Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions

Protein Engineering, Design and Selection

Volumn 27, Issue 10, 2014, Pages 419-429

  Diem, Michael D ^a   Hyun, Linus ^a   Yi, Fang ^a   Hippensteel, Randi ^a   Kuhar, Elise ^a   Lowenstein, Cassandra ^a   Swift, Edward J ^a   O'Neil, Karyn T ^a   Jacobs, Steven A ^a   Marx, James ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b NONE

Author keywords

Consensus; FN3; Library; Scaffold

Indexed keywords

LIBRARIES; MOLECULES; SCAFFOLDS; SCAFFOLDS (BIOLOGY);

AFFINITY MATURATION; BINDING INTERFACE; BINDING PROTEINS; CONSENSUS; PROTEIN DESIGN; PROTEIN-PROTEIN INTERACTIONS; TARGET BINDING; THERAPEUTIC PROTEIN;

PROTEINS;

BINDING PROTEIN; CENTYRIN FN3; INTERLEUKIN 17; SCATTER FACTOR RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PROTEIN BINDING;

BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MUTAGENESIS; NONHUMAN; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; GENE LIBRARY; MOLECULAR GENETICS; MOUSE; PROCEDURES; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; GENE LIBRARY; INTERLEUKIN-17; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE ALIGNMENT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930811671     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu016     Document Type: Conference Paper

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