Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study

Cell Stress and Chaperones

Volumn 20, Issue 4, 2015, Pages 575-581

  Garamvölgyi, Zoltán ^a   Prohászka, Zoltán ^b,c   Rigó, János ^a   Kecskeméti, András ^a   Molvarec, Attila ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Gestational diabetes; Heat shock protein 70; Inflammation; Oxidative stress; Pregnancy

Indexed keywords

GLUCOSE; HEAT SHOCK PROTEIN 70; HEMOGLOBIN A1C; INSULIN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ANALYSIS; BLOOD; BODY MASS; GESTATIONAL AGE; GLUCOSE TOLERANCE TEST; METABOLISM; PATHOLOGY; PILOT STUDY; PREGNANCY; STATISTICAL MODEL;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES, GESTATIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATIONAL AGE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INSULIN; LINEAR MODELS; PILOT PROJECTS; PREGNANCY;

EID: 84930872330     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-015-0579-y     Document Type: Article

References (50)

1. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med: J Br Diabet Assoc 15:539–553
2. Asea A (2005) Stress proteins and initiation of immune response: chaperokine activity of hsp72. Exerc Immunol Rev 11:34–45
3. Asea A et al (2000) HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6:435–442
4. Asea A et al (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277:15028–15034
5. Ategbo JM et al (2006) Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J Clin Endocrinol metab 91:4137–4143
6. Basu S, Binder RJ, Ramalingam T, Srivastava PK (2001) CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 14:303–313
7. Ben-Haroush A, Yogev Y, Hod M (2004) Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes. Diabet Med: J Br Diabet Assoc 21:103–113
8. Bruce CR, Carey AL, Hawley JA, Febbraio MA (2003) Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 52:2338–2345
9. Calabrese V et al (2007) Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones 12:299–306
10. Calabrese V et al (2012) Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes. Biochim Biophys Acta 1822:729–736
11. Casey BM, Lucas MJ, McIntire DD, Leveno KJ (1997) Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol 90:869–873
12. Chung J et al (2008) HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A 105:1739–1744
13. Dahlgren J (2006) Pregnancy and insulin resistance. Metab Syndr Relat Disord 4:149–152
14. Dudley DJ (2007) Diabetic-associated stillbirth: incidence, pathophysiology, and prevention. Obstet Gynecol Clin N Am 34:293–307
15. Dybdahl B et al (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 105:685–690
16. Dybdahl B, Slordahl SA, Waage A, Kierulf P, Espevik T, Sundan A (2005) Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction. Heart 91:299–304
17. Fischer CP et al (2006) Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans. J Appl Physiol 100:1679–1687
18. Hightower LE (1991) Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 66:191–197
19. Hod M, Merlob P, Friedman S, Schoenfeld A, Ovadia J (1991) Gestational diabetes mellitus. A survey of perinatal complications in the 1980s. Diabetes 40(Suppl 2):74–78
20. Hunter-Lavin C, Davies EL, Bacelar MM, Marshall MJ, Andrew SM, Williams JH (2004a) Hsp70 release from peripheral blood mononuclear cells. Biochem Biophys Res Commun 324:511–517
21. Hunter-Lavin C et al (2004b) Folate supplementation reduces serum hsp70 levels in patients with type 2 diabetes. Cell Stress Chaperones 9:344–349
22. Jaffe S et al (2013) Induction of the 72 kDa heat shock protein by glucose ingestion in black pregnant women. Cell Stress Chaperones 18:527–530
23. Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD (2011) Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys American journal of physiology. Endocrinol Metab 300:E894–E901
24. Kim C, Newton KM, Knopp RH (2002) Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 25:1862–1868
25. Kimura F et al (2004) Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection. Am J Surg 187:777–784
26. Krause M et al (2014) Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic beta-cell dysfunction and death in vitro. Clin Sci 126:739–752
27. Kurucz I, Morva A, Vaag A, Eriksson KF, Huang X, Groop L, Koranyi L (2002) Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes 51:1102–1109
28. Lappas M, Hiden U, Desoye G, Froehlich J, Hauguel-de Mouzon S, Jawerbaum A (2011) The role of oxidative stress in the pathophysiology of gestational diabetes mellitus. Antioxid Redox Signal 15:3061–3100
29. McCarty MF (2006) Induction of heat shock proteins may combat insulin resistance. Med Hypotheses 66:527–534
30. Molvarec A, Prohaszka Z, Nagy B, Szalay J, Fust G, Karadi I, Rigo J Jr (2006) Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case–control study. J Hum Hypertens 20:780–786
31. Molvarec A et al (2007a) Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J Reprod Immunol 73:172–179
32. Molvarec A et al (2007b) Serum heat shock protein 70 levels are decreased in normal human pregnancy. J Reprod Immunol 74:163–169
33. Molvarec A et al (2009) Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia. Cell Stress Chaperones 14:151–159
34. Molvarec A, Szarka A, Walentin S, Beko G, Karadi I, Prohaszka Z, Rigo J Jr (2011) Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia. Clin Chim Acta; Int J Clin Chem 412:1957–1962
35. Morteza A, Nakhjavani M, Larry M, Nargesi AA, Esteghamati A (2013) Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study. Cell Stress Chaperones 18:815–819
36. Nakhjavani M, Morteza A, Khajeali L, Esteghamati A, Khalilzadeh O, Asgarani F, Outeiro TF (2010) Increased serum HSP70 levels are associated with the duration of diabetes. Cell Stress Chaperones 15:959–964
37. Nakhjavani M et al (2011) Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter? Cell Stress Chaperones 16:195–201
38. Nakhjavani M, Morteza A, Asgarani F, Khalilzadeh O, Ghazizadeh Z, Bathaie SZ, Esteghamati A (2012) The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes. Gene 498:107–111
39. Njemini R, Lambert M, Demanet C, Mets T (2003) Elevated serum heat-shock protein 70 levels in patients with acute infection: use of an optimized enzyme-linked immunosorbent assay. Scand J Immunol 58:664–669
40. Oglesbee MJ, Herdman AV, Passmore GG, Hoffman WH (2005) Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein. Clin Biochem 38:900–904
41. Pockley AG (2003) Heat shock proteins as regulators of the immune response. Lancet 362:469–476
42. Pockley AG, Shepherd J, Corton JM (1998) Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals. Immunol Investig 27:367–377
43. Rodrigues-Krause J et al (2012) Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? Cell Stress Chaperones 17:293–302
44. Saito FH, Damasceno DC, Dallaqua B, Linhares IM, Rudge MV, De Mattos Paranhos Calderon I, Witkin SS (2013) Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats. Cell Stress Chaperones 18:25–33
45. Shaat N, Groop L (2007) Genetics of gestational diabetes mellitus. Curr Med Chem 14:569–583
46. Simar D, Jacques A, Caillaud C (2012) Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects. Cell Stress Chaperones 17:615–621
47. Tamasi L et al (2010) Increased circulating heat shock protein 70 levels in pregnant asthmatics. Cell Stress Chaperones 15:295–300
48. Winkler G et al (2002) Tumor necrosis factor system in insulin resistance in gestational diabetes. Diabetes Res Clin Pract 56:93–99
49. Yabunaka N, Ohtsuka Y, Watanabe I, Noro H, Fujisawa H, Agishi Y (1995) Elevated levels of heat-shock protein 70 (HSP70) in the mononuclear cells of patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 30:143–147
50. Yogev Y, Xenakis EM, Langer O (2004) The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control. Am J Obstet Gynecol 191:1655–1660