
-
-
84902544766
-
Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): A randomised phase 3 double-blind study
-
Calabresi PA, Kieseier BC, Arnold DL, et al. Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol 2014;13(7):657-65
-
(2014)
Lancet Neurol
, vol.13
, Issue.7
, pp. 657-665
-
-
Calabresi, P.A.1
Kieseier, B.C.2
Arnold, D.L.3
-
38
-
-
84925499134
-
-
European Medicines Agency. Last Accessed 14 March 2015]
-
European Medicines Agency. Plegridy: assessment report. 2014. Available from: http://www.ema. europa.eu/ema/[Last Accessed 14 March 2015]
-
(2014)
Plegridy: Assessment Report.
-
-
-
39
-
-
77954595101
-
Optimizing the benefit of multiple sclerosis therapy: The importance of treatment adherence
-
Patti F. Optimizing the benefit of multiple sclerosis therapy: the importance of treatment adherence. Patient Preference Adherence 2010;4:1-9
-
(2010)
Patient Preference Adherence
, vol.4
, pp. 1-9
-
-
Patti, F.1
-
40
-
-
33645099736
-
Adherence, patient preference and dosing frequency: Understanding the relationship
-
Reginster JY, Rabenda V, Neuprez A. Adherence, patient preference and dosing frequency: understanding the relationship. Bone 2006;38(4 Suppl 1):S2-6
-
(2006)
Bone
, vol.38
, Issue.4
, pp. S2-6
-
-
Reginster, J.Y.1
Rabenda, V.2
Neuprez, A.3
-
41
-
-
12144288676
-
Adherence, quality of life, and general satisfaction with co-formulated zidovudine, lamivudine, and abacavir on antiretroviral-experienced patients
-
Clotet B, Carmena J, Pulido F, et al. Adherence, quality of life, and general satisfaction with co-formulated zidovudine, lamivudine, and abacavir on antiretroviral-experienced patients. HIV Clin Trials 2004;5(1):33-9
-
(2004)
HIV Clin Trials
, vol.5
, Issue.1
, pp. 33-39
-
-
Clotet, B.1
Carmena, J.2
Pulido, F.3
|