Corneal cross-linking as an adjuvant therapy in the management of recalcitrant deep stromal fungal keratitis: A randomized trial

American Journal of Ophthalmology

Volumn 160, Issue 1, 2015, Pages 131-134.e5

  Uddaraju, Madhu ^a   Mascarenhas, Jeena ^a   Das, Mano Ranjan ^a   Radhakrishnan, Naveen ^a   Keenan, Jeremy D ^b   Prajna, Lalitha ^a   Prajna, Venkatesh N ^a  

^a ARAVIND EYE HOSPITAL   (India)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CORNEAL CROSSLINKING; CROSS LINKING REAGENT; NATAMYCIN; UNCLASSIFIED DRUG; VORICONAZOLE; COLLAGEN; EYE DROPS; PHOTOSENSITIZING AGENT; RIBOFLAVIN;

ADJUVANT THERAPY; ADULT; ARTICLE; CLINICAL ARTICLE; CONFOCAL MICROSCOPE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA PERFORATION; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; HUMAN; IN VIVO STUDY; KERATOMYCOSIS; KERATOPLASTY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECALCITRANT DEEP STROMAL FUNGAL KERATITIS; SECONDARY ANALYSIS; SLIT LAMP; TREATMENT FAILURE; VISUAL ACUITY CHART; CORNEA; CORNEAL PERFORATION; CORNEAL ULCER; EYE INFECTIONS, FUNGAL; FUNGUS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, TOPICAL; ADULT; ANTIFUNGAL AGENTS; COLLAGEN; COMBINED MODALITY THERAPY; CORNEA; CORNEAL PERFORATION; CORNEAL ULCER; CROSS-LINKING REAGENTS; EYE INFECTIONS, FUNGAL; FEMALE; FUNGI; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NATAMYCIN; OPHTHALMIC SOLUTIONS; PHOTOSENSITIZING AGENTS; RIBOFLAVIN; ULTRAVIOLET RAYS; VORICONAZOLE;

EID: 84930762837     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2015.03.024     Document Type: Article

References (19)

1. J.P. Whitcher, and M. Srinivasan Corneal ulceration in the developing world-a silent epidemic Br J Ophthalmol 81 8 1997 622 623
2. N.V. Prajna, M. Srinivasan, and P. Lalitha Differences in clinical outcomes in keratitis due to fungus and bacteria JAMA Ophthalmol 131 8 2013 1088 1089
3. N.V. Prajna, J. Mascarenhas, and T. Krishnan Comparison of natamycin and voriconazole for the treatment of fungal keratitis Arch Ophthalmol 128 6 2010 672 678
4. P. Lalitha, N.V. Prajna, A. Kabra, K. Mahadevan, and M. Srinivasan Risk factors for treatment outcome in fungal keratitis Ophthalmology 113 4 2006 526 530
5. Z. Li, V. Jhanji, X. Tao, H. Yu, W. Chen, and G. Mu Riboflavin/ultravoilet light-mediated crosslinking for fungal keratitis Br J Ophthalmol 97 5 2013 669 671
6. H. Morén, M. Malmsjö, J. Mortensen, and A. Ohrström Riboflavin and ultraviolet a collagen crosslinking of the cornea for the treatment of keratitis Cornea 29 1 2010 102 104
7. H.M. Anwar, A.M. El-Danasoury, and A.N. Hashem Corneal collagen crosslinking in the treatment of infectious keratitis Clin Ophthalmol 5 2011 1277 1280
8. H.P. Iseli, M.A. Thiel, F. Hafezi, J. Kampmeier, and T. Seiler Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts Cornea 27 5 2008 590 594
9. M.O. Price, L.R. Tenkman, A. Schrier, K.M. Fairchild, S.L. Trokel, and F.W. Price Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology J Refract Surg 28 10 2012 706 713
10. D.G. Said, M.S. Elalfy, and Z. Gatzioufas Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting Ophthalmology 121 7 2014 1377 1382
11. N. Sharma, P. Agarwal, R. Sinha, J.S. Titiyal, T. Velpandian, and R.B. Vajpayee Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series Br J Ophthalmol 95 12 2011 1735 1737
12. T. Kuriakose, M. Kothari, P. Paul, P. Jacob, and R. Thomas Intracameral amphotericin B injection in the management of deep keratomycosis Cornea 21 7 2002 653 656
13. R. Shetty, H. Nagaraja, C. Jayadev, Y. Shivanna, and T. Kugar Collagen crosslinking in the management of advanced non-resolving microbial keratitis Br J Ophthalmol 98 8 2014 1033 1035
14. N.V. Prajna, T. Krishnan, and J. Mascarenhas The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole JAMA Ophthalmol 131 4 2013 422 429
15. E. Spoerl, G. Wollensak, and T. Seiler Increased resistance of crosslinked cornea against enzymatic digestion Curr Eye Res 29 1 2004 35 40
16. S.A.R. Martins, J.C. Combs, and G. Noguera Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis Invest Ophthalmol Vis Sci 49 8 2008 3402 3408
17. V. Kumar, O. Lockerbie, and S.D. Keil Riboflavin and UV-light based pathogen reduction: extent and consequence of DNA damage at the molecular level Photochem Photobiol 80 2004 15 21
18. K. Makdoumi, A. Bäckman, J. Mortensen, and S. Crafoord Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA) Graefes Arch Clin Exp Ophthalmol 248 2 2010 207 212
19. M. Tschopp, J. Stary, and B.E. Frueh Impact of corneal cross-linking on drug penetration in an ex vivo porcine eye model Cornea 31 3 2012 222 226