Activation of hypothalamic oxytocin neurons following tactile stimuli in rats

Neuroscience Letters

Volumn 600, Issue , 2015, Pages 22-27

  Okabe, Shota ^a   Yoshida, Masahide ^a   Takayanagi, Yuki ^a   Onaka, Tatsushi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Fos protein; Hypothalamus; Oxytocin; Stroking; Touch; Ultrasonic vocalizations

Indexed keywords

OXYTOCIN; PROTEIN FOS; PROTEIN C FOS;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMOTION; HYPOTHALAMUS; MALE; MASSAGE; NERVE CELL; NONHUMAN; OXYTOCIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TACTILE STIMULATION; TRANQUILIZING ACTIVITY; ULTRASOUND; ANIMAL; CYTOLOGY; LONG EVANS RAT; METABOLISM; SEPTUM NUCLEUS; STIMULATION; TOUCH; VOCALIZATION;

ANIMALS; HYPOTHALAMUS; MALE; NEURONS; OXYTOCIN; PHYSICAL STIMULATION; PROTO-ONCOGENE PROTEINS C-FOS; RATS, LONG-EVANS; SEPTAL NUCLEI; TOUCH; VOCALIZATION, ANIMAL;

EID: 84930960243     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.05.055     Document Type: Article

References (40)

1. Olausson H., Lamarre Y., Backlund H., Morin C., Wallin B.G., Starck G., Ekholm S., Strigo I., Worsley K., Vallbo A.B., Bushnell M.C. Unmyelinated tactile afferents signal touch and project to insular cortex. Nat. Neurosci. 2002, 5:900-904.
2. Löken L.S., Wessberg J., Morrison I., McGlone F., Olausson H. Coding of pleasant touch by unmyelinated afferents in humans. Nat. Neurosci. 2009, 12:547-548.
3. Gallace A., Spence C. The science of interpersonal touch: an overview. Neurosci. Biobehav. Rev. 2010, 34:246-259.
4. Agren G., Lundeberg T., Uvnäs-Moberg K., Sato A. The oxytocin antagonist 1-deamino-2-D-tyr-(oet)-4-thr-8-orn-oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats. Neurosci. Lett. 1995, 187:49-52.
5. Dunbar R.I.M. The social role of touch in humans and primates: behavioural function and neurobiological mechanisms. Neurosci. Biobehav. Rev. 2010, 34:260-268.
6. Gordon I., Voos A.C., Bennett R.H., Bolling D.Z., Pelphrey K.A., Kaiser M.D. Brain mechanisms for processing affective touch. Hum. Brain Mapp. 2013, 34:914-922.
7. Brudzynski S.M. Ethotransmission: communication of emotional states through ultrasonic vocalization in rats. Curr. Opin. Neurobiol. 2013, 23:310-317.
8. Donaldson Z.R., Young L.J. Oxytocin, vasopressin, and the neurogenetics of sociality. Science 2008, 7:900-904.
9. Kelly A.M., Goodson J.L. Social functions of individual vasopressin-oxytocin cell groups in vertebrates: what do we really know?. Front. Neuroendocrinol. 2014, 35:512-529.
10. Stoop R. Neuromodulation by oxytocin and vasopressin in the central nervous system as a basis for their rapid behavioral effects. Curr. Opin. Neurobiol. 2014, 29:187-193.
11. Carter C.S. Oxytocin pathways and the evolution of human behavior. Annu. Rev. Psychol. 2014, 65:17-39.
12. Knobloch H.S., Grinevich V. Evolution of oxytocin pathways in the brain of vertebrates. Front. Behav. Neurosci. 2014, 8:31.
13. Onaka T., Takayanagi Y., Yoshida M. Roles of oxytocin neurones in the control of stress energy metabolism, and social behaviour. J. Neuroendocrinol. 2012, 24:587-598.
14. Higashida H., Yokoyama S., Kikuchi M., Munesue T. CD38 and its role in oxytocin secretion and social behavior. Horm. Behav. 2012, 61:351-358.
15. Nagasawa M., Mitsui S., En S., Ohtani N., Ohta M., Sakuma Y., Onaka T., Mogi K., Kikusui T. Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science 2015, 348:333-336.
16. Yoshida M., Takayanagi Y., Inoue K., Kimura T., Young L.J., Onaka T., Nishimori K. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J. Neurosci. 2009, 29:2259-2271.
17. Petersson M., Alster P., Lundeberg T., Uvnäs-Moberg K. Oxytocin increases nociceptive thresholds in a long-term perspective in female and male rats. Neurosci. Lett. 1996, 212:87-90.
18. Leng G., Ludwig M. Neurotransmitters and peptides: whispered secrets and public announcements. J. Physiol. 2008, 586:5625-5632.
19. Stock S., Uvnäs-Moberg K. Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anaesthetized rats. Acta. Physiol. Scand. 1988, 132:29-34.
20. Uvnäs-Moberg K., Bruzelius G., Alster P., Lundeberg T. The antinociceptive effect of non-noxious sensory stimulation is mediated partly through oxytocinergic mechanisms. Acta. Physiol. Scand. 1993, 149:199-204.
21. Uvnäs-Moberg K., Handlin L., Petersson M. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Front. Psychol. 2015, 5:1529.
22. Brudzynski S.M. Pharmacological and behavioral characteristics of 22khz alarm calls in rats. Neurosci. Biobehav. Rev. 2001, 25:611-617.
23. Burgdorf J., Kroes R.A., Moskal J.R., Pfaus J.G., Brudzynski S.M., Panksepp J. Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: behavioral concomitants, relationship to reward, and self-administration of playback. J. Comp. Psychol. 2008, 122:357-367.
24. Zhu L., Onaka T. Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli. Eur. J. Neurosci. 2002, 16:2186-2198.
25. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Academic Press, San Diego. sixth ed.
26. Swanson L.W. Brain Maps: Structure Of The Rat Brain 1999, Elsevier, Amsterdam. second ed.
27. Morhenn V., Beavin L.E., Zak P.J. Massage increases oxytocin and reduces adrenocorticotropin hormone in humans. Altern. Ther. Health Med. 2012, 18:11-18.
28. Sofroniew M.V. Projections from vasopressin oxytocin, and neurophysin neurons to neural targets in the rat and human. J. Histochem. Cytochem. 1980, 28:475-478.
29. Roeling T.A.P., Veening J.G., Peters J.P.W., Vermelis M.E.J., Nieuwenhuys R. Efferent connections of the hypothalamic grooming area in the rat. Neuroscience 1993, 56:199-225.
30. Breton J.D., Veinante P., Uhl-Bronner S., Vergnano A.M., Freund-Mercier M.J., Schlichter R., Poisbeau P. Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Mol. Pain 2008, 4:19.
31. Lammel S., Lim B.K., Malenka R.C. Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology 2014, 76:351-359.
32. Heinricher M.M., Tavares I., Leith J.L., Lumb B.M. Descending control of nociception: specificity, recruitment and plasticity. Brain Res. Rev. 2009, 60:214-225.
33. Krassioukov A., Claydon V.E. The clinical problems in cardiovascular control following spinal cord injury: an overview. Prog. Brain Res. 2005, 152:223-229.
34. Insel T.R. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 2010, 65:768-779.
35. Petersson M., Alster P., Lundeberg T., Uvnäs-Moberg K. Oxytocin causes a long-term decrease of blood pressure in female and male rats. Physiol. Behav. 1996, 60:1311-1315.
36. Kurosawa M., Lundeberg T., Ågren G., Lund I., Uvnäs-Moberg K. Massage-like stroking of the abdomen lowers blood pressure in anesthetized rats: influence of oxytocin. J. Auton. Nerv. Syst. 1995, 56:26-30.
37. Willey A.R., Spear L.P. Development of anticipatory 50kHz usv production to a social stimuli in adolescent and adult male Sprague-Dawley rats. Behav. Brain Res. 2012, 226:613-618.
38. Burgdorf J., Knutson B., Panksepp J. Anticipation of rewarding electrical brain stimulation evokes ultrasonic vocalization in rats. Behav. Neurosci. 2000, 114:320-327.
39. Mitsui S., Yamamoto M., Nagasawa M., Mogi K., Kikusui T., Ohtani N., Ohta M. Urinary oxytocin as a noninvasive biomarker of positive emotion in dogs. Horm. Behav. 2011, 60:239-243.
40. Matthiesen A.S., Ransjö-Arvidson A.B., Nissen E., Uvnäs-Moberg K. Postpartum maternal oxytocin release by newborns: effects of infant hand massage and sucking. Birth 2001, 28:13-19.