Urinary oxytocin as a noninvasive biomarker of positive emotion in dogs

Hormones and Behavior

Volumn 60, Issue 3, 2011, Pages 239-243

  Mitsui, Shohei ^a   Yamamoto, Mariko ^a   Nagasawa, Miho ^a   Mogi, Kazutaka ^a   Kikusui, Takefumi ^a   Ohtani, Nobuyo ^a   Ohta, Mitsuaki ^a  

^a AZABU UNIVERSITY   (Japan)

Author keywords

Dog; Positive emotion; Radioimmunoassay; Urinary oxytocin (OT)

Indexed keywords

BIOLOGICAL MARKER; HYDROCORTISONE; OXYTOCIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; EMOTION; EXERCISE; FOOD INTAKE; HYDROCORTISONE URINE LEVEL; MALE; NON INVASIVE PROCEDURE; NONHUMAN; OXYTOCIN BLOOD LEVEL; OXYTOCIN URINE LEVEL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; URINE LEVEL;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; DOGS; EATING; EMOTIONS; HYDROCORTISONE; MALE; MASSAGE; OXYTOCIN; PHYSICAL CONDITIONING, ANIMAL;

EID: 79960564918     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.05.012     Document Type: Article

References (45)

1. Abrantes R.A.B. The expression of emotions in man and canid. J. Small Anim. Pract. 1987, 28:1030-1036.
2. Amico J.A., Ulbrecht J.S., Robinson A.G. Clearance studies of oxytocin in humans using radioimmunoassay measurements of the hormone in plasma and urine. J. Clin. Endocrinol. Metab. 1987, 64:340-345.
3. Amico J.A., Johnston J.M., Vagnucci A.H. Suckling-induced attenuation of plasma cortisol concentrations in postpartum lactating women. Endocr. Res. 1994, 20:79-87.
4. Bello D., White-Traut R., Schwertz D., Pournajafi-Nazarloo H., Carter C.S. An exploratory study of neurohormonal responses of healthy men to massage. J. Altern. Complement. Med. 2008, 14:387-394.
5. Buijs R.M., De Vries G.J., Van Leeuwen F.W., Swaab D.F. Vasopressin and oxytocin: distribution and putative functions in the brain. Prog. Brain Res. 1983, 60:115-122.
6. Carter C. Developmental consequences of oxytocin. Physiol. Behav. 2003, 79:383-397.
7. Chiodera P., Salvarani C., Bacchi-Modena A., Spallanzani R., Cigarini C., Alboni A., Gardini E., Coiro V. Relationship between plasma profiles of oxytocin and adrenocorticotropic hormone during suckling or breast stimulation in women. Horm. Res. 1991, 35:119-123.
8. DeVries A., Glasper E., Detillion C. Social modulation of stress responses. Physiol. Behav. 2003, 79:399-407.
9. Fonberg E., Kostarczyk E., Prechtl J. Training of instrumental responses in dogs socially reinforced by humans. Pavlov. J. Biol. Sci. 1981, 16:183-193.
10. Gingrich B.S., Hout R.L., Wang Z., Insel T.R. Differential Fos expression following microinjection of oxytocin or vasopressin in the prairie vole brain. Ann. N. Y. Acad. Sci. 1997, 807:504-505.
11. Grewen K.M., Girdler S.S., Amico J., Light K.C. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom. Med. 2005, 67:531-538.
12. Haller J., Makara G.B., Barna I., Kovács K., Nagy J., Vecsernyés M. Compression of the pituitary stalk elicits chronic increases in CSF vasopressin, oxytocin as well as in social investigation and aggressiveness. J. Neuroendocrinol. 2003, 8:361-365.
13. Heinrichs M., Meinlschmidt G., Neumann I., Wagner S., Kirschbaum C., Ehlert U., Hellhammer D.H. Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women. J. Clin. Endocrinol. Metab. 2001, 86:4798-4804.
14. Hernandez H., Serafin N., Terrazas A.M., Marnet P.G., Kann G., Delgadillo J.A., Poindron P. Maternal olfaction differentially modulates oxytocin and prolactin release during suckling in goats. Horm. Behav. 2002, 42:232-244.
15. Higuchi T., Honda K., Fukuoka T., Negoro H., Wakabayashi K. Release of oxytocin during suckling and parturition in the rat. J. Endocrinol. 1985, 105:339-346.
16. Kasting N.W. Simultaneous and independent release of vasopressin and oxytocin in the rat. Can. J. Physiol. Pharmacol. 1988, 66:22-26.
17. Kosfeld M., Heinrichs M., Zak P.J., Fischbacher U., Fehr E. Oxytocin increases trust in humans. Nature 2005, 435:673-676.
18. Kostarczyk E., Fonberg E. Heart rate mechanisms in instrumental conditioning reinforced by petting in dogs. Physiol. Behav. 1982, 28:27-30.
19. Landgraf R., Hacker R., Buhl H. Plasma vasopressin and oxytocin in response to exercise and during a day-night cycle in man. Endokrinologie 1982, 79:281-291.
20. Legros J.J., Chiodera P., Geenen V., von Frenckell R. Confirmation of the inhibitory influence of exogenous oxytocin on cortisol and ACTH in man: evidence of reproducibility. Eur. J. Endocrinol. 1987, 114:345-349.
21. Legros J.J., Chiodera P., Geenen V. Inhibitory action of exogenous oxytocin on plasma cortisol in normal human subjects: evidence of action at the adrenal level. Neuroendocrinology 1988, 48:204-206.
22. Lim M.M., Wang Z., Olazábal D.E., Ren X., Terwilliger E.F., Young L.J. Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 2004, 429:754-757.
23. Ludwig M. Dendritic release of vasopressin and oxytocin. J. Neuroendocrinol. 1998, 10:881-895.
24. Matthiesen A.S., Ransjo-Arvidson A.B., Nissen E., Uvnäs-Moberg K. Postpartum maternal oxytocin release by newborns: effects of infant hand massage and sucking. Birth 2001, 28:13-19.
25. Michelini L.C. Oxytocin in the NTS. A new modulator of cardiovascular control during exercise. Ann. N. Y. Acad. Sci. 2001, 940:206-220.
26. Miller S.C., Kennedy C., DeVoe D., Hickey M., Nelson T., Kogan L. An examination of changes in oxytocin levels in men and women before and after interaction with a bonded dog. Anthrozoös 2009, 22:31-42.
27. Mogi K., Ito S., Matsuyama S., Ohara H., Sakumoto R., Yayou K., Ohkura S., Sutoh M., Mori Y., Okamura H. Central administration of neuropeptide B, but not prolactin-releasing peptide, stimulates cortisol secretion in sheep. J. Reprod. Dev. 2008, 54:138-141.
28. Nagasawa M., Kikusui T., Onaka T., Ohta M. Dog's gaze at its owner increases owner's urinary oxytocin during social interaction. Horm. Behav. 2009, 55:434-441.
29. Neumann I. Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul. Pept. 2000, 96:31-38.
30. Nissen E., Uvnäs-Moberg K., Svensson K., Stock S., Widstrom A.M., Winberg J. Different patterns of oxytocin, prolactin but not cortisol release during breastfeeding in women delivered by caesarean section or by the vaginal route. Early Hum. Dev. 1996, 45:103-118.
31. Odendaal J., Meintjes R.A. Neurophysiological correlates of affiliative behaviour between humans and dogs. Vet. J. 2003, 165:296-301.
32. Okamoto Y., Ohtani N., Uchiyama H., Ohta M. The feeding behavior of dogs correlates with their responses to commands. J. Vet. Med. Sci. 2009, 71:1617-1621.
33. Panksepp J. Oxytocin effects on emotional processes: separation distress, social bonding, and relationships to psychiatric disorders. Ann. N. Y. Acad. Sci. 1992, 652:243-252.
34. Pedersen C.A., Caldwell J.D., Drago F., Noonan L.R., Peterson G., Hood L.E., Prange A.J. Grooming behavioral effects of oxytocin. Ann. N. Y. Acad. Sci. 1988, 525:245-256.
35. Quaranta A., Siniscalchi M., Vallortigara G. Asymmetric tail-wagging responses by dogs to different emotive stimuli. Curr. Biol. 2007, 17:199-201.
36. Russell J. Sex, parturition and motherhood without oxytocin?. J. Endocrinol. 1998, 157:343-359.
37. Russell J.A., Douglas A.J., Ingram C.D. Brain preparations for maternity-adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview. Prog. Brain Res. 2001, 133:1-38.
38. Seltzer L.J., Ziegler T.E. Non-invasive measurement of small peptides in the common marmoset (Callithrix jacchus): a radiolabeled clearance study and endogenous excretion under varying social conditions. Horm. Behav. 2007, 51:436-442.
39. Seltzer L.J., Ziegler T.E., Pollak S.D. Social vocalizations can release oxytocin in humans. Proc. Biol. Sci. 2010, 277:2661-2666.
40. Strathearn L., Fonagy P., Amico J., Montague P.R. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 2009, 34:2655-2666.
41. Turner R.A., Altemus M., Enos T., Cooper B., McGuinness T. Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. Psychiatry 1999, 62:97-113.
42. Uvnäs-Moberg K. Physiological and endocrine effects of social contact. Ann. N. Y. Acad. Sci. 1997, 807:146-163.
43. Verbalis J., McCann M., McHale C., Stricker E. Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety. Science 1986, 232:1417-1419.
44. Winslow J.T., Noble P.L., Lyons C.K., Sterk S.M., Insel T.R. Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys. Neuropsychopharmacology 2003, 28:910-918.
45. Witt D., Winslow J., Insel T. Enhanced social interactions in rats following chronic, centrally infused oxytocin. Pharmacol. Biochem. Behav. 1992, 43:855-861.