Trypanosome capping enzymes display a novel two-domain structure

Molecular and Cellular Biology

Volumn 18, Issue 8, 1998, Pages 4612-4619

  Silva, Erika ^a   Ullu, Elisabetta ^a   Kobayashi, Ryuji ^b   Tschudi, Christian ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANYLYLTRANSFERASE; MESSENGER RNA; RNA; SMALL NUCLEAR RNA; TRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRITHIDIA FASCICULATA; ENZYME STRUCTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA CAPPING; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

CRITHIDIA FASCICULATA; TRYPANOSOMA BRUCEI;

EID: 0031855665     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.8.4612     Document Type: Article

References (52)

1. Allison, L. A., M. Moyle, M. Shales, and C. J. Ingles. 1985. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell 42:599-610.
2. Bangs, J. D., P. F. Crain, T. Hashizume, J. A. McCloskey, and J. C. Boothroyd. 1992. Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides. J. Biol. Chem. 267:9805-9815.
3. Cho, E. J., T. Takagi, C. R. Moore, and S. Buratowski. 1997. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 11:3319-3326.
4. Cong, P., and S. Shuman. 1992. Methyltransferase and subunit association domains of vaccinia virus mRNA capping enzyme. J. Biol. Chem. 267:16424-16429.
5. Corden, J. L., D. L. Cadena, J. M. Ahearn, Jr., and M. E. Dahmus. 1985. A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II. Proc. Nati. Acad. Sci. USA 82:7934-7938.
6. Evers, R., A. Hammer, J. Kock, W. Jess, P. Borst, S. Memet, and A. W. Cornelissen. 1989. Trypanosoma brucei contains two RNA polymerase II largest subunit genes with an altered C-terminal domain. Cell 56:585-597.
7. Fantoni, A., A. O. Dare, and C. Tschudi. 1994. RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements. Mol. Cell. Biol. 14:2021-2028.
8. Gunzl, A., E. Ullu, M. Dorner, S. P. Fragoso, K. F. Hoffmann, J. D. Milner, Y. Morita, E. K. Nguu, S. Vanacova, S. Wunsch, A. O. Dare, H. Kwon, and C. Tschudi. 1997. Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elements. Mol. Biochem. Parasitol. 85:67-76.
9. Hakansson, K., A. J. Doherty, S. Shuman, and D. B. Wigley. 1997. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 89:545-553.
10. Higman, M. A., N. Bourgeois, and E. G. Niles. 1992. The vaccinia virus mRNA (guanine-N7-)-methyltransferase requires both subunits of the mRNA capping enzyme for activity. J. Biol. Chem. 267:16430-16437.
11. Ho, C. K., J. L. Van Etten, and S. Shuman. 1996. Expression and characterization of an RNA capping enzyme encoded by Chlorella virus PBCV-1. J. Virol. 70:6658-6664.
12. Itoh, N., K. Mizumoto, and Y. Kaziro. 1984. Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. I. Purification and subunit structure. J. Biol. Chem. 259:13923-13929.
13. Itoh, N., H. Yamada, Y. Kaziro, and K. Mizumoto. 1987. Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization. J. Biol. Chem. 262:1989-1995.
14. Laird, P. W., J. C. Zomerdijk, D. de Korte, and P. Borst. 1987. In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei. EMBO J. 6:1055-1062.
15. Mao, X., B. Schwer, and S. Shuman. 1995. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mol. Cell. Biol. 15:4167-4174.
16. Mao, X., and S. Shuman. 1994. Intrinsic RNA (guanine-7) methyltransferase activity of the vaccinia virus capping enzyme D1 subunit is stimulated by the D12 subunit. Identification of amino acid residues in the D1 protein required for subunit association and methyl group transfer. J. Biol. Chem. 269:24472-24479.
17. McCracken, S., N. Fong, E. Rosonina, K. Yankulov, G. Brothers, D. Siderovski, A. Hessel, S. Foster, A. E. Program, S. Shuman, and D. L. Bentley. 1997. 5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes. Dev. 11:3306-3318.
18. McNally, K. P., and N. Agabian. 1992. Trypanosoma brucei spliced-leader RNA methylations are required for trans splicing in vivo. Mol. Cell. Biol. 12:4844-4851.
19. Mizumoto, K., and Y. Kaziro. 1987. Messenger RNA capping enzymes from eukaryotic cells. Prog. Nucleic Acid Res. Mol. Biol. 34:1-28.
20. Mizumoto, K., Y. Kaziro, and F. Lipmann. 1982. Reaction mechanism of mRNA guanylyltransferase from rat liver: isolation and characterization of a guanylyl-enzyme intermediate. Proc. Natl. Acad. Sci. USA 79:1693-1697.
21. Moss, B., M. J. Ensinger, S. A. Martin, and C. M. Wei. 1975. Modification of the 5′-terminus of mRNA by guanylyl and methyl transferases from vaccinia virus, p. 161-168. In A. L. Haenni and G. Beaud (ed.), In vitro transcription and translation of viral genomes. Institut National de la Santé et de la Recherche Médicale, Paris, France.
22. Mottram, J., K. L. Perry, P. M. Lizardi, R. Luhrmann. N. Agabian, and R. G. Nelson. 1989. Isolation and sequence of four small nuclear U RNA genes of Trypanosoma brucei subsp. brucei: identification of the U2, U4, and U6 RNA analogs. Mol. Cell. Biol. 9:1212-1223.
23. Murphy, W. J., K. P. Watkins, and N. Agabian. 1986. Identification of a novel Y branch structure as an intermediate in trypanosome mRNA processing: evidence for trans splicing. Cell 47:517-525.
24. Nakaar, V., A. O. Dare, D. Hong, E. Ullu, and C. Tschudi. 1994. Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in trypanosomes. Mol. Cell. Biol. 14:6736-6742.
25. Rudenko, G., D. Bishop, K. Gottesdiener, and L. H. Van der Ploeg. 1989. Alpha-amanitin resistant transcription of protein coding genes in insect and bloodstream form Trypanosoma brucei. EMBO J. 8:4259-4263.
26. Rudenko, G., M. G. Lee, and L. H. Van der Ploeg. 1992. The PARP and VSG genes of Trypanosoma brucei do not resemble RNA polymerase II transcription units in sensitivity to Sarkosyl in nuclear run-on assays. Nucleic Acids Res. 20:303-306.
27. Saraste, M., P. R. Sibbald, and A. Wittinghofer. 1990. The P-loop - a common motif in ATP-and GTP-binding proteins. Trends Biochem. Sci. 15:430-434.
28. Shibagaki, Y., N. Itoh, H. Yamada, S. Nagata, and K. Mizumoto. 1992. mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanyly[1]transferase subunit from Saccharomyces cerevisiae. J. Biol. Chem. 267:9521-9528.
29. Shuman, S. 1989. Functional domains of vaccinia virus mRNA capping enzyme. Analysis by limited tryptic digestion. J. Biol. Chem. 264:9690-9695.
30. Shuman, S., and J. Hurwitz. 1981. Mechanism of mRNA capping by vaccinia virus guanylyltransferase: characterization of an enzyme-guanylate intermediate. Proc. Natl. Acad. Sci. USA 78:187-191.
31. Shuman, S., Y. Liu, and B. Schwer. 1994. Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proc. Natl. Acad. Sci. USA 91:12046-12050.
32. Shuman, S., and S. G. Morham. 1990. Domain structure of vaccinia virus mRNA capping enzyme. Activity of the Mr 95,000 subunit expressed in Escherichia coli. J. Biol. Chem. 265:11967-11972.
33. Shuman, S., and B. Schwer. 1995. RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases. Mol. Microbiol. 17:405-410.
34. Shuman, S., M. Surks, H. Furneaux, and J. Hurwitz. 1980. Purification and characterization of a GTP-pyrophosphate exchange activity from vaccinia virions. Association of the GTP-pyrophosphate exchange activity with vaccinia mRNA guanylyltransferase. RNA (guanine-7-)methyltransferase complex (capping enzyme). J. Biol. Chem. 255:11588-11598.
35. Smith, J. L., J. R. Levin, C. J. Ingles, and N. Agabian. 1989. In trypanosomes the homolog of the largest subunit of RNA polymerase II is encoded by two genes and has a highly unusual C-terminal domain structure. Cell 56:815-827.
36. Sutton, R. E., and J. C. Boothroyd. 1986. Evidence for trans splicing in trypanosomes. Cell 47:527-535.
37. Takagi, T., C. R. Moore, F. Diehn, and S. Buratowski. 1997. An RNA 5′-triphosphatase related to the protein tyrosine phosphatases. Cell 89:867-873.
38. Toyama, R., K. Mizumoto, Y. Nakahara, T. Tatsuno, and Y. Kaziro. 1983. Mechanism of the mRNA guanylyltransferase reaction: isolation of N epsilon-phospholysine and GMP (5′ leads to N epsilon) lysine from the guanylylenzyme intermediate. EMBO J. 2:2195-2201.
39. Tschudi, C., F. F. Richards, and E. Ullu. 1986. The U2 RNA analogue of Trypanosoma brucei gambiense: implications for a splicing mechanism in trypanosomes. Nucleic Acids Res. 14:8893-8903.
40. Tutas, D. J., and E. Paoletti. 1977. Purification and characterization of core-associated polynucleotide 5′-triphosphatase from vaccinia virus. J. Biol. Chem. 252:3092-3098.
41. Ullu, E., and C. Tschudi. 1995. Accurate modification of the trypanosome spliced leader cap structure in a homologous cell-free system. J. Biol. Chem. 270:20365-20369.
42. Ullu, E., and C. Tschudi. 1990. Permeable trypanosome cells as a model system for transcription and trans-splicing. Nucleic Acids Res. 18:3319-3326.
43. Ullu, E., and C. Tschudi. 1991. Trans splicing in trypanosomes requires methylation of the 5′ end of the spliced leader RNA. Proc. Natl. Acad. Sci. USA 88:10074-10078.
44. Ullu, E., and C. Tschudi. Unpublished data.
45. Venkatesan, S., A. Gershowitz, and B. Moss. 1980. Modification of the 5′ end of mRNA. Association of RNA triphosphatase with the RNA guanylyltransferase-RNA (guanine-7-)methyltransferase complex from vaccinia virus. J. Biol. Chem. 255:903-908.
46. Walker, J. E., M. Saraste, M. J. Runswick, and N. J. Gay. 1982. Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:945-951.
47. Wang, G. P., L. Deng, C. K. Ho, and S. Shuman. 1997. Phytogeny of mRNA capping enzymes. Proc. Natl. Acad. Sci. USA 94:9573-9578.
48. Wang, R., R. Kobayashi, and J. M. Bishop. 1996. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. USA 93:8425-8430.
49. Yagi, Y., K. Mizumoto, and Y. Kaziro. 1983. Association of an RNA 5′-triphosphatase activity with RNA guanylyltransferase partially purified from rat liver nuclei. EMBO J. 2:611-615.
50. Yamada-Okabe, T., O. Shimmi, R. Doi, K. Mizumoto, M. Arisawa, and H. Yamada-Okabe. 1996. Isolation of the mRNA-capping enzyme and ferric-reductase-related genes from Candida albicans. Microbiology 142:2515-2523.
51. Yue, Z., E. Maldonado, R. Pillutla, H. Cho, D. Reinberg, and A. J. Shatkin. 1997. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. Proc. Natl. Acad. Sci. USA 94:12898-12903.
52. Zwierzynski, T. A., and G. A. Buck. 1990. In vitro capping in Trypanosoma cruzi identifies and shows specificity for the spliced leader RNA and U-RNAs. Nucleic Acids Res. 18:4197-4206.