Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart

Circulation: Arrhythmia and Electrophysiology

Volumn 8, Issue 2, 2015, Pages 409-419

  Lang, Di ^a   Holzem, Katherine ^a   Kang, Chaoyi ^a   Xiao, Mengqian ^a   Hwang, Hye Jin ^a   Ewald, Gregory A ^a   Yamada, Kathryn A ^a   Efimov, Igor R ^a,b,c,d  

^a Department of Biomedical Engineering ^*  (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

Author keywords

Arrhythmia (mechanisms); calcium; heart failure; receptors, adrenergic

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; ADRB1 PROTEIN, HUMAN; ADRB2 PROTEIN, HUMAN; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT;

ACTION POTENTIAL; ADRENERGIC SYSTEM; ARRHYTHMOGENESIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART FAILURE; HEART LEFT VENTRICLE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PURKINJE FIBER; RECEPTOR DOWN REGULATION; SIGNAL DETECTION; SINUS NODE CONDUCTION VELOCITY; ARRHYTHMIAS, CARDIAC; CALCIUM SIGNALING; CASE CONTROL STUDY; COMPLICATION; DRUG EFFECTS; HEART LEFT VENTRICLE FUNCTION; HEART TRANSPLANTATION; HEART VENTRICLE; HEART VENTRICLE REMODELING; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RISK FACTOR; TIME; VOLTAGE SENSITIVE DYE IMAGING;

ACTION POTENTIALS; ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ARRHYTHMIAS, CARDIAC; CALCIUM SIGNALING; CASE-CONTROL STUDIES; HEART FAILURE; HEART TRANSPLANTATION; HEART VENTRICLES; HUMANS; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RISK FACTORS; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84930948656     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.114.002065     Document Type: Article

References (28)

1. Wachter SB, Gilbert EM. Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application. Cardiology. 2012;122:104-112. doi: 10.1159/000339271.
2. Singh BN, Vaughan Williams EM. A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474. Br J Pharmacol. 1970;39:675-687.
3. Priori SG, Napolitano C, Cerrone M. ?-blockers as antiarrhythmic agents. In: Kass RE, Clancy CE, eds. Basis and Treatment of Cardiac Arrhythmias. Berlin, Heidelberg: Springer; 2006:235-266.
4. Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008;102:1389-1397. doi: 10.1161/CIRCRESAHA.107.169011.
5. Litovsky SH, Antzelevitch C. Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. J Am Coll Cardiol. 1989;14:1053-1066.
6. Bristow MR, Hershberger RE, Port JD, Minobe W, Rasmussen R. Beta 1-and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol. 1989;35:295-303.
7. Ruwald MH, Ruwald AC, Jons C, Alexis J, McNitt S, Zareba W, Moss AJ. Effect of metoprolol versus carvedilol on outcomes in MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy). J Am Coll Cardiol. 2013;61:1518-1526. doi: 10.1016/j. jacc.2013.01.020.
8. de Peuter OR, Lussana F, Peters RJ, Büller HR, Kamphuisen PW. A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure. Neth J Med. 2009;67:284-294.
9. Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, Zera P, Menlove R, Shah P, Jamieson S. Beta 1-and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res. 1986;59:297-309.
10. Lang D, Sulkin M, Lou Q, Efimov IR. Optical mapping of action potentials and calcium transients in the mouse heart. J Vis Exp. 2011;55:e3275. doi: 10.3791/3275.
11. Lou Q, Fedorov VV, Glukhov AV, Moazami N, Fast VG, Efimov IR. Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure. Circulation. 2011;123:1881-1890. doi: 10.1161/CIRCULATIONAHA.110.989707.
12. Bartel S, Krause EG, Wallukat G, Karczewski P. New insights into beta2-adrenoceptor signaling in the adult rat heart. Cardiovasc Res. 2003;57:694-703.
13. Engelhardt S, Grimmer Y, Fan GH, Lohse MJ. Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. Mol Pharmacol. 2001;60:712-717.
14. Rohr S. Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc Res. 2004;62:309-322. doi: 10.1016/j. cardiores.2003.11.035.
15. Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA, Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circ Res. 1999;84:43-52.
16. Beau SL, Tolley TK, Saffitz JE. Heterogeneous transmural distribution of beta-adrenergic receptor subtypes in failing human hearts. Circulation. 1993;88:2501-2509.
17. Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 1997;390:88-91. doi: 10.1038/36362.
18. Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Distinct phosphorylation sites on the ?(2)-adrenergic receptor establish a barcode that encodes differential functions of ?-arrestin. Sci Signal. 2011;4:ra51. doi: 10.1126/scisignal.2001707.
19. Damiano RJ Jr, Smith PK, Tripp HF Jr, Asano T, Small KW, Lowe JE, Ideker RE, Cox JL. The effect of chemical ablation of the endocardium on ventricular fibrillation threshold. Circulation. 1986;74:645-652.
20. Saffitz JE, Schuessler RB. Connexin-40, bundle-branch block, and propagation at the Purkinje-myocyte junction. Circ Res. 2000;87:835-836.
21. Spach MS, Dolber PC, Heidlage JF. Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ Res. 1988;62:811-832.
22. Kléber AG, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev. 2004;84:431-488. doi: 10.1152/physrev.00025.2003.
23. Gong H, Sun H, Koch WJ, Rau T, Eschenhagen T, Ravens U, Heubach JF, Adamson DL, Harding SE. Specific beta(2)AR blocker ICI 118, 551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002;105:2497-2503.
24. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994;264:582-586.
25. Crespo LM, Grantham CJ, Cannell MB. Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes. Nature. 1990;345:618-621. doi: 10.1038/345618a0.
26. Bers D. Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, The Netherlands: Kluwer Academic Publishers; 2001.
27. Sato M, Gong H, Terracciano CM, Ranu H, Harding SE. Loss of betaadrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. J Mol Cell Cardiol. 2004;36:43-48.
28. Bogun F, Crawford T, Reich S, Koelling TM, Armstrong W, Good E, Jongnarangsin K, Marine JE, Chugh A, Pelosi F, Oral H, Morady F. Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. Heart Rhythm. 2007;4:863-867. doi: 10.1016/j.hrthm.2007.03.003.