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Volumn 7, Issue , 2015, Pages 551-563

Clinical utility of exemestane in the treatment of breast cancer

Author keywords

Aromatase inhibitors; Breast cancer; Endocrine therapy; Exemestane

Indexed keywords

ANASTROZOLE; EVEROLIMUS; EXEMESTANE; FULVESTRANT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LETROZOLE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TAMOXIFEN;

EID: 84930946220     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: 10.2147/IJWH.S69475     Document Type: Review
Times cited : (23)

References (110)
  • 2
    • 84926457179 scopus 로고    scopus 로고
    • European cancer mortality predictions for the year 2015: Does lung cancer have the highest death rate in EU women?
    • Malvezzi M, Bertuccio P, Rosso T, et al. European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? Ann Oncol. 2015;26(4):779–786.
    • (2015) Ann Oncol , vol.26 , Issue.4 , pp. 779-786
    • Malvezzi, M.1    Bertuccio, P.2    Rosso, T.3
  • 3
    • 84875804295 scopus 로고    scopus 로고
    • Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
    • Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–1403.
    • (2013) Eur J Cancer , vol.49 , Issue.6 , pp. 1374-1403
    • Ferlay, J.1    Steliarova-Foucher, E.2    Lortet-Tieulent, J.3
  • 4
    • 0000524684 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases
    • Beatson G. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet. 1869;2:104–107.
    • (1869) Lancet , vol.2 , pp. 104-107
    • Beatson, G.1
  • 5
    • 17144423592 scopus 로고    scopus 로고
    • Aromatase inhibition: Translation into a success­ful therapeutic approach
    • Geisler J, Lonning PE. Aromatase inhibition: translation into a success­ful therapeutic approach. Clin Cancer Res. 2005;11(8):2809–2821.
    • (2005) Clin Cancer Res , vol.11 , Issue.8 , pp. 2809-2821
    • Geisler, J.1    Lonning, P.E.2
  • 6
    • 0020078292 scopus 로고
    • Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma
    • Santen RJ, Worgul TJ, Lipton A, et al. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma. Ann Intern Med. 1982;96(1):94–101.
    • (1982) Ann Intern Med , vol.96 , Issue.1 , pp. 94-101
    • Santen, R.J.1    Worgul, T.J.2    Lipton, A.3
  • 7
    • 0025372326 scopus 로고
    • Endocrine treatment of breast cancer in women
    • Santen RJ, Manni A, Harvey H, Redmond C. Endocrine treatment of breast cancer in women. Endocr Rev. 1990;11(2):221–265.
    • (1990) Endocr Rev , vol.11 , Issue.2 , pp. 221-265
    • Santen, R.J.1    Manni, A.2    Harvey, H.3    Redmond, C.4
  • 8
    • 0029940269 scopus 로고    scopus 로고
    • Fadrozole HCL (CGS-16949A) versus megestrol acetate treatment of postmenopausal patients with metastatic breast carcinoma: Results of two randomized double blind controlled multiinstitutional trials
    • Buzdar AU, Smith R, Vogel C, et al. Fadrozole HCL (CGS-16949A) versus megestrol acetate treatment of postmenopausal patients with metastatic breast carcinoma: results of two randomized double blind controlled multiinstitutional trials. Cancer. 1996;77:2503–2513.
    • (1996) Cancer , vol.77 , pp. 2503-2513
    • Buzdar, A.U.1    Smith, R.2    Vogel, C.3
  • 9
    • 0343924363 scopus 로고    scopus 로고
    • Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: A phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90). Swiss Group for Clini­cal Cancer Research (SAKK)
    • Thürlimann B, Castiglione M, Hsu-Schmitz SF, et al. Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: a phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90). Swiss Group for Clini­cal Cancer Research (SAKK). Eur J Cancer. 1997;33:1017–1024.
    • (1997) Eur J Cancer , vol.33 , pp. 1017-1024
    • Thürlimann, B.1    Castiglione, M.2    Hsu-Schmitz, S.F.3
  • 10
    • 0038478620 scopus 로고    scopus 로고
    • First-line fadrozole HCI (CGS 16949A) versus tamoxifen in postmenopausal women with advanced breast cancer. Prospective randomised trial of the Swiss Group for Clinical Cancer Research SAKK 20/88
    • Thürlimann B, Beretta K, Bacchi M, et al. First-line fadrozole HCI (CGS 16949A) versus tamoxifen in postmenopausal women with advanced breast cancer. Prospective randomised trial of the Swiss Group for Clinical Cancer Research SAKK 20/88. Ann Oncol. 1996;7(5):471–479.
    • (1996) Ann Oncol , vol.7 , Issue.5 , pp. 471-479
    • Thürlimann, B.1    Beretta, K.2    Bacchi, M.3
  • 11
    • 0030035607 scopus 로고    scopus 로고
    • A randomised study of CGS 16949A (Fadro­zole) versus tamoxifen in previously untreated postmenopausal patients with metastatic breast cancer
    • Falkson CI, Falkson HC. A randomised study of CGS 16949A (fadro­zole) versus tamoxifen in previously untreated postmenopausal patients with metastatic breast cancer. Ann Oncol. 1996;7(5):465–469.
    • (1996) Ann Oncol , vol.7 , Issue.5 , pp. 465-469
    • Falkson, C.I.1    Falkson, H.C.2
  • 12
    • 0028131860 scopus 로고
    • Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer
    • Pérez Carrión R, Alberola Candel V, Calabresi F, et al. Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer. Ann Oncol. 1994;5(Suppl 7):S19–S24.
    • (1994) Ann Oncol , vol.5 , pp. S19-S24
    • Pérez Carrión, R.1    Alberola Candel, V.2    Calabresi, F.3
  • 13
    • 0037130287 scopus 로고    scopus 로고
    • Exemestane, a new steroidal aromatase inhibitor of clinical relevance
    • Lombardi P. Exemestane, a new steroidal aromatase inhibitor of clinical relevance. Biochim Biophys Acta. 2002;1587(2–3):326–337.
    • (2002) Biochim Biophys Acta , vol.1587 , Issue.2-3 , pp. 326-337
    • Lombardi, P.1
  • 14
    • 0038210242 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Smith IE, Dowsett M. Aromatase inhibitors in breast cancer. N Engl J Med. 2003;348(24):2431–2442.
    • (2003) N Engl J Med , vol.348 , Issue.24 , pp. 2431-2442
    • Smith, I.E.1    Dowsett, M.2
  • 15
    • 0002500198 scopus 로고
    • The irreversible inhibition of aromatase (Oestrogen syn­thetase) by steroidal compounds
    • Lombardi P. The irreversible inhibition of aromatase (oestrogen syn­thetase) by steroidal compounds. Curr Pharm Des. 1995;1:23–50.
    • (1995) Curr Pharm Des , vol.1 , pp. 23-50
    • Lombardi, P.1
  • 16
    • 0027859747 scopus 로고
    • Aromatase, its inhibitors and their use in breast cancer treatment
    • Brodie AM. Aromatase, its inhibitors and their use in breast cancer treatment. Pharmacol Ther. 1993;60(3):501–515.
    • (1993) Pharmacol Ther , vol.60 , Issue.3 , pp. 501-515
    • Brodie, A.M.1
  • 17
    • 33846619697 scopus 로고    scopus 로고
    • Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase
    • Hong Y, Yu B, Sherman M, Yuan YC, Zhou D, Chen S. Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase. Mol Endocrinol. 2007;21(2):401–414.
    • (2007) Mol Endocrinol , vol.21 , Issue.2 , pp. 401-414
    • Hong, Y.1    Yu, B.2    Sherman, M.3    Yuan, Y.C.4    Zhou, D.5    Chen, S.6
  • 18
    • 0023751351 scopus 로고
    • 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irrevers­ible aromatase inhibitor
    • Giudici D, Ornati G, Briatico G, Buzzetti F, Lombardi P, di Salle E. 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): a new irrevers­ible aromatase inhibitor. J Steroid Biochem. 1988;30(1–6):391–394.
    • (1988) J Steroid Biochem , vol.30 , Issue.1-6 , pp. 391-394
    • Giudici, D.1    Ornati, G.2    Briatico, G.3    Buzzetti, F.4    Lombardi, P.5    Di Salle, E.6
  • 20
    • 0024351630 scopus 로고
    • Effect of the irreversible aromatase inhibitor FCE 24304 on DMBA-induced mammary tumors in ovariectomized rats treated with testosterone
    • Zaccheo T, Di Salle E. Effect of the irreversible aromatase inhibitor FCE 24304 on DMBA-induced mammary tumors in ovariectomized rats treated with testosterone. Cancer Chemother Pharmacol. 1989;25(2):95–98.
    • (1989) Cancer Chemother Pharmacol , vol.25 , Issue.2 , pp. 95-98
    • Zaccheo, T.1    Di Salle, E.2
  • 21
    • 0024817037 scopus 로고
    • Aromatase inhibition and experimental antitumor activity of FCE 24304, MDL 18962 and SH 489
    • di Salle E, Briatico G, Giudici D, Ornati G, Zaccheo T. Aromatase inhibition and experimental antitumor activity of FCE 24304, MDL 18962 and SH 489. J Steroid Biochem. 1989;34(1–6):431–434.
    • (1989) J Steroid Biochem , vol.34 , Issue.1-6 , pp. 431-434
    • Di Salle, E.1    Briatico, G.2    Giudici, D.3    Ornati, G.4    Zaccheo, T.5
  • 22
    • 0025837943 scopus 로고
    • Comparison of the effects of the irreversible aromatase inhibitor exemestane with atamestane and MDL 18962 in rats with DMBA-induced mammary tumours
    • Zaccheo T, Giudici D, Ornati G, Panzeri A, di Salle E. Comparison of the effects of the irreversible aromatase inhibitor exemestane with atamestane and MDL 18962 in rats with DMBA-induced mammary tumours. Eur J Cancer. 1991;27(9):1145–1150.
    • (1991) Eur J Cancer , vol.27 , Issue.9 , pp. 1145-1150
    • Zaccheo, T.1    Giudici, D.2    Ornati, G.3    Panzeri, A.4    Di Salle, E.5
  • 23
    • 0026446844 scopus 로고
    • Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women
    • Evans TR, Di Salle E, Ornati G, et al. Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women. Cancer Res. 1992;52(21):5933–5939.
    • (1992) Cancer Res , vol.52 , Issue.21 , pp. 5933-5939
    • Evans, T.R.1    Di Salle, E.2    Ornati, G.3
  • 25
    • 2542446523 scopus 로고    scopus 로고
    • The effects of degree of hepatic or renal impairment on the pharmacoki­netics of exemestane in postmenopausal women
    • Jannuzzo MG, Poggesi I, Spinelli R, Rocchetti M, Cicioni P, Buchan P. The effects of degree of hepatic or renal impairment on the pharmacoki­netics of exemestane in postmenopausal women. Cancer Chemother Pharmacol. 2004;53(6):475–481.
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.6 , pp. 475-481
    • Jannuzzo, M.G.1    Poggesi, I.2    Spinelli, R.3    Rocchetti, M.4    Cicioni, P.5    Buchan, P.6
  • 26
    • 0028839205 scopus 로고
    • Endocrinological and clini­cal evaluation of exemestane, a new steroidal aromatase inhibitor
    • Zilembo N, Noberasco C, Bajetta E, et al. Endocrinological and clini­cal evaluation of exemestane, a new steroidal aromatase inhibitor. Br J Cancer. 1995;72(4):1007–1012.
    • (1995) Br J Cancer , vol.72 , Issue.4 , pp. 1007-1012
    • Zilembo, N.1    Noberasco, C.2    Bajetta, E.3
  • 27
    • 15444348553 scopus 로고    scopus 로고
    • Safety, activity and estrogen inhibition by exemestane in postmenopausal women with advanced breast cancer: A phase I study
    • Paridaens R, Thomas J, Wildiers J, et al. Safety, activity and estrogen inhibition by exemestane in postmenopausal women with advanced breast cancer: a phase I study. Anticancer Drugs. 1998;9(8):675–683.
    • (1998) Anticancer Drugs , vol.9 , Issue.8 , pp. 675-683
    • Paridaens, R.1    Thomas, J.2    Wildiers, J.3
  • 28
    • 0030748661 scopus 로고    scopus 로고
    • Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: A phase I study
    • Johannessen DC, Engan T, Di Salle E, et al. Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: a phase I study. Clin Cancer Res. 1997;3(7):1101–1108.
    • (1997) Clin Cancer Res , vol.3 , Issue.7 , pp. 1101-1108
    • Johannessen, D.C.1    Engan, T.2    Di Salle, E.3
  • 29
    • 0032757904 scopus 로고    scopus 로고
    • Exemestane
    • discussion 681–672
    • Scott LJ, Wiseman LR. Exemestane. Drugs. 1999;58(4):675–680. discussion 681–672.
    • (1999) Drugs , vol.58 , Issue.4 , pp. 675-680
    • Scott, L.J.1    Wiseman, L.R.2
  • 30
    • 84882756472 scopus 로고    scopus 로고
    • Aromatase inhibition 2013: Clinical state of the art and questions that remain to be solved
    • Lonning PE, Eikesdal HP. Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved. Endocr Relat Cancer. 2013;20(4):R183–R201.
    • (2013) Endocr Relat Cancer , vol.20 , Issue.4 , pp. R183-R201
    • Lonning, P.E.1    Eikesdal, H.P.2
  • 31
    • 77950353502 scopus 로고    scopus 로고
    • Evaluation of plasma and tissue estrogen sup­pression with third-generation aromatase inhibitors: Of relevance to clinical understanding?
    • Lonning PE, Geisler J. Evaluation of plasma and tissue estrogen sup­pression with third-generation aromatase inhibitors: of relevance to clinical understanding? J Steroid Biochem Mol Biol. 2010;118(4–5):288–293.
    • (2010) J Steroid Biochem Mol Biol , vol.118 , Issue.4-5 , pp. 288-293
    • Lonning, P.E.1    Geisler, J.2
  • 32
    • 0036467847 scopus 로고    scopus 로고
    • Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study
    • Geisler J, Haynes B, Anker G, Dowsett M, Lonning PE. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J Clin Oncol. 2002;20(3):751–757.
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 751-757
    • Geisler, J.1    Haynes, B.2    Anker, G.3    Dowsett, M.4    Lonning, P.E.5
  • 33
    • 65649098606 scopus 로고    scopus 로고
    • A comparative study of exemestane versus anastrozole in patients with postmenopausal breast cancer with visceral metastases
    • Campos SM, Guastalla JP, Subar M, Abreu P, Winer EP, Cameron DA. A comparative study of exemestane versus anastrozole in patients with postmenopausal breast cancer with visceral metastases. Clin Breast Cancer. 2009;9(1):39–44.
    • (2009) Clin Breast Cancer , vol.9 , Issue.1 , pp. 39-44
    • Campos, S.M.1    Guastalla, J.P.2    Subar, M.3    Abreu, P.4    Winer, E.P.5    Cameron, D.A.6
  • 34
    • 83855162902 scopus 로고    scopus 로고
    • Exemestane versus anas­trozole as front-line endocrine therapy in postmenopausal patients with hormone receptor-positive, advanced breast cancer: Final results from the Spanish Breast Cancer Group 2001–03 phase 2 randomized trial
    • Llombart-Cussac A, Ruiz A, Antón A, et al. Exemestane versus anas­trozole as front-line endocrine therapy in postmenopausal patients with hormone receptor-positive, advanced breast cancer: final results from the Spanish Breast Cancer Group 2001–03 phase 2 randomized trial. Cancer. 2012;118(1):241–247.
    • (2012) Cancer , vol.118 , Issue.1 , pp. 241-247
    • Llombart-Cussac, A.1    Ruiz, A.2    Antón, A.3
  • 35
    • 77955774641 scopus 로고    scopus 로고
    • Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer
    • Riemsma R, Forbes CA, Kessels A, et al. Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer. Breast Cancer Res Treat. 2010;123(1):9–24.
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.1 , pp. 9-24
    • Riemsma, R.1    Forbes, C.A.2    Kessels, A.3
  • 36
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: Results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group
    • Buzdar AU, Jonat W, Howell A, et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group. Cancer. 1998;83(6):1142–1152.
    • (1998) Cancer , vol.83 , Issue.6 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3
  • 37
    • 0031943424 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor for advanced breast cancer: Double-blind random­ized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate
    • Dombernowsky P, Smith I, Falkson G, et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind random­ized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol. 1998;16(2):453–461.
    • (1998) J Clin Oncol , vol.16 , Issue.2 , pp. 453-461
    • Dombernowsky, P.1    Smith, I.2    Falkson, G.3
  • 38
    • 0034128928 scopus 로고    scopus 로고
    • Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a phase III randomized double-blind trial. The Exemestane Study Group
    • Kaufmann M, Bajetta E, Dirix LY, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. The Exemestane Study Group. J Clin Oncol. 2000;18(7):1399–1411.
    • (2000) J Clin Oncol , vol.18 , Issue.7 , pp. 1399-1411
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3
  • 39
    • 0035498544 scopus 로고    scopus 로고
    • Arimidex Writing Com­mittee; Investigators Committee Members. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma
    • Bonneterre J, Buzdar A, Nabholtz JM, et al; Arimidex Writing Com­mittee; Investigators Committee Members. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer. 2001;92(9):2247–2258.
    • (2001) Cancer , vol.92 , Issue.9 , pp. 2247-2258
    • Bonneterre, J.1    Buzdar, A.2    Nabholtz, J.M.3
  • 40
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmeno­pausal women: Results of a North American multicenter randomized trial. Arimidex Study Group
    • Nabholtz JM, Buzdar A, Pollak M, et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmeno­pausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol. 2000;18(22):3758–3767.
    • (2000) J Clin Oncol , vol.18 , Issue.22 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3
  • 41
    • 0037841365 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy in postmenopausal patients with hormone-dependent advanced breast cancer: A prospective, randomized, phase III study
    • Milla-Santos A, Milla L, Portella J, et al. Anastrozole versus tamoxifen as first-line therapy in postmenopausal patients with hormone-dependent advanced breast cancer: a prospective, randomized, phase III study. Am J Clin Oncol. 2003;26(3):317–322.
    • (2003) Am J Clin Oncol , vol.26 , Issue.3 , pp. 317-322
    • Milla-Santos, A.1    Milla, L.2    Portella, J.3
  • 42
    • 0038460245 scopus 로고    scopus 로고
    • Phase III study of letro­zole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: Analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    • Mouridsen H, Gershanovich M, Sun Y, et al. Phase III study of letro­zole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J Clin Oncol. 2003;21(11):2101–2109.
    • (2003) J Clin Oncol , vol.21 , Issue.11 , pp. 2101-2109
    • Mouridsen, H.1    Gershanovich, M.2    Sun, Y.3
  • 43
    • 54449099359 scopus 로고    scopus 로고
    • Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of meta­static breast cancer in postmenopausal women: The European Organisa­tion for Research and Treatment of Cancer Breast Cancer Cooperative Group
    • Paridaens RJ, Dirix LY, Beex LV, et al. Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of meta­static breast cancer in postmenopausal women: the European Organisa­tion for Research and Treatment of Cancer Breast Cancer Cooperative Group. J Clin Oncol. 2008;26(30):4883–4890.
    • (2008) J Clin Oncol , vol.26 , Issue.30 , pp. 4883-4890
    • Paridaens, R.J.1    Dirix, L.Y.2    Beex, L.V.3
  • 44
    • 0032729804 scopus 로고    scopus 로고
    • Multicenter, phase II trial of exemestane as third-line hormonal therapy of postmenopausal women with metastatic breast cancer. Aromasin Study Group
    • Jones S, Vogel C, Arkhipov A, et al. Multicenter, phase II trial of exemestane as third-line hormonal therapy of postmenopausal women with metastatic breast cancer. Aromasin Study Group. J Clin Oncol. 1999;17(11):3418–3425.
    • (1999) J Clin Oncol , vol.17 , Issue.11 , pp. 3418-3425
    • Jones, S.1    Vogel, C.2    Arkhipov, A.3
  • 45
    • 17144472154 scopus 로고    scopus 로고
    • Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibi­tors: A phase II trial
    • Lønning PE, Bajetta E, Murray R, et al. Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibi­tors: a phase II trial. J Clin Oncol. 2000;18(11):2234–2244.
    • (2000) J Clin Oncol , vol.18 , Issue.11 , pp. 2234-2244
    • Lønning, P.E.1    Bajetta, E.2    Murray, R.3
  • 46
    • 19944422403 scopus 로고    scopus 로고
    • Southern Italy Oncology Group. Phase II study of sequential hormonal therapy with anastrozole/exemestane in advanced and metastatic breast cancer
    • Iaffaioli RV, Formato R, Tortoriello A, et al; Southern Italy Oncology Group. Phase II study of sequential hormonal therapy with anastrozole/exemestane in advanced and metastatic breast cancer. Br J Cancer. 2005;92(9):1621–1625.
    • (2005) Br J Cancer , vol.92 , Issue.9 , pp. 1621-1625
    • Iaffaioli, R.V.1    Formato, R.2    Tortoriello, A.3
  • 47
    • 32044460822 scopus 로고    scopus 로고
    • Sequential treatment with exemestane and non-steroidal aromatase inhibitors in advanced breast cancer
    • Bertelli G, Garrone O, Merlano M, et al. Sequential treatment with exemestane and non-steroidal aromatase inhibitors in advanced breast cancer. Oncology. 2005;69(6):471–477.
    • (2005) Oncology , vol.69 , Issue.6 , pp. 471-477
    • Bertelli, G.1    Garrone, O.2    Merlano, M.3
  • 48
    • 33744823312 scopus 로고    scopus 로고
    • Exemestane in metastatic breast cancer: Effective therapy after third-generation non-steroidal aromatase inhibitor failure
    • Steele N, Zekri J, Coleman R, et al. Exemestane in metastatic breast cancer: effective therapy after third-generation non-steroidal aromatase inhibitor failure. Breast. 2006;15(3):430–436.
    • (2006) Breast , vol.15 , Issue.3 , pp. 430-436
    • Steele, N.1    Zekri, J.2    Coleman, R.3
  • 49
    • 34547153161 scopus 로고    scopus 로고
    • Exemestane after non-steroidal aromatase inhibitors for post-menopausal women with advanced breast cancer
    • Chin YS, Beresford MJ, Ravichandran D, Makris A. Exemestane after non-steroidal aromatase inhibitors for post-menopausal women with advanced breast cancer. Breast. 2007;16(4):436–439.
    • (2007) Breast , vol.16 , Issue.4 , pp. 436-439
    • Chin, Y.S.1    Beresford, M.J.2    Ravichandran, D.3    Makris, A.4
  • 50
    • 34948911484 scopus 로고    scopus 로고
    • Randomized multicenter crossover phase II trial to compare exemestane (E) vs. anastrozole (A) in postmenopausal patients (pt) withadvanced breast cancer (ABC) and positive hormone receptors (HR). Final efficacy analysis of GEICAM 2001–03 study
    • Mayordomo J, Llombart A, Martin M, et al. Randomized multicenter crossover phase II trial to compare exemestane (E) vs. anastrozole (A) in postmenopausal patients (pt) withadvanced breast cancer (ABC) and positive hormone receptors (HR). Final efficacy analysis of GEICAM 2001–03 study. J Clin Oncol. 2006;24(Suppl):638.
    • (2006) J Clin Oncol , vol.24 , pp. 638
    • Mayordomo, J.1    Llombart, A.2    Martin, M.3
  • 51
    • 34247104592 scopus 로고    scopus 로고
    • Clinical evaluation of the use of exemestane as further hormonal therapy after nonsteroidal aromatase inhibitors in postmenopausal metastatic breast cancer patients
    • Carlini P, Michelotti A, Ferretti G, et al. Clinical evaluation of the use of exemestane as further hormonal therapy after nonsteroidal aromatase inhibitors in postmenopausal metastatic breast cancer patients. Cancer Invest. 2007;25(2):102–105.
    • (2007) Cancer Invest , vol.25 , Issue.2 , pp. 102-105
    • Carlini, P.1    Michelotti, A.2    Ferretti, G.3
  • 52
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized pla­cebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: Results from EFECT
    • Chia S, Gradishar W, Mauriac L, et al. Double-blind, randomized pla­cebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. J Clin Oncol. 2008;26(10):1664–1670.
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3
  • 53
    • 84883050535 scopus 로고    scopus 로고
    • SoFEA Investigators. Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): A composite, multicentre, phase 3 randomised trial
    • Johnston SR, Kilburn LS, Ellis P, et al; SoFEA Investigators. Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial. Lancet Oncol. 2013;14(10):989–998.
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 989-998
    • Johnston, S.R.1    Kilburn, L.S.2    Ellis, P.3
  • 54
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012;366(6):520–529.
    • (2012) N Engl J Med , vol.366 , Issue.6 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 55
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • Forbes JF, Cuzick J, Buzdar A, Howell A, Tobias JS, Baum M. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 2008;9(1):45–53.
    • (2008) Lancet Oncol , vol.9 , Issue.1 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3    Howell, A.4    Tobias, J.S.5    Baum, M.6
  • 56
    • 33947510501 scopus 로고    scopus 로고
    • Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: Update of study BIG 1-98
    • Coates AS, Keshaviah A, Thürlimann B, et al. Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. J Clin Oncol. 2007;25(5):486–492.
    • (2007) J Clin Oncol , vol.25 , Issue.5 , pp. 486-492
    • Coates, A.S.1    Keshaviah, A.2    Thürlimann, B.3
  • 57
    • 74549170977 scopus 로고    scopus 로고
    • Results of the first planned analysis of the TEAM (Tamoxifen exemestane adjuvant multinational) prospective randomized phase III trial in hormone sensitive postmeno­pausal early breast cancer
    • [abstract 15]
    • Jones SE, Seynaeve C, Hasenburg A, et al. Results of the first planned analysis of the TEAM (tamoxifen exemestane adjuvant multinational) prospective randomized phase III trial in hormone sensitive postmeno­pausal early breast cancer. Cancer Res. 2009;69:67s. [abstract 15].
    • (2009) Cancer Res , vol.69 , Issue.67s
    • Jones, S.E.1    Seynaeve, C.2    Hasenburg, A.3
  • 58
    • 34447574894 scopus 로고    scopus 로고
    • Improved overall survival in postmenopausal women with early breast cancer after anastrozole initi­ated after treatment with tamoxifen compared with continued tamoxifen: The ARNO 95 Study
    • Kaufmann M, Jonat W, Hilfrich J, et al. Improved overall survival in postmenopausal women with early breast cancer after anastrozole initi­ated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 Study. J Clin Oncol. 2007;25(19):2664–2670.
    • (2007) J Clin Oncol , vol.25 , Issue.19 , pp. 2664-2670
    • Kaufmann, M.1    Jonat, W.2    Hilfrich, J.3
  • 59
    • 84857508799 scopus 로고    scopus 로고
    • Tamoxifen and anastrozole as a sequencing strategy: A randomized controlled trial in postmeno­pausal patients with endocrine-responsive early breast cancer from the Austrian Breast and Colorectal Cancer Study Group
    • Dubsky PC, Jakesz R, Mlineritsch B, et al. Tamoxifen and anastrozole as a sequencing strategy: a randomized controlled trial in postmeno­pausal patients with endocrine-responsive early breast cancer from the Austrian Breast and Colorectal Cancer Study Group. J Clin Oncol. 2012;30(7):722–728.
    • (2012) J Clin Oncol , vol.30 , Issue.7 , pp. 722-728
    • Dubsky, P.C.1    Jakesz, R.2    Mlineritsch, B.3
  • 60
    • 84876106789 scopus 로고    scopus 로고
    • Switching to anastro­zole versus continued tamoxifen treatment of early breast cancer: Long term results of the Italian Tamoxifen Anastrozole trial
    • Boccardo F, Guglielmini P, Bordonaro R, et al. Switching to anastro­zole versus continued tamoxifen treatment of early breast cancer: long term results of the Italian Tamoxifen Anastrozole trial. Eur J Cancer. 2013;49(7):1546–1554.
    • (2013) Eur J Cancer , vol.49 , Issue.7 , pp. 1546-1554
    • Boccardo, F.1    Guglielmini, P.2    Bordonaro, R.3
  • 61
    • 84857605861 scopus 로고    scopus 로고
    • Disease-related outcomes with long-term follow-up: An updated analysis of the intergroup exemestane study
    • Bliss JM, Kilburn LS, Coleman RE, et al. Disease-related outcomes with long-term follow-up: an updated analysis of the intergroup exemestane study. J Clin Oncol. 2012;30(7):709–717.
    • (2012) J Clin Oncol , vol.30 , Issue.7 , pp. 709-717
    • Bliss, J.M.1    Kilburn, L.S.2    Coleman, R.E.3
  • 62
    • 81255157751 scopus 로고    scopus 로고
    • BIG 1-98 Collaborative Group, International Breast Cancer Study Group (IBCSG). Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: The BIG 1-98 randomised clinical trial at 8.1 years median follow-up
    • Regan MM, Neven P, Giobbie-Hurder A, et al; BIG 1-98 Collaborative Group, International Breast Cancer Study Group (IBCSG). Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8.1 years median follow-up. Lancet Oncol. 2011;12(12):1101–1108.
    • (2011) Lancet Oncol , vol.12 , Issue.12 , pp. 1101-1108
    • Regan, M.M.1    Neven, P.2    Giobbie-Hurder, A.3
  • 63
    • 78751647876 scopus 로고    scopus 로고
    • Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): A randomised phase 3 trial
    • van de Velde CJ, Rea D, Seynaeve C, et al. Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial. Lancet. 2011;377(9762):321–331.
    • (2011) Lancet , vol.377 , Issue.9762 , pp. 321-331
    • Van De Velde, C.J.1    Rea, D.2    Seynaeve, C.3
  • 64
    • 7444259675 scopus 로고    scopus 로고
    • A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    • Goss PE, Ingle JN, Martino S, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med. 2003;349(19):1793–1802.
    • (2003) N Engl J Med , vol.349 , Issue.19 , pp. 1793-1802
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 65
    • 38449107897 scopus 로고    scopus 로고
    • Austrian Breast and Colorectal Cancer Study Group. Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: Results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a
    • Jakesz R, Greil R, Gnant M, et al; Austrian Breast and Colorectal Cancer Study Group. Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a. J Natl Cancer Inst. 2007;99(24):1845–1853.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.24 , pp. 1845-1853
    • Jakesz, R.1    Greil, R.2    Gnant, M.3
  • 66
    • 42949104549 scopus 로고    scopus 로고
    • Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: Intention-to-treat analysis of the National Surgical Adju­vant Breast and Bowel Project B-33 trial
    • Mamounas EP, Jeong JH, Wickerham DL, et al. Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adju­vant Breast and Bowel Project B-33 trial. J Clin Oncol. 2008;26(12):1965–1971.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 1965-1971
    • Mamounas, E.P.1    Jeong, J.H.2    Wickerham, D.L.3
  • 67
    • 10744223655 scopus 로고    scopus 로고
    • Intergroup Exemestane Study. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer
    • Coombes RC, Hall E, Gibson LJ, et al; Intergroup Exemestane Study. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med. 2004;350(11):1081–1092.
    • (2004) N Engl J Med , vol.350 , Issue.11 , pp. 1081-1092
    • Coombes, R.C.1    Hall, E.2    Gibson, L.J.3
  • 68
    • 84876082087 scopus 로고    scopus 로고
    • Exemestane versus anas­trozole in postmenopausal women with early breast cancer: NCIC CTG MA.27 –a randomized controlled phase III trial
    • Goss PE, Ingle JN, Pritchard KI, et al. Exemestane versus anas­trozole in postmenopausal women with early breast cancer: NCIC CTG MA.27 –a randomized controlled phase III trial. J Clin Oncol. 2013;31(11):1398–1404.
    • (2013) J Clin Oncol , vol.31 , Issue.11 , pp. 1398-1404
    • Goss, P.E.1    Ingle, J.N.2    Pritchard, K.I.3
  • 69
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365(9472):1687–1717.
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 70
    • 0035795683 scopus 로고    scopus 로고
    • Five versus more than five years of tamoxifen for lymph node-negative breast cancer: Updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial
    • Fisher B, Dignam J, Bryant J, Wolmark N. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J Natl Cancer Inst. 2001;93(9):684–690.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.9 , pp. 684-690
    • Fisher, B.1    Dignam, J.2    Bryant, J.3    Wolmark, N.4
  • 71
    • 0030479062 scopus 로고    scopus 로고
    • Postchemotherapy adjuvant tamox­ifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group
    • Tormey DC, Gray R, Falkson HC. Postchemotherapy adjuvant tamox­ifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group. J Natl Cancer Inst. 1996;88(24):1828–1833.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.24 , pp. 1828-1833
    • Tormey, D.C.1    Gray, R.2    Falkson, H.C.3
  • 72
    • 0035925617 scopus 로고    scopus 로고
    • Scottish adjuvant tamoxifen trial: A randomized study updated to 15 years
    • Stewart HJ, Prescott RJ, Forrest AP. Scottish adjuvant tamoxifen trial: a randomized study updated to 15 years. J Natl Cancer Inst. 2001;93(6):456–462.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.6 , pp. 456-462
    • Stewart, H.J.1    Prescott, R.J.2    Forrest, A.P.3
  • 73
    • 84874745627 scopus 로고    scopus 로고
    • Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
    • Davies C, Pan H, Godwin J, et al; Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381(9869):805–816.
    • (2013) Lancet , vol.381 , Issue.9869 , pp. 805-816
    • Davies, C.1    Pan, H.2    Godwin, J.3
  • 74
    • 84874745627 scopus 로고    scopus 로고
    • Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 in 6,953 women with early breast cancer
    • Davies C, Pan H, Godwin J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 in 6,953 women with early breast cancer. J Clin Oncol. 2013;381(9869):805–816.
    • (2013) J Clin Oncol , vol.381 , Issue.9869 , pp. 805-816
    • Davies, C.1    Pan, H.2    Godwin, J.3
  • 75
    • 24744450378 scopus 로고    scopus 로고
    • Randomized trial of letrozole fol­lowing tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: Updated findings from NCIC CTG MA.17
    • Goss PE, Ingle JN, Martino S, et al. Randomized trial of letrozole fol­lowing tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst. 2005;97(17):1262–1271.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.17 , pp. 1262-1271
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 76
    • 74049164267 scopus 로고    scopus 로고
    • Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: Final results of the ATENA lipid substudy
    • Markopoulos C, Dafni U, Misitzis J, et al. Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: final results of the ATENA lipid substudy. Breast Cancer Res. 2009;11(3):R35.
    • (2009) Breast Cancer Res , vol.11 , Issue.3 , pp. R35
    • Markopoulos, C.1    Dafni, U.2    Misitzis, J.3
  • 77
    • 78449310837 scopus 로고    scopus 로고
    • Aromatase Inhibitors (AIs) versus not (placebo/observation) as late extended adjuvant therapy for postmenopausal women with early stage breast cancer (BC): Overviews of randomized trials of AIs after ∼5 years of tamoxifen
    • abstr 4081
    • Goss P, Mamounas E, Jakesz R, et al. Aromatase Inhibitors (AIs) versus not (placebo/observation) as late extended adjuvant therapy for postmenopausal women with early stage breast cancer (BC): overviews of randomized trials of AIs after ∼5 years of tamoxifen. Cancer Res. 2009;69(24 Suppl):abstr 4081.
    • (2009) Cancer Res , vol.69 , Issue.24
    • Goss, P.1    Mamounas, E.2    Jakesz, R.3
  • 78
    • 84883325272 scopus 로고    scopus 로고
    • Panel Members. Personal­izing the treatment of women with early breast cancer: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
    • Goldhirsch A, Winer EP, Coates AS, et al; Panel Members. Personal­izing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013;24(9):2206–2223.
    • (2013) Ann Oncol , vol.24 , Issue.9 , pp. 2206-2223
    • Goldhirsch, A.1    Winer, E.P.2    Coates, A.S.3
  • 79
    • 1542359096 scopus 로고    scopus 로고
    • Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for pre­menopausal advanced breast cancer
    • Forward DP, Cheung KL, Jackson L, Robertson JF. Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for pre­menopausal advanced breast cancer. Br J Cancer. 2004;90(3):590–594.
    • (2004) Br J Cancer , vol.90 , Issue.3 , pp. 590-594
    • Forward, D.P.1    Cheung, K.L.2    Jackson, L.3    Robertson, J.F.4
  • 80
    • 78049300397 scopus 로고    scopus 로고
    • Suppression of ovarian function in combination with an aromatase inhibitor as treatment for advanced breast cancer in pre-menopausal women
    • Cheung KL, Agrawal A, Folkerd E, Dowsett M, Robertson JF, Winterbottom L. Suppression of ovarian function in combination with an aromatase inhibitor as treatment for advanced breast cancer in pre-menopausal women. Eur J Cancer. 2010;46(16):2936–2942.
    • (2010) Eur J Cancer , vol.46 , Issue.16 , pp. 2936-2942
    • Cheung, K.L.1    Agrawal, A.2    Folkerd, E.3    Dowsett, M.4    Robertson, J.F.5    Winterbottom, L.6
  • 81
    • 77957592529 scopus 로고    scopus 로고
    • Phase II trial of anas­trozole plus goserelin in the treatment of hormone receptor-positive, metastatic carcinoma of the breast in premenopausal women
    • Carlson RW, Theriault R, Schurman CM, et al. Phase II trial of anas­trozole plus goserelin in the treatment of hormone receptor-positive, metastatic carcinoma of the breast in premenopausal women. J Clin Oncol. 2010;28(25):3917–3921.
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 3917-3921
    • Carlson, R.W.1    Theriault, R.2    Schurman, C.M.3
  • 82
    • 60549097419 scopus 로고    scopus 로고
    • Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria. Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • Gnant M, Mlineritsch B, Schippinger W, et al; Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med. 2009;360(7):679–691.
    • (2009) N Engl J Med , vol.360 , Issue.7 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 83
    • 79959565208 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
    • Gnant M, Mlineritsch B, Stoeger H, et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011;12(7):631–641.
    • (2011) Lancet Oncol , vol.12 , Issue.7 , pp. 631-641
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3
  • 84
    • 84903904384 scopus 로고    scopus 로고
    • TEXT and SOFT Investiga­tors; International Breast Cancer Study Group. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer
    • Pagani O, Regan MM, Walley BA, et al; TEXT and SOFT Investiga­tors; International Breast Cancer Study Group. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014;371(2):107–118.
    • (2014) N Engl J Med , vol.371 , Issue.2 , pp. 107-118
    • Pagani, O.1    Regan, M.M.2    Walley, B.A.3
  • 85
    • 84921838679 scopus 로고    scopus 로고
    • SOFT Investigators; Inter­national Breast Cancer Study Group. Adjuvant ovarian suppression in premenopausal breast cancer
    • Francis PA, Regan MM, Fleming GF, et al; SOFT Investigators; Inter­national Breast Cancer Study Group. Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med. 2015;372(5):436–446.
    • (2015) N Engl J Med , vol.372 , Issue.5 , pp. 436-446
    • Francis, P.A.1    Regan, M.M.2    Fleming, G.F.3
  • 86
    • 84878107936 scopus 로고    scopus 로고
    • SERM Chemoprevention of Breast Cancer Overview Group. Selective oestrogen receptor modulators in prevention of breast cancer: An updated meta-analysis of individual participant data
    • Cuzick J, Sestak I, Bonanni B, et al; SERM Chemoprevention of Breast Cancer Overview Group. Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data. Lancet. 2013;381(9880):1827–1834.
    • (2013) Lancet , vol.381 , Issue.9880 , pp. 1827-1834
    • Cuzick, J.1    Sestak, I.2    Bonanni, B.3
  • 87
    • 75749092296 scopus 로고    scopus 로고
    • Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    • Dowsett M, Cuzick J, Ingle J, et al. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol. 2010;28(3):509–518.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 509-518
    • Dowsett, M.1    Cuzick, J.2    Ingle, J.3
  • 88
    • 84896489393 scopus 로고    scopus 로고
    • IBIS-II investigators. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): An international, double-blind, randomised placebo-controlled trial
    • Cuzick J, Sestak I, Forbes JF, et al; IBIS-II investigators. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet. 2014;383(9922):1041–1048.
    • (2014) Lancet , vol.383 , Issue.9922 , pp. 1041-1048
    • Cuzick, J.1    Sestak, I.2    Forbes, J.F.3
  • 89
    • 79959403574 scopus 로고    scopus 로고
    • NCIC CTG MAP.3 Study Investigators. Exemestane for breast-cancer prevention in postmeno­pausal women
    • Goss PE, Ingle JN, Alés-Martínez JE, et al; NCIC CTG MAP.3 Study Investigators. Exemestane for breast-cancer prevention in postmeno­pausal women. N Engl J Med. 2011;364(25):2381–2391.
    • (2011) N Engl J Med , vol.364 , Issue.25 , pp. 2381-2391
    • Goss, P.E.1    Ingle, J.N.2    Alés-Martínez, J.E.3
  • 90
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Geisler J, King N, Anker G, et al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res. 1998;4(9):2089–2093.
    • (1998) Clin Cancer Res , vol.4 , Issue.9 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3
  • 91
    • 34247266976 scopus 로고    scopus 로고
    • Aromatase inhibitors and bone health in women with breast cancer
    • Chien AJ, Goss PE. Aromatase inhibitors and bone health in women with breast cancer. J Clin Oncol. 2006;24(33):5305–5312.
    • (2006) J Clin Oncol , vol.24 , Issue.33 , pp. 5305-5312
    • Chien, A.J.1    Goss, P.E.2
  • 92
    • 41949094767 scopus 로고    scopus 로고
    • Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230
    • Eastell R, Adams JE, Coleman RE, et al. Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. J Clin Oncol. 2008;26(7):1051–1057.
    • (2008) J Clin Oncol , vol.26 , Issue.7 , pp. 1051-1057
    • Eastell, R.1    Adams, J.E.2    Coleman, R.E.3
  • 93
    • 29544433211 scopus 로고    scopus 로고
    • A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer
    • Breast International Group (BIG) 1-98 Collaborative Group
    • Breast International Group (BIG) 1-98 Collaborative Group; Thürlimann B, Keshaviah A, et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med. 2005;353(26):2747–2757.
    • (2005) N Engl J Med , vol.353 , Issue.26 , pp. 2747-2757
    • Thürlimann, B.1    Keshaviah, A.2
  • 94
    • 0030070093 scopus 로고    scopus 로고
    • Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women
    • Powles TJ, Hickish T, Kanis JA, Tidy A, Ashley S. Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women. J Clin Oncol. 1996;14(1):78–84.
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 78-84
    • Powles, T.J.1    Hickish, T.2    Kanis, J.A.3    Tidy, A.4    Ashley, S.5
  • 95
    • 24644434439 scopus 로고    scopus 로고
    • Effects of exemestane admin­istered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer
    • Lønning PE, Geisler J, Krag LE, et al. Effects of exemestane admin­istered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer. J Clin Oncol. 2005;23(22):5126–5137.
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 5126-5137
    • Lønning, P.E.1    Geisler, J.2    Krag, L.E.3
  • 96
    • 33747058527 scopus 로고    scopus 로고
    • Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: A companion study to NCIC CTG MA.17
    • Perez EA, Josse RG, Pritchard KI, et al. Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17. J Clin Oncol. 2006;24(22):3629–3635.
    • (2006) J Clin Oncol , vol.24 , Issue.22 , pp. 3629-3635
    • Perez, E.A.1    Josse, R.G.2    Pritchard, K.I.3
  • 97
    • 33750522464 scopus 로고    scopus 로고
    • Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: A randomised, placebo-controlled study
    • Geisler J, Lønning PE, Krag LE, et al. Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: a randomised, placebo-controlled study. Eur J Cancer. 2006;42(17):2968–2975.
    • (2006) Eur J Cancer , vol.42 , Issue.17 , pp. 2968-2975
    • Geisler, J.1    Lønning, P.E.2    Krag, L.E.3
  • 98
    • 33846545851 scopus 로고    scopus 로고
    • Intergroup Exemestane Study. Survival and safety of exemestane versus tamoxifen after 2-3 years’ tamoxifen treatment (Intergroup Exemestane Study): A randomised controlled trial
    • Coombes RC, Kilburn LS, Snowdon CF, et al; Intergroup Exemestane Study. Survival and safety of exemestane versus tamoxifen after 2-3 years’ tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial. Lancet. 2007;369(9561):559–570.
    • (2007) Lancet , vol.369 , Issue.9561 , pp. 559-570
    • Coombes, R.C.1    Kilburn, L.S.2    Snowdon, C.F.3
  • 99
    • 33846545488 scopus 로고    scopus 로고
    • Intergroup Exemestane Study Group. Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): A randomised controlled study
    • Coleman RE, Banks LM, Girgis SI, et al; Intergroup Exemestane Study Group. Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study. Lancet Oncol. 2007;8(2):119–127.
    • (2007) Lancet Oncol , vol.8 , Issue.2 , pp. 119-127
    • Coleman, R.E.1    Banks, L.M.2    Girgis, S.I.3
  • 100
    • 66149136937 scopus 로고    scopus 로고
    • Effects of exemestane and tamoxifen on bone health within the Tamoxifen Exemestane Adjuvant Multicentre (TEAM) trial: Results of a German, 12-month, prospective, randomised substudy
    • Hadji P, Ziller M, Kieback DG, et al. Effects of exemestane and tamoxifen on bone health within the Tamoxifen Exemestane Adjuvant Multicentre (TEAM) trial: results of a German, 12-month, prospective, randomised substudy. Ann Oncol. 2009;20(7):1203–1209.
    • (2009) Ann Oncol , vol.20 , Issue.7 , pp. 1203-1209
    • Hadji, P.1    Ziller, M.2    Kieback, D.G.3
  • 101
    • 4444273111 scopus 로고    scopus 로고
    • Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ova­riectomized rats
    • Goss PE, Qi S, Cheung AM, Hu H, Mendes M, Pritzker KP. Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ova­riectomized rats. Clin Cancer Res. 2004;10(17):5717–5723.
    • (2004) Clin Cancer Res , vol.10 , Issue.17 , pp. 5717-5723
    • Goss, P.E.1    Qi, S.2    Cheung, A.M.3    Hu, H.4    Mendes, M.5    Pritzker, K.P.6
  • 102
    • 84897462874 scopus 로고    scopus 로고
    • Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): A companion analysis of a ran­domised controlled trial
    • Goss PE, Hershman DL, Cheung AM, et al. Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a ran­domised controlled trial. Lancet Oncol. 2014;15(4):474–482.
    • (2014) Lancet Oncol , vol.15 , Issue.4 , pp. 474-482
    • Goss, P.E.1    Hershman, D.L.2    Cheung, A.M.3
  • 103
    • 36048956448 scopus 로고    scopus 로고
    • Aromatase inhibitor-asso­ciated arthralgia and/or bone pain: Frequency and characterization in non-clinical trial patients
    • Presant CA, Bosserman L, Young T, et al. Aromatase inhibitor-asso­ciated arthralgia and/or bone pain: frequency and characterization in non-clinical trial patients. Clin Breast Cancer. 2007;7(10):775–778.
    • (2007) Clin Breast Cancer , vol.7 , Issue.10 , pp. 775-778
    • Presant, C.A.1    Bosserman, L.2    Young, T.3
  • 104
    • 41549083745 scopus 로고    scopus 로고
    • Long-term safety of aromatase inhibitors in the treatment of breast cancer
    • Nabholtz JM. Long-term safety of aromatase inhibitors in the treatment of breast cancer. Ther Clin Risk Manag. 2008;4(1):189–204.
    • (2008) Ther Clin Risk Manag , vol.4 , Issue.1 , pp. 189-204
    • Nabholtz, J.M.1
  • 105
    • 10744233292 scopus 로고    scopus 로고
    • The effect of exemestane on serum lipid profile in postmenopausal women with metastatic breast cancer: A companion study to EORTC Trial 10951, ‘Randomized phase II study in first line hormonal treatment for metastatic breast cancer with exemestane or tamoxifen in postmenopausal patients’
    • Atalay G, Dirix L, Biganzoli L, et al. The effect of exemestane on serum lipid profile in postmenopausal women with metastatic breast cancer: a companion study to EORTC Trial 10951, ‘Randomized phase II study in first line hormonal treatment for metastatic breast cancer with exemestane or tamoxifen in postmenopausal patients’. Ann Oncol. 2004;15(2):211–217.
    • (2004) Ann Oncol. , vol.15 , Issue.2 , pp. 211-217
    • Atalay, G.1    Dirix, L.2    Biganzoli, L.3
  • 106
    • 36049032413 scopus 로고    scopus 로고
    • Comparison of menopausal symptoms during the first year of adjuvant therapy with either exemestane or tamoxifen in early breast cancer: Report of a Tamoxifen Exemestane Adjuvant Multicenter trial substudy
    • Jones SE, Cantrell J, Vukelja S, et al. Comparison of menopausal symptoms during the first year of adjuvant therapy with either exemestane or tamoxifen in early breast cancer: report of a Tamoxifen Exemestane Adjuvant Multicenter trial substudy. J Clin Oncol. 2007;25:4765–4771.
    • (2007) J Clin Oncol , vol.25 , pp. 4765-4771
    • Jones, S.E.1    Cantrell, J.2    Vukelja, S.3
  • 107
    • 84858288976 scopus 로고    scopus 로고
    • Long-term assessment of quality of life in the Intergroup Exemestane Study: 5 years post-randomisation
    • Fallowfield LJ, Kilburn LS, Langridge C, Snowdon CF, Bliss JM, Coombes RC. Long-term assessment of quality of life in the Intergroup Exemestane Study: 5 years post-randomisation. Br J Cancer. 2012;106:1062–1067.
    • (2012) Br J Cancer , vol.106 , pp. 1062-1067
    • Fallowfield, L.J.1    Kilburn, L.S.2    Langridge, C.3    Snowdon, C.F.4    Bliss, J.M.5    Coombes, R.C.6
  • 108
    • 36048965807 scopus 로고    scopus 로고
    • Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer
    • Bender CM, Sereika SM, Brufsky AM, et al. Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer. Menopause. 2007;14(6):995–998.
    • (2007) Menopause , vol.14 , Issue.6 , pp. 995-998
    • Bender, C.M.1    Sereika, S.M.2    Brufsky, A.M.3
  • 109
    • 77957161009 scopus 로고    scopus 로고
    • Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial
    • Phillips KA, Ribi K, Sun Z, et al. Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial. Breast. 2010;19:388–395.
    • (2010) Breast , vol.19 , pp. 388-395
    • Phillips, K.A.1    Ribi, K.2    Sun, Z.3
  • 110
    • 77950475217 scopus 로고    scopus 로고
    • Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: Results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial
    • Schilder CM, Seynaeve C, Beex LV, et al. Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial. J Clin Oncol. 2010;28:1294–1300.
    • (2010) J Clin Oncol , vol.28 , pp. 1294-1300
    • Schilder, C.M.1    Seynaeve, C.2    Beex, L.V.3


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