Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 16, Issue 2, 2015, Pages 249-253

  Yuan, Yi Ming ^a   Luo, Li ^a   Guo, Zhen ^b   Yang, Ming ^a   Ye, Ren Song ^c   Luo, Chuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b ENT Department Pixian TCM Hospital   (China)

^c SHANGHAI EIGHTH PEOPLE'S HOSPITAL   (China)

Author keywords

chronic obstructive pulmonary disease; PAH; RAAS; Smoking

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATHETERIZATION; CONTROLLED STUDY; DRUG ACTIVITY; LONG TERM EXPOSURE; LUNG ARTERY PRESSURE; LUNG PARENCHYMA; MALE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RADIOIMMUNOASSAY; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RIGHT VENTICULAR SYSTOLIC PRESSURE; SMOKING; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT; WESTERN BLOTTING; ANIMAL; BLOOD PRESSURE; DRUG EFFECTS; ENZYMOLOGY; HEART VENTRICLE; HYPERTENSION, PULMONARY; LUNG; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; SYSTOLE;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; HEART VENTRICLES; HYPERTENSION, PULMONARY; LOSARTAN; LUNG; MALE; PEPTIDYL-DIPEPTIDASE A; RATS, SPRAGUE-DAWLEY; RENIN-ANGIOTENSIN SYSTEM; SMOKING; SYSTOLE;

EID: 84930917146     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320315576256     Document Type: Article

References (20)

1. Rosanio S, Pelliccia F, Gaudio C, et al. Pulmonary arterial hypertension in adults: novel drugs and catheter ablation techniques show promise? Systematic review on pharmacotherapy and interventional strategies. Biomed Res Int. 2014 ; 2014: 743868
2. Wang J, Chen Y, Lin C, et al. Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2014 ; 306: C364 - C373
3. Xing AP, Hu XY, Shi YW, et al. Implication of PDGF signaling in cigarette smoke-induced pulmonary arterial hypertension in rat. Inhal Toxicol. 2012 ; 24: 468-475
4. Chung WK, Deng L, Carroll JS, et al. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. J Heart Lung Transplant. 2009 ; 28: 373-379
5. de Man FS, Tu L, Handoko ML, et al. Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 ; 186: 780-789
6. Li G, Liu Y, Zhu Y, et al. ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats. Lung ; 2013 ; 2013. 327.
7. Becker MO1, Kill A, Kutsche M, et al. Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis. Am J Respir Crit Care Med. 2014 ; 190: 808-817
8. Kanno S, Wu YJ, Lee PC, et al. Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. Circulation. 2001 ; 104: 945-950
9. Pernomian L, Pernomian L, Baraldi Araújo Restini C.. Counter-regulatory effects played by the ACE-Ang II-AT1 and ACE2-Ang-(1-7)-Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications. Vasa. 2014 ; 43: 404-414
10. Gaddam RR, Chambers S, Bhatia M.. ACE and ACE2 in inflammation: a tale of two enzymes. Inflamm Allergy Drug Targets. 2014 ; 13: 224-234
11. Ma C, Xin H, Jiang XY, et al. Relationship between renal injury and the antagonistic roles of angiotensin-converting enzyme (ACE) and ACE2. Genet Mol Res. 2014 ; 13: 2333-2342
12. Thorne D, Adamson J.. A review of in vitro cigarette smoke exposure systems. Exp Toxicol Pathol. 2013 ; 65: 1183-1193
13. Kode A, Yang SR, Rahman I.. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res. 2006 ; 7: 132
14. Selman M, Cisneros-Lira J, Gaxiola M, et al. Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs. Chest. 2003 ; 123: 1633-1641
15. Lee JH1, Lee DS, Kim EK, et al. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 ; 172: 987-993
16. Noronha-Dutra AA1, Epperlein MM, Woolf N. Effect of cigarette smoking on cultured human endothelial cells. Cardiovasc Res. 1993 ; 27: 774-778
17. Gu Q, Wang B, Zhang XF, et al. Contribution of renin-angiotensin system to exercise-induced attenuation of aortic remodeling and improvement of endothelial function in spontaneously hypertensive rats. Cardiovasc Pathol. 2014 ; 23: 298-305
18. Karram T, Abbasi A, Keidar S, et al. Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure. Am J Physiol Heart Circ Physiol. 2005 ; 289: H1351 - H1358
19. Lu L, Guo L, Xie TT, et al. Angiotensin converting enzyme is involved in the cardiac hypertrophy induced by sinoaortic denervation in rats. Cardiovasc Pathol. 2015 ; 24: 41-48
20. Wösten-van Asperen RM, Lutter R, Specht PA, et al. Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist. J Pathol. 2011 ; 225: 618-627