The messenger RNA decapping and recapping pathway in Trypanosoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages 6967-6972

  Ignatochkina, Anna V ^a   Takagi, Yuko ^b,d   Liu, Yancheng ^a   Nagata, Kyosuke ^a   Ho, C Kiong ^a,b,c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Cap methylation; mRNA decapping; mRNA recapping; RNA repair; Trypanosoma brucei

Indexed keywords

CAPPED RNA; ENZYME; GUANOSINE DIPHOSPHATE; MESSENGER RNA; RNA; TRYPANOSOMA BRUCEI CYTOPLASMIC CAPPING ENZYME 1; TRYPANOSOMA BRUCEI MRNA DECAPPING ENZYME 2; UNCLASSIFIED DRUG; 5' UNTRANSLATED REGION; CGM1 PROTEIN, TRYPANOSOMA BRUCEI; GUANYLYLTRANSFERASE; MRNA DECAPPING ENZYMES; NUCLEOTIDYLTRANSFERASE; OLIGONUCLEOTIDE; PROTOZOAL PROTEIN; RIBONUCLEASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; RNA REPAIR; SIGNAL TRANSDUCTION; TRANS SPLICING; TRYPANOSOMA BRUCEI; 5' UNTRANSLATED REGION; DNA METHYLATION; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MOLECULAR CLONING; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

5' UNTRANSLATED REGIONS; CLONING, MOLECULAR; DNA METHYLATION; ENDORIBONUCLEASES; MICROSCOPY, FLUORESCENCE; NUCLEOTIDYLTRANSFERASES; OLIGONUCLEOTIDES; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA CAPS; RNA, MESSENGER; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84930644171     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424909112     Document Type: Article

References (37)

1. Furuichi Y, Shatkin AJ (2000) Viral and cellular mRNA capping: Past and prospects. Adv Virus Res 55:135-184.
2. Shuman S (2001) Structure, mechanism, and evolution of the mRNA capping apparatus. Prog Nucleic Acid Res Mol Biol 66:1-40.
3. Bangs JD, Crain PF, Hashizume T, McCloskey JA, Boothroyd JC (1992) Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides. J Biol Chem 267(14):9805-9815.
4. Kuge H, Richter JD (1995) Cytoplasmic 3′ poly(A) addition induces 5′ cap ribose methylation: Implications for translational control of maternal mRNA. EMBO J 14(24):6301-6310.
5. Zamudio JR, Mittra B, Campbell DA, Sturm NR (2009) Hypermethylated cap 4 maximizes Trypanosoma brucei translation. Mol Microbiol 72(5):1100-1110.
6. Parker R, Sheth U (2007) P bodies and the control of mRNA translation and degradation. Mol Cell 25(5):635-646.
7. Dunckley T, Parker R (1999) The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J 18(19):5411-5422.
8. Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (2002) The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc Natl Acad Sci USA 99(20):12663-12668.
9. Jiao X, Chang JH, Kilic T, Tong L, Kiledjian M (2013) A mammalian pre-mRNA 5′ end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell 50(1):104-115.
10. Lykke-Andersen J (2002) Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol 22(23):8114-8121.
11. Cao D, Parker R (2003) Computational modeling and experimental analysis of nonsense-mediated decay in yeast. Cell 113(4):533-545.
12. Muhlrad D, Parker R (1994) Premature translational termination triggers mRNA decapping. Nature 370(6490):578-581.
13. Eulalio A, Behm-Ansmant I, Izaurralde E (2007) P bodies: At the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8(1):9-22.
14. Mukherjee C, et al. (2012) Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability. Cell Reports 2(3):674-684.
15. Schoenberg DR, Maquat LE (2009) Re-capping the message. Trends Biochem Sci 34(9):435-442.
16. Schibler U, Perry RP (1976) Characterization of the 5′ termini of hn RNA in mouse L cells: Implications for processing and cap formation. Cell 9(1):121-130.
17. Spencer E, Loring D, Hurwitz J, Monroy G (1978) Enzymatic conversion of 5′-phosphate-terminated RNA to 5′-di- and triphosphate-terminated RNA. Proc Natl Acad Sci USA 75(10):4793-4797.
18. Otsuka Y, Kedersha NL, Schoenberg DR (2009) Identification of a cytoplasmic complex that adds a cap onto 5′-monophosphate RNA. Mol Cell Biol 29(8):2155-2167.
19. Agabian N (1990) Trans splicing of nuclear pre-mRNAs. Cell 61(7):1157-1160.
20. Liang XH, Haritan A, Uliel S, Michaeli S (2003) trans and cis splicing in trypanosomatids: Mechanism, factors, and regulation. Eukaryot Cell 2(5):830-840.
21. Ho CK, Shuman S (2001) Trypanosoma brucei RNA triphosphatase. Antiprotozoal drug target and guide to eukaryotic phylogeny. J Biol Chem 276(49):46182-46186.
22. Ruan J-P, Shen S, Ullu E, Tschudi C (2007) Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA. Mol Biochem Parasitol 156(2):246-254.
23. Takagi Y, Sindkar S, Ekonomidis D, Hall MP, Ho CK (2007) Trypanosoma brucei encodes a bifunctional capping enzyme essential for cap 4 formation on the spliced leader RNA. J Biol Chem 282(22):15995-16005.
24. Arhin GK, Ullu E, Tschudi C (2006) 2′-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39. Mol Biochem Parasitol 147(1):137-139.
25. Arhin GK, Li H, Ullu E, Tschudi C (2006) A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei. RNA 12(1):53-62.
26. Hall MP, Ho CK (2006) Functional characterization of a 48 kDa Trypanosoma brucei cap 2 RNA methyltransferase. Nucleic Acids Res 34(19):5594-5602.
27. Zamudio JR, et al. (2006) Complete cap 4 formation is not required for viability in Trypanosoma brucei. Eukaryot Cell 5(6):905-915.
28. Silva E, Ullu E, Kobayashi R, Tschudi C (1998) Trypanosome capping enzymes display a novel two-domain structure. Mol Cell Biol 18(8):4612-4619.
29. Hall MP, Ho CK (2006) Characterization of a Trypanosoma brucei RNA cap (guanine N-7) methyltransferase. RNA 12(3):488-497.
30. Banerjee H, et al. (2009) Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: Substrate specificity studies on the recombinant and endogenous proteins. RNA 15:1554-1564.
31. Mildvan AS, et al. (2005) Structures and mechanisms of Nudix hydrolases. Arch Biochem Biophys 433(1):129-143.
32. Weng J, et al. (2008) Guide RNA-binding complex from mitochondria of trypanosomatids. Mol Cell 32(2):198-209.
33. Güther MLS, Urbaniak MD, Tavendale A, Prescott A, Ferguson MAJ (2014) Highconfidence glycosome proteome for procyclic form Trypanosoma brucei by epitopetag organelle enrichment and SILAC proteomics. J Proteome Res 13(6):2796-2806.
34. Wang LK, Shuman S (2002) Mutational analysis defines the 5′-kinase and 3′-phosphatase active sites of T4 polynucleotide kinase. Nucleic Acids Res 30(4):1073-1080.
35. Weitzer S, Martinez J (2007) The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs. Nature 447(7141):222-226.
36. Cohen LS, et al. (2005) Dcp2 Decaps m2,2,7GpppN-capped RNAs, and its activity is sequence and context dependent. Mol Cell Biol 25(20):8779-8791.
37. Milone J, Wilusz J, Bellofatto V (2002) Identification of mRNA decapping activities and an ARE-regulated 3′ to 5′ exonuclease activity in trypanosome extracts. Nucleic Acids Res 30(18):4040-4050.