The xanthine derivative KMUP-1 attenuates serotonin-induced vasoconstriction and k+-channel inhibitory activity via the PKC pathway in pulmonary arteries

International Journal of Biological Sciences

Volumn 11, Issue 6, 2015, Pages 633-642

  Dai, Zen Kong ^a   Liu, Yu Wei ^b   Hsu, Jong Hau ^a   Yeh, Jwu Lai ^b   Chen, Ing Jun ^b   Wu, Jiunn Ren ^a   Wu, Bin Nan ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

K+ channel inhibition; Kv1.5 protein; PKC signaling; Pulmonary artery smooth muscle cells; Pulmonary vasoconstriction; Serotonin

Indexed keywords

KMUP 1; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL; PROTEIN KINASE C; SEROTONIN; XANTHINE DERIVATIVE;

ANIMAL; CHEMISTRY; DRUG EFFECTS; IN VITRO STUDY; MALE; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; PULMONARY ARTERY; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASOCONSTRICTION;

ANIMALS; IN VITRO TECHNIQUES; MALE; MUSCLE CONTRACTION; MYOCYTES, SMOOTH MUSCLE; PIPERIDINES; POTASSIUM CHANNELS; PROTEIN KINASE C; PULMONARY ARTERY; RATS, SPRAGUE-DAWLEY; SEROTONIN; VASOCONSTRICTION; XANTHINES;

EID: 84930683514     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.11127     Document Type: Article

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