Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection

Neuropsychopharmacology

Volumn 40, Issue 8, 2015, Pages 1877-1887

  Ip, Fanny Cf ^a,b   Fu, Wing Yu ^a   Cheng, Elaine Yl ^a   Tong, Estella Ps ^a   Lok, Ka Chun ^a   Liang, Yan ^a   Ye, Wen Cai ^b   Ip, Nancy Y ^a,b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; ANEMOSIDE A3; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR A1; HERBACEOUS AGENT; MONOAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; NEUROTRANSMITTER; NEUROTROPHIN; SERINE; UNCLASSIFIED DRUG; N METHYLASPARTIC ACID; SAPONIN; TRITERPENE;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; COGNITION; CONTROLLED STUDY; HIPPOCAMPUS; LONG TERM POTENTIATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULSATILLA; PULSATILLA CHINENSIS; RAT; REFERENCE MEMORY; SIGNAL TRANSDUCTION; SPATIAL MEMORY; SYNAPSE; ANIMAL; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; ESCAPE BEHAVIOR; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPLORATORY BEHAVIOR; IN VITRO STUDY; INFARCTION, MIDDLE CEREBRAL ARTERY; INSTITUTE FOR CANCER RESEARCH MOUSE; MAZE TEST; METABOLISM; MOUSE; NERVE CELL NETWORK; PATHOLOGY; PREFRONTAL CORTEX; SPATIAL ORIENTATION; SPRAGUE DAWLEY RAT;

ANIMALS; COGNITION; DISEASE MODELS, ANIMAL; ESCAPE REACTION; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; IN VITRO TECHNIQUES; INFARCTION, MIDDLE CEREBRAL ARTERY; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; N-METHYLASPARTATE; NERVE NET; NEUROPROTECTIVE AGENTS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SPATIAL NAVIGATION; SYNAPSES; TRITERPENES;

EID: 84930818252     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.37     Document Type: Article

References (39)

1. Anggono V, Huganir RL (2012). Regulation of AMPA receptor trafficking and synaptic plasticity. Curr Opin Neurobiol 22: 461-469.
2. Cahill L, Prins B, Weber M, McGaugh JL (1994). Beta-adrenergic activation and memory for emotional events. Nature 371: 702-704.
3. Chang PK, Verbich D, McKinney RA (2012). AMPA receptors as drug targets in neurological disease-advantages, caveats, and future outlook. Eur J Neurosci 35: 1908-1916.
4. Cheng L, Zhang M, Zhang P, Song Z, Ma Z, Qu H (2008). Silver complexation and tandem mass spectrometry for differentiation of triterpenoid saponins from the roots of Pulsatilla chinensis (Bunge) Regel. Rapid Commun Mass Spectrom 22: 3783-3790.
5. Derkach VA, Oh MC, Guire ES, Soderling TR (2007). Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci 8: 101-113.
6. Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R (2003). PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 6: 136-143.
7. Gao XD, Ye WC, Yu AC, Zhang Y, Tan RX, Li M et al (2003). Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med 69: 171-174.
8. Geyer MA, Vollenweider FX (2008). Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci 29: 445-453.
9. Greer PL, Greenberg ME (2008). From synapse to nucleus: calciumdependent gene transcription in the control of synapse development and function. Neuron 59: 846-860.
10. Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL et al (2007). Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell 131: 160-173.
11. Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C et al (2011). Serotonin mediates cross-modal reorganization of cortical circuits. Neuron 69: 780-792.
12. Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S (2004). Glutamate receptors: RNA editing and death of motor neurons. Nature 427: 801.
13. Kumar J, Mayer ML (2013). Functional insights from glutamate receptor ion channel structures. Annu Rev Physiol 75: 313-337.
14. Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000). Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405: 955-959.
15. Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G et al (2003). Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112: 631-643.
16. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M et al (2010). mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329: 959-964.
17. Lukoyanov NV, Paula-Barbosa MM (2000). A single high dose of dizocilpine produces long-lasting impairment of the water maze performance in adult rats. Neurosci Lett 285: 139-142.
18. Lynch G (2006). Glutamate-based therapeutic approaches: ampakines. Curr Opin Pharmacol 6: 82-88.
19. Mammen AL, Kameyama K, Roche KW, Huganir RL (1997). Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem 272: 32528-32533.
20. Manahan-Vaughan D, von Haebler D, Winter C, Juckel G, Heinemann U (2008). A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats. Hippocampus 18: 125-134.
21. Minichiello L (2009). TrkB signalling pathways in LTP and learning. Nat Rev Neurosci 10: 850-860.
22. Muller WE, Mutschler E, Riederer P (1995). Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia. Pharmacopsychiatry 28: 113-124.
23. Normann C, Clark K (2005). Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus. Brain Res 1037: 187-193.
24. Palop JJ, Mucke L (2010). Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13: 812-818.
25. Paoletti P, Bellone C, Zhou Q (2013). NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 14: 383-400.
26. Parsons CG, Stoffler A, Danysz W (2007). Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse. Neuropharmacology 53: 699-723.
27. Rebola N, Srikumar BN, Mulle C (2010). Activity-dependent synaptic plasticity of NMDA receptors. J Physiol 588: 93-99.
28. Riedel G, Platt B, Micheau J (2003). Glutamate receptor function in learning and memory. Behav Brain Res 140: 1-47.
29. Sheng M, Sabatini BL, Sudhof TC (2012). Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol 4: a005777.
30. Shepherd JD, Huganir RL (2007). The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu Rev Cell Dev Biol 23: 613-643.
31. Talantova M, Sanz-Blasco S, Zhang X, Xia P, AkhtarMW, Okamoto S et al (2013). Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci USA 110: E2518-E2527.
32. Tully T, Bourtchouladze R, Scott R, Tallman J (2003). Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov 2: 267-277.
33. Waltereit R, Weller M (2003). Signaling from cAMP/PKA to MAPK and synaptic plasticity. Mol Neurobiol 27: 99-106.
34. Waxman EA, Lynch DR (2005). N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 11: 37-49.
35. Yamada KA (2000). Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease. Expert Opin Investig Drugs 9: 765-778.
36. Ye WC, Ji NN, Zhao SX, Liu JH, Ye T, McKervey MA et al (1996). Triterpenoids from Pulsatilla chinensis. Phytochemistry 42: 799-802.
37. Yokoi N, Fukata M, Fukata Y (2012). Synaptic plasticity regulated by protein-protein interactions and posttranslational modifications. Int Rev Cell Mol Biol 297: 1-43.
38. Zhang DM, Lin SM, Lau CW, Yiu A, Wang J, Li Y et al (2010). Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med 76: 1814-1819.
39. Zheng Y, Zhou F, Wu X, Wen X, Li Y, Yan B et al (2010). 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo. J Ethnopharmacol 128: 615-622.