Oxytocin increases nociceptive thresholds in a long-term perspective in female and male rats

Neuroscience Letters

Volumn 212, Issue 2, 1996, Pages 87-90

  Petersson, Maria ^a   Alster, Pawel ^a   Lundeberg, Thomas ^a   Uvnäs Moberg, Kerstin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Long term treatment; Naloxone; Nociception; Oxytocin; Oxytocin antagonist; Tail flick test

Indexed keywords

NALOXONE; OPIATE RECEPTOR; OXYTOCIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; LATENT PERIOD; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; TAIL FLICK TEST; WITHDRAWAL REFLEX;

EID: 0030581088     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12773-7     Document Type: Article

References (15)

1. [1] Argiolas, A. and Gessa, G.L., Central functions of oxytocin, Neurosci. Biobehav. Rev., 15 (1990) 217-231.
2. [2] Arletti, R., Benelli, A. and Bertolini, A., Influence of oxytocin on nociception and morphine antinociception, Neuropeptides, 24 (1993) 125-129.
3. [3] Berge, O., Garcia-Cabrera, I. and Hole, K., Response latencies in the tail-flick test depend on tail skin temperature, Neurosci. Lett., 86 (1988) 284-288.
4. [4] Crowley, W., Rodriguez-Sierra, J. and Komisaruk, B., Analgesia induced by vaginal stimulation in rats is apparently independent of a morphine-sensitive process, Psychopharmacology, 54 (1977) 223-225.
5. [5] Gintzler, A., Peters, L. and Komisaruk, B., Attenuation of pregnancy-induced analgesia by hypogastric neurectomy in rats, Brain Res., 277 (1983) 186-188.
6. [6] Jones, P.M. and Robinsson, I.C., Differential clearance of neurophysin and neurohypophyseal peptides from the cerebrospinal fluid in conscious guinea pigs, Neuroendocrinology, 34 (1982) 297-302.
7. [7] Madrazo, I., Franco-Bourland, R., Léon-Meza, V. and Mena, I., Intraventricular somatostatin-14, arginine vasopressin and oxytocin: analgesic effects in patient with intractable cancer pain, Appl. Neurophysiol., 50 (1987) 427-131.
8. [8] Martinez-Gómez, M., Cruz, Y., Salas, M., Hudson, R. and Pacheco, P., Assessing pain threshold in the rat; changes with estrus and time of day, Physiol. Behav., 55 (1994) 651-657.
9. [9] Petersson, M., Alster, P., Lundeberg, T. and Uvnäs-Moberg, K., Oxytocin causes a long-term decrease of blood pressure in female and male rats, Physiol. Behav., (1996) in press.
10. [10] Sawchenko, P.E. and Swanson, L.E., Immunohistochemical identification of paraventricular hypothalamic neurons that project to the medulla or the spinal cord in the rat, J. Comp. Neurol., 205 (1982) 260-272.
11. [11] Uvnäs-Moberg, K., Role of efferent and afferent vagal nerve activity on behaviour and metabolism during reproduction - integrating function of oxytocin, Psychoneuroendocrinology, 19 (1994) 687-695.
12. [12] Uvnäs-Moberg, K., Ahlenius, S., Hillegaart, V. and Alster, P., High doses of oxytocin cause sedation and low doses cause an anxiolytic like effect in male rats, Pharmacol. Biochem. Behav., 49 (1994) 101-106.
13. [13] Uvnäs-Moberg, K., Alster, P. and Petersson, M., Dissociation of oxytocin effects on body weight in two variants of female Sprague-Dawley rats, Integr. Phys. Behav. Sci., 31 (1996) 44-55.
14. [14] Uvnäs-Moberg, K., Bruzelius, G., Alster, P., Bileviciute, I. and Lundeberg, T., Oxytocin increases and a specific oxytocin antagonist decreases pain threshold in male rats, Acta Physiol. Scand., 144 (1992) 487-488.
15. [15] Yang, J., Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system, Spine, 8 (1994) 867-871.