L-Tryptophan activates mammalian target of rapamycin and enhances expression of tight junction proteins in intestinal porcine epithelial cells

Journal of Nutrition

Volumn 145, Issue 6, 2015, Pages 1156-1162

  Wang, Hao ^a   Ji, Yun ^a   Wu, Guoyao ^a,b   Sun, Kaiji ^a   Sun, Yuli ^a   Li, Wei ^a   Wang, Bin ^a   He, Beibei ^a   Zhang, Qing ^a   Dai, Zhaolai ^a   Wu, Zhenlong ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cell proliferation; Intestinal epithelial cells; Mammalian target of rapamycin; Pig; Tight junction; Tryptophan

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA 1; CARRIER PROTEINS AND BINDING PROTEINS; CLAUDIN 1; CLAUDIN 4; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MESSENGER RNA; OCCLUDIN; PROTEIN ZO1; PROTEIN ZO2; SOLUTE CARRIER FAMILY 3 MEMBER 1; SOLUTE CARRIER FAMILY 6 MEMBER 14; SOLUTE CARRIER FAMILY 6 MEMBER 19; TIGHT JUNCTION PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ACTIVE TRANSPORT; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; EXPERIMENTAL PIG; INTESTINE EPITHELIUM CELL; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; TURNOVER TIME; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; INTESTINE; INTESTINE CELL; METABOLISM; PIG; SIGNAL TRANSDUCTION; SMALL INTESTINE; TIGHT JUNCTION; UPREGULATION;

ANIMALIA; MAMMALIA; SUIDAE; SUS;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CLAUDIN-1; CLAUDIN-4; ENTEROCYTES; INTESTINE, SMALL; INTESTINES; MULTIPROTEIN COMPLEXES; OCCLUDIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SWINE; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS; TOR SERINE-THREONINE KINASES; TRYPTOPHAN; UP-REGULATION;

EID: 84930793529     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.209817     Document Type: Article

References (44)

1. Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids 2009;37:1-17.
2. Moehn S, Pencharz PB, Ball RO. Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studies. J Nutr 2012;142:2231S-5S.
3. Fernstrom JD. Large neutral amino acids: dietary effects on brain neurochemistry and function. Amino Acids 2013;45:419-30.
4. Fernstrom JD. Effects and side effects associated with the nonnutritional use of tryptophan by humans. J Nutr 2012;142:2236S-44S.
5. Peters JC. Tryptophan nutrition and metabolism: an overview. Adv Exp Med Biol 1991;294:345-58.
6. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397-414.
7. Lesurtel M, Soll C, Graf R, Clavien PA. Role of serotonin in the hepatogastroIntestinal tract: an old molecule for new perspectives. Cell Mol Life Sci 2008;65:940-52.
8. Bender DA. Biochemistry of tryptophan in health and disease. Mol Aspects Med 1983;6:101-97.
9. Mawe GM, Coates MD, Moses PL. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther 2006;23:1067-76.
10. Wu G, Bazer FW, Cross HR. Land-based production of animal protein:impacts, efficiency, and sustainability. Ann N Y Acad Sci 2014;1328:18-28.
11. Suryawan A, Nguyen HV, Almonaci RD, Davis TA. Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway. J Anim Sci Biotechnol 2012;3:DOI: 10.1186/2049-1891-3-3.
12. Wu G, Bazer FW, Dai Z, Li D, Wang J, Wu Z. Amino acid nutrition in animals: protein synthesis and beyond. Annu Rev Anim Biosci 2014;2:387-417.
13. Cortamira NO, Seve B, Lebreton Y, Ganier P. Effect of dietary tryptophan on muscle, liver and whole-body protein synthesis in weaned piglets: relationship to plasma insulin. Br J Nutr 1991;66:423-35.
14. Dai ZL, Wu G, Zhu WY. Amino acid metabolism in intestinal bacteria:links between gut ecology and host health. Front Biosci (Landmark Ed) 2011;16:1768-86.
15. Koopmans SJ, Guzik AC, van derMeulen J, Dekker R, Kogut J, Kerr BJ, Southern LL. Effects of supplemental L-tryptophan on serotonin, cortisol, intestinal integrity, and behavior in weanling piglets. J Anim Sci 2006;84:963-71.
16. Le Floc'h N, Gondret F, Matte JJ, Quesnel H. Towards amino acid recommendations for specific physiological and patho-physiological states in pigs. Proc Nutr Soc 2012;71:425-32.
17. Chen L, Li P, Wang J, Li X, Gao H, Yin Y, Hou Y, Wu G. Catabolism of nutritionally essential amino acids in developing porcine enterocytes. Amino Acids 2009;37:143-52.
18. Wang W, Wu Z, Lin G, Hu S, Wang B, Dai Z, Wu G. Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cells. J Nutr 2014;144:1540-8.
19. Haynes TE, Li P, Li X, Shimotori K, Sato H, Flynn NE, Wang J, Knabe DA, Wu G. L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Amino Acids 2009;37:131-42.
20. Bröer S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev 2008;88:249-86.
21. Buddington RK, Elnif J, Puchal-Gardiner AA, Sangild PT. Intestinal apical amino acid absorption during development of the pig. Am J Physiol Regul Integr Comp Physiol 2001;280:R241-7.
22. Steffansen B, Nielsen CU, Brodin B, Eriksson AH, Andersen R, Frokjaer S. Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption. Eur J Pharm Sci 2004;21:3-16.
23. Wu G. Amino acids: biochemistry and nutrition. Boca Raton (FL): CRC Press; 2013.
24. Dai ZL, Zhang J,Wu G, Zhu WY. Utilization of amino acids by bacteria from the pig small intestine. Amino Acids 2010;39:1201-15.
25. Suryawan A, Davis TA. Regulation of protein synthesis by amino acids in muscle of neonates. Front Biosci (Landmark Ed) 2011;16:1445-60.
26. Dowling RJ, Topisirovic I, Alain T, BidinostiM, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010;328:1172-6.
27. Rhoads JM,Niu X, Odle J, Graves LM. Role of mTOR signaling in intestinal cell migration. Am J Physiol Gastrointest Liver Physiol 2006;291:G510-7.
28. Wu G. Functional amino acids in nutrition and health. Amino Acids 2013;45:407-11.
29. Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends Cell Biol 2014;24:400-6.
30. Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, et al. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem 2011;286:34800-8.
31. Shen YB, Voilque G, Kim JD, Odle J, Kim SW. Effects of increasing tryptophan intake on growth and physiological changes in nursery pigs. J Anim Sci 2012;90:2264-75.
32. Shen YB, Voilque G, Odle J, Kim SW. Dietary L-tryptophan supplementation with reduced large neutral amino acids enhances feed efficiency and decreases stress hormone secretion in nursery pigs under social-mixing stress. J Nutr 2012;142:1540-6.
33. Anthony TG, Reiter AK, Anthony JC, Kimball SR, Jefferson LS. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. Am J Physiol Endocrinol Metab 2001;281:E430-9.
34. Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 1990;70:43-77.
35. Dave MH, Schulz N, Zecevic M, Wagner CA, Verrey F. Expression of heteromeric amino acid transporters along the murine intestine. J Physiol 2004;558:597-610.
36. Ferraris RP, Diamond JM. Specific regulation of intestinal nutrient transporters by their dietary substrates. Annu Rev Physiol 1989;51:125-41.
37. Cohen LL, Huang KC. Intestinal Transport of Tryptophan and Its Derivatives. Am J Physiol 1964;206:647-52.
38. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science 2001;294:1102-5.
39. Hou Y, Wang L, Yi D, Wu G. N-acetylcysteine and intestinal health: a focus on mechanisms of its action. Front Biosci (Landmark Ed) 2015;20:872-91.
40. Marc Rhoads J,Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 2009;37:111-22.
41. Jacobi SK, Odle J. Nutritional factors influencing intestinal health of the neonate. Adv Nutr 2012;3:687-96.
42. Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, et al. Glutamine and intestinal barrier function. Amino Acids 2014 Jun 26 (Epub ahead of print; DOI: 10.1007/s00726-0141773-4).
43. Matter K, Balda MS. Signalling to and from tight junctions. Nat Rev Mol Cell Biol 2003;4:225-36.
44. Rezaei R, Wang W, Wu Z, Dai Z, Wang J, Wu G. Biochemical and physiological bases for utilization of dietary amino acids by young Pigs. J Anim Sci Biotechnol 2013;4:7.