The Chlamydia pneumoniae inclusion membrane protein Cpn1027 interacts with host cell Wnt signaling pathway regulator cytoplasmic activation/ proliferation-associated protein 2 (Caprin2)

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Flores, Rhonda ^a   Zhong, Guangming ^a  

^a University of Texas Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PROTEIN BCL 2; PROTEIN CPN1027; UNCLASSIFIED DRUG; CAPRIN2 PROTEIN, HUMAN; CELL CYCLE PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN BINDING;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL MEMBRANE; CELL PROLIFERATION; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; HOST CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; WNT SIGNALING PATHWAY; CELL LINE; CHEMISTRY; CHLAMYDIA PNEUMONIAE; GENE SILENCING; GENETICS; METABOLISM; PROTEIN DOMAIN; PROTEIN TRANSPORT;

CHLAMYDOPHILA PNEUMONIAE;

APOPTOSIS; BACTERIAL PROTEINS; BETA CATENIN; CELL CYCLE PROTEINS; CELL LINE; CHLAMYDOPHILA PNEUMONIAE; GENE KNOCKDOWN TECHNIQUES; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN TRANSPORT; WNT SIGNALING PATHWAY;

EID: 84930643382     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127909     Document Type: Article

References (43)

1. Campbell LA, Kuo CC (2004) Chlamydia pneumoniae - an infectious risk factor for atherosclerosis? Nat Rev Microbiol 2: 23-32. PMID: 15035006
2. Asner SA, Jaton K, Kyprianidou S, Nowak AM, Greub G (2014) Chlamydia pneumoniae: possible association with asthma in children. Clin Infect Dis 58: 1198-1199. doi: 10.1093/cid/ciu034 PMID: 24429432
3. Hu H, Pierce GN, Zhong G (1999) The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J Clin Invest 103: 747-753. PMID: 10074493
4. Cao F, Castrillo A, Tontonoz P, Re F, Byrne GI (2007) Chlamydia pneumoniae - induced macrophage foam cell formation is mediated by Toll-like receptor 2. Infect Immun 75: 753-759. PMID: 17145941
5. Hackstadt T (1998) The diverse habitats of obligate intracellular parasites. Curr Opin Microbiol 1: 82-87. PMID: 10066459
6. Clifton DR, Fields KA, Grieshaber SS, Dooley CA, Fischer ER, Mead DJ, et al. (2004) A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin. Proc Natl Acad Sci U S A 101: 10166-10171. PMID: 15199184
7. Hybiske K, Stephens RS (2007) Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci U S A 104: 11430-11435. PMID: 17592133
8. Hackstadt T, Scidmore-Carlson MA, Shaw EI, Fischer ER (1999) The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion. Cell Microbiol 1: 119-130. PMID: 11207546
9. Cortes C, Rzomp KA, Tvinnereim A, Scidmore MA, Wizel B (2007) Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with multiple Rab GTPases. Infect Immun 75: 5586-5596. PMID: 17908815
10. Moore ER, Ouellette SP (2014) Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: an expanded role for Inc proteins. Front Cell Infect Microbiol 4: 157. doi: 10.3389/ fcimb.2014.00157 PMID: 25401095
11. Toh H, Miura K, Shirai M, Hattori M (2003) In silico inference of inclusion membrane protein family in obligate intracellular parasites chlamydiae. DNA Res 10: 9-17. PMID: 12693550
12. Subtil A, Parsot C, Dautry-Varsat A (2001) Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery. Mol Microbiol 39: 792-800. PMID: 11169118
13. Chen C, Chen D, Sharma J, Cheng W, Zhong Y, Liu K, et al. (2006) The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis. Infect Immun 74: 4826-4840. PMID: 16861671
14. Dehoux P, Flores R, Dauga C, Zhong G, Subtil A (2011) Multi-genome identification and characterization of chlamydiae-specific type III secretion substrates: the Inc proteins. BMC Genomics 12: 109. doi: 10.1186/1471-2164-12-109 PMID: 21324157
15. Flores R, Luo J, Chen D, Sturgeon G, Shivshankar P, Zhong Y, et al. (2007) Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae. Microbiology 153: 777-786. PMID: 17322198
16. Luo J, Jia T, Flores R, Chen D, Zhong G (2007) Hypothetical protein Cpn0308 is localized in the Chlamydia pneumoniae inclusion membrane. Infect Immun 75: 497-503. PMID: 17101661
17. Luo J, Jia T, Zhong Y, Chen D, Flores R, Zhong G (2007) Localization of the hypothetical protein Cpn0585 in the inclusion membrane of Chlamydia pneumoniae-infected cells. Microb Pathog 42: 111-116. PMID: 17236746
18. Luo J, Liu G, Zhong Y, Jia T, Liu K, Chen D, et al. (2007) Characterization of hypothetical proteins Cpn0146, 0147, 0284 & 0285 that are predicted to be in the Chlamydia pneumoniae inclusion membrane. BMC Microbiol 7: 38. PMID: 17504539
19. Li Z, Chen C, Chen D, Wu Y, Zhong Y, Zhong G (2008) Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome. Infect Immun 76: 2746-2757. doi: 10.1128/IAI.00010-08 PMID: 18391011
20. Hackstadt T, Rockey DD, Heinzen RA, Scidmore MA (1996) Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane. EMBO J 15: 964-977. PMID: 8605892
21. Su H, McClarty G, Dong F, Hatch GM, Pan ZK, Zhong G (2004) Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J Biol Chem 279: 9409-9416. PMID: 14676189
22. Wolf K, Plano GV, Fields KA (2009) A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signalling via interaction with human Act1. Cell Microbiol 11: 769-779. doi: 10.1111/j.1462-5822.2009.01290.x PMID: 19159390
23. Fan T, Lu H, Hu H, Shi L, McClarty GA, Nance DM, et al. (1998) Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187: 487-496. PMID: 9463399
24. Xiao Y, Zhong Y, Greene W, Dong F, Zhong G (2004) Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine. Infect Immun 72: 5470-5474. PMID: 15322047
25. Zhong Y, Weininger M, Pirbhai M, Dong F, Zhong G (2006) Inhibition of staurosporine-induced activation of the proapoptotic multidomain Bcl-2 proteins Bax and Bak by three invasive chlamydial species. J Infect 53: 408-414. PMID: 16490255
26. Grigoryan T, Wend P, Klaus A, Birchmeier W (2008) Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 22: 2308-2341. doi: 10.1101/gad.1686208 PMID: 18765787
27. Cadigan KM, Liu YI (2006) Wnt signaling: complexity at the surface. J Cell Sci 119: 395-402. PMID: 16443747
28. Ding Y, Xi Y, Chen T, Wang JY, Tao DL, Wu ZL, et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol 182: 865-872. doi: 10.1083/jcb.200803147 PMID: 18762581
29. Prozialeck WC, Fay MJ, Lamar PC, Pearson CA, Sigar I, Ramsey KH (2002) Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells. Infect Immun 70: 2605-2613. PMID: 11953402
30. Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116: 1175-1186. PMID: 12615961
31. Beurel E, Jope RS (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79: 173-189. PMID: 16935409
32. Gietz RD, Schiestl RH (2007) High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2: 31-34. PMID: 17401334
33. Izumi KM (2001) The yeast two-hybrid assay to identify interacting proteins. Methods Mol Biol 174: 249-258. PMID: 11357652
34. Izumi KM, Kieff ED (1997) The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. Proc Natl Acad Sci U S A 94: 12592-12597. PMID: 9356494
35. Sharma J, Zhong Y, Dong F, Piper JM, Wang G, Zhong G (2006) Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect Immun 74: 1490-1499. PMID: 16495519
36. Zhong G, Reis e Sousa C, Germain RN (1997) Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proc Natl Acad Sci U S A 94: 13856-13861. PMID: 9391117
37. Xiao Y, Zhong Y, Su H, Zhou Z, Chiao P, Zhong G (2005) NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis. J Immunol 174: 1701-1708. PMID: 15661934
38. Wang J, Zhang Y, Lu C, Lei L, Yu P, Zhong G (2010) A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J Immunol 185: 1670-1680. doi: 10.4049/jimmunol.1001240 PMID: 20581152
39. Rodgers AK, Budrys NM, Gong S, Wang J, Holden A, Schenken RS, et al. (2011) Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility. Fertil Steril 96: 715-721. doi: 10.1016/j.fertnstert.2011.06.021 PMID: 21742324
40. Bannantine J, Griffiths R, Viratyosin W, Brown W, Rockey D (2000) A secondary structure motif predictive of protein localization to the chlamydial inclusion membrane. Cell Microbiol 2: 35-47. PMID: 11207561
41. Rockey D, Scidmore M, Bannantine J, Brown W (2002) Proteins in the chlamydial inclusion membrane. Microbes Infect 4: 333-340. PMID: 11909744
42. Miao H, Jia T, Xie S, Wang X, Zhao J, Chu Y, et al. (2014) Structural Insights into the C1q Domain of Caprin-2 in Canonical Wnt Signaling. J Biol Chem Oct 20. pii: jbc.M114.591636. [Epub ahead of print].
43. Moorhead A, Jung J, Smirnov A, Kaufer S, Scidmore M (2010) Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion. Infect Immun 78: 1990-2007. doi: 10.1128/IAI.01340-09 PMID: 20231409