Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents

Phytomedicine

Volumn 17, Issue 12, 2010, Pages 911-920

  Nibret, E ^a   Wink, M ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Essential oil; Hagenia abyssinica; HL 60; Leonotis ocymifolia; Moringa stenopetala; Trypanosoma brucei brucei

Indexed keywords

ABSINTHOL; BENZYL ISOTHIOCYANATE; CAMPHOR; CARVACROL; CARVONE; CARYOPHYLLENE OXIDE; CEDRENE; CINEOLE; CINNAMALDEHYDE; CITRONELLAL; ESSENTIAL OIL; HAGENIA ABYSSINICA OIL; ISOBORNYLACETATE; ISOBUTYLISOTHIOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; LEONOTIS OCYMIFOLIA OIL; LIMONENE; LIMONENE EPOXIDE; LINALOOL; MORINGA STENOPETALA OIL; MYRTENAL; NEROLIDOL; PIPERITONE; ROSE OXIDE; SAFROLE; STYRENE OXIDE; TERPINEN 4 OL; THYMOL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERBENONE;

ARTICLE; CHEMICAL COMPOSITION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; HAGENIA ABYSSINICA; HUMAN; HUMAN CELL; LEONOTIS OCYMIFOLIA; MEDICINAL PLANT; MORINGA; MORINGA STENOPETALA; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; HUMANS; LAMIACEAE; LEUKEMIA; MORINGA; OILS, VOLATILE; PHYTOTHERAPY; PLANT EXTRACTS; ROSACEAE; TRYPANOCIDAL AGENTS;

HAGENIA ABYSSINICA; LAMIACEAE; LEONOTIS; MORINGA STENOPETALA; MORINGACEAE; ROSACEAE; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 77956614752     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.02.009     Document Type: Article

References (41)

1. Abate G., Gebre-Igziabher T., Taddesse M. A Study of Medicinal Plants of Ethiopia. The Identity of Some of the Plants 1976, Part 1A, Department of Biology, Science Faculty, Addis Ababa University.
2. Abate G. Etse Debdabe: Ethiopian Traditional Medicine 1989, Biology Department, Science Faculty, Addis Ababa University.
3. Abebe D., Ayehu A. Medicinal Plants and Enigmatic Health Practices of Northern Ethiopia 1993, B.S.P.E, Addis Ababa.
4. Arruda D.C., D'Alexandri F.L., Katzin A., Uliana S.R.B. Antileishmanial activity of the terpene nerolidol. Antimicrob. Agents Chemother. 2005, 49:1679-1687.
5. Bakkali F., Averbeck S., Averbeck D., Idaomar M. Biological effects of essential oils. Food Chem. Toxicol. 2008, 46:446-475.
6. Baltz T., Baltz D., Giroud C., Crockett J. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi. T. rhodesiense and T. gambiense. EMBO J. 1985, 4:1273-1277.
7. Cattand P., Jann J., Lucas P. Sleeping sickness surveillance: an essential step towards elimination. Trop. Med. Int. Health 2001, 6:348-361.
8. de Carvalho C.C.R.C., da Fonseca M.M.R. Carvone: why and how should one bother to produce this terpene. Food Chem. 2006, 95:413-422.
9. Donelson J.E. Antigenic variation and the African trypanosome genome. Acta Trop. 2003, 85:391-404.
10. Eilert U., Wolters B., Nahrstedt A. The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala. Planta Med. 1981, 42:55-61.
11. Friedman M., Henika P.R., Mandrell R.E. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli. Listeria monocytogenes, and Salmonella enterica. J. Food Prot. 2002, 65:1545-1560.
12. Geerts S., Holmes P.H. Drug Management and Parasite Resistance in Bovine Trypanosomiasis in Africa (PAAT Technical and Scientific Series No. 1) 1998, FAO.
13. Habtemariam S., Gray A.I., Waterman P.G. Diterpenes from the leaves of Leonotis ocymifolia var. raineriana. J. Nat. Prod. 1994, 57:1570-1574.
14. Hagan E.C., Hansen W.H., Fitzhugh O.G., Jenner P.M., Jones W.I., Taylor J.M., Long E.L., Nelson A.A., Brouwer J.B. Food flavourings and compounds of related structure. II. Subacute and chronic toxicity. Food Cosmet. Toxicol. 1967, 5:141-157.
15. Hedberg O. Rosaceae. Flora of Ethiopia. Pittosporaceae to Araliaceae 1989, vol. 3. The National Herbarium of Biology Department, Addis Ababa University and Uppsala University, 43 pp.
16. 50 in studies of drug resistance of malaria parasites. Acta Trop. 1993, 55:257-261.
17. 13C NMR assignments of three labdane diterpenoids isolated from Leonotis ocymifolia and six other related compounds. Magn. Reson. Chem. 2003, 41:147-151.
18. Jenner P.M., Hagan E.C., Taylor J.M., Cook E.L., Fitzhugh O.G. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet. Toxicol. 1964, 2:327-343.
19. Klopell F.C., Lemos M., Sousa J.B., Comunello E., Maistro E., Bastos J.K., de Andrade S.F. Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae). Z. Naturforsch. 2007, 62C:537-542.
20. Küçük M., Güleç C., Yaşar A., Üçüncü O., Yayli N., Coşkunçelebi K., Terzioĝlu, Yayli N. Chemical composition and antimicrobial activities of the essential oils of Teucrium chamaedrys subsp. chamaedrys T. orientale var. puberulens, and T. chamaedry subsp. lydium. Pharm. Biol. 2006, 44:592-599.
21. Lu A.Y.H., Miwa G.T. Molecular properties and biological functions of microsomal epoxide hydrase. Annu. Rev. Pharmacol. Toxicol. 1980, 20:513-531.
22. Mekonnen Y., Gessese A. Documentation of the uses of M. stenopetala and its possible antileishmanial and antifertility effects. SINET Eth. J. Sci. 1998, 21:287-295.
23. Mekonnen Y., Yardlely V., Rock P., Croft S. In vitro antitrypanosomal activity of Moringa stenopetala leaves and roots. Phytother. Res. 1999, 13:538-539.
24. Miyoshi N., Watanabe E., Osawa T., Okuhira M., Murata Y., Ohshima H., Nakamura Y. ATP depletion alters the mode of cell death induced by benzyl isothiocyanate. Biochim. Biophys. Acta 2008, 1782:566-573.
25. Oyedeji O.A., Afolayan A.J. Comparative study of the essential oil composition and antimicrobial activity of Leonotis leonurus and L. ocymifolia in the Eastern Cape, South Africa. S. Afr. J. Bot. 2005, 71:114-116.
26. Reichling J. Plant-microbe interactions and secondary metabolites with antibacterial, antifungal and antiviral properties. Functions and Biotechnology of Plant Secondary Metabolites. Annual Plant Reviews 2010, vol. 39:214-347. Wiley-Blackwell.
27. Rolón M., Vega C., Escario J.A., Gómez-Barrio A. Development of resazurin microtiter assay for drug testing of Trypanosoma cruzi epimastigotes. Parasitol. Res. 2006, 99:103-107.
28. Ryding O. Lamiaceae. Flora of Ethiopia and Eritrea, Gentianaceae to Cyclocheilaceae 2006, vol. 5:548-549. The National Herbarium of Biology Department, Addis Ababa University and Uppsala University.
29. Schnitzler P., Wiesenhofer K., Reichling J. Comparative study on the cytotoxicity of different Myrtaceae essential oils on cultured Vero and RC-37 cells. Pharmazie 2008, 63:830-835.
30. Stammati A., Bonsi P., Zucco F., Moezelaar R., Alakomi H.-L., von Wright A. Toxicity of selected plant volatiles in microbial and mammalian short-term assays. Food Chem. Toxicol. 1999, 37:813-823.
31. Tang L., Zhang Y. Mitochondria are the primary target in isothiocyanate induced apoptosis in human bladder cancer cells. Mol. Cancer Ther. 2005, 4:1250-1259.
32. Ultee A., Kets E.P.W., Smid E.J. Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereus. Appl. Environ. Microbiol. 1999, 65:4606-4610.
33. Vagionas K., Graikou K., Chinou I.B. Chemical analysis and antimicrobial activity of essential oils from the aromatic plants Artemisia afra Jacq. and Leonotis ocymifolia (Burm. F.) Iwarsson var. raineriana (Vision 1) Iwarsson growing in Tanzania. J. Essent. Oil Res. 2007, 19:396-400.
34. Verdcourt B. Moringaceae. Flora of Ethiopia and Eritrea: Magnoliaceae to Flacourtiaceae, vol. 2, Part 1 2000, 160-162. The National Herbarium of Biology Department, Addis Ababa University and Uppsala University.
35. Wink M. Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr. Drug Metab. 2008, 9:996-1009.
36. Wink M., Schimmer O. Modes of action of defensive secondary metabolites. Function of Plant Secondary Metabolites and their Exploitation in Biotechnology. Annual Plant Reviews 1999, vol. 3:17-133. Sheffield Academic Press/CRC Press.
37. Wink M., Schimmer O. Molecular modes of action of defensive secondary metabolites. Functions and Biotechnology of Plant Secondary Metabolites. Annual Plant Reviews 2010, vol. 39:21-161. Wiley-Blackwell.
38. Witz G. Biological interactions of α, β-unsaturated aldehydes. Free Radic. Biol. Med. 1989, 7:333-349.
39. Woldemariam T.Z., Fell A.F., Linley P.A. Chromatographic and spectroscopic studies on the constituents in male and female flowers of Hagenia abyssinica. J. Pharm. Biomed. Anal. 1990, 8:859-865.
40. Woldemariam T.Z., Fell A.F., Linley P.A., Bibby M.C., Phillips R.M. Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica. J. Pharm. Biomed. Anal. 1992, 10:555-560.
41. Yawetz A., Agosin M. Epoxide hydrase in Trypanosoma cruzi epimastigotes. Biochim. Biophys. Acta 1979, 585:210-219.