Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1851, Issue 9, 2015, Pages 1186-1193

  Yue, Hong Wei ^a   Liu, Jing ^a   Liu, Ping Ping ^b   Li, Wen Jing ^a   Chang, Fen ^a   Miao, Jun Ying ^a   Zhao, Jing ^a  

^a SHANDONG UNIVERSITY   (China)

^b Yantai Mountain Hospital   (China)

Author keywords

Apoptosis; Autophagy; Cardiomyocyte; Lipid raft; Sphingosylphosphorylcholine (SPC)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BECLIN 1; BETA CYCLODEXTRIN; CASPASE 3; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE LIPID; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B ALPHA; PROTEIN KINASE B BETA; PROTEIN SERINE THREONINE KINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; S6 KINASE; SPHINGOSYLPHOSPHORYLCHOLINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; AKT1 PROTEIN, HUMAN; BETA CYCLODEXTRIN DERIVATIVE; CARRIER PROTEIN; EIF4EBP1 PROTEIN, RAT; HYBRID PROTEIN; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; PHOSPHORYLCHOLINE; PROTEIN KINASE B; PTEN PROTEIN, RAT; SPHINGOSINE; SPHINGOSINE PHOSPHORYLCHOLINE; STRESS ACTIVATED PROTEIN KINASE 1; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; CYTOMETRY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VITRO STUDY; LIPID RAFT; LYSOSOME; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRIMARY CELL CULTURE; SPRAGUE DAWLEY RAT;

ADENINE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; AUTOPHAGY; BETA-CYCLODEXTRINS; CARRIER PROTEINS; GENE EXPRESSION REGULATION; MAP KINASE KINASE 4; MEMBRANE MICRODOMAINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MYOCYTES, CARDIAC; PHOSPHOPROTEINS; PHOSPHORYLCHOLINE; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SPHINGOSINE; TOR SERINE-THREONINE KINASES;

EID: 84930643536     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2015.04.001     Document Type: Article

References (38)

1. D. Meyer zu Heringdorf, H.M. Himmel, and K.H. Jakobs Sphingosylphosphorylcholine-biological functions and mechanisms of action Biochim. Biophys. Acta 1582 2002 178 189
2. J.R. Nofer, B. Levkau, I. Wolinska, R. Junker, M. Fobker, A. von Eckardstein, U. Seedorf, and G. Assmann Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids J. Biol. Chem. 276 2001 34480 34485
3. E.S. Jeon, M.J. Lee, S.M. Sung, and J.H. Kim Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK J. Cell. Biochem. 100 2007 1536 1547
4. M.M. Ptaszynska, M.L. Pendrak, M.L. Stracke, and D.D. Roberts Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration Mol. Cancer Res. 8 2010 309 321
5. M.C. Michel, A.C. Mulders, M. Jongsma, A.E. Alewijnse, and S.L. Peters Vascular effects of sphingolipids Acta Paediatr. 96 2007 44 48
6. T. Katayama, S. Yoshiyama, H. Tanaka, H.H. Wang, A. Nakamura, and K. Kohama Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells J. Pharmacol. Sci. 102 2006 339 342
7. S. Li, H. Tanaka, H.H. Wang, S. Yoshiyama, H. Kumagai, A. Nakamura, D.L. Brown, S.E. Thatcher, G.L. Wright, and K. Kohama Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation Am. J. Physiol. Heart Circ. Physiol. 291 2006 H1262 H1272
8. K. Sekiguchi, T. Yokoyama, M. Kurabayashi, F. Okajima, and R. Nagai Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes Circ. Res. 85 1999 1000 1008
9. C. Herzog, M. Schmitz, B. Levkau, I. Herrgott, J. Mersmann, J. Larmann, K. Johanning, M. Winterhalter, J. Chun, F.U. Muller, F. Echtermeyer, R. Hildebrand, and G. Theilmeier Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury Mediat. Inflamm. 2010 2010 425191
10. D. Ge, Q. Jing, N. Meng, L. Su, Y. Zhang, S. Zhang, J. Miao, and J. Zhao Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells J. Cell. Physiol. 226 2011 2827 2833
11. H. Yue, W. Li, P. Liu, J. Gao, J. Miao, and J. Zhao Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells Biochem. Biophys. Res. Commun. 453 3 2014 502 507
12. X. Cao, A. Chen, P. Yang, X. Song, Y. Liu, Z. Li, X. Wang, L. Wang, and Y. Li Alpha-lipoic acid protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy Biochem. Biophys. Res. Commun. 441 2013 935 940
13. M. Volkers, M.H. Konstandin, S. Doroudgar, H. Toko, P. Quijada, S. Din, A. Joyo, L. Ornelas, K. Samse, D.J. Thuerauf, N. Gude, C.C. Glembotski, and M.A. Sussman Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage Circulation 128 2013 2132 2144
14. N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev. 18 2004 1926 1945
15. A.H. Chaanine, and R.J. Hajjar AKT signalling in the failing heart Eur. J. Heart Fail. 13 2011 825 829
16. I. Shiojima, S. Schiekofer, J.G. Schneider, K. Belisle, K. Sato, M. Andrassy, G. Galasso, and K. Walsh Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts Am. J. Pathol. 181 2012 1969 1976
17. S.A. Santi, and H. Lee The Akt isoforms are present at distinct subcellular locations Am. J. Physiol. Cell Physiol. 298 2010 C580 C591
18. Y. Zhang, K. Ikejima, H. Honda, T. Kitamura, Y. Takei, and N. Sato Glycine prevents apoptosis of rat sinusoidal endothelial cells caused by deprivation of vascular endothelial growth factor Hepatology 32 2000 542 546
19. Y. Lee, H.Y. Lee, and A.B. Gustafsson Regulation of autophagy by metabolic and stress signaling pathways in the heart J. Cardiovasc. Pharmacol. 60 2012 118 124
20. M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
21. D. Rotter, and B.A. Rothermel Targets, trafficking, and timing of cardiac autophagy Pharmacol. Res. 66 2012 494 504
22. X. Wang, X.L. Wang, H.L. Chen, D. Wu, J.X. Chen, X.X. Wang, R.L. Li, J.H. He, L. Mo, X. Cen, Y.Q. Wei, and W. Jiang Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK Biochem. Pharmacol. 88 2014 334 350
23. R.J. Henning, P. Sanberg, and E. Jimenez Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes Cytotherapy 16 2014 1158 1168
24. X. Hou, Z. Hu, H. Xu, J. Xu, S. Zhang, Y. Zhong, X. He, and N. Wang Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway Cardiovasc. Diabetol. 13 2014 78
25. J.R. McMullen, M.C. Sherwood, O. Tarnavski, L. Zhang, A.L. Dorfman, T. Shioi, and S. Izumo Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload Circulation 109 2004 3050 3055
26. M. Reis-Sobreiro, G. Roue, A. Moros, C. Gajate, J. de la Iglesia-Vicente, D. Colomer, and F. Mollinedo Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma Blood Cancer J. 3 2013 e118
27. N. Morikage, H. Kishi, M. Sato, F. Guo, S. Shirao, T. Yano, M. Soma, K. Hamano, K. Esato, and S. Kobayashi Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft Circ. Res. 99 2006 299 306
28. J. Garcia Cordero, M. Leon Juarez, Y.M.J.A. Gonzalez, L. Cedillo Barron, and B. Gutierrez Castaneda Caveolin-1 in lipid rafts interacts with dengue virus NS3 during polyprotein processing and replication in HMEC-1 cells PLoS One 9 2014 e90704
29. M.S. Song, L. Salmena, and P.P. Pandolfi The functions and regulation of the PTEN tumour suppressor Nat. Rev. Mol. Cell Biol. 13 2012 283 296
30. K. Liliom, G. Sun, M. Bunemann, T. Virag, N. Nusser, D.L. Baker, D.A. Wang, M.J. Fabian, B. Brandts, K. Bender, A. Eickel, K.U. Malik, D.D. Miller, D.M. Desiderio, G. Tigyi, and L. Pott Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors Biochem. J. 355 2001 189 197
31. V.A. Snetkov, G.D. Thomas, B. Teague, R.M. Leach, Y. Shaifta, G.A. Knock, P.I. Aaronson, and J.P. Ward Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2 + entry Hypertension 51 2008 239 245
32. R. Betto, A. Teresi, F. Turcato, G. Salviati, R.A. Sabbadini, K. Krown, C.C. Glembotski, L.A. Kindman, C. Dettbarn, Y. Pereon, K. Yasui, and P.T. Palade Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes Biochem. J. 322 Pt 1 1997 327 333
33. E. Gonzalez, and T.E. McGraw The Akt kinases: isoform specificity in metabolism and cancer Cell Cycle 8 2009 2502 2508
34. C. Shi, J. Wu, M. Fu, B. Zhang, J. Wang, X. Yang, and Y. Chi Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes Biochem. Biophys. Res. Commun. 452 2014 308 314
35. G.F. Nixon, F.A. Mathieson, and I. Hunter The multi-functional role of sphingosylphosphorylcholine Prog. Lipid Res. 47 2008 62 75
36. A. Kleger, T. Busch, S. Liebau, K. Prelle, S. Paschke, M. Beil, A. Rolletschek, A. Wobus, E. Wolf, G. Adler, and T. Seufferlein The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells Cell. Signal. 19 2007 367 377
37. E. Afrasiabi, T. Blom, S. Balthasar, and K. Tornquist Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase Mol. Cell. Endocrinol. 274 2007 43 52
38. A.L. Cavalli, N.W. O'Brien, S.B. Barlow, R. Betto, C.C. Glembotski, P.T. Palade, and R.A. Sabbadini Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes Am. J. Physiol. Cell Physiol. 284 2003 C780 C790