Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 6, 2015, Pages E852-E860

  Jiang, Chao ^a   Hou, Xiaoying ^a,b   Wang, Cheng ^a   May, Jeffrey V ^c   Butnev, Viktor Y ^c   Bousfield, George R ^c   Davis, John S ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^c WICHITA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTRADIOL; FULLY GLYCOSYLATED RECOMBINANT HUMAN FOLLITROPIN; HYPOGLYCOSYLATED RECOMBINANT HUMAN FOLLITROPIN; PROGESTERONE; RECOMBINANT FOLLITROPIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG; FOLLITROPIN; ISOPROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ESTROGEN SYNTHESIS; GENETIC TRANSCRIPTION; GLYCOSYLATION; GRANULOSA CELL; HUMAN; HUMAN CELL; HYPOPHYSIS CELL; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEROIDOGENESIS; CARBOHYDRATE ANALYSIS; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; ENZYME ACTIVATION; FEMALE; METABOLISM; PHOSPHORYLATION;

CARBOHYDRATE SEQUENCE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; GLYCOSYLATION; GRANULOSA CELLS; HUMANS; PHOSPHORYLATION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS;

EID: 84930798528     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1317     Document Type: Article

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