Investigation into the antioxidant and antidiabetic potential of moringa stenopetala: Identification of the active principles

Natural Product Communications

Volumn 10, Issue 3, 2015, Pages 475-478

  Habtemariam, Solomon ^a  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

Diabetes; Moringa stenopetala; Neochlorogenic acid; Oxidative damage; Pancreatic cells; Rutin

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALPHA GLUCOSIDASE; CHLOROGENIC ACID; MORINGA STENOPETALA EXTRACT; NEOCHLOROGENIC ACID; PLANT EXTRACT; RUTOSIDE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTIOXIDANT;

ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; FRACTIONATION; HUMAN; HUMAN CELL; IC50; MORINGA; MORINGA STENOPETALA; NONHUMAN; PANCREAS ISLET BETA CELL; PLANT LEAF; PLANT SEED; CELL LINE; CHEMISTRY; DRUG EFFECTS;

ANTIOXIDANTS; CELL LINE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MORINGA; PLANT LEAVES;

EID: 84930971880     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1501000324     Document Type: Article

References (45)

1. Anwar F, Latif S, Ashraf M, Gilani AH. (2007) Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy Research, 21, 17-25
2. Bosch CH (2004) Moringa stenopetala (Baker f.) Cufod, pp. 395-397. In G.J.H. Grubben and O.A. Denton, (eds.). PROTA 2: Vegetables/Legumes. Wageningen, the Netherlands
3. Melesse A, Steingass H, Boguhn J, Schollenberger M, Rodehutscord M. (2012) Altitudinal and seasonal variations in nutritional composition of leaf and green pod fractions of Moringa stenopetala and Moringa oleifera. Agroforest Systems, 86, 505-518.
4. Nardos A, Makonnen Y, Debella A. (2011) Hypoglycemic and antihyperglycemic activities of Ethanol extract and fractions of Moringa stenopetala leaves in normoglycemic and alloxan induced diabetic mice. Journal of Pharmacy and Pharmacology, 20, 2220-2225
5. Toma A, Makonnen E, Debella A, Tesfaye B. (2012) Antihyperglycemic effect on chronic administration of butanol fraction of ethanol extract of Moringa stenopetala leaves in alloxan induced diabetic mice. Asian Pacific Journal of Tropical Biomedicine, 2, S1606-S1610
6. Ghebreselassie D, Mekonnen Y, Gebru G, Ergete W, Huruy K. (2011) The effects of Moringa stenopetala on blood parameters and histopathology of liver and kidney in mice. Ethiopian Journal of Health Development, 25, 51-57
7. Mekonnen Y, Yardley V, Rock P, Croft S. (1999) In vitro antitrypanosomal activity of Moringa stenopetala leaves and roots. Phytotherapy Research, 13, 538-539
8. Mengistu M, Abebe Y, Mekonnen Y, Tolessa T. (2012) In vivo and in vitro hypotensive effect of aqueous extract of Moringa stenopetala. African Health Sciences, 12, 545-551
9. Mekonnen Y. (1999) Effects of ethanol extract of Moringa stenopetala leaves on guinea-pig and mouse smooth muscle. Phytotherapy Research, 13, 442-444
10. Nibret E, Wink M. (2010) Trypanocidal an antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala and their main individual constituents. Phytomedicine, 17, 911-920
11. Meskerem A, Boonkaewwan C. (2013) Protective effects of Moringa stenopetala leaf supplemented diets on Eimeria tenella infected Broiler Chickens in Debre Zeit, Central, Ethiopia. Kasetsart Journal (Natural Science), 47, 398-406.
12. Mekonnen Y, Gebreyesus T. (2000) Chemical investigation of the leaves of Moringa stenopetalla. Bulletin of the Chemical Society of Ethiopia, 14, 51-56
13. Bennett RN, Mellon FA, Foidl N, Pratt JH, Dupont MS, Perkins L, Kroon PA. (2003) Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. Journal of Agricultural and Food Chemistry, 51, 3546-3553
14. Mekonnen Y, Dräger B (2003) Glucosinolates in Moringa stenopetala. Planta Medica, 69, 380-382.
15. Habtemariam S (2011) a-Glucosidase inhibitory activity of kaempferol-3-O-rutinoside. Natural Product Communications, 6, 201-203.
16. Habtemariam S (2008) Activity-guided isolation and identification of free radical-scavenging components from ethanolic extract of boneset (leaves of Eupatorium perfoliatum). Natural Product Communications, 3, 1317-1320
17. Habtemariam S (2013) Antihyperlipidemic components of Cassia auriculata aerial parts: Identification through in vitro studies. Phytotherapy Research, 27, 152-155
18. Morishita H, Iwahashi H, Osaka N, Kido R. (1984) Chromatographic separation and identification of naturally occurring chlorogenic acids by 1H nuclear magnetic resonance spectroscopy and mass spectrometry. Journal of Chromatography, 315, 253-260.
19. Habtemariam S, Varghese GK (2014) The antidiabetic therapeutic potential of dietary polyphenols. Current Pharmaceutical Biotechnology, 15, 391-400
20. Toma A, Makonnen E, Mekonnen Y, Debella A, Addisakwattana S. (2014). Intestinal a-glucosidase and some pancreatic enzymes inhibitory effect of hydroalcholic extract of Moringa stenopetala leaves. BMC Complementary and Alternative Medicine, 14, 180
21. Hsu, CY, Shih HY, Chia YC, Lee CH, Ashida H, Lai YK, Weng CF (2014) Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation. Molecular Nutrition & Food Research, 58, 1168-1176
22. Hunyadi A, Martins A, Hsieh TJ, Seres A, Zupkó I. (2012) Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats. PLoS One 7, e50619
23. Kamalakkannan N, Prince PS. (2006) Antihyperglycaemic and antioxidant effect of rutin, a polyphenol flavonoid, in streptozotocin-induced diabetic wistar rats. Basic and Clinical Pharmacology and Toxicology, 98, 97-103
24. Kamalakkannan N, Stanely MPP (2006) The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. Journal of Pharmacy and Pharmacology, 58, 1091-1098
25. Mondal A, Maity TK, Pal D. (2012) Hypoglycaemic effect of Melothria heterophylla in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 50, 1151-1156
26. Rauter AP, Martins A, Borges C, Mota-Filipe H, Pinto R, Sepodes B, Justino J. (2010) Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytotherapy Research, 24, S133-S138
27. Stanely MPP, Kamalakkannan, N. (2006) Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats. Journal of Pharmacy and Pharmacology, 58, 1373-1383.
28. Krishna KM, Annapurna A, Gopal GS, Chalam CR, Madan K, Kumar VK, Prakash, GJ. (2005) Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Canadian Journal of Physiology and Pharmacology, 83, 343-355
29. Fernandes AA, Novelli EL, Okoshi K, Okoshi MP, Di Muzio BP, Guimarães JF, Fernandes, JA. (2010) Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomedicine & Pharmacotherapy, 64, 214-219
30. Hao HH, Shao ZM, Tang DQ, Lu Q, Chen X, Yin XX, Wu J, Chen H. (2012) Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sciences, 91, 959-967
31. Tang DQ, Wei YQ, Gao YY, Yin XX, Yang DZ, Mou J, Jiang XL. (2011) Protective effects of rutin on rat glomerular mesangial cells cultured in high glucose conditions. Phytotherapy Research, 25, 1640-1647
32. Wang SW, Wang YJ, Su YJ, Zhou WW, Yang SG, Zhang R, Zhao M, Li YN, Zhang Z P, Zhan, DW, Liu RT. (2012) Rutin inhibits P-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. NeuroToxicology, 33, 482-490
33. Selloum L, Bouriche H, Tigrine C, Boudoukha C. (2003) Antiinflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. Experimental and Toxicologic Pathology, 54, 313-318
34. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. (2001) Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Il Farmaco, 56, 683-687
35. Kamalakkannan N, Stanely MPP. (2006) Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Molecular and Cellular Biochemistry, 293, 211-219
36. Esmaeili MA, Sadeghi H (2009) Pancreatic P-cell protective effect of rutin and apigenin isolated from Teucrium polium. Pharmacologyonline, 2, 341-353.
37. Gao H, Huang Y-N, Gao B, Xu P-Y, Inagaki C, Kawabata J. (2008) a-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L. Food Chemistry, 106, 1195-1201
38. Li YQ, Zhou FC, Gao F, Bian JS, Shan, F. (2009) Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. Journal of Agricultural and Food Chemistry, 57, 11463-11468
39. Tundis R, Loizzo MR, Menichini F. (2010) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: An update. Mini Reviews in Medicinal Chemistry, 10, 315-331.
40. Bonora E. (2008) Protection of pancreatic beta-cells: is it feasible? Nutrition, Metabolism & Cardiovascular Diseases, 18, 74-83
41. Habtemariam S, Dagne E. (2010) Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol. Planta Medica, 76, 589-594
42. Habtemariam S, Jackson C. (2007) Antioxidant and cytoprotective activity of leaves of Peltiphyllum peltatum (Torr.) Engl. Food Chemistry, 105, 498-503
43. Habtemariam S. (2011) Methyl-3-O-methyl gallate and gallic acid from the leaves of Peltiphyllum peltatum: isolation and comparative antioxidant, prooxidant, and cytotoxic effects in neuronal cells. Journal of Medicinal Food, 14, 1412-1418.
44. Roselli M, Lentini G, Habtemariam S. (2012) Phytochemical, antioxidant and anti-alpha-glucosidase activity evaluations of Bergenia cordifolia. Phytotherapy Research, 26, 908-914
45. Habtemariam S. (2007) Antioxidant activity of knipholone anthrone. Food Chemistry, 102, 1042-1047.