Fructus phyllanthi tannin fraction induces apoptosis and inhibits migration and invasion of human lung squamous carcinoma cells in vitro via MAPK/MMP pathways

Acta Pharmacologica Sinica

Volumn 36, Issue 6, 2015, Pages 758-768

  Zhao, Hai Juan ^a,b   Liu, Ting ^a   Mao, Xin ^a,b   Han, Shu Xian ^a   Liang, Ri Xin ^a   Hui, Lian Qiang ^a   Cao, Chun Yu ^a   You, Yun ^a   Zhang, Lan Zhen ^b  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

apoptosis; lung squamous carcinoma; MAPK; metastasis; MMPs; Phyllanthus emblica L; tannins

Indexed keywords

ANTIMETASTATIC AGENT; FRUCTUS PHYLLANTHI TANNIN; GELATINASE B; HERBACEOUS AGENT; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FRUCTUS PHYLLANTHI; GELATINASE A; MATRIX METALLOPROTEINASE; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; TANNIN DERIVATIVE;

A549 CELL LINE; APOPTOSIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CHEMOTAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; FIBROSARCOMA CELL LINE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOFLUORESCENCE; IN VITRO STUDY; LUNG CANCER CELL LINE; METASTASIS INHIBITION; MTT ASSAY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; CARCINOMA, SQUAMOUS CELL; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIBETAN MEDICINE; TIME FACTOR; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INHIBITORY CONCENTRATION 50; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MEDICINE, TIBETAN TRADITIONAL; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; PHOSPHORYLATION; TANNINS; TIME FACTORS;

EID: 84930660946     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.130     Document Type: Article

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