Neural correlates of self-focused attention in social anxiety

Social Cognitive and Affective Neuroscience

Volumn 10, Issue 6, 2014, Pages 856-862

  Boehme, Stephanie ^a,b   Miltner, Wolfgang H R ^b   Straube, Thomas ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

fMRI; Insula; mPFC; Self focused attention; Social anxiety

Indexed keywords

ADOLESCENT; ADULT; ANXIETY; ASSOCIATION; ATTENTION; BRAIN; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHOBIA; PHYSIOLOGY; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; ANXIETY; ATTENTION; BRAIN; CUES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PHOBIC DISORDERS; YOUNG ADULT;

EID: 84930850092     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsu128     Document Type: Article

References (81)

1. Abraham, A., Kaufmann, C., Redlich, R., et al. (2013). Self-referential and anxiety-relevant information processing in subclinical social anxiety: an fMRI study. Brain Imaging and Behavior, 7, 35-48.
2. Alden, L.E., Teschuk, M., Tee, K. (1992). Public self-awareness and withdrawal from social interactions. Cognitive Therapy and Research, 16, 249-67.
3. Amir, N., Klumpp, H., Elias, J., et al. (2005). Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biological Psychiatry, 57, 975-81.
4. Amodio, D.M., Frith, C.D. (2006). Meeting of minds: the medial frontal cortex and social cognition. Nature Review Neuroscience, 7, 268-277.
5. Blair, K., Geraci, M., Devido, J., et al. (2008a). Neural response to self- and other referential praise and criticism in generalized social phobia. Archives of General Psychiatry, 65, 1176-84.
6. Blair, K., Shaywitz, J., Smith, B.W., et al. (2008b). Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. American Journal of Psychiatry, 165, 1193-202.
7. Blair, K.S., Geraci, M., Hollon, N., et al. (2010). Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions. American Journal of Psychiatry, 167, 1526-32.
8. Blair, K.S., Geraci, M., Otero, M., et al. (2011). Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobia. Psychiatry Research: Neuroimaging, 193, 38-45.
9. Blair, K.S., Geraci, M., Smith, B.W., et al. (2012). Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/ generalized anxiety disorder. Biological Psychiatry, 72, 476-82.
10. Blanke, O., Arzy, S. (2005). The out-of-body experience: disturbed self-processing at the temporo-parietal junction. Neuroscientist, 11, 16-24.
11. Boehme, S., Ritter, V., Tefikow, S., et al. (2013). Brain activation during anticipatory anxiety in social anxiety disorder. Social Cognitive and Affective Neuroscience, 9, 1413-18.
12. Bögels, S.M., Lamers, C.T.J. (2002). The causal role of self-awareness in blushing-anxious, socially-anxious and social phobics individuals. Behaviour Research and Therapy, 40, 1367-84.
13. Bögels, S.M., Mansell, W. (2004). Attention processes in the maintenance and treatment of social phobia: hypervigilance, avoidance and self-focused attention. Clinical Psychology Review, 24, 827-56.
14. Bögels, S.M., Alberts, M., de Jong, P.J. (1996). Self-consciousness, self-focused attention, blushing propensity and fear of blushing. Personality and Individual Differences, 21, 573-81.
15. Clark, D.M., McManus, F. (2002). Information processing in social phobia. Biological Psychiatry, 51, 92-100.
16. Clark, D.M., Wells, A. (1995). A cognitive model of social phobia. In: Heimberg, R.G., Liebowitz, M.R., Hope, D.A., Schneier, F.R., editors. Social Phobia: Diagnosis, Assessment, and Treatment. New York: Guilford Press, pp. 69-93.
17. Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155-59.
18. Craig, A.D. (2002). How do you feel? Interoception: the sense of the physiological condition of the body. Nature Review Neuroscience, 3, 655-66.
19. Craig, A.D. (2003). Interoception: the sense of the physiological condition of the body. Current Opinion in Neurobiology, 13, 500-5.
20. Craig, A.D. (2004). Human feelings: why are some more aware than others? Trends in Cognitive Sciences, 8, 239-41.
21. Craig, A.D. (2009). How do you feel_now? The anterior insula and human awareness. Nature Reviews Neuroscience, 10, 59-70.
22. Critchley, H., Daly, E., Phillips, M., et al. (2000). Explicit and implicit neural mechanisms for processing of social information from facial expressions: a functional magnetic resonance imaging study. Human Brain Mapp, 9, 93-105.
23. Critchley, H.D. (2004). The human cortex responds to an interoceptive challenge. Proceedings of the National Academy Science of the United States of America, 101, 6333-34.
24. Critchley, H.D., Wiens, S., Rotshtein, P., Ohman, A., Dolan, R.J. (2004). Neural systems supporting interoceptive awareness. Nature Neuroscience, 7, 189-95.
25. Damasio, A.R., Grabowski, T.J., Bechara, A., et al. (2000). Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience, 3, 1049-56.
26. Etkin, A., Wager, T.D. (2007). Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164, 1476-88.
27. Faul, F., Erdfelder, E., Lang, A.G., Buchner, A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39, 175-91.
28. Forman, S.D., Cohen, J.D., Fitzgerald, M., Eddy, W.F., Mintun, M.A., Noll, D.C. (1995). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine, 33, 636-47.
29. Frith, C.D., Frith, U. (1999). Interacting minds-a biological basis. Science, 286, 1692-95.
30. Frith, C.D., Frith, U. (2006). The neural basis of mentalizing. Neuron, 50, 531-34.
31. Funnell, E. (2001). Evidence for scripts in semantic dementia: implications for theories of semantic memory. Cognitive Neuropsychology, 18, 323-41.
32. Gentili, C., Gobbini, M.I., Ricciardi, E., et al. (2008). Differential modulation of neural activity throughout the distributed neural system for face perception in patients with Social Phobia and healthy subjects. Brain Res Bull, 77, 286-92.
33. Goebel, R., Esposito, F., Formisano, E. (2006). Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: from single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Human Brain Mapping, 27, 392-401.
34. Goldin, P.R., Gross, J.J. (2010). Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. Emotion, 10, 83-91.
35. Goldin, P.R., Manber, T., Hakimi, S., Canli, T., Gross, J.J. (2009). Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Archives of General Psychiatry, 66, 170-80.
36. Hackmann, A., Surawy, C., Clark, D.M. (1998). Seeing yourself through other's eyes: a study of spontaneously occurring images in social phobia. Behavioural and Cognitive Psychotherapy, 26, 3-12.
37. Hinrichsen, H., Clark, D.M. (2003). Anticipatory processing in social anxiety: two pilot studies. Journal of Behavior Therapy and Experimental Psychiatry, 34, 205-18.
38. Ingram, R.E. (1990). Self-Focused Attention in Clinical Disorders: Review and a Conceptual Model. Washington, DC: ETATS-UNIS, American Psychological Association.
39. Johnson, S.C., Baxter, L.C., Wilder, L.S., Pipe, J.G., Heiserman, J.E., Prigatano, G.P. (2002). Neural correlates of self-reflection. Brain, 125, 1808-14.
40. Kelley, W.M., Macrae, C.N., Wyland, C.L., Caglar, S., Inati, S., Heatherton, T.F. (2002). Finding the self? an event-related fMRI study. Journal of Cognitive Neuroscience, 14, 785-94.
41. Klumpp, H., Angstadt, M., Phan, K.L. (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89, 273-276.
42. Labuschagne, I., Phan, K.L., Wood, A., et al. (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. The International Journal of Neuropsychopharmacology, 15, 883-96.
43. Lancaster, J.L., Tordesillas-Gutiérrez, D., Martinez, M., et al. (2007). Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Human Brain Mapping, 28, 1194-205.
44. LeDoux, J. (1998). Fear and the brain: where have we been, and where are we going? Biological Psychiatry, 44, 1229-38.
45. Lorberbaum, J.P., Kose, S., Johnson, M.R., et al. (2004). Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport, 15, 2701-5.
46. Maldjian, J.A., Laurienti, P.J., Burdette, J.H. (2004). Precentral gyrus discrepancy in electronic versions of the Talairach atlas. Neuroimage, 21, 450-55.
47. Maldjian, J.A., Laurienti, P.J., Kraft, R.A., Burdette, J.H. (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage, 19, 1233-39.
48. Mansell, W., Clark, D.M. (1999). How do i appear to others? social anxiety and processing of the observable self. Behaviour Research and Therapy, 37, 419-34.
49. Mansell, W., Clark, D.M., Ehlers, A. (2003). Internal versus external attention in social anxiety: an investigation using a novel paradigm. Behaviour Research and Therapy, 41, 555-72.
50. Mellings, T.M., Alden, L.E. (2000). Cognitive processes in social anxiety: the effects of selffocus, rumination and anticipatory processing. Behaviour Research and Therapy, 38, 243-57.
51. Mitchell, J.P., Banaji, M.R., Macrae, C.N. (2005). The link between social cognition and self-referential thought in the medial prefrontal cortex. Journal of Cognitive Neuroscience, 17, 1306-15.
52. Moriguchi, Y., Ohnishi, T., Mori, T., Matsuda, H., Komaki, G.E.N. (2007). Changes of brain activity in the neural substrates for theory of mind during childhood and adolescence. Psychiatry and Clinical Neurosciences, 61, 355-63.
53. Northoff, G., Bermpohl, F. (2004). Cortical midline structures and the self. Trends in Cognitive Sciences, 8, 102-7.
54. Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J. (2006). Self-referential processing in our brain_a meta-analysis of imaging studies on the self. Neuroimage, 31, 440-57.
55. Öhman, A., Mineka, S. (2001). Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychological Review, 108, 483-522.
56. Olson, I.R., Plotzker, A., Ezzyat, Y. (2007). The enigmatic temporal pole: a review of findings on social and emotional processing. Brain, 130, 1718-31.
57. Paulus, M.P., Stein, M.B. (2006). An insular view of anxiety. Biological Psychiatry, 60, 383-87.
58. Phan, K.L., Coccaro, E.F., Angstadt, M., et al. (2013). Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia. Biological Psychiatry, 73, 329-36.
59. Phan, K.L., Fitzgerald, D.A., Cortese, B.M., Seraji-Bozorgzad, N., Tancer, M.E., Moore, G.J. (2005). Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 Tesla. Neuroreport, 16, 183-86.
60. Pujol, J., Giménez, M., Ortiz, H., et al. (2013). Neural response to the observable self in social anxiety disorder. Psychological Medicine, 43, 721-31.
61. Qin, P., Northoff, G. (2011). How is our self related to midline regions and the defaultmode network? Neuroimage, 57, 1221-33.
62. Quadflieg, S., Mohr, A., Mentzel, H., Miltner, W., Straube, T. (2008). Modulation of the neural network involved in the processing of anger prosody: the role of task-relevance and social phobia. Biological Psychology, 78, 129-37.
63. Rapee, R.M., Heimberg, R.G. (1997). A cognitive-behavioral model of anxiety in social phobia. Behaviour Research and Therapy, 35, 741-56.
64. Schmidt, S., Mohr, A., Miltner, W.H.R., Straube, T. (2010). Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. Biological Psychology, 84, 304-12.
65. Schulz, C., Mothes-Lasch, M., Straube, T. (2013). Automatic neural processing of disorder-related stimuli in social anxiety disorder (SAD): faces and more. Frontiers in Psychology, 4, 1-16.
66. Stangier, U., Heidenreich, T. (2005). Liebowitz social anxiety scale. In: Scalarum, C.I.P., editor. Internationale Skalen für Psychiatrie (Internatioal Scales for Psychiatry). Weinheim: Beltz, pp. 299-306.
67. Stangier, U., Clark, D.M., Ehlers, E. (2006). Soziale Phobie. Göttingen: Hogrefe.
68. Stein, M., Goldin, P., Sareen, J., Zorrilla, L., Brown, G. (2002). Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry, 59, 1027-34.
69. Stein, M.B., Torgrud, L.J., Walker, J.R. (2000). Social phobia symptoms, subtypes, and severity: findings from a community survey. Archives of General Psychiatry, 57, 1046-52.
70. Straube, T., Kolassa, I.T., Glauer, M., Mentzel, H., Miltner, W. (2004). Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biological Psychiatry, 56, 921-30.
71. Straube, T., Mentzel, H., Miltner, W. (2005). Common and distinct brain activation to threat and safety signals in social phobia. Neuropsychobiology, 52, 163-68.
72. Talairach, J., Tournoux, P. (1988). Co-Planar Stereotaxic Atlas of the Human Brain. 3-Dimensional Proportional System: An Approach to Cerebral Imaging, Stutgart: Thieme.
73. Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., et al. (2002). Automated anatomical labeling of activations in spm using a macroscopic anatomical parcellation of the mni mri single-subject brain. Neuroimage, 15, 273-89.
74. van der Meer, L., Costafreda, S., Aleman, A., David, A.S. (2010). Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neuroscience & Biobehavioral Reviews, 34, 935-46.
75. Van Overwalle, F. (2009). Social cognition and the brain: a meta-analysis. Human Brain Mapping, 30, 829-58.
76. Wells, A., Papageorgiou, C. (1998). Social phobia: effects of external attention on anxiety, negative beliefs, and perspective taking. Behavior Therapy, 29, 357-70.
77. Wong, Q.J., Moulds, M.L. (2011). Impact of anticipatory processing versus distraction on multiple indices of anxiety in socially anxious individuals. Behaviour Research and Therapy, 49, 700-6.
78. Woody, S.R. (1996). Effects of focus of attention on anxiety levels and social performance of individuals with social phobia. Journal of Abnormal Psychology, 105, 61-9.
79. Woody, S.R., Rodriguez, B.F. (2000). Self-focused attention and social anxiety in social phobics and normal controls. Cognitive Therapy and Research, 24, 473-88.
80. Yoon, K.L., Fitzgerald, D.A., Angstadt, M., McCarron, R.A., Phan, K.L. (2007). Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Research, 154, 93-98.
81. Ziv, M., Goldin, P., Jazaieri, H., Hahn, K., Gross, J. (2013). Is there less to social anxiety than meets the eye? Behavioral and neural responses to three socio-emotional tasks. Biology of Mood & Anxiety Disorders, 3, 5.