메뉴 건너뛰기




Volumn 463, Issue 3, 2015, Pages 161-166

Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer

Author keywords

Cancer therapeutics; mTORC1; PI3K AKT; PRAS40

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROLINE RICH AKT SUBSTRATE OF 40 KDA; PROTEIN KINASE B; UNCLASSIFIED DRUG; AKT1S1 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84930924235     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.041     Document Type: Short Survey
Times cited : (38)

References (53)
  • 1
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • M.A. Lawlor, and D.R. Alessi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114 2001 2903 2910
    • (2001) J. Cell Sci. , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 2
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between akt, TSC2 and the two mTOR complexes
    • J. Huang, and B.D. Manning A complex interplay between akt, TSC2 and the two mTOR complexes Biochem. Soc. Trans. 37 2009 217 222
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 3
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes. Dev. 18 2004 1926 1945
    • (2004) Genes. Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 6
    • 77956626055 scopus 로고    scopus 로고
    • PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts
    • A.A. Kazi, and C.H. Lang PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts Mol. Med. 16 2010 359 371
    • (2010) Mol. Med. , vol.16 , pp. 359-371
    • Kazi, A.A.1    Lang, C.H.2
  • 8
    • 0142150204 scopus 로고    scopus 로고
    • Involvement of the Akt/PKB signaling pathway with disease processes
    • P. Sen, S. Mukherjee, D. Ray, and S. Raha Involvement of the Akt/PKB signaling pathway with disease processes Mol. Cell Biochem. 253 2003 241 246
    • (2003) Mol. Cell Biochem. , vol.253 , pp. 241-246
    • Sen, P.1    Mukherjee, S.2    Ray, D.3    Raha, S.4
  • 9
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 10
    • 84866479521 scopus 로고    scopus 로고
    • PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection
    • Z.Z. Chong, Y.C. Shang, S. Wang, and K. Maiese PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection PLoS One 7 2012 e45456
    • (2012) PLoS One , vol.7
    • Chong, Z.Z.1    Shang, Y.C.2    Wang, S.3    Maiese, K.4
  • 11
    • 1242274413 scopus 로고    scopus 로고
    • Neuroprotective role of a proline-rich akt substrate in apoptotic neuronal cell death after stroke: Relationships with nerve growth factor
    • A. Saito, P. Narasimhan, T. Hayashi, S. Okuno, M. Ferrand-Drake, and P.H. Chan Neuroprotective role of a proline-rich akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor J. Neurosci. 24 2004 1584 1593
    • (2004) J. Neurosci. , vol.24 , pp. 1584-1593
    • Saito, A.1    Narasimhan, P.2    Hayashi, T.3    Okuno, S.4    Ferrand-Drake, M.5    Chan, P.H.6
  • 12
    • 33644858950 scopus 로고    scopus 로고
    • Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia
    • A. Saito, T. Hayashi, S. Okuno, T. Nishi, and P.H. Chan Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia Stroke 37 2006 513 517
    • (2006) Stroke , vol.37 , pp. 513-517
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 13
    • 84868662619 scopus 로고    scopus 로고
    • Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern beta-amyloid apoptotic injury of microglia
    • Y.C. Shang, Z.Z. Chong, S. Wang, and K. Maiese Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern beta-amyloid apoptotic injury of microglia Curr. Neurovasc Res. 9 2012 239 249
    • (2012) Curr. Neurovasc Res. , vol.9 , pp. 239-249
    • Shang, Y.C.1    Chong, Z.Z.2    Wang, S.3    Maiese, K.4
  • 15
    • 84899098781 scopus 로고    scopus 로고
    • Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes
    • J. Hao, F. Li, W. Liu, Q. Liu, S. Liu, H. Li, and H. Duan Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes J. Cell Physiol. 229 2014 1069 1077
    • (2014) J. Cell Physiol. , vol.229 , pp. 1069-1077
    • Hao, J.1    Li, F.2    Liu, W.3    Liu, Q.4    Liu, S.5    Li, H.6    Duan, H.7
  • 18
    • 80155141166 scopus 로고    scopus 로고
    • PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases
    • W. Kim, H. Youn, K.M. Seong, H.J. Yang, Y.J. Yun, T. Kwon, Y.H. Kim, J.Y. Lee, Y.W. Jin, and B. Youn PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases Radiat. Res. 176 2011 539 552
    • (2011) Radiat. Res. , vol.176 , pp. 539-552
    • Kim, W.1    Youn, H.2    Seong, K.M.3    Yang, H.J.4    Yun, Y.J.5    Kwon, T.6    Kim, Y.H.7    Lee, J.Y.8    Jin, Y.W.9    Youn, B.10
  • 19
    • 84857710881 scopus 로고    scopus 로고
    • PRAS40 is a functionally critical target for EWS repression in ewing sarcoma
    • L. Huang, Y. Nakai, I. Kuwahara, and K. Matsumoto PRAS40 is a functionally critical target for EWS repression in ewing sarcoma Cancer Res. 72 2012 1260 1269
    • (2012) Cancer Res. , vol.72 , pp. 1260-1269
    • Huang, L.1    Nakai, Y.2    Kuwahara, I.3    Matsumoto, K.4
  • 20
    • 84918841143 scopus 로고    scopus 로고
    • Phospho-PRAS40 predicts trastuzumab response in patients with HER2-positive metastatic breast cancer
    • K. Yuan, H. Wu, Y. Wang, H. Chen, M. Jiao, and R. Fu Phospho-PRAS40 predicts trastuzumab response in patients with HER2-positive metastatic breast cancer Oncol. Lett. 9 2015 785 789
    • (2015) Oncol. Lett. , vol.9 , pp. 785-789
    • Yuan, K.1    Wu, H.2    Wang, Y.3    Chen, H.4    Jiao, M.5    Fu, R.6
  • 21
    • 34249679614 scopus 로고    scopus 로고
    • mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • S.G. Dann, A. Selvaraj, and G. Thomas mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer Trends Mol. Med. 13 2007 252 259
    • (2007) Trends Mol. Med. , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 23
    • 84900645303 scopus 로고    scopus 로고
    • Prognostic role of phospho-PRAS40 (Thr246) expression in gastric cancer
    • Y.Z. Lu, A.M. Deng, L.H. Li, G.Y. Liu, and G.Y. Wu Prognostic role of phospho-PRAS40 (Thr246) expression in gastric cancer Arch. Med. Sci. 10 2014 149 153
    • (2014) Arch. Med. Sci. , vol.10 , pp. 149-153
    • Lu, Y.Z.1    Deng, A.M.2    Li, L.H.3    Liu, G.Y.4    Wu, G.Y.5
  • 24
    • 0014761971 scopus 로고
    • Cancer mortality among diabetics
    • I.I. Kessler Cancer mortality among diabetics J. Natl. Cancer Inst. 44 1970 673 686
    • (1970) J. Natl. Cancer Inst. , vol.44 , pp. 673-686
    • Kessler, I.I.1
  • 26
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 27
    • 21544483506 scopus 로고    scopus 로고
    • Functional and therapeutic significance of Akt deregulation in malignant melanoma
    • G.P. Robertson Functional and therapeutic significance of Akt deregulation in malignant melanoma Cancer Metastasis Rev. 24 2 2005 273 285
    • (2005) Cancer Metastasis Rev. , vol.24 , Issue.2 , pp. 273-285
    • Robertson, G.P.1
  • 28
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • J.Q. Cheng, C.W. Lindsley, G.Z. Cheng, H. Yang, and S.V. Nicosia The Akt/PKB pathway: molecular target for cancer drug discovery Oncogene 24 2005 7482 7492
    • (2005) Oncogene , vol.24 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 29
    • 26044474979 scopus 로고    scopus 로고
    • Expression of proline-rich akt-substrate PRAS40 in cell survival pathway and carcinogenesis
    • B. Huang, and G. Porter Expression of proline-rich akt-substrate PRAS40 in cell survival pathway and carcinogenesis Acta Pharmacol. Sin. 26 2005 1253 1258
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 1253-1258
    • Huang, B.1    Porter, G.2
  • 33
    • 84894289173 scopus 로고    scopus 로고
    • Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells
    • I. Baricevic, D.L. Roberts, and A.G. Renehan Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells Horm. Metab. Res. 46 2014 85 93
    • (2014) Horm. Metab. Res. , vol.46 , pp. 85-93
    • Baricevic, I.1    Roberts, D.L.2    Renehan, A.G.3
  • 34
    • 84919619702 scopus 로고    scopus 로고
    • Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells
    • X. Yu, B. Zheng, and R. Chai Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells Biosci. Rep. 34 2014
    • (2014) Biosci. Rep. , vol.34
    • Yu, X.1    Zheng, B.2    Chai, R.3
  • 35
    • 79956271546 scopus 로고    scopus 로고
    • Viral hepatitis B and hepatocellular carcinoma
    • P. Michielsen, and E. Ho Viral hepatitis B and hepatocellular carcinoma Acta Gastroenterol. Belg 74 2011 4 8
    • (2011) Acta Gastroenterol. Belg , vol.74 , pp. 4-8
    • Michielsen, P.1    Ho, E.2
  • 36
    • 84930930544 scopus 로고    scopus 로고
    • Knockdown of myosin VI inhibits proliferation of hepatocellular carcinoma cells in vitro
    • Feb 19 [Epub ahead of print]
    • X. Ma, J. Yan, W. Chen, P. Du, J. Xie, H. Yu, and H. Wu Knockdown of myosin VI inhibits proliferation of hepatocellular carcinoma cells in vitro Chem. Biol. Drug Des. 2015 Feb 19 http://dx.doi.org/10.1111/cbdd.12544 [Epub ahead of print]
    • (2015) Chem. Biol. Drug Des.
    • Ma, X.1    Yan, J.2    Chen, W.3    Du, P.4    Xie, J.5    Yu, H.6    Wu, H.7
  • 38
    • 84856329735 scopus 로고    scopus 로고
    • Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
    • N. Khan, F. Afaq, F.H. Khusro, V. Mustafa Adhami, Y. Suh, and H. Mukhtar Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin Int. J. Cancer 130 2012 1695 1705
    • (2012) Int. J. Cancer , vol.130 , pp. 1695-1705
    • Khan, N.1    Afaq, F.2    Khusro, F.H.3    Mustafa Adhami, V.4    Suh, Y.5    Mukhtar, H.6
  • 42
    • 34248545489 scopus 로고    scopus 로고
    • PRAS40 deregulates apoptosis in malignant melanoma
    • S.V. Madhunapantula, A. Sharma, and G.P. Robertson PRAS40 deregulates apoptosis in malignant melanoma Cancer Res. 67 2007 3626 3636
    • (2007) Cancer Res. , vol.67 , pp. 3626-3636
    • Madhunapantula, S.V.1    Sharma, A.2    Robertson, G.P.3
  • 43
    • 11244318619 scopus 로고    scopus 로고
    • On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake
    • A. Shimaya, K.S. Kovacina, and R.A. Roth On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake J. Biol. Chem. 279 2004 55277 55282
    • (2004) J. Biol. Chem. , vol.279 , pp. 55277-55282
    • Shimaya, A.1    Kovacina, K.S.2    Roth, R.A.3
  • 47
    • 84863602663 scopus 로고    scopus 로고
    • Simultaneous modulation of COX-2, p300, akt, and apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
    • J. Wang, X. Xiao, Y. Zhang, D. Shi, W. Chen, L. Fu, L. Liu, F. Xie, T. Kang, W. Huang, and W. Deng Simultaneous modulation of COX-2, p300, akt, and apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells J. Pineal Res. 53 2012 77 90
    • (2012) J. Pineal Res. , vol.53 , pp. 77-90
    • Wang, J.1    Xiao, X.2    Zhang, Y.3    Shi, D.4    Chen, W.5    Fu, L.6    Liu, L.7    Xie, F.8    Kang, T.9    Huang, W.10    Deng, W.11
  • 50
    • 78049286314 scopus 로고    scopus 로고
    • Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability
    • M. Skrzypczak, K. Goryca, T. Rubel, A. Paziewska, M. Mikula, D. Jarosz, J. Pachlewski, J. Oledzki, and J. Ostrowski Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability PLoS One 5 2010
    • (2010) PLoS One , vol.5
    • Skrzypczak, M.1    Goryca, K.2    Rubel, T.3    Paziewska, A.4    Mikula, M.5    Jarosz, D.6    Pachlewski, J.7    Oledzki, J.8    Ostrowski, J.9
  • 51
    • 0043244946 scopus 로고    scopus 로고
    • Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression
    • D.K. Vanaja, J.C. Cheville, S.J. Iturria, and C.Y. Young Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression Cancer Res. 63 2003 3877 3882
    • (2003) Cancer Res. , vol.63 , pp. 3877-3882
    • Vanaja, D.K.1    Cheville, J.C.2    Iturria, S.J.3    Young, C.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.