Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: The role of protein kinase Cδ and Ca2+ entry

Hypertension

Volumn 51, Issue 2, 2008, Pages 239-245

  Snetkov, Vladimir A ^a   Thomas, Gavin D ^a   Teague, Bonnie ^a   Leach, Richard M ^a   Shaifta, Yasin ^a   Knock, Greg A ^a   Aaronson, Philip I ^a   Ward, Jeremy P T ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

L type Ca2+ channels; Lysosphingolipids; Protein kinase C ; Pulmonary artery; Sphingosylphosphorylcholine

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 AMINOETHOXYDIPHENYLBORANE; CALCIUM ION; CATION CHANNEL; DILTIAZEM; PROSTAGLANDIN F1 ALPHA; PROTEIN KINASE C DELTA; RHO KINASE; ROTTLERIN; SPHINGOSYLPHOSPHORYLCHOLINE; U 436619; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ANIMAL CELL; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CELL CULTURE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; MALE; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; STEREOSPECIFICITY; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; DILTIAZEM; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; INTRACELLULAR MEMBRANES; MALE; MYOCYTES, SMOOTH MUSCLE; OSMOLAR CONCENTRATION; PHOSPHORYLCHOLINE; POTASSIUM; PROTEIN KINASE C-DELTA; PULMONARY ARTERY; RATS; RATS, WISTAR; SPHINGOSINE; VASOCONSTRICTION; VASOMOTOR SYSTEM;

EID: 38549165708     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.104802     Document Type: Article

References (28)

1. Meyer zu Heringdorf D, Himmel HM, Jakobs KH. Sphingosylphosphorylcholine- biological functions and mechanisms of action. Biochim Biophys Acta. 2002;1582:178-189.
2. Alewijnse AE, Peters SL, Michel MC. Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. Br J Pharmacol. 2004;143:666-684.
3. Duong CQ, Bared SM, Abu-Khader A, Buechler C, Schmitz A, Schmitz G. Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. Biochim Biophys Acta. 2004;1682:112-119.
4. Thomas GD, Snetkov VA, Patel R, Leach RM, Aaronson PI, Ward JP. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. Cardiovasc Res. 2005;68:56-64.
5. Bischoff A, Czyborra P, Fetscher C, Meyer Zu Heringdorf D, Jakobs KH, Michel MC. Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. Br J Pharmacol. 2000;130:1871-1877.
6. Nakao F, Kobayashi S, Mogami K, Mizukami Y, Shirao S, Miwa S, Todoroki-Ikeda N, Ito M, Matsuzaki M. Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. Circ Res. 2002;91:953-960.
7. Shirao S, Kashiwagi S, Sato M, Miwa S, Nakao F, Kurokawa T, Todoroki-Ikeda N, Mogami K, Mizukami Y, Kuriyama S, Haze K, Suzuki M, Kobayashi S. Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. Circ Res. 2002;91:112-119.
8. Morikage N, Kishi H, Sato M, Guo F, Shirao S, Yano T, Soma M, Hamano K, Esato K, Kobayashi S. Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. Circ Res. 2006;99:299 -306.
9. Hemmings DG. Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. Naunyn Schmiedebergs Arch Pharmacol. 2006;373:18-29.
10. Meyer Zu Heringdorf D. Lysophospholipid receptor-dependent and -independent calcium signaling. J Cell Biochem. 2004;92:937-948.
11. Liliom K, Sun G, Bunemann M, Virag T, Nusser N, Baker DL, Wang DA, Fabian MJ, Brandts B, Bender K, Eickel A, Malik KU, Miller DD, Desiderio DM, Tigyi G, Pott L. Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem J. 2001;355:189-197.
12. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawainami S, Imokawa G. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Investig Dermatol. 1996;106:1242-1249.
13. Meyer Zu Heringdorf D, Jakobs KH. Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta. 2007;1768:923-940.
14. Seuwen K, Ludwig MG, Wolf RM. Receptors for protons or lipid messengers or both? J Recept Signal Transduct Res. 2006;26:599-610.
15. MacLean MR, Morecroft I. Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol. 2001;134:614-620.
16. Snetkov VA, Aaronson PI, Ward JP, Knock GA, Robertson TP. Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat. Br J Pharmacol. 2003;140:97-106.
17. Snetkov VA, Knock GA, Baxter L, Thomas GD, Ward JP, Aaronson PI. Mechanisms of the prostaglandin F2{alpha}-induced rise in [Ca2+]i in rat intrapulmonary arteries. J Physiol. 2006;571:147-163.
18. Coussin F, Scott RH, Nixon GF. Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels. Biochem Pharmacol. 2003;66:1861-1870.
19. Ward JP, Knock GA, Snetkov VA, Aaronson PI. Protein kinases in vascular smooth muscle tone-role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol Ther. 2004;104:207-231.
20. Keef KD, Hume JR, Zhong J. Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases. Am J Physiol. 2001; 281:C1743-C1756.
21. Obejero-Paz CA, Auslender M, Scarpa A. PKC activity modulates availability and long openings of L-type Ca2+ channels in A7r5 cells. Am J Physiol. 1998;275:C535-C543.
22. Schuhmann K, Groschner K. Protein kinase-C mediates dual modulation of L-type Ca2+ channels in human vascular smooth muscle. FEBS Lett. 1994;341:208-212.
23. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994;199:93-98.
24. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 1994;210:287-297.
25. Li C, Wernig F, Leitges M, Hu Y, Xu Q. Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J. 2003;17:2106-2108.
26. Jeon ES, Kang YJ, Song HY, Im DS, Kim HS, Ryu SH, Kim YK, Kim JH. Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. Cell Signal. 2005;17:777-787.
27. Summers BA, Overholt JL, Prabhakar NR. Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. J Neurophysiol. 2000;84:1636-1644.
28. Afrasiabi E, Blom T, Ekokoski E, Tuominen RK, Tornquist K. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. Cell Signal. 2006;18:1671-1678.