C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 10, 2015, Pages E891-E898

  Yuan, Yuexing ^a,c   Lau, Wayne Bond ^a   Su, Hui ^b   Sun, Yang ^b   Yi, Wei ^b   Du, Yunhui ^a   Christopher, Theodore ^b   Lopez, Bernard ^b   Wang, Yajing ^a   Ma, Xin Liang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Adiponectin; Cardiokine; CTRP9; Diabetes; Proteolysis

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q TUMOR NECROSIS FACTOR RELATED PROTEIN 9; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLOBULAR PROTEIN; ISOPROTEIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ADIPONECTIN; ADIPOQ PROTEIN, MOUSE; CARDIOTONIC AGENT; CTRP9 PROTEIN, MOUSE; GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HEART INJURY; INCUBATION TIME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROCESSING; 3T3 CELL LINE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DIABETIC CARDIOMYOPATHIES; ENZYME ACTIVE SITE; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; LIPID DIET; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN DEGRADATION; PROTEIN FOLDING;

3T3-L1 CELLS; ADIPONECTIN; ANIMALS; CARDIOTONIC AGENTS; CATALYTIC DOMAIN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DIET, HIGH-FAT; GLYCOPROTEINS; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEOLYSIS;

EID: 84930845466     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00450.2014     Document Type: Article

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