Higher adiponectin and lower hemoglobin levels in older men: Causal or confounded by androgens?

Journal of Internal Medicine

Volumn 278, Issue 1, 2015, Pages 95-96

  Schooling, C M ^a,b   Zhao, Jie ^b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ANDROGEN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; HEMOGLOBINS;

AGED; ANDROGEN THERAPY; CROSS-SECTIONAL STUDY; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; LETTER; MALE; META ANALYSIS (TOPIC); OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; AGING; BLOOD; HUMANS; METABOLISM;

ADIPONECTIN; AGING; HEMOGLOBINS; HUMANS; MALE;

EID: 84930926012     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12362     Document Type: Letter

References (13)

1. Lewerin C, Johansson H, Lerner UH et al. High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study. J Intern Med 2014. doi: 10.1111/joim.12340. [Epub ahead of print].
2. Fernandez-Balsells MM, Murad MH, Lane M et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2010; 95: 2560-75.
3. Tsang CW, Lazarus R, Smith W, Mitchell P, Koutts J, Burnett L. Hematological indices in an older population sample: derivation of healthy reference values. Clin Chem 1998; 44: 96-101.
4. Kapoor D, Clarke S, Stanworth R, Channer KS, Jones TH. The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. Eur J Endocrinol 2007; 156: 595-602.
5. Page ST, Herbst KL, Amory JK et al. Testosterone administration suppresses adiponectin levels in men. J Androl 2005; 26: 85-92.
6. Page ST, Amory JK, Bowman FD et al. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 2005; 90: 1502-10.
7. Frederiksen L, Hojlund K, Hougaard DM et al. Testosterone therapy decreases subcutaneous fat and adiponectin in aging men. Eur J Endocrinol 2012; 166: 469-76.
8. Andreasson AN, Unden AL, Elofsson S, Brismar K. Leptin and adiponectin: distribution and associations with cardiovascular risk factors in men and women of the general population. Am J Hum Biol 2012; 24: 595-601.
9. Shi Z, Araujo AB, Martin S, O'Loughlin P, Wittert GA. Longitudinal changes in testosterone over five years in community-dwelling men. J Clin Endocrinol Metab 2013; 98: 3289-97.
10. Lewerin C, Nilsson-Ehle H, Jacobsson S et al. Serum estradiol associates with blood hemoglobin in elderly men: the MrOS Sweden study. J Clin Endocrinol Metab 2014; 99: 2549-56.
11. Vandenput L, Labrie F, Mellstrom D et al. Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men. J Bone Miner Res 2007; 22: 220-7.
12. Patel CJ, Ioannidis JP. Placing epidemiological results in the context of multiplicity and typical correlations of exposures. J Epidemiol Community Health 2014; 68: 1096-100.
13. Patel CJ, Rehkopf DH, Leppert JT et al. Systematic evaluation of environmental and behavioural factors associated with all-cause mortality in the United States National Health and Nutrition Examination Survey. Int J Epidemiol 2013; 42: 1795-810.