Twenty-five years of glutamate in schizophrenia: Are we there yet?

Schizophrenia Bulletin

Volumn 38, Issue 5, 2012, Pages 911-913

  Javitt, Daniel C ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

D serine; glutamate; glycine; glycine transport inhibitor; metabotropic; NMDA receptor; schizophrenia

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CLOZAPINE; DIZOCILPINE; GLUTAMIC ACID; ISONIAZID; KETAMINE; LAMOTRIGINE; LITHIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE;

ANIMAL BEHAVIOR; ARTICLE; CELL VACUOLE; COGNITIVE DEFECT; DRUG EFFICACY; HUMAN; NERVE CELL PLASTICITY; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PARKINSON DISEASE; PRIORITY JOURNAL; SCHIZOPHRENIA; SUBSTANCE ABUSE;

ANTIPSYCHOTIC AGENTS; GLUTAMIC ACID; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PHENCYCLIDINE; PSYCHOSES, SUBSTANCE-INDUCED; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 84866684683     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbs100     Document Type: Article

References (12)

1. Domino EF, Luby ED. Phencyclidine/schizophrenia: one view toward the past, the other to the future. Schizophr Bull. 2012. In press.
2. Coyle JT. The NMDA receptor and schizophrenia: a brief history. Schizophr Bull. 2012. In press.
3. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148:1301-1308.
4. Javitt DC. Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia. Schizophr Bull. In press.
5. Goff D. D-cycloserine: an evolving role in learning and neuroplasticity in schizophrenia. Schizophr Bull. In press.
6. Tamminga CA, Southcott S, Sacco C, Gao XM, Ghose S. Glutamate dysfunction in hippocampus: relevance of dentate gyrus and ca3 signaling. Schizophr Bull. 2012. In press.
7. Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res. 1999;33:523-533.
8. Morgan CJ, Muetzelfeldt L, Curran HV. Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study. Addiction. 2010;105:121-133.
9. Moghaddam B, Krystal JH. Capturing the angel in angel dust: twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophr Bull. In press.
10. Lewis DA, Gonzalez-Burgos G. NMDA receptor hypofunction, parvalbumin-positive neurons and cortical gamma oscillations in schizophrenia. Schizophr Bull. In press.
11. Javitt DC, Schoepp D, Kalivas PW, et al. Translating glutamate: from pathophysiology to treatment. Sci Transl Med. 2011;3:102mr102.
12. Chen GM, Weston JK. The analgesic and anesthetic effects of 1-(1-phenylcyclohexyl)-piperidine HCl in the monkey. Anesth Analg. 1960;39:132-137.