-
1
-
-
33646198040
-
B cell immunobiology in disease: Evolving concepts from the clinic
-
Martin F, Chan AC. B cell immunobiology in disease: Evolving concepts from the clinic. Annu Rev Immunol. 2006 ; 24: 467-496
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 467-496
-
-
Martin, F.1
Chan, A.C.2
-
2
-
-
0025946132
-
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis
-
Taniguchi T, Kobayashi T, Kondo J, et al. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem. 1991 ; 266: 15790-15796
-
(1991)
J Biol Chem
, vol.266
, pp. 15790-15796
-
-
Taniguchi, T.1
Kobayashi, T.2
Kondo, J.3
-
3
-
-
1542269021
-
Tyrosine kinase inhibitors: A new approach for asthma
-
Wong WS, Leong KP. Tyrosine kinase inhibitors: A new approach for asthma. Biochim Biophys Acta. 2004 ; 1697: 53-69
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 53-69
-
-
Wong, W.S.1
Leong, K.P.2
-
4
-
-
0030457522
-
Downstream signals initiated in mast cells by Fc epsilon RI and other receptors
-
Beaven MA, Baumgartner RA. Downstream signals initiated in mast cells by Fc epsilon RI and other receptors. Curr Opin Immunol. 1996 ; 8: 766-772
-
(1996)
Curr Opin Immunol
, vol.8
, pp. 766-772
-
-
Beaven, M.A.1
Baumgartner, R.A.2
-
5
-
-
16244397342
-
An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment
-
Meltzer EO, Berkowitz RB, Grossbard EB. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J Allergy Clin Immunol. 2005 ; 115: 791-796
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 791-796
-
-
Meltzer, E.O.1
Berkowitz, R.B.2
Grossbard, E.B.3
-
6
-
-
62249125407
-
Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases
-
Bajpai M. Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases. IDrugs. 2009 ; 12: 174-185
-
(2009)
IDrugs
, vol.12
, pp. 174-185
-
-
Bajpai, M.1
-
7
-
-
65349104905
-
Of mice and men: An open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk
-
Podolanczuk A, Lazarus AH, Crow AR, Grossbard E, Bussel JB. Of mice and men: An open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk. Blood. 2009 ; 113: 3154-3160
-
(2009)
Blood
, vol.113
, pp. 3154-3160
-
-
Podolanczuk, A.1
Lazarus, A.H.2
Crow, A.R.3
Grossbard, E.4
Bussel, J.B.5
-
8
-
-
55849114400
-
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
-
Weinblatt ME, Kavanaugh A, Burgos-Vargas R, et al. Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial. Arthritis Rheum. 2008 ; 58: 3309-3318
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3309-3318
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Burgos-Vargas, R.3
-
9
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med. 2010 ; 363: 1303-1312
-
(2010)
N Engl J Med
, vol.363
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
10
-
-
43949092440
-
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
-
Bahjat FR, Pine PR, Reitsma A, et al. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum. 2008 ; 58: 1433-1444
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1433-1444
-
-
Bahjat, F.R.1
Pine, P.R.2
Reitsma, A.3
-
11
-
-
77954229590
-
Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
-
Deng GM, Liu L, Bahjat FR, Pine PR, Tsokos GC. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010 ; 62: 2086-2092
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2086-2092
-
-
Deng, G.M.1
Liu, L.2
Bahjat, F.R.3
Pine, P.R.4
Tsokos, G.C.5
-
12
-
-
70350356241
-
Autoinhibition and adapter function of Syk
-
Kulathu Y, Grothe G, Reth M. Autoinhibition and adapter function of Syk. Immunol Rev. 2009 ; 232: 286-299
-
(2009)
Immunol Rev
, vol.232
, pp. 286-299
-
-
Kulathu, Y.1
Grothe, G.2
Reth, M.3
-
13
-
-
33645956556
-
Toll-like receptor stimulation as a third signal required for activation of human naïve B cells
-
Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naïve B cells. Eur J Immunol. 2006 ; 36: 810-816
-
(2006)
Eur J Immunol
, vol.36
, pp. 810-816
-
-
Ruprecht, C.R.1
Lanzavecchia, A.2
-
14
-
-
0029913381
-
Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
-
Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest. 1996 ; 97: 2063-2073
-
(1996)
J Clin Invest
, vol.97
, pp. 2063-2073
-
-
Desai-Mehta, A.1
Lu, L.2
Ramsey-Goldman, R.3
Datta, S.K.4
-
15
-
-
33645076274
-
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
-
Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med. 2006 ; 203: 553-561
-
(2006)
J Exp Med
, vol.203
, pp. 553-561
-
-
Ehlers, M.1
Fukuyama, H.2
McGaha, T.L.3
Aderem, A.4
Ravetch, J.V.5
-
16
-
-
0036093704
-
A role for Toll in autoimmunity
-
Krieg AM. A role for Toll in autoimmunity. Nat Immunol. 2002 ; 3: 423-424
-
(2002)
Nat Immunol
, vol.3
, pp. 423-424
-
-
Krieg, A.M.1
-
17
-
-
44749092679
-
A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling
-
Rowland SL, Tremblay MM, Ellison JM, Stunz LL, Bishop GA, Hostager BS. A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling. J Immunol. 2007 ; 179: 4645-4653
-
(2007)
J Immunol
, vol.179
, pp. 4645-4653
-
-
Rowland, S.L.1
Tremblay, M.M.2
Ellison, J.M.3
Stunz, L.L.4
Bishop, G.A.5
Hostager, B.S.6
-
18
-
-
0034650867
-
Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions
-
Jalukar SV, Hostager BS, Bishop GA. Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions. J Immunol. 2000 ; 164: 623-630
-
(2000)
J Immunol
, vol.164
, pp. 623-630
-
-
Jalukar, S.V.1
Hostager, B.S.2
Bishop, G.A.3
-
19
-
-
84861659948
-
Amplification of toll-like receptor-mediated signaling through Syk in human B cell activation
-
Iwata S, Yamaoka K, Niiro H, et al. Amplification of toll-like receptor-mediated signaling through Syk in human B cell activation. J Allergy Clin Immunol. 2012 ; 129: 1594-1601
-
(2012)
J Allergy Clin Immunol
, vol.129
, pp. 1594-1601
-
-
Iwata, S.1
Yamaoka, K.2
Niiro, H.3
-
20
-
-
0031229830
-
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
-
Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997 ; 40: 1725-1725
-
(1997)
Arthritis Rheum
, vol.40
, pp. 1725
-
-
Hochberg, M.C.1
-
21
-
-
0027325557
-
The BILAG index: A reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus
-
Hay EM, Bacon PA, Gordon C, et al. The BILAG index: A reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus. Q J Med. 1993 ; 86: 447-458
-
(1993)
Q J Med
, vol.86
, pp. 447-458
-
-
Hay, E.M.1
Bacon, P.A.2
Gordon, C.3
-
22
-
-
0026768566
-
Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. III. Development of a computerised clinical chart and its application to the comparison of different indices of disease activity. The European Consensus Study Group for Disease Activity in SLE
-
Bencivelli W, Vitali C, Isenberg DA, et al. Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. III. Development of a computerised clinical chart and its application to the comparison of different indices of disease activity. The European Consensus Study Group for Disease Activity in SLE. Clin Exp Rheumatol. 1992 ; 10: 549-554
-
(1992)
Clin Exp Rheumatol
, vol.10
, pp. 549-554
-
-
Bencivelli, W.1
Vitali, C.2
Isenberg, D.A.3
-
23
-
-
0029829026
-
B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events
-
Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest. 1996 ; 98: 2549-2557
-
(1996)
J Clin Invest
, vol.98
, pp. 2549-2557
-
-
Liossis, S.N.1
Kovacs, B.2
Dennis, G.3
Kammer, G.M.4
Tsokos, G.C.5
-
24
-
-
37849047224
-
A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE
-
Nicholas MW, Dooley MA, Hogan SL, et al. A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. Clin Immunol. 2008 ; 126: 189-201
-
(2008)
Clin Immunol
, vol.126
, pp. 189-201
-
-
Nicholas, M.W.1
Dooley, M.A.2
Hogan, S.L.3
-
25
-
-
0033564251
-
CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
-
Fujimoto M, Poe JC, Jansen PJ, Sato S, Tedder TF. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. J Immunol. 1999 ; 162: 7088-7094
-
(1999)
J Immunol
, vol.162
, pp. 7088-7094
-
-
Fujimoto, M.1
Poe, J.C.2
Jansen, P.J.3
Sato, S.4
Tedder, T.F.5
-
26
-
-
5044223172
-
The multifaceted roles of TRAFs in the regulation of B cell function
-
Bishop GA. The multifaceted roles of TRAFs in the regulation of B cell function. Nat Rev Immunol. 2004 ; 4: 775-786
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 775-786
-
-
Bishop, G.A.1
-
27
-
-
62749177521
-
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses
-
Kobayashi T, Kim TS, Jacob A, et al. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS One. 2009 ; 4: e4736 - e4736
-
(2009)
PLoS One
, vol.4
-
-
Kobayashi, T.1
Kim, T.S.2
Jacob, A.3
-
28
-
-
84861829947
-
Evaluation of TRAF6 in a large multi-ancestral lupus cohort
-
Namjou B, Choi CB, Harley IT, et al. Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis Rheum. 2012 ; 64: 1960-1969
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1960-1969
-
-
Namjou, B.1
Choi, C.B.2
Harley, I.T.3
-
29
-
-
45349091226
-
Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
-
Jacobi AM, Reiter K, Mackay M, et al. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum. 2008 ; 58: 1762-1773
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1762-1773
-
-
Jacobi, A.M.1
Reiter, K.2
Mackay, M.3
-
30
-
-
79953314262
-
Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in long-term remission after B cell depletion therapy with rituximab
-
Iwata S, Saito K, Tokunaga M, et al. Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in long-term remission after B cell depletion therapy with rituximab. J Rheumatol. 2011 ; 38: 633-641
-
(2011)
J Rheumatol
, vol.38
, pp. 633-641
-
-
Iwata, S.1
Saito, K.2
Tokunaga, M.3
-
31
-
-
84866114867
-
B-cell or T-cell-dominant recurrence after rituximab therapy in patients with SLE
-
Iwata S, Saito K, Tokunaga M, Tanaka Y. B-cell or T-cell-dominant recurrence after rituximab therapy in patients with SLE. Ann Rheum Dis. 2012 ; 71: 1749-1750
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1749-1750
-
-
Iwata, S.1
Saito, K.2
Tokunaga, M.3
Tanaka, Y.4
-
32
-
-
0038142387
-
A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
-
Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood. 2003 ; 101: 4500-4504
-
(2003)
Blood
, vol.101
, pp. 4500-4504
-
-
Bernasconi, N.L.1
Onai, N.2
Lanzavecchia, A.3
|