Selective inhibition of extracellular oxidants liberated from human neutrophils - A new mechanism potentially involved in the anti-inflammatory activity of hydroxychloroquine

International Immunopharmacology

Volumn 28, Issue 1, 2015, Pages 175-181

  Jančinová, Viera ^a   Pažoureková, Silvia ^a   Lucová, Marianna ^a   Perečko, Tomáš ^a   Mihalová, Danica ^a   Bauerová, Katarína ^a   Nosá̘, Radomír ^a   Drábiková, Katarína ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

Author keywords

Adjuvant arthritis; Chemiluminescence; Hydroxychloroquine; Intracellular calcium; Neutrophil; Protein kinase C

Indexed keywords

HYDROXYCHLOROQUINE SULFATE; METHOTREXATE; OXIDIZING AGENT; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA II; PROTEIN KINASE C DELTA; PROTEIN P40; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; ANTIOXIDANT; HYDROXYCHLOROQUINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ADJUVANT ARTHRITIS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL FREE SYSTEM; CELL ISOLATION; CHEMOLUMINESCENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; EXPERIMENTAL ARTHRITIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; MALE; MONOTHERAPY; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RESPIRATORY BURST; ANIMAL; CALCIUM SIGNALING; DRUG EFFECTS; EXTRACELLULAR SPACE; IN VITRO STUDY; LEUKOCYTE COUNT; LEWIS RAT; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; YOUNG ADULT;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ARTHRITIS, EXPERIMENTAL; CALCIUM SIGNALING; EXTRACELLULAR SPACE; HUMANS; HYDROXYCHLOROQUINE; IN VITRO TECHNIQUES; LEUKOCYTE COUNT; MALE; METHOTREXATE; MIDDLE AGED; NADPH OXIDASE; NEUTROPHILS; OXIDANTS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, INBRED LEW; RESPIRATORY BURST; YOUNG ADULT;

EID: 84930942954     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.05.048     Document Type: Article

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